Genomic analysis of a patient's tumor is the cornerstone of precision oncology, but it does not address whether metastases should be treated differently. Here we tested whether comparative single-cell RNA sequencing (scRNA-seq) of a primary small intestinal neuroendocrine tumor to a matched liver metastasis could guide the treatment of a patient's metastatic disease. Following surgery, the patient was put on maintenance treatment with a somatostatin analog. However, the scRNA-seq analysis revealed that the neuroendocrine epithelial cells in the liver metastasis were less differentiated and expressed relatively little SSTR2, the predominant somatostatin receptor. There were also differences in the tumor microenvironments. RNA expression of vascular endothelial growth factors was higher in the primary tumor cells, reflected by an increased number of endothelial cells. Interestingly, vascular expression of the major VEGF receptors was considerably higher in the liver metastasis, indicating that the metastatic vasculature may be primed for expansion and susceptible to treatment with angiogenesis inhibitors. The patient eventually progressed on Sandostatin, and although consideration was given to adding an angiogenesis inhibitor to her regimen, her disease progression involved non-liver metastases that had not been characterized. Although in this specific case comparative scRNA-seq did not alter treatment, its potential to help guide therapy of metastatic disease was clearly demonstrated.

BACKGROUND AND PURPOSE:

Conventional nonadhesive liquid embolic agents currently are the criterion standard for endovascular embolization of cerebral AVMs. However, inadequate distal penetration into the nidus and unstable proximal plug formation are the major limitations of this approach and of the currently available embolic materials. The aim of this study was to evaluate the hypothetic efficacy of combining liquid embolic agents with different properties and viscosities for use in endovascular embolization of cerebral AVMs.

Live streaming isn’t a trend; it’s fast becoming the dominant form of communication in the connected age. In fact, 78% of online audiences are already […]

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वैश्विक महामारी कोरोना वायरस से निपटने के लिए लगाया गया लॉकडाउन जारी है। आज लॉकडाउन 3.0 का छठा दिन है। वहीं, देशभर में संक्रमित मरीजों की संख्या में लगातार बढ़ोतरी हो रही है

A sci-fi collection explores extreme corporate futures, such as a Tinder-run city where you can swipe left or right for everything from sex to teachers

देश के साथ-साथ उत्तर प्रदेश में भी कोरोना संक्रमितों की संख्या में इजाफा होता जा रहा है।

दिल्ली में कोरोना वायरस के बढ़ते प्रकोप के कारण हरियाणा और उत्तर प्रदेश सरकार ने अपनी सीमाओं पर सख्ती बढ़ा दी है। लॉकडाउन के दौरान दिल्ली से सटे गुरुग्राम, नोएडा और गाजियाबाद के बॉर्डर को सील कर दिया गया है।

On bank holiday... Friday. For NHS charities.

It delivers almost all the functionality Apple promised, with a steep Apple-like price tag to match.

Chelsea news and gossip is coming in thick and fast so Express Sport is on hand to bring you all the very latest from Stamford Bridge.

Liverpool are looking to make Sadio Mane an offer that would tarnish Real Madrid's hopes of signing him.

Jurgen Klopp never got to manage Steven Gerrard at Liverpool but the pair still have a strong relationship given their connections to the club.

The summer transfer window is nearly upon us as Manchester United, Chelsea, Liverpool, Arsenal and the rest of the Premier League look to strengthen for whenever the new season starts. Express Sport brings you the latest updates throughout the day.

A military exercise in Australia demonstrates how small drones can airdrop critical medical supplies to soldiers in combat

DJ D-Nice, Miley Cyrus, Ben Gibbard, and a lot of Diplo.

Today, Microsoft and Ebb Studios revealed that Xbox Series X would be getting the launch exclusivity for Scorn

Epic Games has issued a warning ahead of the Party Royale event, but it might not be the only problem facing players this evening.

Anna Marie is pleading with Square Enix to make a game based on their latest video. Chris is developing non-wearable pants. But Manny has the...

