Tsuneya Ikezu
Oct 2, 2024; 44:e1170242024-e1170242024
Symposium

New Version reduces production costs with easily understood images and animations

On Sept. 27-28, Penn State Schuylkill hosted the 84th annual Pennsylvania Communication Association (PCA) conference for the first time, welcoming over 80 participants from more than 40 colleges. Valerie Schrader, professor of communication arts and PCA president, organized the event, with Penn State Schuylkill faculty and students presenting 17 projects. Several students and faculty received top paper and presentation awards.

Alaina G. Levine, president of Quantum Success Solutions LLC, professional speaker, STEM career coach, and author, will give the fall 2024 A. Dixon and Betty F. Johnson Lecture in Scientific Communication at 7 p.m. on Nov. 21 in 100 Thomas Building on the Penn State University Park campus. The free public lecture is open to the Penn State community.

Offices in need of digital communications assistance for the spring 2025 semester can receive support from CommAgency, Penn State’s student-run media production agency. Clients for spring 2025 should inquire by Nov. 17, 2024.

Using the EMX solver, X-FAB design engineers can efficiently develop next-generation RF technology for the latest communication standards (including sub-6GHz 5G, mmWave, UWB, etc.), which are enabling technologies for communications and electric vehicle (EV) wireless applications. (read more)

Expert: Western Public Health Authorities’ Communication Missteps in Dealing with COVID Led to Public Mistrust Expert: Western Public Health Authorities’ Communication Missteps in Dealing with COVID Led to Public Mistrust

ADB has a vacancy for the position of Senior Administration and Communications Assistant in the Strategy, Policy and Partnerships Department. The deadline for submitting applications is on 26-NOV-2024.

Quantum light is key to futuristic quantum technologies, but researchers have been creating it in the same way for 60 years – now liquid crystals offer an easier way to produce it

Thanks to artificial intelligence, understanding animals may be closer than we think. But we may not like what they are going to tell us, says RSPCA chief executive Chris Sherwood

Background:

Discharge communication between hospitalists and primary care clinicians is essential to improve care coordination, minimize adverse events, and decrease unplanned health services use. Health-related social needs are key drivers of health, and hospitalists and primary care clinicians value communicating social needs at discharge.

Solid tumors that arise in the body interact with neurons, which influences cancer progression and treatment response. Here, we discuss key questions in the field, including defining the nature of interactions between tumors and neural circuits and defining how neural signals shape the tumor microenvironment. This information will allow us to optimally target neural signaling to improve outcomes for cancer patients.

Anorectal malformations (ARMs) constitute a group of congenital defects of the gastrointestinal and urogenital systems. They affect males and females, with an estimated worldwide prevalence of 1 in 5000 live births. These malformations are clinically heterogeneous and can be part of a syndromic presentation (syndromic ARM) or as a nonsyndromic entity (nonsyndromic ARM). Despite the well-recognized heritability of nonsyndromic ARM, the genetic etiology in most patients is unknown. In this study, we describe three siblings with diverse congenital anomalies of the genitourinary system, anemia, delayed milestones, and skeletal anomalies. Genome sequencing identified a novel, paternally inherited heterozygous Caudal type Homeobox 2 (CDX2) variant (c.722A > G (p.Glu241Gly)), that was present in all three affected siblings. The variant identified in this family is absent from population databases and predicted to be damaging by most in silico pathogenicity tools. So far, only two other reports implicate variants in CDX2 with ARMs. Remarkably, the individuals described in these studies had similar clinical phenotypes and genetic alterations in CDX2. CDX2 encodes a transcription factor and is considered the master regulator of gastrointestinal development. This variant maps to the homeobox domain of the encoded protein, which is critical for interaction with DNA targets. Our finding provides a potential molecular diagnosis for this family's condition and supports the role of CDX2 in anorectal anomalies. It also highlights the clinical heterogeneity and variable penetrance of ARM predisposition variants, another well-documented phenomenon. Finally, it underscores the diagnostic utility of genomic profiling of ARMs to identify the genetic etiology of these defects.

T-lymphoblastic lymphoma (T-LLy) is the most common lymphoblastic lymphoma in children and often presents with a mediastinal mass. Lymphomatous suprarenal masses are possible but rare. Here, we discuss the case of a previously healthy 3-yr-old male who presented with mediastinal T-LLy with bilateral suprarenal masses. Following initial treatment, surgical biopsy of persisting adrenal masses revealed bilateral neuroblastoma (NBL). A clinical genetics panel for germline cancer predisposition did not identify any pathogenic variants. Combination large panel (864 genes) profiling analysis in the context of a precision oncology study revealed two novel likely pathogenic heterozygous variants: SMARCA4 c.1420-1G > T p.? and EZH2 c.1943G > C p.(Ile631Phefs*44). Somatic analysis revealed potential second hits/somatic variants in EZH2 (in the T-LLy) and a segmental loss in Chromosome 19p encompassing SMARCA4 (in the NBL). Synchronous cancers, especially at a young age, warrant genetic evaluation for cancer predisposition; enrollment in a precision oncology program assessing germline and tumor DNA can fulfill that purpose, particularly when standard first-line genetic testing is negative and in the setting of tumors that are not classic for common cancer predisposition syndromes.

Thanks to artificial intelligence, understanding animals may be closer than we think. But we may not like what they are going to tell us, says RSPCA chief executive Chris Sherwood

House Republicans on Tuesday demanded that each member of President Biden's cabinet preserve all relevant documents and communications, a move that signals future investigations into the Biden administration.

Announcement Number: TN-20-EI-00897-MP
Closing Date: 29 June 2020

Berlin ; Boston : De Gruyter Saur, [2023]

Cambridge : Open Book Publishers, [2023]

Abingdon, Oxon : Routledge, 2017.

Berlin ; Boston : De Gruyter, [2023]

A new app, Good Vibes, introduces the deaf-blind to a tactile language that could transform their lives

In August 2022 this year, Central Board of Indirect Taxes & Custom (CBIC) issued a detailed clarification on reporting of information about reversal of ITC as well as ineligible ITC

At the core of positive workplace communications is the management of employee relationships.

Making decisions is simpler with meetings and board communication. It is vital for every board to maintain transparency, a diversity of opinion and a focus on decision-making. Board members are under pressure to produce outcomes and this requires a constant flow of information between members. Luckily, technology can enhance the way we communicate. With a […]

National Bureau of Economic Research

Springer

National Bureau of Economic Research

IEEE / Institute of Electrical and Electronics Engineers Incorporated

IEEE / Institute of Electrical and Electronics Engineers Incorporated

IEEE / Institute of Electrical and Electronics Engineers Incorporated

IEEE / Institute of Electrical and Electronics Engineers Incorporated

IEEE / Institute of Electrical and Electronics Engineers Incorporated

IEEE / Institute of Electrical and Electronics Engineers Incorporated

Université Catholique de Louvain