Discover the 10 things that you should never do on a cruise ship balcony. Some of them are rules from the cruise line, which if you break you could find yourself thrown off your cruising vacation (or even banned by the cruise line for life!). Some are things that will make your and the other cruisers around you have a more enjoyable cruise. And some even could save you a lot of embarrassment....

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Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 60+ cruises.

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What are the things you should never do in your cruise cabin and stateroom? I explore the 11 big things that you should never do and why. Some of these are about being respectful of the crew and other passengers, but some could get you into trouble and even have you disembarked from the cruise. Are you guilty of any of these?

SUPPORT THE CHANNEL BY:
Buying my Cruise T-shirts: http://bit.ly/TFTStoreBooking your next cruise with CRUISEDIRECT.COM: http://bit.ly/TFTBookCruise

Gary Bembridge's Tips For Travellers aims to help you make more of your precious travel time and money on land and when cruising the oceans or rivers of the world. To help you, in every video I draw on my first-hand tips and advice from travelling every month for over 20 years and 74 cruises at time of recording.

Follow Tips For Travellers on:
Instagram: http://www.instagram.com/garybembridge

Facebook: http://www.facebook.com/tipsfortravellers

Twitter: http://www.twitter.com/garybembridge

Envivio announces that Atyaf Telecommunications and Infrastructure International has selected Envivio Muse software-based encoding solutions to power its live and on-demand TV Everywhere services. Atyaf is a leading IPTV service provider for the Middle East region, based in Bahrain.

The recently launched over-the-top multi-screen service delivers more than 130 channels in multiple adaptive bit-rate profiles for delivery to connected TV sets, PCs, Android and Apple iOS devices. In the new multi-screen headend, Atyaf is using Envivio Muse Live and Muse On-Demand on the Envivio 4Caster appliances, as well as Envivio 4Manager for headend control and monitoring.

With his latest threats to weaken the dollar, we’re seeing this pattern once again.

The president and his team of unelected bureaucrats have siphoned power away from the legislature.

The tax plan has benefited the wealthy while ballooning the deficit.

They know more than anyone how difficult it is to get funding for colleges.

The Trump administration continues its war on consumers

Back in college, I took a class on statistics and never forgot the first lesson my professor taught us, which was, “Anyone can manipulate numbers to make them mean whatever they want.” I see this point magnified today by the …

Improve your understanding of Scrum through the proven experience and collected wisdom of experts around the world. Based on real-life experiences, the 97 essays in this unique book provide a wealth of knowledge and expertise from established practitioners who have dealt with specific problems and challenges with Scrum. You’ll find out more about the rules and roles of this framework, as well as tactics, strategies, specific patterns to use with Scrum, and stories from the trenches.

Around 2 300 Telkom employees have opted for voluntary severance packages since the start of a business restructuring process early this year, a spokesperson said on Tuesday.

Arsene Wenger says Liverpool will be regarded as 2019/20 Premier League winners even if the season is abandoned because of the coronavirus.

Everglades

The Amateur Traveler talks to Jon Miller of the Rest of Everest podcast about his journeys in Nepal. Jon originally went to Nepal as part of a film he was shooting on an Everest expedition, but as Jon tells it you come for the mountain but fall in love with the people and the culture. Jon describes Kathmandu with is various temples or stupas like Swayambhunath (the monkey temple) and Boudhanath with crowds of people performing a kora around them. He tells us places to get a good meal in Thamel (the tourist district) and suggests a day trip to the well preserved city of Bhaktapur. After Katmandu Jon tells us about trekking and also hiking up to Everest basecamp where the altitude can be very challenging (and Jon lives up at 6000 feet at home in Colorado).

Hear about travel to South Florida (Miami, Everglades National Park, and the Florida Keys) as the Amateur Traveler talks to Erik Smith from onmyfeetorinmymind.com about this diverse region.

Disclosure: Some of the links below may contain affiliate links from Patriot Depot, a sister company of The Western Journal. By making purchases through these links, you’ll be helping to support The Western Journal. Being a conservative woman in a liberal world can be a daunting existence, but speaking isn’t always required to be heard.…

The post 6 Products Every Conservative Woman Should Own appeared first on The Western Journal.

Najibullah Quraishi has covered the war in Afghanistan for more than a decade, but embedding with ISIS fighters who've recently emerged there "was the most risky and dangerous job ever I've done in my life," he says.

How Do Home Sales Affect the Economy in Your State?

