Editing and/or saving an action column can take up to a minute to display a window. There are no workarounds identified at this time.

In SAS Customer Intelligence Studio,  when you add  Reply- node variable values in the Define Value dialog box, you might notice that two identically labeled data-grid variables are

The SAS 9.4M4 (TS1M4) Hot Fix D7G004 for ODS Templates installs national language support (NLS) content regardless of whether the languages were installed during the initial deployment. Having sparse

The divalent anion sodium symporter (DASS) family (SLC13) plays critical roles in metabolic homeostasis, influencing many processes, including fatty acid synthesis, insulin resistance, and adiposity. DASS transporters catalyze the Na+-driven concentrative uptake of Krebs cycle intermediates and sulfate into cells; disrupting their function can protect against age-related metabolic diseases and can extend lifespan. An inward-facing crystal structure and an outward-facing model of a bacterial DASS family member, VcINDY from Vibrio cholerae, predict an elevator-like transport mechanism involving a large rigid body movement of the substrate-binding site. How substrate binding influences the conformational state of VcINDY is currently unknown. Here, we probe the interaction between substrate binding and protein conformation by monitoring substrate-induced solvent accessibility changes of broadly distributed positions in VcINDY using a site-specific alkylation strategy. Our findings reveal that accessibility to all positions tested is modulated by the presence of substrates, with the majority becoming less accessible in the presence of saturating concentrations of both Na+ and succinate. We also observe separable effects of Na+ and succinate binding at several positions suggesting distinct effects of the two substrates. Furthermore, accessibility changes to a solely succinate-sensitive position suggests that substrate binding is a low-affinity, ordered process. Mapping these accessibility changes onto the structures of VcINDY suggests that Na+ binding drives the transporter into an as-yet-unidentified conformational state, involving rearrangement of the substrate-binding site–associated re-entrant hairpin loops. These findings provide insight into the mechanism of VcINDY, which is currently the only structurally characterized representative of the entire DASS family.

Deep proteome coverage in bottom-up proteomics requires peptide-level fractionation to simplify the complex peptide mixture before analysis by tandem mass spectrometry. By decreasing the number of co-eluting precursor peptide ions, fractionation effectively reduces the complexity of the sample leading to higher sample coverage and reduced bias towards high abundance precursors that are preferentially identified in data-dependent acquisition strategies. To achieve this goal, we report a bead-based off-line peptide fractionation method termed CIF or Carboxylate modified magnetic bead-based isopropanol gradient peptide fractionation. CIF is an extension of the SP3 (single-pot solid-phase-enhanced sample preparation) strategy and provides an effective but complementary approach to other commonly used fractionation methods including strong cation exchange (SCX) and reversed phase (RP)-based chromatography. We demonstrate that CIF is an effective offline separation strategy capable of increasing the depth of peptide analyte coverage both when used alone or as a second dimension of peptide fractionation in conjunction with high pH RP. These features make it ideally suited for a wide range of proteomic applications including the affinity purification of low abundance bait proteins.

With less than a week left until Angels pitchers and catchers report to Spring Training, it's time for the final Angels Inbox of the offseason.

Suboxone is a medicine prescribed to treat opioid use disorder. But in recent times, it has gained a poor reputation for contributing to severe side effects, such as dental damage and decay. Many patients have had to undergo costly dental repair surgery to treat the gum and tooth issues they faced. But the side effects […]

The post How To Cope With the Psychological Symptoms of Suboxone Withdrawal first appeared on What is Psychology?.

