The Chicago-based center has been years in the making.

Legislation to create a regulatory sandbox will “allow innovators in the energy sector both the physical and legislative space to carry out their development and testing of technologies,” Minister of Home Affairs Walter Roban said. Speaking in the House of Assembly today [May 20] the Minister said, “Today I am tabling the Bill entitled the […]

The YAO Youth Baseball League continued at the YAO Ball Park on Kindley Field this weekend, with the Phillies, Red Sox, Blue Jays, and Diamondbacks all earning wins. Cal Ripken Division [Ages 10-12]: Phillies 14 Red Sox 5 The Phillies had an all-around team effort in their 14-5 win over the Red Sox. The Phillies […]

Eva Frazzoni, the Bermuda women’s national football team captain, scored in AFC Sudbury’s 3-0 win at home to Bowers & Pitsea Ladies in the Adobe Women’s FA Cup first round today [November 3]. The midfielder opened the scoring in the 29th minute with a well-taken header. AFC Sudbury Women have reached the second-round proper of […]

Eva Frazzoni scored in AFC Sudbury’s 2-1 win away to Dulwich Hamlet in the FA Women’s National League Division One South East today [November 10]. The Bermuda women’s national team captain netted her side’s second goal to make it 2-0 in the first half. Related Stories Kenni Thompson Scores For Bournemouth Kenni Thompson Scores For […]

CariGenetics — in partnership with The 2 Frontiers Project and BIOS — led and funded a local study that could help save coral reefs around the world which are being affected by climate change. A spokesperson said, “Since its launch last October, CariGenetics continues to conduct ground-breaking research which will have a positive impact, not […]

“Bermuda has taken a significant step towards sustainable energy development with the introduction of the Electricity Amendment Act 2022 [Consequential Amendments] Regulations 2023,” said Minister of Home Affairs Walter Roban regarding the act, which went into effect on 9th May 2023. “This Act paved the way for introducing the Electricity [Innovative Licence] Regulations 2023 which […]

Od hraní v menších klubech až po vyprodané, velkoryse produkované koncerty – taková je hudební cesta britského hudebníka, producenta a skladatele Alexandera Kotze, známějšího pod jménem Elderbrook. Ten patří mezi přední postavy současné britské elektronické a indie-dance scény. O jeho kvalitách se můžete přesvědčit sami – vystoupí 14. 11. v pražském SaSaZu. O jeho začátcích, tlaku na výkon, životě s rodinou i o vniku unikátního „cinematic“ zvuku se dočtete v rozhovoru pro Reflex.

In the Class of 2028, 71.5% of students qualify for financial aid and 21.7% of the class are lower-income students eligible for federal Pell grants.

Any complaints, queries or suggestions about content on News24 may be sent to our public editor George Claassen.

M. Wang
Aug 1, 2012; 11:492-500
Technological Innovation and Resources

Wisdom to my mind is a bit of a paradox. It is subjective and context-dependent, but inherently universal. I say this, because for something to be wise it ought to be applicable across time and space, yet whether the claims are appraised as being “wise” hinges on the perception of a past, present or future audience. It is beyond the self, yet dependent upon the self. So that then begs the fantasy writing question: What if the self is not human? If culture already morphs the form and substance of wisdom, what effect might a different state of being have on it?

That would be terribly dull to prescribe, but I can help get some readers’ creativity going. Below I have listed relevant questions with examples you might consider when building your setting, so you may merrily thread into your fantastic realms to shape oddities rich and strange.

I would advise readers of this article to try and let go of their own presumptions on what is wise for the sake of worldbuilding. There are few cultures in our modern, human world whose philosophers deem obtuse narcissists dressed in mink robes as being wise, but why wouldn’t a race of bobcat-folk?

Continue reading Questions for Worldbuilding the Concept of Wisdom at Mythic Scribes.

MS Brown
Jul 1, 1980; 21:505-517
Reviews

12 August 2020

Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20 (ring finger protein 20) in shaping chromatin landscape and preserving genomic stability. However, the mechanism that mobilizes SMURF2 in response to DNA damage remains unclear. Using biochemical approaches and MS analysis, we show that upon the onset of the DNA-damage response, SMURF2 becomes phosphorylated at Ser384 by ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is required for its interaction with RNF20. We demonstrate that a SMURF2 mutant with an S384A substitution has reduced capacity to ubiquitinate RNF20 while promoting Smad3 ubiquitination unabatedly. More importantly, mouse embryonic fibroblasts expressing the SMURF2 S384A mutant show a weakened ability to sustain the DSB response compared with those expressing WT SMURF2 following etoposide treatment. These data indicate that SMURF2-mediated RNF20 ubiquitination and degradation controlled by ataxia telangiectasia mutated–induced phosphorylation at Ser384 constitutes a negative feedback loop that regulates DSB repair.

