Scientists used AI to transform tourist photos into a 3D digital map of Antarctic penguin colonies – even as researchers debate whether to harness or discourage tourism in this remote region

Title: More Evidence Fitness Trackers Can Boost Your Health
Category: Health News
Created: 7/26/2022 12:00:00 AM
Last Editorial Review: 7/27/2022 12:00:00 AM

Although the progressive histologic steps leading to endometrial cancer (EndoCA), the most common female reproductive tract malignancy, from endometrial hyperplasia are well-established, the molecular changes accompanying this malignant transformation in a single patient have never been described. We had the unique opportunity to investigate the paired histologic and molecular features associated with the 12-yr development of EndoCA in a postmenopausal female who could not undergo hysterectomy and instead underwent progesterone treatment. Using a specially designed 58-gene next-generation sequencing panel, we analyzed a total of 10 sequential biopsy samples collected over this time frame. A total of eight pathogenic/likely pathogenic mutations in seven genes, APC, ARID1A, CTNNB1, CDKN2A, KRAS, PTEN, and TP53, were identified. A PTEN nonsense mutation p.W111* was present in all samples analyzed except histologically normal endometrium. Apart from this PTEN mutation, the only other recurrent mutation was KRAS G12D, which was present in six biopsy samplings, including histologically normal tissue obtained at the patient's first visit but not detectable in the cancer. The PTEN p.W111* mutant allele fractions were lowest in benign, inactive endometrial glands (0.7%), highest in adenocarcinoma (36.9%), and, notably, were always markedly reduced following progesterone treatment. To our knowledge, this report provides the first molecular characterization of EndoCA development in a single patient. A single PTEN mutation was present throughout the 12 years of cancer development. Importantly, and with potential significance toward medical and nonsurgical management of EndoCA, progesterone treatments were consistently noted to markedly decrease PTEN mutant allele fractions to precancerous levels.

Secretary of State was questioned on Good Morning Britain over the pledge - with host asking 'how much will it have gone up by then?'

An artificial intelligence model that can identify the calls of eight whale species is helping researchers track the elusive whale behind a perplexing sound in the Pacific

Scientists used AI to transform tourist photos into a 3D digital map of Antarctic penguin colonies – even as researchers debate whether to harness or discourage tourism in this remote region

Humans perfected how to identify wild animals over millennia, and now biologists are rediscovering the exceptional worth of the tracks and marks left behind

1. Trump Tracker: Fox News Anchor Nominated To Lead Pentagon  NDTV
2. Trump nominates Army veteran and Fox News host Pete Hegseth for defence secretary  The Hindu
3. Trump's defense choice stuns the Pentagon, raises questions about the Fox News host's experience  Hindustan Times
4. 'We are in a new place': Bernstein reacts to Hegseth's comments about women in combat roles  CNN
5. Pete Hegseth: Ex-Army man, Fox News host, is US's 2nd youngest Defence Secretary  India Today

A new battery plant under construction in South Carolina will supply BMW factories.

“Magic mirror in the hand, who has the most wrinkles in the land?” has transcended from Snow White to 21st century camera technology.

In response to President Obama’s National Cancer Moonshot initiative to eliminate cancer, the USPTO has launched the “Cancer Immunotherapy Pilot Program.” The Pilot Program provides an accelerated review for applications related to cancer immunotherapy and is set to launch in July 2016. According to the USPTO, this initiative: aims to cut the time it takes to...… Continue Reading

Stay On Track With 2016 With These Quick Tips

An aerial view of your mowing path helps you remember to switch up your pattern for optimum turf health.

New observations from the James Webb Space Telescope are exposing the pathways that water takes to reach terrestrial planets

Not all winged dinosaurs were necessarily capable of full flight, but this anatomical feature may have enabled them to travel further by flapping or gliding

Scientists used AI to transform tourist photos into a 3D digital map of Antarctic penguin colonies – even as researchers debate whether to harness or discourage tourism in this remote region

The International Monetary Fund has collated information on the tax and non-tax policy responses of some 193 jurisdictions to COVID-19.

India could see a medlinkdengue vaccine/medlink (!--ref1--) by 2026, according to K Anand Kumar, Managing Director of Indian Immunologicals (IIL).

A single score is developed to describe the level of cytokines in the saliva, and this score is linked with the severity of clinical gum inflammation,

Funded by the UK government, this project will help to transform climate and water policies in the Global South.

The post Water Resilience Tracker enables cross-sectoral collaboration first appeared on International Water Management Institute (IWMI).

For the first time, scientists have tracked the fate of medlinkstem cells/medlink decades after a medlinktransplant/medlink, shedding light on

Wearables in Diabetes Management: Smartwatches and smart rings can accurately monitor blood glucose levels (BGLs) anywhere and anytime.

