vent

These are the best Indianapolis food and drink events in July

Sample Indy's best burgers, crush a bunch of ice cream and load up on discounts at restaurants.

       




vent

How coronavirus hit operating income for Lucas Oil Stadium, Indiana Convention Center

Operating revenues for the Indiana Convention Center and Lucas Oil Stadium dropped by 60 percent in March, during coronavirus, compared to last year.

       




vent

Whale that washed ashore in Ventura County towed out to sea

The animal's cause of death was inconclusive because a full examination was hampered by stay-at-home and social distancing orders issued amid the coronavirus pandemic.




vent

Peyton Manning roasts Tom Brady in announcing charity golf event

Peyton Manning, Tom Brady, Tiger Woods and Phil Mickelson are playing for COVID-19 relief on May 24.

       




vent

Vandoorne crashes off pole position twice in eventful esports weekend

In one weekend Stoffel Vandoorne manages to qualify on pole position in two races and crash out of both of them.




vent

Coronavirus: Dutch sporting events without fans until there is vaccine

Sporting events in the Netherlands will have to take place without fans until there is a coronavirus vaccine, Dutch Health Minister Hugo de Jonge says.




vent

The VR experience in ‘The Walking Dead: Saints & Sinners’ prevents it from being just a zombie cliche

It's difficult to count the number of video games in which someone is standing around a corner clutching a weapon and waiting for their mortal enemy to pass. But until recently it wasn't possible to physically experience that scenario.




vent

Baby Yoda toys are finally arriving. Sure, they missed the holidays — but at least that prevented spoilers.

Products for the popular character from the Disney Plus hit "The Mandalorian" are about to hit stores.




vent

Fan conventions are being postponed amid covid-19 concerns — but Comic-Con is still a go

Big fan-culture events in Florida and California have just been postponed. May's Awesome Con D.C. takes a wait-and-see approach.




vent

‘Half-Life: Alyx’: The most exhilarating VR adventure game to date

"Half Life: Alyx" will transport you to an incredibly vivid science fiction world.




vent

As dating apps try to pivot to virtual events, some users are trying to get people to violate social distancing rules

  • Dating apps like Tinder, Bumble, and Hinge have reported increased use amid the coronavirus pandemic, while touting virtual dating alternatives for users instead of meeting up in person.
  • Swaths of users are still encouraging matches to break quarantine to have sex and go on dates, despite social distancing guidelines and fines to comply with them.
  • An illustrator on Instagram has been collecting screenshots of these situations, and told Business Insider that users will brand themselves as "badasses," dispute the effectiveness of isolating, and lash out in anger and hurl abusive language when they're rejected.
  • Spokespeople for Grindr, Tinder and Bumble told Business Insider they've informed users to adhere to social-distancing guidelines, but did not respond to inquiries about actions they're taking against users in places where violating lockdown orders can be against the law.
  • Visit Business Insider's homepage for more stories.

As millions remain confined to their homes to prevent the spread of coronavirus, the desire for human contact and connection has risen dramatically and led some to search for ways to break those social distancing rules.

Popular dating apps — including Tinder, Bumble, and Hinge — have reported significant increases during the outbreak of swiping activity, matches between users, and messages exchanged. It's also led to the introduction of a breed of users who are interested in shirking lockdown orders, and are encouraging their matches to join them in doing the same.

Dating app users have shared stories across social media, and recently with Mashable, about messages they've received from matches who ask them to come over or want to hook up. Artist Samantha Rothenberg, who uses the handle @violetclair on Instagram, has been collecting these screenshots from followers, and told Business Insider she's received close to a thousand of such stories.

"Because of how common it is, I can honestly say that anyone who is on a dating app right now has dealt with this," Rothenberg told Business Insider. "People are horny, and a lot of people are putting that ahead of the risk and the danger."

For dating platforms whose end goal is inherently to bring its millions of users together in real life, the coronavirus outbreak has put them in a curious predicament. Dating apps are forced to balance a desire to keep people on their platform for the sake of business, with a moral responsibility to discourage users to engage in behavior with potential life-or-death implications.