I’m often asked if I miss working in the House of Commons. Of course I do; it’s one of the most amazing places in the world and remains the cockpit of our nation.There are obviously days I miss it more than others, usually around the big national moments. Whatever your view of Kim Leadbeater’s private member’s bill—the Terminally Ill Adults (End of Life) Bill—its second reading this month will be one of those big moments.Kim is a friend of mine, and we spoke before she decided to put her bill forward after it topped the private members’ ballot at the start of the new parliament. My advice was to proceed with great care, to remember that this will take over your career in many ways, and to read the report produced earlier this year by the Health and Social Care Committee, which I chaired, on the subject of assisted dying/assisted...

Actor/TV personality Whoopi Goldberg turns 69 and singer Julia Michaels turns 30, among the famous birthdays for Nov. 13.

In a universe not unlike ours, a tech-environmentalist group claims to have created an AI that is the direct “voice of the earth,” a computer connected via electrodes to the mycelium network under an ancient forest named S.A.N (Sentient Advocate of Nature). The film imagines what nature thinks of human impact on the planet, as a renowned reporter conducts a world-first interview with S.A.N.

Maryland's legislature has proposed a unique way to fund schools and also wants to hold school districts more accountable for how they spend their money as part of a new funding formula.

The state wants to test its middle school students in the mathematics courses in which they're enrolled, rather than with the state tests created for that each student's particular grade.

Emerging research in nonhuman animals implicates cerebellar projections to the ventral tegmental area (VTA) in appetitive behaviors, but these circuits have not been characterized in humans. Here, we mapped cerebello-VTA white matter connectivity in a cohort of men and women using probabilistic tractography on diffusion imaging data from the Human Connectome Project. We uncovered the topographical organization of these connections by separately tracking from parcels of cerebellar lobule VI, crus I/II, vermis, paravermis, and cerebrocerebellum. Results revealed that connections between the cerebellum and VTA predominantly originate in the right cerebellar hemisphere, interposed nucleus, and paravermal cortex and terminate mostly ipsilaterally. Paravermal crus I sends the most connections to the VTA compared with other lobules. We discovered a mediolateral gradient of connectivity, such that the medial cerebellum has the highest connectivity with the VTA. Individual differences in microstructure were associated with measures of negative affect and social functioning. By splitting the tracts into quarters, we found that the socioaffective effects were driven by the third quarter of the tract, corresponding to the point at which the fibers leave the deep nuclei. Taken together, we produced detailed maps of cerebello-VTA structural connectivity for the first time in humans and established their relevance for trait differences in socioaffective regulation.

We used virus-mediated anterograde and retrograde tracing, optogenetic modulation, immunostaining, in situ hybridization, and patch-clamp recordings in acute brain slices to study the release mechanism and μ-opioid modulation of the dual glutamatergic/GABAergic inputs from the ventral tegmental area and supramammillary nucleus to the granule cells of the dorsal hippocampus of male and female mice. In keeping with previous reports showing that the two transmitters are released by separate active zones within the same terminals, we found that the short-term plasticity and pharmacological modulation of the glutamatergic and GABAergic currents are indistinguishable. We further found that glutamate and GABA release at these synapses are both virtually completely mediated by N- and P/Q-type calcium channels. We then investigated μ-opioid modulation of these synapses and found that activation of μ-opioid receptors (MORs) strongly inhibits the glutamate and GABA release, mostly through inhibition of presynaptic N-type channels. However, the modulation by MORs of these dual synapses is complex, as it likely includes also a disinhibition due to downmodulation of local GABAergic interneurons which make direct axo-axonic contacts with the dual glutamatergic/GABAergic terminals. We discuss how this opioid modulation may enhance LTP at the perforant path inputs, potentially contributing to reinforce memories of drug-associated contexts.

The first plane to fly nonstop from New York to Paris will reside on the ground level of the National Air and Space Museum for the next five months as it undergoes preservation (Courtesy of the National Air and Space Museum)

How do hens react when they see the movement of a rooster's waddle?

