Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.

I am still holding on a call to the Internal Revenue Service, even though I called (800) 829-0115 two hours ago. This telephone number is the one often included in notices from the Internal Revenue Service for overdue business taxes. … Continue reading →

An Offer in Compromise is an agreement between the taxpayer and the government that settles a tax liability for payment of less than the full amount owed. The Internal Revenue Service will generally accept an Offer in Compromise when it … Continue reading →

Connecticut General Assembly Majority Leader Joe Aresimowicz speaking at the 2014 CEUI Convention. Joe Aresimowicz, in speaking to a governmental employee union group in 2014, assured governmental union employees that he would be looking out for them: "You guys have one of your own that sits in the caucus room of the General Assembly. You cannot replicate that." "I will never allow an anti-collective bargaining bill to be called to the House floor. I'm the majority leader. I can make that guarantee." "Please, stand together, stand as brothers and sisters, and be a family. And make sure we are looking out for our own." Continue reading →

Tucker: There’s no value more American than free speech Liberals working to crack down on the First Amendment, ban speech they don’t like. GOOD EVENING, AND WELCOME TO “TUCKER CARLSON TONIGHT.” It’s hard to think of an ideal more American … Continue reading →

IBM announced today a new experimental laboratory for nanotechnology research in Brazil. The NanoLab is part of a $4M investment within the recently upgraded IBM Research-Brazil lab in Rio de Janeiro and will focus on projects related to research in Oil & Gas, Agriculture and Health across Latin America.

Today IBM and Eurobank announced the first cloud-based digital platform for online international commercial trading. Using IBM's industry-leading Digital Experience software, with advanced cloud capabilities and social offerings, Eurobank is uniting exporters and importers from around the globe to enhance international trade operations and increase transactions.

IBM today announced that M-Industry, one of the world’s largest private label consumer goods company and subsidiary of Switzerland’s largest retailer and supermarket chain, Migros Group, has launched a new IBM designed mobile offering to transform how product promoters work.

China Construction Bank (Asia) Corporation Limited (“CCB (Asia)”) and IBM today announced the development of the first blockchain-enabled bancassurance project in Hong Kong. Built on the IBM Blockchain Platform, the solution is designed to streamline CCB (Asia)’s bancassurance process and greatly enhance customer experience and the quality of services delivered through faster transaction processing time and increased transparency.

IBM will host New Zealand's first SmartCamp in Auckland on Sept. 17.

IBM Poland and WINUEL SA (subsidiary of Sygnity Group), today announced the first Polish Smart Metering software package to enable intelligent electricity use in more than 15 million households in Poland. The solution was developed jointly with the IBM Software Laboratory in Krakow.

Apple et IBM annoncent plus de 100 apps MobileFirst pour iOS !

IBM Australia partners with Australia’s first Pride Centre to connect LGBTIQ community in Australia

IBM (NYSE: IBM) today announced it has partnered with academia, government and industry to launch the Smart Transport Research Centre (STRC) based at Queensland University of Technology (QUT), which is being opened today by the Minister for Transport, the honourable Annastacia Palasczuk. IBM will contribute its global consulting expertise and technology in developing smarter traffic solutions to help make Australia’s transportation infrastructure smarter, improve commuter experiences and reduce environmental impact.

One of Australia’s leading digital banks taps cognitive technology to simplify the home loan application process with innovative virtual assistan

Icon Group first in Australia to adopt world-leading technology as part of its comprehensive cancer care offering

IBM (NYSE: IBM) today announced the successful implementation of a first of its kind smart grid data management platform, designed and built with Ausgrid to give the utility more data from part of its electricity distribution grid.

Starting on Star Wars Day, for one week you can enjoy artistic renditions of your favorite films and series.

     It looks as though my first 3 mile cycle came back with negative results!!  Picture this: 


     I'm deep in concentration, the sweat dripping from my brow; the race is on.  I don't know if I'll finish, thoughts are pouring over me like warm syrup, I'm near the home stretch : King Edward and Queen Elizabeth Riveres are being held captive while the fate of their English lands are in turmoil and being held captive by the evil Lord Warwick!
      All of a sudden, the concentration of my exercise, as opposed to the concentration on King Edward and his "golden body" stop. My foot slips off the pedal and all of Phillipa Gregory's glorious characters go tumbling down the cycle along with the rest of my Kindle. 
     I finish off my 3 mile cycle near tears! What will become of King Edward and his lands? Will Queen Elizabeth be able to survive after the loss of her mother? Will Henry Tudor (yes the cute Henry Tudor that is the star of the hit SHOW time series, The Tudors) obtain the crown (even though if you have read any of Phillipa Gregory's novels, or seen the movie The Other Boleyn Girl you know the answer to that question)?
    Lukily, I get to find out more on Tuesday when Amazon.Com sends me another kindle to replace the one that, malfunctioned. Hey, she asked me if I dropped it, not if it fell...
     On to exerceise news!  Currently weighing in at 245 LBS.  Thats 2 LBS less that I did when I started the blog, lord knows weight flucuation sucks.  I plan to never be 250 + again.  Hello world, don't hate me because I'm beautiful!!!!
    I'll be blogging my exercise routine for the next 8 months later on today. I welcome all comments!!

Dick Kovacevich, former CEO of Wells Fargo bank, thinks most Americans should return to work in...

STUDIO 54 – THE FIRST FIVE MINUTES

It was “the only” time, and for sure, the best years of my life. Though it’s still not clear when or how, but at some point, I began running with the Beautiful People (BPs).

I Mean…What?!?

