We derive sufficient conditions for exponential decay of solutions of the delay negative feedback equation with distributed delay. The conditions are written in terms of exponential moments of the distribution. Our method only uses elementary tools of calculus and is robust towards possible extensions to more complex settings, in particular, systems of delay differential equations. We illustrate the applicability of the method to particular distributions - Dirac delta, Gamma distribution, uniform and truncated normal distributions.

We prove that all non-degenerate relative equilibria of the planar Newtonian $n$--body problem can be continued to spaces of constant curvature $kappa$, positive or negative, for small enough values of this parameter. We also compute the extension of some classical relative equilibria to curved spaces using numerical continuation. In particular, we extend Lagrange's triangle configuration with different masses to both positive and negative curvature spaces.

Event-related potential (ERP) speller can be utilized in device control and communication for locked-in or severely injured patients. However, problems such as inter-subject performance instability and ERP-illiteracy are still unresolved. Therefore, it is necessary to predict classification performance before performing an ERP speller in order to use it efficiently. In this study, we investigated the correlations with ERP speller performance using a resting-state before an ERP speller. In specific, we used spectral power and functional connectivity according to four brain regions and five frequency bands. As a result, the delta power in the frontal region and functional connectivity in the delta, alpha, gamma bands are significantly correlated with the ERP speller performance. Also, we predicted the ERP speller performance using EEG features in the resting-state. These findings may contribute to investigating the ERP-illiteracy and considering the appropriate alternatives for each user.

A standard approach to evaluating language models analyzes how models assign probabilities to valid versus invalid syntactic constructions (i.e. is a grammatical sentence more probable than an ungrammatical sentence). Our work uses ambiguous relative clause attachment to extend such evaluations to cases of multiple simultaneous valid interpretations, where stark grammaticality differences are absent. We compare model performance in English and Spanish to show that non-linguistic biases in RNN LMs advantageously overlap with syntactic structure in English but not Spanish. Thus, English models may appear to acquire human-like syntactic preferences, while models trained on Spanish fail to acquire comparable human-like preferences. We conclude by relating these results to broader concerns about the relationship between comprehension (i.e. typical language model use cases) and production (which generates the training data for language models), suggesting that necessary linguistic biases are not present in the training signal at all.

Due to the exponential growth of biomedical literature, event and relation extraction are important tasks in biomedical text mining. Most work only focus on relation extraction, and detect a single entity pair mention on a short span of text, which is not ideal due to long sentences that appear in biomedical contexts. We propose an approach to both relation and event extraction, for simultaneously predicting relationships between all mention pairs in a text. We also perform an empirical study to discuss different network setups for this purpose. The best performing model includes a set of multi-head attentions and convolutions, an adaptation of the transformer architecture, which offers self-attention the ability to strengthen dependencies among related elements, and models the interaction between features extracted by multiple attention heads. Experiment results demonstrate that our approach outperforms the state of the art on a set of benchmark biomedical corpora including BioNLP 2009, 2011, 2013 and BioCreative 2017 shared tasks.

This work deals with the efficient numerical solution of the time-fractional heat equation discretized on non-uniform temporal meshes. Non-uniform grids are essential to capture the singularities of "typical" solutions of time-fractional problems. We propose an efficient space-time multigrid method based on the waveform relaxation technique, which accounts for the nonlocal character of the fractional differential operator. To maintain an optimal complexity, which can be obtained for the case of uniform grids, we approximate the coefficient matrix corresponding to the temporal discretization by its hierarchical matrix (${cal H}$-matrix) representation. In particular, the proposed method has a computational cost of ${cal O}(k N M log(M))$, where $M$ is the number of time steps, $N$ is the number of spatial grid points, and $k$ is a parameter which controls the accuracy of the ${cal H}$-matrix approximation. The efficiency and the good convergence of the algorithm, which can be theoretically justified by a semi-algebraic mode analysis, are demonstrated through numerical experiments in both one- and two-dimensional spaces.