Victor Ambros and Gary Ruvkun discovered microRNA, tiny molecules that play a crucial role in how cells develop, paving the way for new treatments for diseases

It's curtains for the NASA mission's close relationship with the satellite

A Sudbury pharmacy technician has come up with a better way to do her job, while also improving patient safety. Now her method is being used at Sudbury's hospital, and is getting interest from others.

Max Topolnisky, a 100-year-old Second World War veteran, was out selling poppies for the Lockerby Legion in Sudbury, Ont., two days before he died, on Nov. 1, 2024.

The National Math and Science Initiative's new tool aims to help the field look for patterns in STEM data, so educators and policy folks can fill in holes.

A draft proposal of Penn State’s institutional strategic plan has been unveiled and shared with the community for feedback and discussion. All faculty, staff and students at all campuses are encouraged to visit the Strategic Plan website to review and provide feedback on the draft plans for four goal areas.

Aiming to reinvigorate debate over polarizing issues, Penn State graduate and longtime volunteer James P. Jimirro has made a gift to create a debate series, which is projected to raise the University’s profile as a national leader in showcasing free speech in action.

Street evangelism - that’s how Nicolas ended up carrying a 2 meter high cardboard coffin on a bus across Santiago, Chile.

Starlink has been looking to enter India for years and its plans got a major boost last month when New Delhi said it wouldn't auction spectrum for satellite broadband but rather award it administratively - just as Musk wanted. Rival Indian telecom billionaire Mukesh Ambani had wanted an auction.

Wilmington, Del.— The World Trade Center of Greater Philadelphia and Export Delaware announce, “Selling to the World, Growing a Vibrant, Inclusive, and Connected Economy for Greater Philadelphia” a program to expand small business exports that feature a new Global Supplier Diversity Initiative to support minority- and women-owned businesses. For the first time, minority- and women-owned […]

Five Delaware minority and/or veteran-owned small businesses completed Export Delaware’s new signature training program, “Selling to the World.” Export Delaware partnered with the World Trade Center of Greater Philadelphia to develop this groundbreaking initiative. Participants learned how to develop an export strategy, find qualified buyers, navigate logistics and shipping, learn about export finance, international patents, […]

WILMINGTON, Del. – After reviewing customer feedback from three Community Conversations in Wilmington and Newark last week, DART will make a series of improvements. The recent Community Conversations offered DART riders, and the general public, the opportunity to provide feedback and share their experiences since DART’s service changes in mid-December. “The Community Conversations were intended […]

SAS Visual Text Analytics can easily analyze similar words and phrases coming from various cultural heritage-related documents to construct a heritage wordbook that cultural workers can use to identify what relevant conservation technique to use on a structure/artifact.

Building a cultural wordbook via SAS Visual Text Analytics was published on SAS Users.

  Arts & Economic Prosperity 6 Study Highlights Vital Role of Arts and Culture in Building More Livable Communities Around the Country   Wilmington, Del. (July 1, 2024) – The Delaware Division of the Arts today announced that Delaware’s nonprofit arts and culture industry generated $209.5 million in economic activity in 2022, according to the […]

The Delaware Department of Agriculture announced today that Mark Short has been named the new Delaware Standardbred Breeders’ Fund (DESBF) administrator. He will begin his new role as the DESBF administrator on November 1.

DNREC continued to diversify marine habitat for angling and diving experiences on Delaware’s renowned artificial reef system today by sinking two vintage vessels – a retired City of Baltimore fireboat and a World War II-era tugboat – onto Reef Site 11, the Redbird Reef, that also contains 750 retired NYC "Redbird" subway cars.

The Delaware State Fire Commission is thrilled to announce the Groundbreaking Ceremony for our new building scheduled for Friday, September 6, 2024, at 11:00 am. The ceremony will be held at the Delaware Fire Service Center, 1463 Chestnut Grove Road, Dover, Delaware. “Our long-awaited new building will replace the current one attached to the rear […]

On Friday, September 6, 2024, the Delaware State Fire Prevention Commissioners held their groundbreaking ceremony for their new building. The Commissioners wanted to express their sincere gratitude for everyone’s presence at the groundbreaking ceremony. The support and encouragement mean a great deal to us, and we are truly thankful for all who attended and participated […]

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