Product Info: Developer: Goonswarm Publisher: Black Tower Website: Sin Slayers Twitter: @sinslayersgame

Here we go…the latest episode of This Week On Xbox. Remember, you can watch This Week On Xbox from the Community section of the Xbox One dashboard in Canada, the UK and the US or watch it on the Xbox YouTube channel (This Week on Xbox Playlist). Leave a comment below or hit me up on Twitter and let me know […]

The prime minister has refused to go head-to-head with Ed Miliband – and the multi-party debate we are getting will be a 90-minute cry for help on behalf of the democratic system

Last week, Germany chose its entry for this year’s Eurovision: Heart of Stone, performed by Andreas Kümmert, former winner of the German version of The Voice (which is known as The Voice of Germany in its native country, rather than Die Stimme von Deutschland. Presumably the producers didn’t want to put viewers off by making it sound too German).

After wailing his guts out and winning the public vote, Kümmert abruptly announced, on live TV, that he didn’t actually want to “do” Eurovision after all, and awarded his “prize” to the runner-up instead. A chorus of boos broke out. German boos. Buhen.

Glenn, a former boxer and owner of popular Times Square bar Jimmy's Corner, died of coronavirus early Thursday morning at 89.

We sat down with the founder and owner of Nicolai Bikes to talk about the past, present, and future.
( Photos: 17, Comments: 92 )

Inspired by the iconic Drag Race "unboxing," Shangela takes an audio quiz on unboxing videos found on YouTube.

The Kings look dominant in the 2-1 win over the Pittsburgh Penguins.

He’s teaching a class on how to be a good guy.

Glenn, a former boxer and owner of popular Times Square bar Jimmy's Corner, died of coronavirus early Thursday morning at 89.

Glenn, a former boxer and owner of popular Times Square bar Jimmy's Corner, died of coronavirus early Thursday morning at 89.

Roger Mayweather, uncle and trainer to Floyd Mayweather Jr. who won 59 career bouts, died Tuesday at age 58.

These are unprecedented times for farmers, accustomed to selling produce to restaurants. Many have shifted to CSA boxes and other methods to cope

Are you looking in to buying an Android TV Box and you don't know where to begin? Maybe you already have one but you have questions on how to set it up and install the best apps.

The post Android TV Boxes: The Ultimate Guide appeared first on Kodi Tips.

Evander Holyfield has confirmed he is coming out of retirement.

Boxing news - Express Sport brings you the latest ongoings in the boxing world, including updates on Anthony Joshua, Mike Tyson and more.

A since deleted video by Jimmy Kimmel alleges that Vice President Mike Pence delivered empty boxes of personal protective equipment.

Now is the time to stay at home and allow us to bring much needed supplies to your front door.

Jimmy Kimmel tweeted and deleted a video clip that purportedly showed Vice President Mike Pence delivering empty PPE boxes to a health care center

Here's what we know about a Jimmy Kimmel video clip supposedly showing Mike Pence delivering empty PPE boxes.

• Business Insider surveyed enterprise technology companies to determine who's still hiring amid the coronavirus pandemic.
• Companies like Amazon Web Services, Slack, Okta, Box, and Zoom are actively hiring, while others like Microsoft, Google, and SAP have slowed hiring to prioritize recruiting in key areas.
• Below is a list of 19 enterprise tech companies that are hiring, and the types of roles they are trying to fill.
• Visit Business Insider's homepage for more stories.

As companies across industries slow or stop hiring amid the public health and economic crisis caused by the coronavirus, Business Insider surveyed enterprise technology companies to find out who is still hiring, and the types of roles they're trying to fill.

The results include companies actively hiring — such as Amazon Web Services, Slack, Okta, Box, and Zoom — while others like Microsoft, Google, and SAP have slowed hiring to prioritize recruiting in key areas.

Responses come directly from companies, but be aware that hiring alone may not paint a complete picture of what's going on at each one. VMware, for example, told Business Insider that it's hiring, particularly in a few key areas related to its cloud business — but also told employees in an internal memo that it was freezing all salaries.

Oracle, Nvidia, and Palo Alto Networks declined to comment on whether they are still hiring. Workday, Adobe, IBM, Cisco, Stripe, Qualcomm and HP did not reply to requests for more information.

