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2 Dozens Original Glazed Donuts $28 + $7.50/$12 Delivery ($0 C&C/ $65 Order) @ Krispy Kreme (Excludes SA)

Unbox 24 of our iconic Original Glazed® Doughnuts for only $28! ????

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Offer available on Signature Pack Product only.
Offer is not available in Krispy Kreme Stores, 7-Eleven, Woolworths, Coles, Costco, bp-Connect, Krispy Kreme South Australia, Jesters or via third party delivery partners and Same-Day Pick-Up Menu.
Offer is subject to stock availability. Whilst stocks last. Terms and conditions apply. See full T&Cs here.




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Untangling DeSantis-Disney legal dispute could take years

The potential legal battle between Gov. Ron DeSantis and Disney over Reedy Creek could take years and cost millions.




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Florida Hispanics drawn to Trump despite race-baiting, deportation threats

Economic and social issues were more important for many voters. Interviews with Osceola County voters of Puerto Rican heritage show the trend.




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Antec Unveils CX600M Trio PC Case To Put Your Compact Gaming Setup On Full Display

It can take quite a bit of effort to build a small form factor (SFF) showpiece, but if you're up for the challenge, Antec's new CX600M Trio case lineup will put your setup on full display with 4mm tempered glass panels on the front, one of the sides, and up top. From the renders we've seen (like the one above), you could build a stunning system




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LG Develops First-Ever Stretchable Display With Amazing Elasticity And Micro LEDs

LG is bending the rules of physics with its first-ever stretchable display that expands with impressive elasticity and micro-LEDs. The new display is capable of expanding up to 50%, the highest rate of elongation in the industry. Companies have been pushing the boundaries of what screens can do in the last few years. From Motorola’s concept




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Displays 101: Here’s What To Look For In Your Next Monitor Or TV

Have you ever read a monitor review or looked at monitor specification pages and wondered what all the terms meant? In this article, we're going to go over display basics, explaining the core specifications of monitors and what you should look for when shopping for a new display. Most of the information and terminology in this post will apply...




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[ H.629.1 (11/19) ] - Scenarios, framework and metadata for digitalized artwork images display system

Scenarios, framework and metadata for digitalized artwork images display system




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Resolution 62 - (Rev. Dubai, 2012) - Dispute settlement

Resolution 62 - (Rev. Dubai, 2012) - Dispute settlement




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[ N.11 (11/88) ] - Essential transmission performance objectives for international sound-programme centres (ISPC)

Essential transmission performance objectives for international sound-programme centres (ISPC)




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HSTP-IPTV-ISPF - IPTV retail service provider model

HSTP-IPTV-ISPF - IPTV retail service provider model




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JSTR-OPTR - Optimizing bit rates and transmission resolution by considering display characteristics and available bandwidth

JSTR-OPTR - Optimizing bit rates and transmission resolution by considering display characteristics and available bandwidth




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[ D.170 (2010) Supplement 1 (05/10) ] - Dispute management guidelines

Dispute management guidelines




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[ D.170 (2010) Supplement 2 (05/10) ] - Dispute process guidelines

Dispute process guidelines




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Operational Bulletin No. 1199 (1.VII.2020) and Annexed List: <br/> List of International Signalling Point Codes (ISPC) (According to Recommendation ITU-T Q.708 (03/99)) (Position on 1 July 2020)

Operational Bulletin No. 1199 (1.VII.2020) and Annexed List:
List of International Signalling Point Codes (ISPC) (According to Recommendation ITU-T Q.708 (03/99)) (Position on 1 July 2020)




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List of International Signalling Point Codes (ISPC) (According to Recommendation ITU-T Q.708 (03/99))

List of International Signalling Point Codes (ISPC) (According to Recommendation ITU-T Q.708 (03/99))




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Operational Bulletin No. 1295 (1.VII.2024) and Annexed List: <br/> List of International Signalling Point Codes (ISPC) (According to Recommendation ITU-T Q.708 (03/99)) (Position on 1 July 2024)

Operational Bulletin No. 1295 (1.VII.2024) and Annexed List:
List of International Signalling Point Codes (ISPC) (According to Recommendation ITU-T Q.708 (03/99)) (Position on 1 July 2024)




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List of International Signalling Point Codes (ISPC) (According to Recommendation ITU-T Q.708 (03/99))

List of International Signalling Point Codes (ISPC) (According to Recommendation ITU-T Q.708 (03/99))




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Superwhisper

Tempted to try Superwhisper!