When I started this blog more than 10 years ago, I had one goal: to entertain as many people as possible with my travel stories. I got away from that goal in recent years, focusing on guides for travelers instead, realizing that it’s hard to earn a living when you tell stories like these. But …

I’m Telling Stories I’ve Never Told Before — on Patreon! Read More »

The post I’m Telling Stories I’ve Never Told Before — on Patreon! appeared first on Adventurous Kate.

There's a lot you can get out of a solo trip that's often impossible when you're not on your own.

The post Why Everyone Should Travel Solo … Sometimes appeared first on Vagabondish.

Passport renewal isn't quite simple, but it is straightforward. You just need to prepare with the right forms, supporting documentation, and some patience.

The post Passport Renewal: Everything American Travelers Need to Know appeared first on Vagabondish.

From better campsite cooking to car maintenance to smartphone-free communication, here are 12 gadgets to up your car camping game.

The post Up Your Car Camping Game with These 12 Clever Gadgets appeared first on Vagabondish.

If you've never had enough room to take your bike road-tripping, Oyama's origami-inspired folding electric bike is here to change your mind.

The post I Never Thought I’d Want (or Need) an Electric Folding Bike … But This Changed My Mind appeared first on Vagabondish.

MPU 046: Workflows with Merlin Mann II « Mac Power Users

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I have the life that I have because I've made a lot of weird decisions, and they've worked out well.

Not gonna lie to you. I'm a huge nerd. Surprised?

Yep. I can recite big chunks of The Big Lebowski from memory. I can argue for an hour on the merits of Dick York over Dick Sargent. And, I can—and frequently do—catch myself thinking Catwoman, Batgirl, Princess Leia, and Emma Peel should have a light-hearted pillow fight that ends with an hour of genial french-kissing.

Pretty much like you, probably. I dunno, maybe your version includes Kitty Pryde. Po-tay-to/Po-taht-o, right?

Perhaps most saliently, by virtue of having spent a solid 2,399 days as a Fake Productivity Guru, I have been provided with an unquestionably Janusian monkey's paw of a gift; I now know a lot about workflows. Nerdy, nerdy workflows.

I can tell you a few things that almost always work, I can tell you a handful of things that almost never work, and—best or worst of all—I can tell you thousands of things that might work. Sometimes. Maybe. Kinda. For some people. For now.

And, at the risk of gay-marrying my arrogance to my hypocrisy, I can tell you that I also know enough about the unholy diarrhea of potential options for Theoretical Productivity to share two big patterns:

1. Getting your workflow right matters.
2. Getting your workflow right to the exclusion of the actual work is a fool's game.

But. Managing to get the most useful and most elegant and least fiddly mix of 1 and 2 right is super-hard. Especially for nerds. Especially for me.

So, as I type this today, I believe there can be no greater testament to these claims—or, at least, no greater place to test the veracity of these claims for yourself—than in this TWO AND A HALF HOUR-long interview for Mac Power Users.

It is reeeeeeeeally nerdy. Almost intolerably nerdy. Just…overwhelmingly nerdy.

But, man, is it ever really good, and really fat with the most insanely granular details of How I Work.

Lo, even these 928.5 days after officially retiring from productivity pr0n, my desire to not "vend stroke material for your joyless addiction to puns about procrastination and systems for generating more taxonomically satisfying meta-work" is tempered by a (widely under-reported) practical streak.

Yes: I continue to despise empty advice about rearranging deck chairs on The Titanic. But, yes: I do also still very much enjoy talking about how all the tips and tricks can or can't work in the context of work you care about. That matters. It really does.

So. Here goes. A one hundred and forty six minute-long, Joyce-ian amble through the Big Stuff and the Little Stuff. David and Katie were very patient.

How I name text files. Why I break iOS apps. Why I love the letter "x." Why I won't row out to islands any more. How a 115,000 word book manuscript is "like a house full of confederate money." How "The Cloud" broke in New Zealand. How I use MultiMarkdown, Scrivener, TextExpander, OmniFocus, TextMate, Notational Velocity, Dropbox, and an explosive combination of Elements, Notesy, Nebulous, Simplenote, CF Outliner, iThoughts, Instacast, Good Reader, and wow wow wow.

How I try not to fiddle—how I sometimes succeed and often don't. But, how I try.

Anyhow. There you go. A perfectly nerdy bookend to last year's first Magnum Opus MPU interview on these same topics, Mac Power Users Episode 46 is just insanely nerdy. And, what have you.

I hope you like it. I hope it's useful. I hope you don't use it to replace real work.

And, as ever, I really hope Batgirl starts having more sexy pillow fights.

Enjoy. And, God save you.

