NEW YORK (AP) — Three children have now died in New York state from a possible complication from the coronavirus involving swollen blood vessels and heart problems, Gov. Andrew Cuomo said Saturday. At least 73 children in New York have been diagnosed with symptoms similar to Kawasaki disease — a rare inflammatory condition in children […]

Doctors in the U.S. and Europe are reporting a small wave of cases of what looks like a "shock syndrome" in young people. They have low blood pressure, inflamed hearts and other serious symptoms.

Police in Albany suspect an attack on an automatic teller machine may be linked to a similar incident on the south coast a a few months earlier.

Nigerian police have arrested a man after the death of a West Australian woman who was caught up in an online romance scam.

No new cases are identified on the day Tasmania records its second coronavirus death, an elderly man in southern Tasmania who was a passenger on the Ruby Princess cruise ship.

An outreach worker linked to a medically supervised safe injecting room in Melbourne's inner east is among a group of people now charged with trafficking the drug heroin.

An inquest into the deaths of two young vets who took a drug linked to almost 20 suicides per year within the industry urges better mental health support for veterinary professionals.

The number of new coronavirus cases recorded in Victoria remains low, but authorities are still concerned about a growing cluster at a private psychiatric clinic.

Victorian Treasurer Tim Pallas says Victoria has recorded 17 new cases of coronavirus overnight with 11 of them linked to meat processing plant Cedar Meats in Broolyn, May 5, 2020.

Victorian Treasurer Tim Pallas also announced additional tax relief for families and businesses impacted by pandemic lockdown measures, May 5, 2020.

Victorian Premier Daniel Andrews says the state's total has been brought up to 1,454 confirmed cases of coronavirus with 106,000 tests conducted over the past week and a half.

A post-prison release service in far-western NSW blames delays at the Newcastle morgue for a spike in ice benders by some of its grief-stricken Aboriginal clients waiting up to six weeks to bury loved ones.

Leaked forms show the besieged Liberal MP did not disclose her membership of organisations linked to the Chinese Government's foreign interference operations when she ran for preselection for her federal seat.

Dark-coloured jerseys could lead to poor performance, increased rates of injury, and even jeopardise the careers of young rugby league players, researchers say.

The makers of Rexona, the deodorant identified by retailers and police as the product most misused by Queensland children, acknowledges its product was implicated in five deaths across two states through misuse but says there is "nothing that currently exists" to fix the problem.

As Queensland Opposition leader Deb Frecklington weighs in on the state's chroming crisis, BP recalls how it went about combatting misuse of its own product almost two decades ago.

A club linked to a long-term business partner of the Gold Coast Mayor Tom Tate may escape paying a $137,000 debt owed to the council.

Seven people who have eaten frozen pomegranate purchased at Coles have been diagnosed with a unique strain of hepatitis A, prompting a recall of what the company behind the product describes as "a relatively small batch".

There are several discussion groups on LinkedIn dedicated to Root Cause Analysis in one way or another. I follow a couple of them, but the one I like the most has a serious problem. So, being the dynamic (ha) and proactive (haha) person that I am, I created a new one. This new LinkedIn group […]

1. Children in US and UK dying from syndrome linked to COVID-19  World Socialist Web Site
2. Rare illness linked to coronavirus kills New York five-year-old  9News
3. Coronavirus US: Andrew Cuomo’s sad announcemet about chld infections  NEWS.com.au
4. Some children with COVID-19 showing symptoms similar to Kawasaki Disease  NEWS10 ABC
5. New fears around 'entirely different chapter' of coronavirus after boy dies from rare illness  Yahoo News Australia
6. View Full coverage on Google News

A team of Princeton researchers led by Bridgett vonHoldt found that microbes are linked to cancer in a threatened species: the Santa Catalina foxes, found only on one island off the California coast.

Garcia Luna, accused of turning a blind eye toward murderous drug overlord Joaquin “El Chapo” Guzman while serving as Mexico’s secretary of public security from 2006-12, arrived in Brooklyn Federal Court with his attorney for a Friday afternoon hearing.

Dear RSS Ground users,

Due to the recent changes in LinkedIn developers documentation and specifications, some of the remote LinkedIn account management options require a substantial update. For this reason and at this moment RSS Ground LinkedIn Poster can only make posts to your personal feed. Posting to specific company pages is not currently available.

However, our development team has undertaken all the necessary efforts and updated the functionality of the poster. Right now we are ...

The post LinkedIn Poster issues appeared first on RSSground.com.

LinkedIn has finally approved our app! After the recent LinkedIn platform updates and long-awaited app review LinkedIn Poster is back to its normal functionality.

The post LinkedIn Company Pages Posting is Resumed appeared first on RSSground.com.

At least eight athletes who played in Staples Center on March 10-11 have contracted the coronavirus. Here is the story of the last four days inside the arena.

One in three cases of COVID-19 in Sacramento County have been linked to church gatherings, public health officials said.