Keep up to date with all the latest coronavirus news from Glasgow, Scotland and beyond - LIVE

दिल्ली में कोरोना वायरस के चलते हुए लॉकडाउन के तीसरे चरण का आज छठा दिन है। हालांकि अब भी दिल्ली में पॉजिटिव केसों की संख्या कम नहीं हो रही है।

Platform sandals meet 40-denier tights as rock’n’roll goes bourgeois at Paris fashion week

At his Celine catwalk show on Friday night, the designer Hedi Slimane distilled what looks to be the most compelling trend of this season of fashion shows. Working title: rock’n’roll bourgeois.

Slim knee-length dresses were worn with slinky chain belts; towering platform sandals with sensible 40-denier semi-sheer tights; slim bootcut velvet trousers worn with Princess-line above-the-knee coats. This was a masterclass in Parisian allure: take one part Avenue Montaigne privilege, and mix with one part backstage pass. Shaken, not stirred.

The novel coronavirus pandemic has now killed more than 275,000 people worldwide. Over 3.9 million people across the world have been diagnosed with COVID-19, the disease caused by the new respiratory virus, according to data compiled by the Center for Systems Science and Engineering at Johns Hopkins University. The actual numbers are believed to be much higher due to testing shortages, many unreported cases and suspicions that some governments are hiding the scope of their nations' outbreaks.

Football is back. It returned on a warm, cloudless Friday night in Jeonju, South Korea, a mid-sized city about 200 kilometres directly south of Seoul. The United States beat Mexico here ...

Parasites are a huge global treat to human life, but some of them could actually help us treat disease. Parasitologist Charlotte Evans explores the secret lives of these frightening organisms.

A number of studies have found a link between air pollution and increased covid-19 deaths, but it isn't clear why. Both attack the lungs, but it could just be that more people live in polluted areas

Host Aziz Ansari touched upon the Women's Marches, racism and immigration in his monologue.

Alec Baldwin also returned to the 'SNL' stage as Donald Trump in the cold open.

Alf Ingve Berntsen, who worked with the teenage striker at Byrne FK, believes a heavyweight European outfit should already have signed the Norwegian

The former Reds midfielder has saluted the efforts of a team that could have regressed again after missing out on the Premier League crown in 2019

The Rossoneri icon has sought to talk up the importance of defenders in any ambitious side, with those at Anfield having found one of real “quality”

The Netherlands international has become a talismanic presence for club country, but the commanding centre-half believes there is more to come

UFC returns to action this weekend with an action-packed card of action from Florida.The mixed martial arts organisation comes back after a coronavirus-enforced hiatus on Saturday night in Jacksonville with a 11-fight bill headlined by Tony Ferguson’s clash against Justin Gaethje for the interim lightweight title.

Damien Comolli, who took the England international to Anfield, saw the Reds enter into transfer talks with the Cottagers during the summer of 2012

LIVERPOOL midfielder Georginio Wijnaldum will be pivotal for Jurgen Klopp at Manchester City..

Club captain Jordan Henderson, summer signing Naby Keita and centre back Joe Gomez were all absent for the shock midweek Champions League defeat to Red Star Belgrade..

Liverpool already have one song synonymous with the club but they did attempt to officially do likewise with another. The Reds tried to trademark 'Allez Allez Allez'..

Approved organisations will now be able to receive funds directly...

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On Sunday, the iForIndia concert hosted by Karan Johar and...

The post iForIndia Becomes World’s Biggest Live Fundraiser On Facebook Raising ₹52 Crores appeared first on Man's World India.

The real house from ‘The Conjuring’ movie set to be...

The post The Real House From ‘The Conjuring’ To Be Live-Streamed For A Week appeared first on Man's World India.

PIERS MORGAN launched another blistering attack on Boris Johnson, accusing the prime minister of encouraging the public to break the lockdown through "absurdly reckless" leaks to the media.

THE UK reached a grim milestone today as the total number of coronavirus deaths is believed to have surpassed 36,000.

Past public health crises inspired innovations in infrastructure, education, fundraising and civic debate

Congratulations to first-time mother Echo the cheetah!

The two-day virtual event will bring scientists and many other experts to highlight success stories in conservation

The ongoing COVID-19 outbreak in La Loche is being attributed to citizens who've ignored physical distancing measures.

Justin Bieber and his wife Hailey Baldwin are opening up in an intimate series for Facebook Watch in which they discuss their marriage, their problems and their lives together.

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