Estimating the direction of functional connectivity (FC) can help further elucidate complex brain function. However, the estimation of directed FC at the voxel level in fMRI data, and evaluating its performance, has yet to be done. We therefore developed a novel directed seed-based connectivity analysis (SCA) method based on normalized pairwise Granger causality that provides greater detail and accuracy over ROI-based methods. We evaluated its performance against 145 cortical retrograde tracer injections in male and female marmosets that were used as ground truth cellular connectivity on a voxel-by-voxel basis. The receiver operating characteristic (ROC) curve was calculated for each injection, and we achieved area under the ROC curve of 0.95 for undirected and 0.942 for directed SCA in the case of high cell count threshold. This indicates that SCA can reliably estimate the strong cellular connections between voxels in fMRI data. We then used our directed SCA method to analyze the human default mode network (DMN) and found that dlPFC (dorsolateral prefrontal cortex) and temporal lobe were separated from other DMN regions, forming part of the language-network that works together with the core DMN regions. We also found that the cerebellum (Crus I-II) was strongly targeted by the posterior parietal cortices and dlPFC, but reciprocal connections were not observed. Thus, the cerebellum may not be a part of, but instead a target of, the DMN and language-network. Summarily, our novel directed SCA method, visualized with a new functional flat mapping technique, opens a new paradigm for whole-brain functional analysis.

More on The Music Box: http://j.mp/KX15yK The artists behind the most eccentric place in New Orleans present their wacky homemade instruments

From the inventor's New Jersey film studio, the delight of cats doing things on film was discovered early in 1894

Legendary company designs new twists for classics with 3D CAD software

The Berks LaunchBox in partnership with Penn State Berks will host its free 3D Modeling and Printing Workshop for Manufacturing Companies from 3 to 5 p.m. on Tuesday, Nov. 12, in Reading, Pennsylvania.

The Berks LaunchBox recently announced seven recipients of the second round of the “IMAGINE Your Business” grants.

Amateur boxing champion Marley "Baby Bug" McNealy shows off her masterful skills and signature tricks with her speed bag training videos.

Penn State Brandywine’s and Penn State Berks’ LaunchBoxes, powered by Penn State, collaborated with Penn State Great Valley to hold the fall 2024 Idea TestLab Pitch Competition on Nov. 4. Six startup entrepreneurs participated in the competition, which was held at Great Valley.

The North Central Pennsylvania (NCPA) LaunchBox powered by Penn State DuBois marked a year of significant achievements in 2023-24 by fostering regional industry growth and workforce development. A key highlight of the year was the LaunchBox’s pivotal role in the North Central Pressed Materials Strategy Development Consortium, an initiative aimed at advancing the pressed material industry in central Pennsylvania.

A single woman tells what it's like to serve God in the Arabian Peninsula.

OM’s Arabian Peninsula field leader shares stories of ministry among Gulf Arabs using what he calls a "four-box" model.

The lower-end Xbox Series S has run into hardware bottlenecks in the past when it comes to new releases, and concerns have been raised about whether the console would be able to run GTA 6 without problems. Take-Two Interactive CEO Strauss Zelnick has now downplayed those concerns, saying he is “not worried” about GTA 6 performance on Xbox Series S.

Arjun Kapoor played the role of antagonist Danger Lanka in Singham Again

For Immediate Release | May 11, 2022 (Milford, DE) – Delaware Libraries invite local families to the Milford Public Library, 11 SE Front St, Milford, DE 19963, on Wednesday, May 11 at 11:00am to celebrate the arrival of a new interactive, literacy tool for children. The Toniebox, a reading device for preschoolers and elementary school […]

Over the past week, Delawareans continued to receive unsolicited packages of mysterious seeds appearing to originate in China. Due to the increased volume of people reporting the receipt of illegally shipped seeds, USDA has requested the assistance of the state departments of agriculture in collecting seeds from residents. The Delaware Department of Agriculture (DDA) has processed more than 40 packages of seeds to be tested by USDA’s Animal and Plant Health Inspection Service (APHIS).

Here Mudassar Khan has explained

Here Mudassar Khan has explained

Here Mudassar Khan has explained

Here Mudassar Khan has explained

Here Mudassar Khan has explained

The United States Department of Agriculture’s Animal and Plant Health Inspection Service (USDA-APHIS) has confirmed a find of box tree moth (BTM; Cydalima perspectalis) at a private residence in Kent County, Delaware. The box tree moth is a federally regulated pest that primarily feeds on boxwood species (Buxus spp.). If left unchecked, it causes significant damage and can potentially kill the plants. Boxwoods are a popular ornamental evergreen shrub common to many landscape environments in the United States.