The accurate assembly of the system matrix is an important step in any code that solves partial differential equations on a mesh. We either explicitly set up a matrix, or we work in a matrix-free environment where we have to be able to quickly return matrix entries upon demand. Either way, the construction can become costly due to non-trivial material parameters entering the equations, multigrid codes requiring cascades of matrices that depend upon each other, or dynamic adaptive mesh refinement that necessitates the recomputation of matrix entries or the whole equation system throughout the solve. We propose that these constructions can be performed concurrently with the multigrid cycles. Initial geometric matrices and low accuracy integrations kickstart the multigrid, while improved assembly data is fed to the solver as and when it becomes available. The time to solution is improved as we eliminate an expensive preparation phase traditionally delaying the actual computation. We eliminate algorithmic latency. Furthermore, we desynchronise the assembly from the solution process. This anarchic increase of the concurrency level improves the scalability. Assembly routines are notoriously memory- and bandwidth-demanding. As we work with iteratively improving operator accuracies, we finally propose the use of a hierarchical, lossy compression scheme such that the memory footprint is brought down aggressively where the system matrix entries carry little information or are not yet available with high accuracy.

Correlation alignment (CORAL), a representative domain adaptation (DA) algorithm, decorrelates and aligns a labelled source domain dataset to an unlabelled target domain dataset to minimize the domain shift such that a classifier can be applied to predict the target domain labels. In this paper, we implement the CORAL on quantum devices by two different methods. One method utilizes quantum basic linear algebra subroutines (QBLAS) to implement the CORAL with exponential speedup in the number and dimension of the given data samples. The other method is achieved through a variational hybrid quantum-classical procedure. In addition, the numerical experiments of the CORAL with three different types of data sets, namely the synthetic data, the synthetic-Iris data, the handwritten digit data, are presented to evaluate the performance of our work. The simulation results prove that the variational quantum correlation alignment algorithm (VQCORAL) can achieve competitive performance compared with the classical CORAL.

In this paper, we analyze the symbol error rate (SER) performance of the simultaneous wireless information and power transfer (SWIPT) enabled three-node differential decode-and-forward (DDF) relay networks, which adopt the power splitting (PS) protocol at the relay. The use of non-coherent differential modulation eliminates the need for sending training symbols to estimate the instantaneous channel state informations (CSIs) at all network nodes, and therefore improves the power efficiency, as compared with the coherent modulation. However, performance analysis results are not yet available for the state-of-the-art detectors such as the approximate maximum-likelihood detector. Existing works rely on Monte-Carlo simulation to show that there exists an optimal PS ratio that minimizes the overall SER. In this work, we propose a near-optimal detector with linear complexity with respect to the modulation size. We derive an accurate approximate SER expression, based on which the optimal PS ratio can be accurately estimated without requiring any Monte-Carlo simulation.

Welcome back! In the first part of this series, we looked at a very "low-level" way to interact with a relational database by sending it raw SQL strings and retrieving the results. We created a very simple Express application that we can use as an example and deployed it on Heroku with a Postgres database.

In this part, we're going to examine a few libraries which build on top of that foundation, adding layers of abstraction that let you read and manipulate database data in a more "JavaScript-like" way.

PRINCE Raoden of Arelon awoke early that morning, completely unaware that he had been damned for all eternity. What a way to start a novel. As a reader, I don’t think about the first words of a book when…

Warm summer nights are on the way.…

The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below −10° C.

The present disclosure involves systems, software, and computer-implemented methods for providing process intelligence by correlating events from multiple business process systems to a single business scenario using configurable correlation strategies. An example method includes identifying a raw event associated with a sending business process and a receiving business process, identifying a sending business process attribute associated with the sending business process and a receiving business process attribute associated with the receiving business process, determining a correlation strategy for associating the raw event with a business scenario instance, the determination based at least in part on the sending business process attribute and the receiving business process attribute, and generating a visibility scenario event from the raw event according to the correlation strategy, the visibility scenario event associated with the business scenario instance.

A data warehouse is constructed using the relational mapping of a transactional database without reconstructing the data relationships of the transactional database. First, an application programmer analyzes an object model in order to describe facts and dimensions using the objects, attributes, and paths of the object model. Each of the dimensions has an identifier that correlates an item in the transactional database to a dimension record in the data warehouse. The fact and dimension descriptions are saved to a description file. Second, a Data Warehouse Engine (DWE) then access the description file and uses the object model, fact and dimension descriptions, and object-relational mapping to map transactional data to the data warehouse.