Since the start of the outbreak, apps have rolled out in-app virtual dating options and touted ways users can go on virtual dates. However, the prevalence of users who are trying to meet up in person, as documented by Rothenberg and screenshots across social media, raise questions about whether these dating platforms are doing enough to stymie such behavior in the time of coronavirus.

Rothenberg has long collected screenshots of users' horror stories from dating app interactions, which she often will depict in illustrations she posts to her Instagram account. But ever since the pandemic led states to instill lockdown orders starting in March, nearly all of the screenshots she's received have had to do with coronavirus.

These lockdown-violating users fall into a few general categories, according to Rothenberg. There's the users who try to paint themselves as "badasses" for breaking the rules, though Rothenberg says they're more like "a--holes." There are the matches who propose meeting up and, after getting rejected, reverse course to say they're were joking or "testing" you, she says. You'll also encounter the anti-quarantine user, whose reasoning is based on claims about herd immunity and the ineffectiveness of social distancing measures.

The last group is made up of users who react to "no" with anger and verbal abuse, Rothenberg told Business Insider. Women told Mashable recently about encounters with men on dating apps who badgered and harassed them after they turned down in-person meetings, going to the point of gaslighting.

These types of users are what led Rothenberg to launch a petition on Change.org to hold dating apps responsible for enforcing social distancing guidelines during the pandemic. She's also been active about calling out dating apps in her Instagram Stories she posts with screenshots she receives.

"People are angry, they tell me, 'can you believe this, this is disgusting, this is wrong,'" Rothenberg said. "Because I have this platform, I feel I have a bit of a responsibility to put these [stories] out in the open and share, and bring some light into what's going on out there to people who may not know."

In late March, platforms sent out various messages and alerts to their users that Rothenberg documented on Instagram. A message to Bumble users from CEO Whitney Wolfe Herd said: "Please don't meet your Bumble matches IRL for now." Hinge users were told to "stay safe and keep connected."

Tinder, arguably the most well-know dating app, also discouraged users to meet up in a platform-wide message sent March 26.

"We know there's a lot to stay to each other as we all do our best to stay healthy and prevent the spread of the coronavirus," the message from Tinder said. "We hope to be a place for connecting during this challenging time, but it's important to stress that now is not the time to meet IRL with your match."

Dating apps' responsibilities to pivot from IRL to TXT

As companies across industries adjust business to stay afloat, dating apps have transitioned to emphasize alternatives to in-person meetups. Although online dating success has long been measured by the amount of conversations that turn to real-life connections, platforms are forced to rethink their strategy as users continue turning to them en masse. A poll conducted by Hinge found that 70% of its users said they were open to going on dates on Zoom, FaceTime, and other video platforms.

Some dating brands have introduced new features amid the pandemic. Hinge launched "Date from Home" in April, where users can indicate to a match they're ready to move their conversation off-app. Plenty of Fish started rolling out a livestreaming feature in March to users in the U.S. to allow matches to go on short virtual dates. Tinder, relatively late to the game, announced this week it was launching a video chat feature by the end of June.

A spokesperson for Match Group — the parent company on Tinder, Hinge, Plenty of Fish, and other dating platforms — told Business Insider that it made updates to its products "to help users better navigate stay-from-home policies and date digitally via phone or video."

Other apps that already enabled video chat and voice call, like The League and Bumble, are pushing these features to their users more than ever. 

But while users on these dating apps are swiping and messaging at new highs, the transition to virtual-only hasn't been as seamless for those on Grindr, the most popular dating app for gay men. Steve, a 26-year-old living in Washington, D.C., told Business Insider that activity on Grindr is "completely dead." He said he doesn't check the app nearly as often any more, but messages he does get on the app are largely from people who say they want to meet up despite the quarantine.

Grindr, like other apps, has attempted to pivot to virtual dating: The platform recently introduced Circles, where groups of up to 20 users can join chats centered around certain topics and interests. However, Steve said he's seen these groups largely dissolve into "all d--k pics."

"I dont think Grindr has the ability to rebrand itself honestly at this point for something other than hookups," Steve said. "They tried to take the opportunity to rebrand itself as something else, and it just right away became sexual."

A Grindr spokesperson told Business Insider it had sent in-app notifications to all users asking them to "refrain from in-person meetings right now."Nonetheless, an app-wide message sent to users — and shared by users on Twitter — made no mention of asking users to social distance. 