Here are 19 enterprise companies still hiring in some form amid the pandemic, and what they're looking for:

Amazon Web Services is actively hiring, with no hiring freezes in place, the company says. Amazon at large has more than 20,000 job postings in US corporate roles.

Slack is "actively hiring," in a range of positions including engineers, data scientists, designers and customer experience experts, a spokesperson told Business Insider.

The company has moved to a virtual hiring process – all interviews are conducted over video and onboarding happens remotely.

Slack has 213 open positions listed on its website at the time of this writing.

Box is "currently hiring," a spokesperson said, across roles in engineering, sales, marketing, customer success, finance, compliance, business operations, product and product design.

Box's website listed 76 open jobs at the time of this writing.

In additional to moving interviews online, the company has introduced new practices like virtual coffee chats with candidates and videos from employees to learn more about Box's culture. For new hires, the company has switched start dates to once per month and started a buddy system to help with onboarding.

Zoom is hiring across the US and internationally for positions including in sales, engineering, legal, and security.

"We did have an extremely ambitious hiring goal already for this year," Lynne Oldham, Zoom's chief people officer, recently told Business Insider. "So where we're seeing additional need is around the places that we touch the customer."

The company had 81 open positions listed on its website as of this writing.

DocuSign "has moved forward with its hiring as previously planned," a spokesperson said, and is hiring in roles across customer services, sales and business development, engineering and IT, marketing, finance, legal, and workplace teams.

The company is also continuing its internship program virtually and plans to bring on more than 100 interns this summer.

DocuSign had 338 positions listed on its careers website as of this writing.

Dell-owned VMware is still hiring, a spokesperson said, and has "hundreds of open roles across R&D, IT, sales, customer services and support, marketing, finance, HR, legal, and business administration."

But the company is also freezing salaries and suspending retirement matching, according to a memo obtained by Business Insider. A spokesperson confirmed that "there have been a number of cost management changes impacting the VMware workforce."

VMware interviews take place virtually.

Microsoft has frozen hiring for some roles, citing uncertainty related to the coronavirus crisis.

"We continue to seek industry-leading talent in a range of disciplines as we continue to invest in certain strategic areas," a Microsoft spokesperson told Business Insider last month. "However, in light of the uncertainties presented by COVID-19, we are temporarily pausing recruitment for other roles."

Microsoft declined to provide more information about for which positions it's still hiring, and which roles are seeing a pause in hiring.

Microsoft's subsidiaries include LinkedIn and GitHub.

German software giant SAP is still hiring in essential areas, but has pledged to reduce hiring and discretionary spending as "precautionary measures" during the pandemic.

The company "will continue to hire carefully selected people into roles that will rapidly contribute to our competitive edge,"a spokesperson said, which it said include in "essential areas" such as innovation, and research and development. 

SAP said its candidate selection has remained the same, but the interviews are conducted virtually. New hires are onboarded virtually and sent SAP-issued equipment to their private addresses so they don't have to go to the office.

Google is slowing down hiring for the remainder of the year, CEO Sundar Pichai told the company in an email seen by Business insider.

Pichai said the company is enacting a hiring freeze on all but a select few "strategic areas" for the remainder of 2020. He wrote in the email that the company needed to "carefully prioritize" recruiting employees to serve its "greatest user and business needs."

Dell Technologies is not "hiring broadly," but subsidiary companies like VMware and Secureworks still are, a Dell spokesperson told Business Insider.

Dell Technologies is still continuing its early-in-career programs and summer internships, although they've become remote. 

"We are constantly evolving our hiring strategy based on business needs," the spokesperson said.

Okta is still actively hiring, Okta's chief people officer Kristina Johnson confirmed to Business Insider.

"We're continuously evaluating what we need as a business during this time, listening to customers, and tailoring our hiring plans to meet those needs," Johnson said. "Okta is in a unique position during this uncertain time in that we had the right infrastructure in place from the get-go to make remote work and remote on-boarding fairly routine."

Okta's main hiring focus areas are in customer service, engineering, and sales, Johnson said. 