Bring some 'oomph' to your audience with these simple content hacks

Read the in depth Review of Mi Box 4K Audio Video. Know detailed info about Mi Box 4K configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Microsoft Xbox One S 500GB Console White Gaming. Know detailed info about Microsoft Xbox One S 500GB Console White configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Xbox Series X Gaming. Know detailed info about Xbox Series X configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Born in a poor village, Algerian boxer Imane Khelif has overcome numerous obstacles throughout her life to win a controversial Paris Olympics gold on Friday.

Hello Community,

Is there any simple way how i can get the coordinates of all the shapes in a layout view?

Currently i'm flattening the layout, getting all the lpps from CV and using setof to get all the shapes of a layer and looping through them to get the coordinates.

Is there a way to do it without having to flatten the layout view and shapes merged or any other elegant way to do it if we flatten it?

Also, dbWriteSkill doesn't give output how i desired

Thanks,

Shankar

I'm trying to use Jasper for checking parameter propagation in a large design. I have a list of top-level parameters, each with a HDL path of a module parameter somewhere lower in the hierarchy that's supposed to receive its value from the top-level module. The FPV app seems like an excellent tool for this, but elaborating the entire design in it is extremely time-consuming and memory-intensive. So, I'm trying to black-box everything but the interesting HDL paths. I thought using `elaborate -top dut_module_name -bbox_i * -no_bbox_i inst_foo -no_bbox_i inst_bar (...)` would work, but it doesn't. Jasper just starts flooding the log with warnings from modules that are definitely not on the whitebox list, and eventually dies due to insufficient memory. When I use -bbox_m * it correctly elaborates the top-level module with all of its sub-modules black-boxed. But then the -no_bbox_i switches have no effect. Could anyone suggest a working solution for this use case?

Xbox Game Pass Ultimate gives gamers access to hundreds of games, exclusive deals, and more. Three-month stackable memberships are on sale for £28.35.

Save 10% on the the Microsoft Xbox Series X at Walmart.

In a tragic incident in Rawalpindi’s Shah Khalid Colony, three siblings, 2-year-old Zohan, 6-year-old Saira, and 7-year-old Faria, lost their lives after being confined in a box. The children were left alone at home, intensifying the sorrow of the situation. According to reports from a Rescue spokesperson, the parents, who were employed in different jobs—the ... Read more

The post Tragedy Strikes as Three Siblings Found Dead Locked in Box appeared first on Pakistan Tribune.

A new book from the science-writing legend is an Attenborough-esque romp through some of the wonders of the natural world. Just beware the title's misfiring metaphor

Extract

Living with a respiratory illness requires patients to manage a wide range of symptoms, many of which will worsen as a disease progresses. Breathlessness is a hallmark feature of respiratory conditions, occurring in almost all individuals with COPD and interstitial lung disease (ILD) [1, 2]. Cough is present in 78% of people with ILD and is frequently distressing, with physical, social and emotional impacts [1, 3].

Chris plays real life PC building simulator. Kelley is shocked there's a bug in the Switch version. Josh has a heart episode while retrieving a necktie. And we all learn what true chicken love is.

The post RPG Cast – Episode 747: “Cute Little Cow Boxes” appeared first on RPGamer.

Take-Two CEO Strauss Zelnick in the company's latest earnings report said he isn't worried about Rockstar getting Grand Theft Auto VI to run on the Xbox Series S.

"Look, we support the platforms where the consumers are for as long as they’re there, and we find a way to support platforms despite different levels of tech," said Zelnick (via VideoGamesChronicle) when asked about the Xbox Series S.

Zelnick added, "Our labels are really good at that. I’m not really worried. I’ve never worried about where hardware was going. And I’ve said this many times over the years because, first of all, I don’t worry about things over which I have zero control.