For users across these dating apps who encourage the violating of social distancing guidelines, it's unclear how much responsibility platforms have to keep their users' indoors. In some states under lockdown, authorities have doled out fines and even arrested residents found failing to follow at-home guidelines.

Grindr, Bumble and Match Group — the parent company of Tinder, Hinge, Plenty of Fish and others — told Business Insider in statements they have encouraged users to adhere to coronavirus guidelines from the World Health Organization and the Center for Disease Control.

None of the companies responded to Business Insider's requests for comment about whether asking to violate social-distancing guidelines on the platforms is a breach of policy or would garner any ban or suspension on a user.

SEE ALSO: What you need to know about Grimes, the Canadian musician who just had a baby with tech billionaire Elon Musk

Join the conversation about this story »

NOW WATCH: Why electric planes haven't taken off yet




vent

America is going into an economic coma. Here’s how we (eventually) wake up from it.

A framework for how Congress should be thinking about the immediate economic challenges ahead — and the tools available to address them.




vent

Channel24.co.za | A wildlife safari, comedy show, and 3 other virtual events to keep you entertained this weekend

We may not be able to go out during the national lockdown, but that does not mean that we can't attend events.




vent

AT#39 - DuVine Adventures - Bike and Wine Tours

DuVine Adventures - Bike and Wine Tours




vent

AT#54 - Latin American Travel Adventure

Chicago, Illionois




vent

AT#149 - Travel to Siberia, Russia - (Mis)Adventure Travel

Siberia, Russia - (Mis)Adventure Travel




vent

AT#191 - Adventure Travel to Venezuela

The Amateur Traveler talks to Diana Higuera who is a native of Venezuela who worked for a number of years as a tour guide on adventure tours to see Venezuela's wildlife and natural beauty. Diana takes us on a virtual tour starting in Margarita island, then heading to the Los Roques archipelago north of Venezuela, then in an indian canoe up the Orinoco river. From there we will head to the tepuis (table top mountains) in Canaima National Park in Venezuela's Amazon basin. There we will see the highest waterfall in the world at Angel Falls. We will also go behind Sapo falls. Along the way we will see birds, monkeys and anacondas. We will fish for piranas, pet crocodiles and eat street food in Venezuela.




vent

AT#217 - The Life of Adventure Travel Tour Guide

The Amateur Traveler talks to Madeline Jhawar from Italy Beyond the Obvious about life as a tour guide for an adventure travel company. Madeline was previously on the Amateur Traveler talking about Travel to Sicily. Madeline talks about her misconceptions about what being a tour guide would be like and the reality of keeping a group of people happy (and not lost). She guided hiking and biking tours primarily in Italy. What skills do you need to be a successful tour guide? It might not be what you think.




vent

AT#274 - Adventure Travel in Botswana

The Amateur Traveler talks to Spencer Quong who is a adventure travel guide about his recent trip to Botswana in south central Africa. After reading the No. 1 Ladies Detective Agency his traveling companions were drawn to this country and its incredible wildlife.




vent

AT#328 - Adventure Travel in Costa Rica

The Amateur Traveler talks about adventure travel in Costa Rica. From rafting on the Pacuare river and ziplining through the Monteverde Cloud forest to snorkeling off the Nicoya Peninsula, Costa Rica can be a great destination for adventure travel.




vent

Talking Adventure Games with Dave Gilbert

Game designer and publisher Dave Gilbert founded Wadjet Eye Games in 2006.  This interview features conversation about point and click adventure games; digital game development, marketing and publishing; and the relationship between art, passion and real world commerce.

Jeffery Klaehn: How did you first become interested in point and click adventure games?

Dave Gilbert: I played King’s Quest at a very impressionable age! I typed the word “jump” and I saw Graham actually jump, and I was so blown away that I’ve been playing them ever since.

JK: You founded Wadjet Eye Games in 2006 to sell your game, The Shivah, commercially, then moved to pursue game design on a full-time basis and released The Blackwell Legacy, the first in what would become a series of five games.  What are your thoughts on these games and on the market then compared to now?