First off welcome to my site The Razors Edge. If you've been to this site before you were probably expecting to find my old website which delt with post apocalyptic survival. I've decided to do a complete overhaul including the content. Now this site deals with topics such as basic SEO tips ( Search Engine Optimization ) for those new to creating websites and blogs, movie reviews, general tips and advice, videos, and anything and everything in-between. Basically same name completly different taste

When it comes to making a bug out bag, or having an emergency bag for long road trips, or camping, and hiking trips. One of if not the most important items you need for your emergency gear is a first aid kit. And while they can be bought almost anywhere, there contents can vary depending on there size or price range. Regardless of your budget there are some items you should always have present in your first aid kit. Here is a list of 12 things I recommend everyone have that aren’t always included in an off the shelf first aid kit.

New story… First contact… Sarah watched the video screen as the rover Odin crawled across the surface of the planet Asgard. It was easy to think the video was in real time, but the reality was that the newly discovered planet Asgard was a little less than a light day from Earth. When Asgard was...

People First is an organisation run by and for people with learning disabilities.

Michael McEwan speaks to Rosie Smith, one of the members, who tells him about the work of the organisation. 

Transcript of episode

Music Credit: Make your dream a reality by Scott Holmes.

In 2006 Mencap produced a comprehensive review of short break provision. Now, 10 years on, they are revisiting the support available for family carers to see whether recent policy initiatives and investment have delivered the much-needed change. A total of 264 family carers responded to their survey on short breaks provision and experiences of caring. They also sent Freedom of Information requests to all 152 local authorities in England that provide social care services. This report looks at short breaks provision in a climate of cuts to central and local government budgets. It examines the extent to which these cuts have impacted on the lives of people with a learning disability and their family carers. It also looks at the state of affairs for family carers of children and young people across the full spectrum of learning disability; from people with mild and moderate learning disabilities, to people with severe and profound disabilities.

If we do some digging into the revision archives of the National Electrical Code (NEC), we can pretty much trace every requirement to one thing: saving lives! That is why the NEC exists; its purpose, the practical safeguarding of persons and property

Fox News' Pete Hegseth calls for people to go out and get infected by coronavirus: "Now that we are learning more, herd immunity is our friend. Healthy people getting out there -- they are going to have to have some courage." pic.twitter.com/PCSHm9yUAW

— Justin Baragona (@justinbaragona) May 7, 2020

I like to be training in the gym, see a guy’s cock through his shorts take him to the showers and fuck like crazy, sex on the beach, and all sorts of role play. Wanna join in? Chat with Chirs Morgan.

The post Flirt4Free: Chirs Morgan appeared first on QueerClick.

Nickelodeon used its Kids' Choice Awards show broadcast to premiere the first footage of its trademark green slime floating on board the International Space Station.

For nearly a century, Airstream has been designing campers built for both adventurous forever roamers or big families looking to enjoy summer time trips together. Now, the iconic camper brand has just introduced its latest concept, which is geared towards sustainable travelers of all types. The 2020 Atlas Camper features a solar-paneled rooftop and an ultra luxurious living space.[...]

Pacific Northwest architecture firm Mahlum has made history with the certification of its new architecture studio as Portland's first Living Building Challenge (LBC) project. As an LBC-certified workspace, Mahlum's new studio meets rigorous sustainability targets including net-zero embodied carbon emissions and the diversion of almost all construction waste from the landfill. The project is the 48th LBC-certified project in the United States and 57th in the world. [...]

We’ve had several cycles of so-called “panic buying” of firearms and ammunition in the last twenty years.  There was Y2K, when credible authorities warned us that the ticking of the clocks into the Year 2000 would blast all of the … Read more

By Dan Duddy  Published: May 06th, 2020 

By Dan Duddy  Published: May 07th, 2020 

Jedi Master Luke Skywalker, Lor San Tekka, and young Ben Solo encounter the Knights of Ren

A quick festive period podcast for you, looking back at Mikel Arteta's first game in charge of Arsenal. With me to discuss the 1-1 draw with Bournemouth is Lewis Ambrose. We chat about the game, some small tactical tweaks, the promising signs, as well as Nicolas Pepe, Alexandre Lacazette, and Mesut Ozil. Also on the agenda, the Granit Xhaka situation as he makes it clear he wants to leave the club in January.

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Your first year in network marketing can be a real struggle.? There are many challenges.? This includes rejection, time wasters, and much more.

To be successful and generate Success University Leads you need to think in a different way and have a system that will work for you and your future team. This article will give you some tips on what you need to focus on in your first year in network marketing to get an abundance of Success University leads.

 A 57-year-old man from El Salvador who was being held at the Otay Mesa Detention Center in California died from Covid-19 on Wednesday. This is the first confirmed death from the coronavirus at an ICE detention center. Carlos Escobar-Mejia has been detained at the center since Jan. 10 after having lived in the U.S. for 40 years. While at the detention center, he was on a list of people who are medically vulnerable to the virus and are therefore eligible for immediate release but was hospitalized before the list was fully put together. According to ICE, 705 out of 1,460 detainees tested positive for Covid-19. At the Otay Mesa center alone, there are 140 cases of Covid-19 out of the 649 detainees there, making it the facility with the largest number of positive tests among detainees. The Otay Mesa center is owned by the private prison company CoreCivic, which has not commented on the situation there. ICE maintains that it is caring for its detainees in light of the pandemic, but detainees have said that they do not have enough space to socially distance, that they do not have enough clean masks, and that guards are not adhering to CDC […]

Oswin enjoying her first supervised enrichment activity. It ended when the nearby construction made a loud upsetting bang. #cat https://ift.tt/2TSjmef

Welcome to the first episode of Cartoon Brew's new podcast hosted by Jen Hurler.

The post Cartoon Brew Launches A New Podcast – Listen To The First Episode Here appeared first on Cartoon Brew.