"Secondly, I believe in the audience. The audience is going to show up if you have great properties, and so we just have to make sure to be on an array of platforms."

Zelnick added PC is an important platform to release games on, despite the fact Grand Theft Auto VI has not been announced for PC.

"If one platform diminishes in value, there’s always another one," he said. "So we’re seeing great growth in PC right now, for example. And I have been able to view that open formats would continue to grow. PC is an open format.

"I do think PC will continue to be a more and more important part of the console business going forward, and that isn’t complicated for us to support at all. So the bottom line is we are selective about which platforms we support. We make the tech work when we can make it work as long as the audience is big enough to make that worthwhile."

Grand Theft Auto VI will launch for the PlayStation 5 and Xbox Series X|S in Fall 2025.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463023/take-two-ceo-is-not-worried-about-grand-theft-auto-vi-performance-on-xbox-series-s/

Here we see data representing the sales through to consumers and change in sales performance of the three current platforms (PlayStation 5, Xbox Series X|S, and Nintendo Switch) and two legacy platforms (PlayStation 4 and Xbox One) over comparable periods for 2021, 2022, 2023, and 2024. Also shown is the market share for each of the consoles over the same periods.

Year to Date Sales Comparison (Same Periods Covered)

Market Share (Same Periods Covered)

2021 – (January 2021 to October 2021)

2022 – (January 2022 to October 2022)

2023 – (January 2023 to October 2023)

2024 – (January 2024 to October 2024)

"Year to date" sales for 2021, 2022, 2023, and 2024 sales are shown in series at the top of the table and then just below a comparison of 2024 versus 2023 and 2024 versus 2022 is displayed.  This provides an easy-to-view summary of all the data.

Total Sales and Market Share for Each Year

Microsoft

• Xbox Series X|S
• 0.09 million units sold year-to-date
• Down year-on-year 0.03 million units (-23.2%)

Nintendo

• Nintendo Switch
• 2.47 million units sold year-to-date
• Down year-on-year 0.75 million units (-23.4%)

Sony

• PlayStation 5
• 1.16 million units sold year-to-date
• Down year-on-year 0.94 million units (-44.9%)
• PlayStation 4
• 0.01 million units sold year-to-date
• Down year-on-year 0.05 million (-77.2%)

Note: VGChartz 2024 estimates through October includes 44 weeks, while 2023, 2022, and 2021 estimates includes 43 weeks.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463009/ps5-vs-xbox-series-xs-vs-switch-2024-japan-sales-comparison-charts-through-october/

Microsoft and several retailers are currently running a promotion for the standard Xbox Series X in the US.

The Xbox Series X is available for $449, a $50 discount, at the Microsoft Store, GameStop, and Best Buy. It isn't known when this deal will end.

The recently released 1 TB All-Digital Robot White Xbox Series X, 2TB Disc Drive Galaxy Black Xbox Series, and the two Xbox Series S SKUs have not been discounted at this time.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463036/xbox-series-x-discounted-by-50-to-449/

Following a tease, Microsoft and Activision Blizzard have announced Spyro Reignited Trilogy will release for Xbox Game Pass tomorrow, November 12.

VGChartz staff gave Spyro Reignited Trilogy an 8 out of 10 and stated, "it was wise to steer away from marketing the collection as a remaster because that label undercuts the developers’ level of dedication and investment in revitalizing these games."

Read details on the trilogy below:

Remade from the ground up, the Spyro Reignited Trilogy features all three of the original games that started it all – Spyro the Dragon, Spyro 2: Ripto’s Rage, and Spyro: Year of the Dragon, amazing for the original fans and new players alike.

Spyro the Dragon

Our new favorite little purple dragon starts on a quest to rescue his dragon friends who have been turned into crystal by the villain Gnasty Gnorc (what an unfortunate and yet apt name!). Spyro explores vibrant Dragon Realms, collects gems, and flambés his enemies, all while learning to how breathe fire and glide.

Spyro 2: Ripto’s Rage!