Dental compositions are provided comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof: wherein n is an integer from about 2 to about 5.

Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a chemical library relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

Shape memory and pseudoelastic martensitic behavior is enabled by a structure in which there is provided a crystalline ceramic material that is capable of undergoing a reversible martensitic transformation and forming martensitic domains, during such martensitic transformation, that have an elongated domain length. The ceramic material is configured as a ceramic material structure including a structural feature that is smaller than the elongated domain length of the ceramic material.

Methods and a kit. A cement forming method includes nucleating an acidic metallophosphate reaction mixture with first particles, resulting in forming a settable metallophosphate cement from the acidic metallophosphate reaction mixture. The first particles include a first metal oxide. Each particle of the first particles independently have a particle size in a range from about 15 microns to about 450 microns. A method for applying cement includes seeding a solution with particles, resulting in forming a settable cement from the solution. The particles have a size in a range from about 15 microns to about 450 microns. The solution includes a first metal oxide reacting with phosphate. The settable cement is applied to a substrate. A cement application kit is also described.

A method of frequency-domain filtering is provided that includes a plurality of filters, the plurality of filters including at least one constrained filter(s) W=I, I and at least one unconstrained filter(s) W=1,K− The method includes cascading the W k=i,K unconstrained filter(s). A single constraint window C is applied to the cascaded W=i,K unconstrained filter(s). The W=1,I constrained filter(s) are cascaded with the constrained cascaded Wk=1,K unconstrained filter(s) to form a resulting filter Wll=C(W 1{circle around (x)} . . . {circle around (x)} W){circle around (x)} W . . . W. The frequency domain representation of the single constraint window C may be based, at least in part, on a time domain representation of a single constraint window C that has been circularly shifted such that the frequency domain representation of the constraint window matches a property of the frequency domain representation of the cascaded W=1,K unconstrained filters.

The present invention aims to provide a surface modification method for a rubber vulcanizate or a thermoplastic elastomer, which can impart excellent sliding properties and excellent durability against repeated sliding motion and can allow the surface to maintain the sealing properties, without using expensive self-lubricating plastics. The present invention relates to a surface modification method for modifying a rubber vulcanizate or a thermoplastic elastomer as an object to be modified, the method including: step 1 of forming polymerization initiation points on the object to be modified; step 2 of radically polymerizing a monomer, starting from the polymerization initiation points, by irradiation with LED light at 300 nm to 400 nm to grow polymer chains on a surface of the object to be modified; and step 3 of esterifying, transesterifying or amidating side chains of the polymer chains.

According to an embodiment, based on task border information, and first-type dependency relationship information containing N number of nodes corresponding to data accesses to one set of data, containing edges representing dependency relationship between the nodes, and having at least one node with an access reliability flag indicating reliability/unreliability of corresponding data access; task border edges, of edges extending over task borders, are identified that have an unreliable access node linked to at least one end, and presentation information containing unreliable access nodes is generated. According to dependency existence information input corresponding to the set of data, conversion information indicating absence of data access to the unreliable access nodes is output. According to the conversion information, the first-type dependency relationship information is converted into second-type dependency relationship information containing M number of nodes (0≦M≦N) corresponding to data accesses to the set of data and containing edges representing inter-node dependency relationship.

A computing section is provided with a plurality of computing units and correlatively stores entries of configuration information that describes configurations of the plurality of computing units with physical configuration numbers that represent the entries of configuration information and executes a computation in a configuration corresponding to a designated physical configuration number. A status management section designates a physical configuration number corresponding to a status to which the computing section needs to advance the next time for the computing section and outputs the status to which the computing section needs to advance the next time as a logical status number that uniquely identifies the status to which the computing section needs to advance the next time in an object code. A determination section determines whether or not the computing section has stored an entry of configuration information corresponding to the status to which the computing section needs to advance the next time based on the logical status number that is output from the status management section. A rewriting section correlatively stores the entry of the configuration information and a physical configuration number corresponding to the entry of the configuration information in the computing section when the determination section determines that the computing section has not stored the entry of configuration information corresponding to the status to which the computing section needs to advance the next time.