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visionOS 2.2 Beta Adds Wide and Ultrawide Modes To Mac Virtual Display

Apple released the first beta of visionOS 2.2, introducing new "Wide" and "Ultrawide" modes for the Mac Virtual Display feature on the Vision Pro headset. MacRumors reports: Apple has previously said the ultra-wide version of Mac Virtual Display is equivalent to having two physical 4K displays sitting side by side on a desk. Mac Virtual Display is now available in three sizes: Normal, Wide, and Ultrawide. visionOS 2.2 will likely be released to the public in December alongside iOS 18.2, iPadOS 18.2, macOS Sequoia 15.2, watchOS 11.2, tvOS 18.2, and other updates. Further reading: Apple Delays Cut-price Vision Headset Until 2027, Analyst Ming-Chi Kuo Says

Read more of this story at Slashdot.




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LG's New Stretchable Display Can Grow By 50%

An anonymous reader quotes a report from Tom's Hardware: LG Display, one of the global leaders in display technologies, unveiled a new stretchable display prototype that can expand by up to 50%. This makes it the most stretchable display in the industry, more than doubling the previous record of 20% elongation. [...] The prototype being flexed in [this image] is a 12-inch screen with a 100-pixel-per-inch resolution and full RGB color that expands to 18-inches when pulled. LG Display said that it based the stretchable display on a "special silicon material substrate used in contact lenses" and then improved its properties for better "stretchability and flexibility." It also used a new wiring design structure and a micro-LED light source, allowing users to repeatedly stretch the screen over 10,000 times with no effect on image quality.

Read more of this story at Slashdot.




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National Hispanic Contractors Association Announces Partnership with International Roofing Expo

The partnership is a significant step forward in promoting diversity, equity, and inclusion within the roofing industry while providing resources to Hispanic roofing professionals.




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International Roofing Expo 2024 Champions Hispanic Roofing Community Through Strategic Partnerships

This year’s International Roofing Expo emphasizes the many outreach efforts dedicated to supporting the Hispanic roofing community for its 2024 event next month in Las Vegas.




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Shop Owner Responds to Dispute with Bold Rooftop Mural

After months of towing disputes with an adjacent apartment building, a tattoo parlor owner painted a provocative mural on his roof to express his frustration over confusing parking signs, drawing both media attention and resident disapproval.




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Wispr Raises $12 Million and Launches Wispr Flow to Replace Keyboards With Voice

Wispr Flow provides voice dictation that works in every app on Macs with auto-edits and AI commands.




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Trump 'dispara' a todo lo que se mueva fuera de EEUU

El político republicano, en la carrera por volver a la Casa Blanca, amenaza con aranceles del 200% a la legendaria John Deere si traslada producción a México Leer




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Investigan los disparos en un campo de fútbol de Granada con dos heridos leves

Los hechos se produjeron pasadas las 20:30 horas del sábado mientras se disputaba un partido de fútbol y se escucharon varias detonaciones que provocaron heridas leves a una pareja que estaba en ese momento en las gradas Leer




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Detienen a un hombre por llevarse a la fuerza a su hija de 10 años y disparar a la casa de un familiar de su ex mujer en Málaga

El hombre tenía orden de alejamiento de su ex pareja Leer





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La Diócesis de Bilbao alerta de estafas telefónicas suplantando al obispo

A través de redes, informa que Joseba Segura "no ha llamado ni llamará nunca para pedir dinero a las comunidades religiosas" Leer




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El mensaje de Sánchez a las 22.50 que dejó a Mazón al mando de la crisis en la noche fatídica: "A disposición"

Le escribió mientras volvía de la India, y el presidente valenciano le contestó que la situación era muy mala. A Montero le pidió a las 21.03 "movilizar" al Ejército Leer




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La rentabilidad de una vivienda en alquiler se dispara un 400% en Málaga si se destina al turismo

Un informe del Ayuntamiento vincula el aumento de los pisos vacacionales con la despoblación en los barrios del centro de la capital de la Costa del Sol Leer




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Dimite el arzobispo de Canterbury por tapar un escándalo de abuso de menores

