Am vergangenen Donnerstag schoben sie sogar die Kanzlerin vor: Seit Wochen schon versucht die „Bild“-Redaktion, den Virologen der Berliner Charité Christian Drosten schlecht dastehen zu lassen. Sie bemüht sich, Drostens Autorität als Wissenschaftler zu untergraben, arbeitet genüsslich frühere Fehleinschätzungen heraus, stellt ihn als Einflüsterer dar, macht ihn zum Kollegenschwein. Damit dieses negative Bild irgendwie passt, […]

Oswin enjoying her first supervised enrichment activity. It ended when the nearby construction made a loud upsetting bang. #cat https://ift.tt/2TSjmef

This paper investigates the effect of a large negative agricultural shock, the boll weevil, on black-white inequality in the first half of the twentieth century. To do this we use complete count census data to generate a linked sample of fathers and their sons. We find that the boll weevil induced enormous labor market and social disruption as more than half of black and white fathers moved to other counties following the arrival of the weevil. The shock impacted black and white sons differently. We compare sons whose fathers initially resided in the same county and find that white sons born after the boll weevil had similar wages and schooling outcomes to white sons born prior to its arrival. In contrast, black sons born after the boll weevil had significantly higher wages and years of schooling, narrowing the black-white wage and schooling gaps. This decrease appears to have been driven by relative improvements in early life conditions and access to schooling both for sons of black fathers that migrated out of the South and sons of black fathers that stayed in the South.

The goal for remote learning during the break “is to maintain the exciting and enriching aspects that Spring Recess provides,” Schools Chancellor Richard Carranza told teachers in a Monday night email.

USC football players looking forward to pro day will not get the chance to participate in it because of the coronavirus pandemic.

Holocaust survivor Rachmil 'Ralph' Hakman spent three years at Auschwitz-Birkenau as a teen. He then spent decades teaching others about the atrocities.

Even when he was being impeached, Trump still had a job to do. Nothing justifies his failure to take early action against the coronavirus.

For actor Andrew Howard, who played Red Scare in HBO's 'Watchmen,' food is a sense-memory trigger when he prepares for a role.

ALAN TITCHMARSH, celebrated and much loved TV gardener, once revealed a genius gardening hack to ensure one of his favourite flowers will grow even better in your own home.

ALAN TITCHMARSH, TV legend and much loved gardener, once revealed his top tips to get the very best strawberries grown at home.

TOADSTOOLS are simply fascinating, scientifically speaking. The familiar caps-on-stalks are only part of a much bigger threadlike organism that lives entirely underground, sending up the familiar parasol structures to distribute their microscopic spores.

We need to educate ourselves and then trust the process the framers' included in the Constitution, a letter to the editor says.

It was clear from the beginning it was going to be totally partisan, yet the hatred for Trump drove them on, a letter to the editor says

Ciro Gomes (PDT), Kim Kataguiri (DEM), Joice Hasselmann (PSL), Alessandro Molon (PSB) e outros autores de pedidos de impeachment de Bolsonaro avaliam as chances do impedimento prosseguir no Congresso.

Did Pelosi or Trump gain the upper hand?

Pulitzer-winning editorial artists aim to find deadline satire in the televised inquiry.

Showrunner Damon Lindelof and his writers and producers have finally solved the show's biggest mystery.

The past 10 years have shown superheroes in entertainment aren't going anywhere.

Pulitzer-winning cartoonists use humor to peer behind all the political posturing.

There is no end to it.

The HBO series' most powerful superhero is no longer hiding in plain sight.

The black comics audience should be more demanding after seeing what the HBO series accomplished.

Cartoonists who have lampooned both administrations take aim differently now.

The scenes they draw include a senator seemingly falling asleep.

Myles stole the show with a towering blonde wig and shiny red mini-dress.

The actress and activist wants to encourage the public to get involved because “showing up is participating in how this all works.”

Any economic improvements aren’t helped by his actions.

strataconf: Read our initial findings of @amplab's open source benchmark for tracking large-scale Query Engines http://t.co/rGgOVeTHQ8 #strataconf

Hear about travel to Richmond, Virginia as the Amateur Traveler talks to Becky Pekora from TheGirlAndGlobe.com about her adopted hometown.

Martin R. Larsen
Jul 1, 2005; 4:873-886
Technology

19 December 2019

Qingbo Shu
Apr 1, 2020; 19:672-689
Research

Large-scale identification of N-linked intact glycopeptides by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in human serum is challenging because of the wide dynamic range of serum protein abundances, the lack of a complete serum N-glycan database and the existence of proteoforms. In this regard, a spectral library search method was presented for the identification of N-linked intact glycopeptides from N-linked glycoproteins in human serum with target-decoy and motif-specific false discovery rate (FDR) control. Serum proteins were firstly separated into low-abundance and high-abundance proteins by acetonitrile (ACN) precipitation. After digestion, the N-linked intact glycopeptides were enriched by hydrophilic interaction liquid chromatography (HILIC) and a portion of the enriched N-linked intact glycopeptides were processed by Peptide-N-Glycosidase F (PNGase F) to generate N-linked deglycopeptides. Both N-linked intact glycopeptides and deglycopeptides were analyzed by LC-MS/MS. From N-linked deglycopeptides data sets, 764 N-linked glycoproteins, 1699 N-linked glycosites and 3328 unique N-linked deglycopeptides were identified. Four types of N-linked glycosylation motifs (NXS/T/C/V, X=P) were used to recognize the N-linked deglycopeptides. The spectra of these N-linked deglycopeptides were utilized for N-linked deglycopeptides library construction and identification of N-linked intact glycopeptides. A database containing 739 N-glycan masses was constructed and utilized during spectral library search for the identification of N-linked intact glycopeptides. In total, 526 N-linked glycoproteins, 1036 N-linked glycosites, 22,677 N-linked intact glycopeptides and 738 N-glycan masses were identified under 1% FDR, representing the most in-depth serum N-glycoproteome identified by LC-MS/MS at N-linked intact glycopeptide level.

19 December 2019

by Doug O’Roark Executive Director, Math Circles of Chicago The New York Times recently published an article entitled “The Right Answer? 8,186,699,633,530,061 (An Abacus Makes It Look Almost Easy)”. Its lead photograph features over 100 children seated at desks, facing … Continue reading →

Nudge blog note: Last night’s Republican debate prompted Richard Thaler to weigh in on Rick Perry’s handling of an HPV vaccine executive order, but not the policy itself. Also, Thaler recently started tweeting. Follow him. By Richard Thaler In the Republican Presidential debate last night at the Reagan library a question emerged about Rick Perry’s [...]

The U.S. Department of Education said Texas must stop using a guideline for special education enrollment that may have led to thousands of children being denied services they were qualified to receive.

Business enterprises -- Computer networks -- Management.

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