Dropbox has temporarily halted its recruiting efforts to figure out the process for onboarding people remotely.

"What we actually ended up doing was we took a pause to just take stock of our onboarding and our approach to onboarding because we wanted to make sure that we weren't bringing people on and that they actually weren't effectively able to onboard," Dropbox COO Olivia Nottebohm told Business Insider.

It's still hiring but has slowed down, only hiring for targeted roles, meaning it's up to managers to hire for key, business critical roles.

"We're trying to just be prudent and nd not get ahead of ourselves given the macro environment that we're in, but we are moving forward to hiring targeted roles," Nottebohm said.

While Dropbox plans to honor pending offers and ongoing interview processes, interviews for new applicants have been put on hold. The college internship program will also take place in the summer remotely.

"Fully remote recruiting and onboarding into a new company comes with unique challenges — bringing new hires into Dropbox takes a great deal of collaboration between many teams, including hiring managers, learning and development, IT, benefits, and recruiting," a Dropbox spokesperson told Business Insider.  

"In order to ensure we're onboarding new hires effectively and managing the strain on these teams during the shelter-in-place orders in effect across the globe, we've paused recruiting efforts temporarily," the spokesperson added.  

In April, ServiceNow promised not to lay off any of its 11,000 employees and also said it plans to keep hiring worldwide this year.

"With this new no layoffs pledge for its 11,000-plus global workforce, ServiceNow continues to take a leading role in how technology companies are responding to this health crisis by helping its own employees and customers get through these challenging and uncertain times," Shane Driggers, vice president of Global Talent Acquisition at ServiceNow, said in a statement to Business Insider.

The company expects to create and fill more than 1,000 new jobs in the US and more worldwide by the end of the year, Driggers says.

"We are leaning into hiring for engineering and sales roles as well as other functions across the business," Driggers said.

Splunk is still hiring for a number of positions across the organization, a spokesperson told Business Insider. Open roles include positions in engineering, sales, finance, accounting, and information technology.

Square is still hiring and focusing on roles like software engineering, data science, product design, sales, marketing, operations, and finance, a spokesperson told Business Insider.

"We are continuing to hire in the US and internationally, focusing on roles that we believe will be the most important to our customers and our business in the coming months," a Square spokesperson said. 

Currently, Square has over 100 open roles. 

Twilio is still hiring across the board and not slowing down, a company spokesperson told Business Insider. There are still open roles in engineering, services, sales, product, and more.

Intel has slowed down external hiring, a spokesperson said. "We have slowed external hiring, but we currently have approximately 1000 open positions that we are actively hiring for."

Atlassian is still hiring across the board, a spokesperson confirmed. This past March was its strongest month of hiring in its history, the company said, as it brought on about 200 new hires. At the end of March, Atlassian had 4,457 employees.

Zendesk is still hiring roles that are "key to our business," but "deprioritizing" the ones that are not as critical.

Zendesk is still hiring roles that are "key to our business," but "deprioritizing" the ones that are not as critical, a Zendesk spokesperson said.

"In response to the global COVID-19 pandemic, Zendesk has been focused on helping our employees, customers, and community at large navigate their immediate needs and plan for the future in this new world," the spokesperson told Business Insider.

The spokesperson said that Zendesk is continuously looking at how to manage its operations to become more efficient and productive, while minimizing disruption to customers. 

"This is standard for all businesses that are looking at their immediate and long-term strategies in order to position themselves for growth," the spokesperson said. "We believe in the strength of our business and our employees, and the resiliency of our customer base, and are in a good position to weather this crisis and emerge as a better, stronger company."

If you are using PayPal as the main payment gateway on your website, you may be wondering how you can complete a test transaction to ensure the payment process is running smoothly. In this tutorial, we will look at how you can use PayPal’s ‘test‘ mode known as Sandbox to complete test transactions with a […]

The post PayPal Test Cards (Sandbox Testing) appeared first on Tips and Tricks HQ.

strataconf: RT @bostontweetup: WEDS 6PM #BostonHealth7 hosted by @bostonpainpoint @mrkrieger @health_box @strataconf http://t.co/U6tj1uLR2Q @kalyankalwa

Hollywood has set its sight on file hosters like Hotfile.com, which was sued this week by the MPAA’s member studios. Many of the legal arguments made against Hotfile could also easily be applied to RapidShare, Megaupload and even cloud-based backup and file synching services like Dropbox. Continue reading on NewTeeVee.com.