A cancelation registry provides a cancelation interface whose implementation registers cancelable items such as synchronous operations, asynchronous operations, type instances, and transactions. Items may be implicitly or explicitly registered with the cancelation registry. A consistent cancelation interface unifies cancelation management for heterogeneous items, and allows cancelation of a group of items with a single invocation of a cancel-registered-items procedure.

Acidic viscoelastic cleaning compositions are disclosed which use non polymer thickening agents. According to the invention, cleaning compositions have been developed using viscoelastic surfactants in acidic cleaning formulations. These provide the dual benefit of thickening as well as an additional cleaning, thereby improving performance. Applicants have also identified several pseudo linking agents which when, used with viscoelastic surfactants provide enhanced viscoelasticity and cleaning.

The invention relates to compositions, methods of use, and methods of manufacture for an intercalated bleach compound and compositions thereof. The intercalated bleach compound has the formula Mx(OCl)y(O)m(OH)n where M is an alkaline earth metal such as magnesium, calcium or mixture thereof. The values of x and y independently equal any number greater than or equal to 1 (e.g., 1, 2, 3, 4, etc.), and m and n independently equal any number greater than or equal to 0 (e.g., 0, 1, 2, 3, 4, etc.), but m and n are not both 0. In addition, the molar ratio of the alkaline earth metal (e.g., magnesium or calcium) to hypochlorite is at least 3:1. In other words, x is ≧3y. The compounds exhibit excellent stability, little or no chlorine bleach odor, exhibit excellent pH buffering characteristics, and less reactivity with organic materials as compared to alternative chlorine bleach products.

User interfaces for displaying relationships between cells in a grid. In one example embodiment, a user interface includes a grid including rows and columns and a plurality of cells each having a specific position in the grid. A first one of the cells is related to a second one of the cells. The grid is configured to display, upon selection of the first cell or second cell, a visual representation of the relationship between the first cell and the second cell.

Architectures and techniques are provided to control the rendering of supplemental content associated with electronic books. For example, electronic books may be associated with content that is in addition to the content originally provided to an individual acquiring the electronic book, such as annotations, social networking site information, media outlet information, and the like. Individuals may control the supplemental electronic book content that is rendered via their client devices via actuation of a physical input device or a representation of an input device shown via a touch sensitive display. The amount of supplemental content that is rendered may correspond to information associated with a specified number of categories of supplemental electronic book content based on a supplemental content rendering level. In other implementations, the amount of supplemental electronic book content that is rendered may correspond to an amount of supplemental content to be rendered for each category of supplemental content.

Alkyl nitrate ester compounds are provided for the delivery of nitric oxide to targeted muscle tissues, and in particular, to normal and dystrophic muscles. In one aspect, nitrate ester compounds are provided having the following formula: wherein, R1 is ONO2, CH2ONO2, CnH2n+1OH, CnH2n+1OH, or CH2CH2CH3, or H;R2 is ONO2, CH2ONO2, Cn'H2n'+1OH, Cn'H2n'+1OH, CH2CH2CH3 or H; andR3 is ONO2, CH2ONO2, Cn'″H2n″+1OH, Cn″H2n″+1OH, CH2CH2CH3 or H; wherein n is an integer from 0 to 9, n' is an integer from 0 to 9, and n″ is an integer from 0 to 9, and n+n'+n″≦9, and wherein at least one of R1, R2, and R3 is an ester nitrate selected from the group consisting of ONO2, CH2ONO2, and combinations thereof.

When a speech sound of at least a predetermined sound pressure is externally input while a time measurement is not being performed, a time measuring circuit starts a time measurement responsive to a signal from a speech detector. When another speech sound of at least a predetermined sound pressure is externally input while a time measurement is being performed by the time measuring circuit, a measurement time measured by the time measuring circuit at this moment is stored in a time information memory. After a predetermined time has elapsed, if a speech recognition circuit recognizes that the externally input speech sound is a "stop" command, the time measurement operation performed by the time measuring circuit is stopped, and the time information stored in the time information memory is read out and displayed as measurement time information on a display unit.

RNA interference is provided for inhibition of Frizzled Related Protein-1 mRNA expression, in particular, for treating patients having glaucoma or at risk of developing glaucoma.