Dave Gilbert: I am Blackwell Legacy’s biggest critic. It was the first game I wrote with the intention of selling commercially – The Shivah was originally freeware, so I don’t count it – and it shows every inch of my inexperience. The gameplay is clunky, the story is told in three giant infodumps, and the main characters weren’t very likable. But that said, I know with absolute certainty that it was the very best game I could have made with the experience, resources and time I had available. So I stand by it.

As for the market, everything is different. Back in 2006, indie games in general were a very new thing. Read the rest




vent

Preventing Phishing With Education

Phishing is incredibly common, yet most people feel it has gotten harder to spot in recent years. Cyber criminals rely on their knowledge of human psychology to make you do things you wouldn’t normally do. They also know that if they scare you enough they can manipulate you into doing what they want you to […]

The post Preventing Phishing With Education appeared first on Dumb Little Man.




vent

INTRODUCING One-on-Ones with Adventurous Kate!

I’m excited to introduce something I’ve wanted to do for quite a long time — private one-on-one calls between me and my readers! This new product is a way for us to have private one-on-one conversations tailored to whatever you want. I got into this business is because I wanted to help women achieve their …

INTRODUCING One-on-Ones with Adventurous Kate! Read More »

The post INTRODUCING One-on-Ones with Adventurous Kate! appeared first on Adventurous Kate.




vent

Introducing Adventurous Kate’s Book Club!

Since starting this blog, I’ve shared hundreds of books with you. Books have been the second topic on this site as long as I can remember, and sharing books with you has been one of my great pleasures. And it goes both ways — you guys have introduced me to some truly wonderful reads as …

Introducing Adventurous Kate’s Book Club! Read More »

The post Introducing Adventurous Kate’s Book Club! appeared first on Adventurous Kate.





vent

Texas Gov Abbott Frees Salon Owner Shelley Luther: “Criminals shouldn’t be released to prevent COVID-19 just to put business owners in their place”

The following article, Texas Gov Abbott Frees Salon Owner Shelley Luther: “Criminals shouldn’t be released to prevent COVID-19 just to put business owners in their place”, was first published on 100PercentFedUp.com.

Texas Governor Greg Abbott just changed the coronavirus order to free Salon A La Mode owner Shelley Luther from jail. Abbott tweeted out a comment about the poor treatment of the business owner: Throwing Texans in jail whose biz’s shut down through no fault of their own is wrong. I am eliminating jail for violating […]

Continue reading: Texas Gov Abbott Frees Salon Owner Shelley Luther: “Criminals shouldn’t be released to prevent COVID-19 just to put business owners in their place” ...




vent

'Quaranscream': Wine spritzer company opens Mother's Day venting hotline

A beverage company in the U.S. is inviting moms to let out a ‘quaranscream’ this Mother’s Day on a designated ‘zero-judgement venting hotline’ for a chance to win its wine spritzers.




vent

Transatlantic Cooperation to Prevent and Stop Mass Atrocities

Invitation Only Research Event

16 February 2015 - 1:00pm to 5:00pm

Chatham House, London

Event participants

Ambassador Lee Feinstein, Founding Dean, School of Global & International Studies, Indiana University
Xenia Wickett, Project Director, US; Dean, The Queen Elizabeth II Academy, Chatham House
Paul Arkwright, Director, Multilateral Policy, Foreign & Commonwealth Office
Dr Patricia Lewis, Research Director, International Security Programme, Chatham House
Jonathan Prentice, Director, London Office & Senior Adviser for European Advocacy, International Crisis Group
Sir John Holmes, Director, The Ditchley Foundation

The international community is in urgent need of successful, cooperative strategies for both preventing mass atrocities before they begin and stopping those in progress. As recent crises have highlighted, effective international cooperation to save lives and preserve peace and security remains largely aspirational. Participants will discuss current thinking on mass atrocity prevention and intervention, and identify how transatlantic cooperation in this space could be more effective.

Attendance at this event is by invitation only.