A statement from Arsenal on Thursday night revealed that the manager had contracted the disease after starting to feel ill.

More than 2,100 nightclubs, hostess bars and discos in South Korea's capital have been shut after 18 new coronavirus cases - with all but one linked to a 29-year-old man.

I’m drawn to LinkedIn now more than ever before. The rate of connection requests I’ve been receiving there has also been accelerating over the past few months. Maybe it’s due to all the uncertainty of the publishing industry but I …

Even the biggest sites on the internet can have problems with their SEO and Google.

Please visit Search Engine Land for the full article.

New York Gov. Andrew Cuomo says three children in the state have now died from a possible complication from the coronavirus involving swollen blood vessels and heart problems.

Marilyn Goudreault
Jan 1, 2009; 8:157-171
Research

(Institute for Operations Research and the Management Sciences) Job performance has long been understood to be the primary equalizing factor affecting promotions for men and women in the workplace, but research shows, women don't gain as much from the same performance improvements as men do. New research in the INFORMS journal Information Systems Research shows training plays an important part in promotions for women in the field of information technology.

(Anglia Ruskin University) A new study has found an association between low average levels of vitamin D and high numbers of COVID-19 cases and mortality rates across 20 European countries.

(Texas A&M University) Spoiling foods, souring wine and worsening wounds have a common culprit -- a process called oxidation. Although the ill effects of these chemical reactions can be curtailed by antioxidants, creating a sturdy platform capable of providing prolonged antioxidant activity is an ongoing challenge.

Taewook Kang
Apr 7, 2020; 0:RA119.001882v1-mcp.RA119.001882
Research

Qingbo Shu
Apr 1, 2020; 19:672-689
Research

Large-scale identification of N-linked intact glycopeptides by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) in human serum is challenging because of the wide dynamic range of serum protein abundances, the lack of a complete serum N-glycan database and the existence of proteoforms. In this regard, a spectral library search method was presented for the identification of N-linked intact glycopeptides from N-linked glycoproteins in human serum with target-decoy and motif-specific false discovery rate (FDR) control. Serum proteins were firstly separated into low-abundance and high-abundance proteins by acetonitrile (ACN) precipitation. After digestion, the N-linked intact glycopeptides were enriched by hydrophilic interaction liquid chromatography (HILIC) and a portion of the enriched N-linked intact glycopeptides were processed by Peptide-N-Glycosidase F (PNGase F) to generate N-linked deglycopeptides. Both N-linked intact glycopeptides and deglycopeptides were analyzed by LC-MS/MS. From N-linked deglycopeptides data sets, 764 N-linked glycoproteins, 1699 N-linked glycosites and 3328 unique N-linked deglycopeptides were identified. Four types of N-linked glycosylation motifs (NXS/T/C/V, X=P) were used to recognize the N-linked deglycopeptides. The spectra of these N-linked deglycopeptides were utilized for N-linked deglycopeptides library construction and identification of N-linked intact glycopeptides. A database containing 739 N-glycan masses was constructed and utilized during spectral library search for the identification of N-linked intact glycopeptides. In total, 526 N-linked glycoproteins, 1036 N-linked glycosites, 22,677 N-linked intact glycopeptides and 738 N-glycan masses were identified under 1% FDR, representing the most in-depth serum N-glycoproteome identified by LC-MS/MS at N-linked intact glycopeptide level.

Host Matt Egan is joined by Online Editor at Techworld.com Scott Carey to break down Microsoft's mega acquisition of LinkedIn. Staff Writer at PC Advisor Chris joins in to discuss all of the news coming out of E3 and how Xbox and Playstation are set to battle it out again this summer, or will Nintendo and Zelda steal the show? (13:00). Finally, David Price comes on to talk about all of the news coming out of Apple's WWDC developer conference this week, from Hair Force One to watchOS, tvOS, macOS and iOS (26:30) And please do share, rate and review the UK Tech Weekly Podcast.  

See acast.com/privacy for privacy and opt-out information.

The onset of obesity-linked type 2 diabetes (T2D) is marked by an eventual failure in pancreatic β-cell function and mass that is no longer able to compensate for the inherent insulin resistance and increased metabolic load intrinsic to obesity. However, in a commonly used model of T2D, the db/db mouse, β-cells have an inbuilt adaptive flexibility enabling them to effectively adjust insulin production rates relative to the metabolic demand. Pancreatic β-cells from these animals have markedly reduced intracellular insulin stores, yet high rates of (pro)insulin secretion, together with a substantial increase in proinsulin biosynthesis highlighted by expanded rough endoplasmic reticulum and Golgi apparatus. However, when the metabolic overload and/or hyperglycemia is normalized, β-cells from db/db mice quickly restore their insulin stores and normalize secretory function. This demonstrates the β-cell’s adaptive flexibility and indicates that therapeutic approaches applied to encourage β-cell rest are capable of restoring endogenous β-cell function. However, mechanisms that regulate β-cell adaptive flexibility are essentially unknown. To gain deeper mechanistic insight into the molecular events underlying β-cell adaptive flexibility in db/db β-cells, we conducted a combined proteomic and post-translational modification specific proteomic (PTMomics) approach on islets from db/db mice and wild-type controls (WT) with or without prior exposure to normal glucose levels. We identified differential modifications of proteins involved in redox homeostasis, protein refolding, K48-linked deubiquitination, mRNA/protein export, focal adhesion, ERK1/2 signaling, and renin-angiotensin-aldosterone signaling, as well as sialyltransferase activity, associated with β-cell adaptive flexibility. These proteins are all related to proinsulin biosynthesis and processing, maturation of insulin secretory granules, and vesicular trafficking—core pathways involved in the adaptation of insulin production to meet metabolic demand. Collectively, this study outlines a novel and comprehensive global PTMome signaling map that highlights important molecular mechanisms related to the adaptive flexibility of β-cell function, providing improved insight into disease pathogenesis of T2D.