MPU 046: Workflows with Merlin Mann II « Mac Power Users

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• Huffduff It

The Shelburne Retirement Residence has been devastated by an outbreak of COVID-19, with 90 per cent of its residents becoming infected.

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo. Herein, we tested whether Ngb-H64Q-CCC can also scavenge CO from CcO and attenuate CO-induced inhibition of mitochondrial respiration. Heart tissue from mice exposed to 3% CO exhibited a 42 ± 19% reduction in tissue respiration rate and a 33 ± 38% reduction in CcO activity compared with unexposed mice. Intravenous infusion of Ngb-H64Q-CCC restored respiration rates to that of control mice correlating with higher electron transport chain CcO activity in Ngb-H64Q-CCC–treated compared with PBS-treated, CO-poisoned mice. Further, using a Clark-type oxygen electrode, we measured isolated rat liver mitochondrial respiration in the presence and absence of saturating solutions of CO (160 μm) and nitric oxide (100 μm). Both CO and NO inhibited respiration, and treatment with Ngb-H64Q-CCC (100 and 50 μm, respectively) significantly reversed this inhibition. These results suggest that Ngb-H64Q-CCC mitigates CO toxicity by scavenging CO from carboxyhemoglobin, improving systemic oxygen delivery and reversing the inhibitory effects of CO on mitochondria. We conclude that Ngb-H64Q-CCC or other CO scavengers demonstrate potential as antidotes that reverse the clinical and molecular effects of CO poisoning.

6 January 2020

Research Event

Event participants

HE Dr Motsoahae Thomas Thabane, Prime Minister of Lesotho
Chair: Ian Lucas MP, Shadow Minister for Africa and the Middle East

CJ Fielding
Feb 1, 1995; 36:211-228
Reviews

Carbon monoxide (CO) remains the most common cause of human poisoning. The consequences of CO poisoning include cardiac dysfunction, brain injury, and death. CO causes toxicity by binding to hemoglobin and by inhibiting mitochondrial cytochrome c oxidase (CcO), thereby decreasing oxygen delivery and inhibiting oxidative phosphorylation. We have recently developed a CO antidote based on human neuroglobin (Ngb-H64Q-CCC). This molecule enhances clearance of CO from red blood cells in vitro and in vivo. Herein, we tested whether Ngb-H64Q-CCC can also scavenge CO from CcO and attenuate CO-induced inhibition of mitochondrial respiration. Heart tissue from mice exposed to 3% CO exhibited a 42 ± 19% reduction in tissue respiration rate and a 33 ± 38% reduction in CcO activity compared with unexposed mice. Intravenous infusion of Ngb-H64Q-CCC restored respiration rates to that of control mice correlating with higher electron transport chain CcO activity in Ngb-H64Q-CCC–treated compared with PBS-treated, CO-poisoned mice. Further, using a Clark-type oxygen electrode, we measured isolated rat liver mitochondrial respiration in the presence and absence of saturating solutions of CO (160 μm) and nitric oxide (100 μm). Both CO and NO inhibited respiration, and treatment with Ngb-H64Q-CCC (100 and 50 μm, respectively) significantly reversed this inhibition. These results suggest that Ngb-H64Q-CCC mitigates CO toxicity by scavenging CO from carboxyhemoglobin, improving systemic oxygen delivery and reversing the inhibitory effects of CO on mitochondria. We conclude that Ngb-H64Q-CCC or other CO scavengers demonstrate potential as antidotes that reverse the clinical and molecular effects of CO poisoning.

Expert

Tratamento genético foi testado em Layla Richards que estava desenganada pelos médicos. Especialistas ressaltam que os resultados são iniciais e podem não ocorrer em outros pacientes.

The post Terapia inédita reverte leucemia incurável em bebê de 1 ano appeared first on Saúde Próspera.

Invitation Only Research Event

Event participants

Yang Cheng, Professor of International Relations, Assistant Dean, School of International Relations and Public Affairs, Shanghai International Studies University
Yu Jie, Senior Research Fellow, Asia-Pacific Programme, Chatham House
Marcin Kaczmarski, Lecturer in Security Studies, University of Glasgow
Natasha Kuhrt, Lecturer, Department of War Studies, King’s College London
Bobo Lo, Non-Resident Fellow, Lowy Institute
Alexey Maslov, Professor, School of Asian Studies, National Research University, Higher School of Economics, Moscow

peterphotographic posted a photo:

Airfix 1:72 RNLI Severn Class - Plymouth Lifeboat

Walthamstow, East London, UK

Chuanan Wei
Proc. Amer. Math. Soc. 148 (2020), 2287-2296.
Abstract, references and article information