Department/project

Richard Gowing

Programme Administrator
+44 (0)20 7389 3270




vent

Joseph Nye, the inventor of the term 'soft power'

3 June 2013 , Volume 69, Number 3

He shares his thoughts on on America’s role in an increasingly affluent world, Russia’s decline and China’s own goals

Alan Philps

Interview.jpg

Photo: Alex Wong/Getty Images




vent

Can Investment Prevent Conflict?




vent

Our Shared Humanity: Welcome and Panel One - The Arc of Intervention




vent

Identification of an Unconventional Subpeptidome Bound to the Behcet's Disease-associated HLA-B*51:01 that is Regulated by Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) [Research]

Human leukocyte antigen (HLA) B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are strongly genetically associated with Behcet's disease (BD). Previous studies have defined two subgroups of HLA-B*51 peptidome containing proline (Pro) or alanine (Ala) at position 2 (P2). Little is known about the unconventional non-Pro/Ala2 HLA-B*51-bound peptides. We aimed to study the features of this novel subpeptidome, and investigate its regulation by ERAP1. CRISPR-Cas9 was used to generate an HLA-ABC-triple knockout HeLa cell line (HeLa.ABC-KO), which was subsequently transduced to express HLA-B*51:01 (HeLa.ABC-KO.B51). ERAP1 was silenced using lentiviral shRNA. Peptides bound to HLA-B*51:01 were eluted and analyzed by mass spectrometry. The characteristics of non-Pro/Ala2, Pro2, and Ala2 peptides and their alteration by ERAP1 silencing were investigated. Effects of ERAP1 silencing on cell surface expression of HLA-B*51:01 were studied using flow cytometry. More than 20% of peptides eluted from HLA-B*51:01 lacked Pro or Ala at P2. This unconventional group of HLA-B*51:01-bound peptides was relatively enriched for 8-mers (with relatively fewer 9-mers) compared with the Pro2 and Ala2 subpeptidomes and had similar N-terminal and C-terminal residue usages to Ala2 peptides (with the exception of the less abundant leucine at position ). Knockdown of ERAP1 increased the percentage of non-Pro/Ala2 from 20% to ~40%, increased the percentage of longer (10-mer and 11-mer) peptides eluted from HLA-B*51:01 complexes, and abrogated the predominance of leucine at P1. Interestingly knockdown of ERAP1 altered the length and N-terminal residue usage of non-Ala2&Pro2 and Ala2 but not the Pro2 peptides. Finally, ERAP1 silencing regulated the expression levels of cell surface HLA-B*51 in a cell-type-dependent manner. In conclusion, we have used a novel methodology to identify an unconventional but surprisingly abundant non-Pro/Ala2 HLA-B*51:01 subpeptidome. It is increased by knockdown of ERAP1, a gene affecting the risk of developing BD. This has implications for theories of disease pathogenesis.




vent

Virtual Event: Chatham House Circular Economy Conference

Research Event

1 April 2020 - 10:00am to 2 April 2020 - 2:30pm

The circular economy, that minimizes waste and keeps materials and products in circulation for as long as possible, is increasingly regarded as a promising model for driving sustainable and resilient economic growth in both developed and emerging economies. To successfully scale circular practices and ensure the transition from a linear to a circular model leaves no one behind, an inclusive and collaborative approach is required.

The current global health crisis has significantly disrupted the global economy and our societies. We are experiencing a radical transformation in the way society, government and businesses operate. The ways we work, socialize, produce and consume have changed dramatically. 
 
Does the current situation offer a window of opportunity to accelerate the transition to a circular economy? Or will it pose further challenges to change the current linear system of ‘take-make-throw away’ to a circular system? 
 
The current situation also highlights the need to ensure the vulnerable are protected and no-one is left behind – in line with the principles of the Sustainable Development Goals (SDGs). The SDGs also remind us that, despite the urgency of the current pandemic, the world needs to keep in mind the long-term nature of the circular economy transition and global sustainability objectives including the global climate targets and meeting the needs of future generations.
 
Until recently, the discussions around the circular economy have predominantly focused on industrialized economies of Europe and China. However, a great deal of circular economy activity is already taking place in emerging economies, as the recent Chatham House report An Inclusive Circular Economy: Priorities for Developing Countries, discusses.
 