Outspoken struggles of the celebrities battling with endometriosis have brought higher consideration to the disease over the past years. An actress cum

UN General Assembly President Csaba Korosi revealed that the goal to end AIDS by 2030 is "badly off track". "We must address these challenges that

The AIDS Society of India (ASI) has urged the government to swiftly include HIV self-testing and pre-exposure prophylaxis (PrEP) in its healthcare policies and programs (!--ref1--).

Wearable Bluetooth devices offer insights into the care provided to residents in care homes, identifying those requiring increased social interaction (!--ref1--).

Scientists have created an innovative genomic method capable of monitoring the spread of various medlinksuperbugs/medlink within a hospital setting, concurrently.

India's first dedicated railway test track, under construction in Rajasthan, is expected to be completed by December 2025 with a total investment of Rs 820 crore, according to the Ministry of Railways.

Bollywood superstar Salman Khan has again received another threat message on Thursday, two days after he got a death threat allegedly from the Lawrence Bishnoi gang.

Enterprise spending on cloud services continues to go up, up, up — to the tune of $675 billion this year — thanks to organizations’ firm embrace of software-as-a-service, the popularity of distributed working, and the arrival of compute-intensive tech like AI. A startup called PointFive believes it has found a better way to get a […]

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Folks dedicated to the world of NFTs have access to loads of analytics and browsing tools, but none of them really work together. At least, that’s how new startup Curio sees things. Curio taps into several different sources of data to provide a powerful analytics tool for both browsing and tracking the value of NFTs. […]

© 2024 TechCrunch. All rights reserved. For personal use only.

The U.S. Energy Information Administration (EIA) has several sets of data on the domestic production of crude oil and natural gas. Depending on your interests, the resources below can help you find the crude oil and natural gas data you need.

When it comes to privacy nightmares, Pinterest is unlikely to be the first social app that springs to mind. But the visual discovery engine’s use of tracking ads is the target of the latest complaint from European privacy rights nonprofit noyb, which accuses it of breaching the bloc’s General Data Protection Regulation (GDPR) by failing […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Bad news for LinkedIn in Europe, where the Microsoft-owned social network has been reprimanded and fined €310 million for privacy violations related to its tracking ads business. The administrative penalties, which are worth around $335 million at current exchange rates, have been issued by Ireland’s Data Protection Commission (DPC) under the European Union’s General Data […]

© 2024 TechCrunch. All rights reserved. For personal use only.

Samsung Health is expanding its role as a personal health management tool with the latest app update, allowing users to view their medical records alongside new features for tracking medications and food. This enhancement marks a major step forward in making

Think about a time when you felt constantly watched or pressured to perform-maybe it was during a board exam, a big presentation at work, or even when you're trying to impress friends at a social gathering. That sense of being under

In today's fast-paced world, vehicle security is paramount. Automobile enthusiasts in India are increasingly turning to vehicle tracking systems. These systems offer a range of benefits that enhance both safety and convenience. By understanding these advantages, car owners can make informed

The scheme was introduced to simplify the visa application process for students from 14 countries, which included India.

Kanoh, on the world heritage site Kalka-Shimla Line in Himachal Pradesh, has no roads, only train tracks

After a dismal decade of underperformance, Formula One’s second-most-successful team has begun to turn things around. A runner-up finish this season, which is well within reach, will mark a definite inflection point in its protracted bid to rejoin the grid’s elite

At the brand new Madras International Karting Arena, drive on the track that Mika Hakkinen, Narain Karthikeyan, and Karun Chandhok raced on The 1.2 kilometre track is India’s first karting circuit built to FIA-CIK (Commission Internationale de Karting) specifications

When promises were introduced in ECMAScript 2015, they had an interesting flaw: if a promise didn’t have a rejection handler and was later rejected, you would have no idea. The rejection silently occurred behind the scenes and, therefore, could easily be missed. The best practice of always attaching rejection handlers to promises emerged due to...

Veteran actor Mukesh Rawal, known for his ‘Vibhishan’ role was run over by a train while crossing railway tracks

The World Health Organization says more than 8 million people were diagnosed with tuberculosis last year

New York, NY : Bloomsbury Academic, 2017.

Avi Schiffmann built the first coronavirus tracker in January 2020, before global organizations were aggregating cases. His dashboard proved essential. At WIRED25, he spoke with Megan Molteni about his plans to visualize candidates' positions for the 2020 election.

6-Time Olympic Gold Medalist Allyson Felix answers the internet's burning questions about track and sprinting. Do sprinters and distance runners really dislike each other? Is the 400 meter really that painful? What's a good 40-yard-dash time? Why do sprinters start with their left foot? Allyson answers all these questions and much more!