Phospholipases A₂ (PLA₂s) catalyze hydrolysis of the sn-2 substituent from glycerophospholipids to yield a free fatty acid (i.e., arachidonic acid), which can be metabolized to pro- or anti-inflammatory eicosanoids. Macrophages modulate inflammatory responses and are affected by Ca²⁺-independent phospholipase A₂ (PLA₂)β (iPLA₂β). Here, we assessed the link between iPLA₂β-derived lipids (iDLs) and macrophage polarization. Macrophages from WT and KO (iPLA₂β–/–) mice were classically M1 pro-inflammatory phenotype activated or alternatively M2 anti-inflammatory phenotype activated, and eicosanoid production was determined by ultra-performance LC ESI-MS/MS. As a genotypic control, we performed similar analyses on macrophages from RIP.iPLA₂β.Tg mice with selective iPLA₂β overexpression in β-cells. Compared with WT, generation of select pro-inflammatory prostaglandins (PGs) was lower in iPLA₂β^–/–, and that of a specialized pro-resolving lipid mediator (SPM), resolvin D2, was higher; both changes are consistent with the M2 phenotype. Conversely, macrophages from RIP.iPLA₂β.Tg mice exhibited an opposite landscape, one associated with the M1 phenotype: namely, increased production of pro-inflammatory eicosanoids (6-keto PGF₁α, PGE₂, leukotriene B₄) and decreased ability to generate resolvin D2. These changes were not linked with secretory PLA₂ or cytosolic PLA₂α or with leakage of the transgene. Thus, we report previously unidentified links between select iPLA₂β-derived eicosanoids, an SPM, and macrophage polarization. Importantly, our findings reveal for the first time that β-cell iPLA₂β-derived signaling can predispose macrophage responses. These findings suggest that iDLs play critical roles in macrophage polarization, and we posit that they could be targeted therapeutically to counter inflammation-based disorders.

An essential mineral in the body have been linked to recovery of COVID-19 patients.

→ Support PsyBlog for just $5 per month. Enables access to articles marked (M) and removes ads.

→ Explore PsyBlog's ebooks, all written by Dr Jeremy Dean:

• Accept Yourself: How to feel a profound sense of warmth and self-compassion
• The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic
• Spark: 17 Steps That Will Boost Your Motivation For Anything
• Activate: How To Find Joy Again By Changing What You Do

Graphical models are commonly used to represent conditional dependence relationships between variables. There are multiple methods available for exploring them from high-dimensional data, but almost all of them rely on the assumption that the observations are independent and identically distributed. At the same time, observations connected by a network are becoming increasingly common, and tend to violate these assumptions. Here we develop a Gaussian graphical model for observations connected by a network with potentially different mean vectors, varying smoothly over the network. We propose an efficient estimation algorithm and demonstrate its effectiveness on both simulated and real data, obtaining meaningful and interpretable results on a statistics coauthorship network. We also prove that our method estimates both the inverse covariance matrix and the corresponding graph structure correctly under the assumption of network “cohesion”, which refers to the empirically observed phenomenon of network neighbors sharing similar traits.

Peng Shi, Zifeng Zhao.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 357--380.

Abstract:
In actuarial research a task of particular interest and importance is to predict the loss cost for individual risks so that informative decisions are made in various insurance operations such as underwriting, ratemaking and capital management. The loss cost is typically viewed to follow a compound distribution where the summation of the severity variables is stopped by the frequency variable. A challenging issue in modeling such outcomes is to accommodate the potential dependence between the number of claims and the size of each individual claim. In this article we introduce a novel regression framework for compound distributions that uses a copula to accommodate the association between the frequency and the severity variables and, thus, allows for arbitrary dependence between the two components. We further show that the new model is very flexible and is easily modified to account for incomplete data due to censoring or truncation. The flexibility of the proposed model is illustrated using both simulated and real data sets. In the analysis of granular claims data from property insurance, we find substantive negative relationship between the number and the size of insurance claims. In addition, we demonstrate that ignoring the frequency-severity association could lead to biased decision-making in insurance operations.