The LockPickingLawyer easily opens this Yale Y500 Combination Key Access padlock with just a sliver of aluminum from a soda can.

Read the rest

The "transient bazaar" known as Lost Horizon Night Market is a covert operation. Worlds are imagined and then built inside the blank canvasses of empty box trucks. For the event, all the "proprietors," and their appointed box trucks, convene in an unsanctioned, though discreet, location. This location is disclosed to would-be "shoppers" via text just a few hours before it starts. Word of the market generally spreads rapidly but not publicly, definitely not by social media. If you're lucky enough to hear about it, you should go.

So, Happy Mutants, this is your heads up. Lost Horizon Night Market: Quarantine Edition is happening Saturday, May 9, from 6:59p EST until 11:59p EST, "rain or shine." This one is a little different, as the spaces are virtual, not in actual, physical trucks. I got a sneak peek yesterday of what's been created and can't wait to dive in deeper. Admission is free, though tips are appreciated. RSVP here.

Previously: Secret box truck 'night market' pops up again in NYC Read the rest

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

Muthu Alagappan explains how topology and analytics are bringing a new look to basketball.

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

Host Matt Egan is joined by Online Editor at Techworld.com Scott Carey to break down Microsoft's mega acquisition of LinkedIn. Staff Writer at PC Advisor Chris joins in to discuss all of the news coming out of E3 and how Xbox and Playstation are set to battle it out again this summer, or will Nintendo and Zelda steal the show? (13:00). Finally, David Price comes on to talk about all of the news coming out of Apple's WWDC developer conference this week, from Hair Force One to watchOS, tvOS, macOS and iOS (26:30) And please do share, rate and review the UK Tech Weekly Podcast.  

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Happy New Year from the UK Tech Weekly Podcast!

We are back this week to discuss what we have been watching (or not watching) over the festive period, including Scott Carey on the meme-marketed sensation of Bird Box and what this says about Netflix's ability to dominate the cultural conversation. Then Tamlin Magee jumps in to talk about the interactive Black Mirror movie Bandersnatch and why it may have been destined to fail.

Lastly David Price steps out of the hosting chair to talk about bendy iPads and Apple's strange rhetoric.

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1 March 2007 , Number 6

The minister paused, leaned forward and fiddled with his cufflinks, ‘It wasn’t about whether the election was rigged or not,’ he said. ‘The truth is, everybody rigged it. We just rigged it better than them.’ Does the next Nigerian presidential election in April promise anything different?

Rays beat reporter Juan Toribio answers fans' questions.

Do you think the Giants are just waiting around and could go after Bryce Harper for a big splash? Beat reporter Maria Guardado answers this question and more from fans.

Reporter Mark Bowman addresses the Braves' offseason as a whole, as well as identifying a Minor League who has a chance at making the club out of Spring Training.

Beat reporter Mark Sheldon answers questions about David Bell's managing style, free agents and who will play center field.

Hi Steve, wondering if this is a rebuild year?

With Greg Holland now signed, will he be the closer or is that still going to be Archie Bradley? Beat reporter Steve Gilbert answers this question and more from fans as Spring Training approaches.

FOUR MORE applicants are vying to provide mobile payment services in various formats, including one applicant seeking to use phone credit as a cash equivalent, but successful applicants will fall under a new framework the regulator calls its “...

Monique Bowley, shared this recipe on Foodie Tuesday, a weekly segment on ABC Radio Melbourne's Drive program at 3.30pm.

You have mail! Inoreader now allows you to subscribe to Email Newsletters just as regular RSS feeds. By creating a…

This paper presents a new open source Python framework for causal discovery from observational data and domain background knowledge, aimed at causal graph and causal mechanism modeling. The cdt package implements an end-to-end approach, recovering the direct dependencies (the skeleton of the causal graph) and the causal relationships between variables. It includes algorithms from the `Bnlearn' and `Pcalg' packages, together with algorithms for pairwise causal discovery such as ANM.