Many countries across sub-Saharan Africa, South Asia, Southeast Asia and Latin America are adopting national policies and launching initiatives to promote the circular economy. To promote collaborative opportunities for an inclusive and sustainable circular economy transition at the international level, a clearer understanding of the opportunities, trade-offs and winners and losers of such a transition is needed.
 
Supporting transformative alliances and finding solutions to overcome challenges especially in poorer countries, disadvantaged industry sectors and consumers is equally critical. In short, a ‘win-win-win’ vision for the environment, people and the economy, needs to be built together with credible pathways to achieving this vision.
 
This virtual conference brings together circular economy leaders from policy, business, academia and civil society across the emerging economies and the developed world to identify best practices, initiatives and existing alliances that can help to build the pathways for achieving this vision.
 
It builds on previous and ongoing research by Chatham House, and others, to drive forward an inclusive circular economy agenda and promote a just transition from linear to circular economic models.
 
The first day of the virtual conference consists of keynote speeches and panel discussions focusing on the cross-cutting themes of just transition and inclusive circular economy as well as interconnections with other global key agendas and themes:
 
  • Inclusive policy approaches for solving the global waste crisis.
  • Financing the circular economy and closing the investment gap.
  • Trade in the circular economy: closed local economies or global collaborating systems?

During the second day of the conference, more specific circular economy themes are discussed in virtual panels including the following topics:

  • Beyond plastic recycling: innovations for sustainable packaging.
  • Advancing multilateral action on marine plastic pollution.
  • Industry 4.0 and circular economy: identifying opportunities for developing countries.

The Chatham House Circular Economy conference forms part of the programme of events to celebrate the Chatham House Centenary highlighting the main goals for the institute’s second century.

Melissa MacEwen

Project Manager, Energy, Environment and Resources Programme




vent

Seventh Meeting of the New Petroleum Producers Discussion Group

Research Event

11 November 2019 - 9:00am to 15 November 2019 - 6:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

The seventh annual meeting of the New Petroleum Producers Discussion Group brings together people from the group's member countries. The meeting includes an international discussion, a national seminar and a range of policy-relevant courses which have been specially tailored to the priorities of the group. This year’s international discussion focused on ‘Building Capacity and Institutions’.

The New Petroleum Producers Discussion Group was first established in 2012 and provides a unique forum which brings together governments from over 30 new and prospective oil and gas producers to share their ideas and experiences. The group is jointly coordinated by Chatham House, the Commonwealth Secretariat, and the Natural Resource Governance Institute (NRGI).

This event was hosted by the Ministry of Energy of Uganda.




vent

Virtual event: Global Forum on Forest Governance Number 30

Research Event

13 July 2020 - 9:00am to 14 July 2020 - 5:00pm
Add to Calendar

Chatham House | 10 St James's Square | London | SW1Y 4LE

The 30th Global Forum on Forest Governance will take place remotely online on 13-14th July 2020. Online registration, with further details, will follow in due course.

Melissa MacEwen

Project Manager, Energy, Environment and Resources Programme




vent

Acting Early, Saving Lives: Prevention and Promotion

Invitation Only Research Event

9 September 2019 - 9:00am to 5:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Universal Health Coverage (UHC) is driving the global health agenda and is embedded in the Sustainable Development Goals (SDGs). According to the World Health Organization, universal health coverage means that ‘all people and communities can use the promotive, preventive, curative, rehabilitative and palliative health services they need, of sufficient quality to be effective, while also ensuring that the use of these services does not expose the user to financial hardship’.

Despite this comprehensive starting point, it has been observed that UHC efforts to date have focused more on provision of treatment services than promotion and prevention strategies. Not only is this a missed opportunity from a financing perspective (public health interventions often offer better value for money than curative services), without robust health promotion and prevention efforts, UHC may not fulfil its potential towards reducing health inequity.

Primary health care (PHC) is a whole-of-society approach to health that aims to ensure the highest possible level of health and well-being and equitable distribution. PHC has been described as the cornerstone of UHC. As set out in the recent World Health Assembly report by the Director-General Primary health care towards universal health coverage: ‘..with its emphasis on promotion and prevention, addressing determinants and a people-centred approach, primary health care has proven to be a highly effective and efficient way to address the main causes of, and risk factors for, poor health...UHC and the health-related Sustainable Development Goals can only be sustainably achieved with a stronger emphasis on primary health care.’