Spyro finds himself in the magical land of Avalar where he is trying to save the realm from the evil sorcerer Ripto and his minions. Along the way, he befriends new entirely new allies, overcomes challenges, complete tasks, and unlocks even more powers to take down Ripto and restore peace.

Spyro: Year of the Dragon

In Spyro: Year of the Dragon, Spyro finds out that the Dragon Eggs have been stolen by the devious Sorceress, sending him on a new mission to recover the eggs and save the dragon population. Our favorite purple dragon meets new friends, learns new abilities, all while exploring more vibrant realms with challenges (and treasures!).

Xbox players have been able to explore the Dragon Realms with Spyro since 2018 with the release of the Reignited Trilogy, and now we’re excited to invite our community to jump into these incredible adventures once again and relive the fun and nostalgia that only Spyro can bring.

Available on Game Pass Standard, Game Pass Ultimate, and PC Game Pass, for cloud, console and PC, it’s sure to ignite some serious fun. Let’s go save the Dragon Realms!

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463034/spyro-reignited-trilogy-headed-to-xbox-game-pass-tomorrow-november-12/

Publisher Kasedo Games and developer Beard Envy have announced he roguelite spaceship repair simulation game, Uncle Chop's Rocket Shop, has been delayed to December 5. It will launch for the PlayStation 5, Xbox Series X|S, Nintendo Switch, and PC via Steam and Epic Games Store.

View the release date trailer below:

Read details on the game below:

Come on down to Uncle Chop’s Rocket Shop, for all your roguelite spaceship repair simulation needs! Wake up, clock in, fix ships, make friends and enemies, pay R.E.N.T., upgrade your workshop, ponder the futility of your existence, go to bed and then do it all over again the next day.

On an asteroid-bound service station in an unfrequented space lane, Wilbur carves out a paltry living as a mechanic, repairing as many ships as he can to afford the ever-rising R.E.N.T payments to his corporate overlord, Uncle Chop. Where most of his customers find meaning in pastimes like worshipping deranged space gods, feeding random crap to a sentient black hole, endlessly digging for The Treasure™ or mentally enslaving donut shop workers, Wilbur lives a more humble life, fixing the galaxy’s ills one broken ship module at a time.

Fix Stuff

Using a range of tools, diagnostic devices, parts and workshop appliances, you’ll be correcting faults in the modules of procedurally generated spaceships. From simple refuel jobs to total overhauls, get ready to frantically fumble, slice, loosen, tighten, grab and drop as you try to complete as many jobs as you can within each daily time limit. With a huge variety of ships and modules, your hands are gonna get real dirty real fast, in some real unusual places.

Read Stuff

Flaunt your basic literacy by consulting manual pages for guidance on diagnosing and correcting faults in spaceship modules, as well as operating workshop appliances. And if basic literacy isn’t your bag, then at least you’ve got pretty diagrams to gawp at! All your IKEA furniture-assembly training has led to this moment.

Upgrade Stuff

Using whatever hard-earned pennies Uncle Chop doesn’t take from you, expand your workshop and kit it out with a range of workstations. From industrial devices to esoteric altars, these workstations will allow you to fix bigger and more lucrative ships.

Talk About Stuff

Interact with a diverse range of oddballs as you engage with both anthology-style storytelling and a multiple-ending, overarching narrative. The lore is (*consults notes*) “deep and rich and good,” with different factions you can choose to ingratiate yourself with – each with their own inane agendas.

Discover Stuff

Narrative and random events, hidden puzzles and upgrades, secret lore—we got all that goodness that ensures each day and gameplay run will feel substantially different from the last.

Do All That Stuff Again, But Better

Meeting those escalating R.E.N.T payments ain’t gonna be easy, but chin up, champ – certain station upgrades will persist across gameplay runs, making life a little more tolerable every time around. You’ll also get faster and smarter the more you do the thing, so keep doing the thing!

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463037/uncle-chops-rocket-shop-releases-december-5-for-ps5-xbox-series-xs-switch-and-pc/