The disclosure is directed to a system and method for establishing a secured wireless connection allowing the exchange of information between a wireless device and aircraft equipment. The secured wireless access system may require a user controlling the wireless device to interact with an onboard interface to initiate a connection. The user may be further required to enter a randomly generated security passcode to pair the mobile device to the aircraft equipment. Further security measures may be implemented, such as tiered user access levels restricting certain equipment and/or information based upon a user identity of the user requesting access.

MRI compatible localization and/or guidance systems for facilitating placement of an interventional therapy and/or device in vivo include: (a) a mount adapted for fixation to a patient; (b) a targeting cannula with a lumen configured to attach to the mount so as to be able to controllably translate in at least three dimensions; and (c) an elongate probe configured to snugly slidably advance and retract in the targeting cannula lumen, the elongate probe comprising at least one of a stimulation or recording electrode. In operation, the targeting cannula can be aligned with a first trajectory and positionally adjusted to provide a desired internal access path to a target location with a corresponding trajectory for the elongate probe. Automated systems for determining an MR scan plane associated with a trajectory and for determining mount adjustments are also described.

A novel phenylcarbamate compound and a pharmaceutical composition containing the same are provided. More specifically, a novel phenylcarbamate compound, a composition for muscle relaxation containing the phenylcarbamate compound as an active ingredient, and a method of muscle relaxation comprising administering a therapeutically effective amount of the phenylcarbamate compound, are provided.

The invention provides a silane compound that includes a hydrophobic group and a silane ester group linked by a hydrophilic group for use as a surface treatment to an inorganic material, such as a pigment, the silane including a hydrophobic group and a silane ester group linked by a hydrophilic group. The invention includes a coated particle including an inorganic material coated with the silane compound(s) and methods of improving the wettability and/or dispersibility of an inorganic material such as a pigment, wherein the method comprises depositing the silane compounds on the surface of a pigment.

Provided are methods for the treatment of a rheumatic disease, such as rheumatoid arthritis, ankylosating spondylitis and/or polymyalgia rheumatic, by administering a delayed-release dosage form of a glucocorticoid to a subject in need thereof wherein the treatment is administered once daily for at least about two weeks. Also provided are methods for the treatment of osteoarthritis by administering a delayed-release dosage form of a glucocorticoid to a subject in need thereof wherein the treatment is administered once daily for at least about two weeks.

This document discloses molecules having the following formulas (“Formula One” & “Formula Two” and “Formula Three”) The Ar1, Het, Ar2, R1, R2, R3, R4, and R5 are further described herein.

A pesticidal composition comprises a synergistically effective amount of a flonicamid-based selective homopteran feeding blocker compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio)propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl) sulfinyl)propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by pests comprises contacting the plant with the synergistic pesticidal composition.

A separator includes a centrifugal drum having a vertical axis of rotation and a feed line for material to be centrifuged. A drive spindle for the centrifugal drum is rotatably mounted on a housing via a bearing, the housing being supported elastically on a machine frame. A drive device includes a motor housing and an electric motor having a stator and an armature which is aligned with the drive spindle. The drive device and the motor housing move with the drive spindle as co-vibrating units during an operation of the separator. The drive device is connected to the machine frame below the bearing at a lower axial end of the bearing via one or more joint elements.

There is disclosed an indicator composition, the application thereof to substrates, and related products. The indicator composition comprises an organic solvent soluble polymer and a redox sensitive material which displays different visible properties in the oxidized and reduced forms. The organic solvent soluble polymer can be at least partially sulfonated polystyrene. The indicator composition can be dissolved in organic solvents such as acetone, ethanol and ethyl acetate to form inks which can be used in a variety of printing processes. The indicator composition can be used to detect oxidizing agents, oxygen, water, reducing agents, UV light, temperature and the passage of time.

Iron/carbon (Fe/C) nanocomposite catalysts are prepared for Fischer-Tropsch synthesis reaction. A preparation method includes steps of mixing iron hydrate salts and a mesoporous carbon support to form a mixture, infiltrating the iron hydrate salts into the carbon support through melt infiltration of the mixture near a melting point of the iron hydrate salts, forming iron-carbide particles infiltrated into the carbon support through calcination of the iron hydrate salts infiltrated into the carbon support under a first atmosphere, and vacuum-drying the iron-carbide particles after passivation using ethanol. Using such catalysts, liquid hydrocarbons are produced.