Más de 10.000 firmas pidieron la renuncia tras la publicación de un informe que reveló hasta 130 casos de abusos y castigos corporales por parte de John Smyth, un abogado que organizaba campamentos cristianos. Leer




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El nuevo desafío de Jorge Bustos: "¡Qué disparate! No voy a ser el sustituto de Carlos Herrera (...) Estoy a mil millas de un gran maestro"

Desde septiembre, Jorge Bustos compagina el micrófono con la página en blanco. Al frente de Mediodía en Cope, el subdirector de EL MUNDO, se enfrenta a un nuevo y exigente desafío: la radio. "Ejecuto mis días más o menos con el rigor de un abad cisterciense", asegura Leer




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Muere un hombre al recibir dos disparos en la puerta de su casa en Elche

Los servicios sanitarios que acudieron al lugar efectuaron tareas de reanimación sin éxito porque la víctima ya estaba muerta Leer




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El fenómeno Doncic: así se ha disparado la audiencia en España de la NBA

El esloveno busca asaltar el anillo con los Mavericks, que se han reforzado con Klay Thompson. Con su debut en las pasadas Finales, aumentó un 61% la audiencia en el país en el que se formó Leer




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Los dispositivos se acumulan

Según Agamben, la acumulación de artefactos de toda clase afecta a nuestra confusión sobre lo que somos.




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El peligroso avispero de Iker Jiménez: ING, los primeros en retirar la publicidad de sus programas

La retirada de publicidad de un programa es un hecho que no suena a nuevo. Ocurrió con GH Revolution y ocurrió con La Noria. Ahora, ING ha abierto la veda en Horizonte y Cuarto Milenio. Y mientras, Iker Jiménez abriendo el aspersor: "Vamos a sacar algo aquí que es realmente demoledor Leer




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DSW Names Crispin its Creative Agency of Record

Footwear and accessories retailer Designer Shoe Warehouse (DSW) has selected Crispin as its new creative agency of record (AOR), the agency shared exclusively with ADWEEK. Crispin will support the brand's internal team with brand strategy, visual identity, and integrated marketing as it evolves DSW's "positioning for the modern consumer," according to the companies. Prior to...




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The Supreme Court rules for Biden administration in a social media dispute with conservative states

The Supreme Court has sided with the Biden administration in a dispute with Republican-led states over controversial social media posts.

The post The Supreme Court rules for Biden administration in a social media dispute with conservative states first appeared on Federal News Network.




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CES 2023 tells us the future of notebooks displays is bright, literally

What does fried chicken and notebooks have in common? Read to find out.



  • Tech Trends and Commentaries

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Aftermath of Israeli airstrikes in Beirut, displaced people seek shelter

Aftermath of Israeli airstrikes in Beirut, displaced people seek shelter




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Grand Prix d'Horlogerie de Genève: the 90 competing timepieces on display

Grand Prix d'Horlogerie de Genève: the 90 competing timepieces on display




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Juliette Binoche launches Paris Christmas window display

Juliette Binoche launches Paris Christmas window display




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The Missing Data: Measuring ISP User Populations

In our physical world, census information is used to inform the planning processes behind the provision of infrastructure, such as schools, hospitals, housing, and similar. It can be used to assess the impact of natural disasters or to understand a society's needs in terms of food and energy security. Demographic data is also used to inform investment and business decisions. You'd think that the Internet itself would be awash with similar information.




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Record labels unhappy with court win, say ISP should pay more for user piracy

Music companies appeal, demanding payment for each song instead of each album.




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The End of Desertification? Disputing Environmental Change in the Drylands

Location: Electronic Resource- 




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Disputing Inaccurate Information on a Credit Report

Disputing Inaccurate Information on a Credit Report



  • Assyrian Financial Network

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Artsakh Uprooted: Aftermaths of Displacement

Artsakh Uprooted: Aftermaths of Displacement



  • Armenian
  • Assyrian and Hellenic Genocide News

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CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion.

This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. 

Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. 

Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. 

Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. 

The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. 

CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years.

 Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn.

sb admin Thu, 02/06/2020 - 14:52
Categories




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Solar storm could disrupt communications and display northern lights to parts of California

A severe geomagnetic storm could disrupt communications and bring northern lights to parts of California, according to a warning from the National Oceanic and Atmospheric Administration.