The 2018 Declaration of Astana has sparked a renewed commitment to PHC. For NCD and mental health advocates there is an opportunity to now build on the foundations of PHC, to deliver more equitable, people-centred and sustainable UHC.

This event sets out why promotive and preventive health services for NCDs and mental health disorders are such an important part of UHC. It will focus on two key dimensions: the role of health promotion and preventative services within UHC in delivering health for all, and sustainable financing through innovative fiscal policy.

As one of the first high level events looking exclusively at prevention in the context of UHC, it will serve as an important reference for those going forward into the High Level Meeting on UHC as well as a unique opportunity for participants from a range of perspectives to discuss the barriers to progress.

The event is convened by Chatham House and the UK Working Group on NCDs – a coalition of over 20 UK-based NGOs with an interest in the inclusion of NCDs as an international development priority.

Objectives

  • To understand how NCD prevention and mental health promotion are a key aspect of universal health coverage.
  • To explore the case for investment in NCD prevention and mental health promotion, for both governments and donors/global health actors.
  • To share experiences of financing and delivering prevention and promotion services, and to reflect on the potential of PHC to support NCD and mental health goals.

Attendance at this event is by invitation only.

Department/project

Alexandra Squires McCarthy

Programme Coordinator, Global Health Programme
+44 (0)207 314 2789




vent

Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice [Research Articles]

Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH). The factors that control progression from simple steatosis to NASH are not fully known. Here, we tested the hypothesis that dietary vitamin E (VitE) supplementation would prevent NASH progression and associated metabolic alterations induced by a Western diet (WD). Hyperphagic melanocortin-4 receptor-deficient (MC4R–/–) mice were fed chow, chow+VitE, WD, or WD+VitE starting at 8 or 20 weeks of age. All groups exhibited extensive hepatic steatosis by the end of the study (28 weeks of age). WD feeding exacerbated liver disease severity without inducing proportional changes in liver triglycerides. Eight weeks of WD accelerated liver pyruvate cycling, and 20 weeks of WD extensively upregulated liver glucose and oxidative metabolism assessed by 2H/13C flux analysis. VitE supplementation failed to reduce the histological features of NASH. Rather, WD+VitE increased the abundance and saturation of liver ceramides and accelerated metabolic flux dysregulation compared with 8 weeks of WD alone. In summary, VitE did not limit NASH pathogenesis in genetically obese mice, but instead increased some indicators of metabolic dysfunction.





vent

Report of the Fourth Meeting of the Conference of the Parties to the Convention on Biological Diversity Serving as the Meeting of the Parties to the Cartagena Protocol on Biosafety

Report of the Fourth Meeting of the Conference of the Parties to the Convention on Biological Diversity Serving as the Meeting of the Parties to the Cartagena Protocol on Biosafety (Advance text)




vent

Report of the seventh meeting of the Liaison Group on Capacity-Building for Biosafety




vent

Report of the Fifth Meeting of the Conference of the Parties to the Convention on Biological Diversity Serving as the Meeting of the Parties to the Cartagena Protocol on Biosafety (COP-MOP 5)




vent

The Electronic Version of the Publication "The Convention on Biological Diversity Year in Review 2011" Is Now Available.




vent

55th edition of the Quarterly Report on the Administration of the Convention on Biological Diversity (October-December 2011)




vent

56th edition of the Quarterly Report on the Administration of the Convention on Biological Diversity (January to March 2012)




vent

57th, 58th and 59th edition of the Quarterly Report on the Administration of the Convention on Biological Diversity (April to June 2012) (July to December 2012) is now available.




vent

The Biannual Report on the Administration of the Convention on Biological Diversity for January to June 2013 is now available (page 27).




vent

The Report of the Joint Aarhus Convention/CBD round table on access to information, public participation and access to justice regarding LMOs/GMOs is now available.




vent

The Biannual Report on the Administration of the Convention on Biological Diversity for July to December 2013 is now available (page 36).




vent

A CBD/Aarhus Convention checklist and summary of tools and resources are now available.




vent

The report of the eleventh meeting of the Liaison Group on Capacity-building for Biosafety is now available.