A fuel processing system for converting a logistical fuel and air into a liquid product comprising methanol. One such system comprises a fuel injection system configured to combine a logistical fuel and ambient air to produce a logistical fuel and air mixture, a synthesis gas production system configured to convert the logistical fuel and air mixture to synthesis gas, and a methanol synthesis system configured to convert the synthesis gas to a crude methanol liquid. Related methods are additionally disclosed.

A device for the collection and processing of information relating to the exposure of one or more persons to one or more products of chemical or biological origin has: at least one coded sensor for automatic or semi-automatic identification of a person likely to be exposed to at least one product,at least one coded sensor for the collection of information relating to the handling of at least one product by the person likely to be exposed to the product,at least one sensor for validating the information collected by the identification and collection sensors,at least one module for reading at least one coded sensor, anda module for processing information collected by the sensors.

A method and apparatus for data processing. The method calculates correlations between a plurality of attributes in a dataset. The attributes are factors involved in transaction processing. The method generates a relationship graph by using the plurality of attributes and the correlations between the plurality of attributes; and extracts a sub-graph from the relationship graph to represent a hypothesis. The hypothesis describes the impacts of the factors on the transaction processing. Also provided is an apparatus for implementing the above data processing method.

Disclosed is a mold hanger for supporting a bottle mold in a blow molding station, the mold hanger comprising a piston and piston sleeve fully contained within the mold hanger configured to push a moveable insert into the mold. Also disclosed is a method of retrofitting an original rotatable blow molding module having multiple existing blow molding stations, each existing mold hanger defining an existing outer envelope. The disclosed method may include providing an improved mold hanger substantially contained within the respective existing outer envelope and including low-profile drive mechanisms configured opposably to drive moveable inserts into the mold. Further disclosed is a method of manufacturing a blow molded bottle with a deep pinch grip, the method including providing within a mold hanger a drive mechanism to drive a moveable insert into the mold. A bottle made by such methods is also disclosed.

A method and apparatus are provided for automatic and hands-free threading of an elastomeric mix into a calender set of rolls comprising one or more pairs of rolls that have a nip between them. A stripper roll is positioned next to one of the rolls forming the nip and is rotated so that the outer surface of the stripper roll moves in a direction opposite to the outer surface of the adjacent roll. The stripper roll removes all or a desired portion of the elastomeric mix from the adjacent roll and causes the same to transfer to another roll. Variables such as e.g., the relative surface speed of the stripper roll, diameter of the stripper roll, and distance of the outer surface of the stripper roll from the adjacent roll can be manipulated to control the amount of the elastomeric mix that is stripped by the stripper roll.

A unitary elastic mold and cutter combination configured to mold and cut moldable material is disclosed herein. The mold and cutter combination comprises an elastic mold cavity having an elastic bottom wall with an embossed inner surface and an elastic sidewall extending from and unitary with a perimeter of the bottom wall. An elastic cutting blade extends from and is unitary with the sidewall of the mold cavity and is configured to cut moldable material and maintain a substantially consistent perimeter upon cutting. The cutting blade comprises a cutting edge disposed between an inner cutting blade surface and an outer cutting blade surface. The mold and cutter combination may have an elasticity sufficient to release molded material therefrom by hand stretching, wherein the cutting edge, inner cutting blade surface, and the inner surface of the sidewall of the mold cavity are stretched by an amount sufficient to release the molded material.

The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.

A platinum complex of a formula (I): whereR1 and R2 are each fluoroalkyl,X is C—H or nitrogen, andL1 is a bidentate, nitrogen-containing heteroaromatic ligand.

A system for loading/unloading sheets is disclosed, some of which also being of metal, and handling method thereof, serving a laser cutting center. The system includes a pair of rails (1, 2), supported at a preset height above a feeding tray (T) of the cutting center, whereon at least one Cartesian robotized hand is movably mounted, capable of moving along horizontal axes X and Y as well as along a vertical axis Z, mutually orthogonal, and including at least two bridge cranes (3, 4) sliding along the rails (1, 2) each of which supports at least one pair of robotized hands (5-8), and the robotized hands (5-8) have an electromagnetic pick-up head which may be coupled with a suction-cup device (103). Feeding tray (T) consists of bars whereon small tesserae (204) of ceramic material are fitted.