By The Office of Energy Efficiency & Renewable Energy Within 25 years, the United States could produce enough biomass to support a bioeconomy, including renewable aquatic and terrestrial biomass resources that could be used for energy and to develop products … Continue reading →

Welcome back! In the first part of this series, we looked at a very "low-level" way to interact with a relational database by sending it raw SQL strings and retrieving the results. We created a very simple Express application that we can use as an example and deployed it on Heroku with a Postgres database.

In this part, we're going to examine a few libraries which build on top of that foundation, adding layers of abstraction that let you read and manipulate database data in a more "JavaScript-like" way.

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This Pen uses: HTML, CSS, JavaScript, and

Summer Camps 2020 Beats and Rhythms Cardiac Camp A medically-supervised resident camp for children with congenital heart disease, who can enjoy traditional camp activities, including outdoor activities, crafts, team building exercises and more, in a safe medically supervised environment.…

The CDC designed a flawed test for COVID-19, then took weeks to figure out a fix so state and local labs could use it. New York still doesn’t trust the test’s accuracy By Caroline Chen, Marshall Allen, Lexi Churchill and Isaac Arnsdorf Propublica…

There's one thing the Innovia Foundation can never say: That it hadn't been told.…

[IMAGE-1] Noah Baumbach's Marriage Story begins as its central marriage is coming to an end. Our two protagonists are fiercely independent, articulate, opinionated creative types: Charlie (Adam Driver) is the director of an avant-garde theater troupe in New York City; Nicole (Scarlett Johansson) is an actress and one of his primary collaborators.…

[IMAGE-1] I honestly don't know how people like Bryan Stevenson keep up the fight. Just Mercy is the true origin story of a literal social justice warrior, a Harvard-educated lawyer who, in the late 1980s, launched the Equal Justice Initiative in Montgomery, Alabama, to take on the neediest, most desperate cases.…

[IMAGE-1] First of all: No. Why would a suddenly single dad to traumatized young children leave said shocked and distressed kids with his new fiancée, who is also the sole survivor of her own massive childhood trauma?…

Back in November, we wrote about local singer-songwriter Eliza Johnson's musical project Eliza Catastrophe and her new album You, which she released on pre-loaded MP3 players. One thing we weren't able to mention in our interview — for contractual reasons — is that she had only a couple months prior auditioned for American Idol, and her performance finally aired on the ABC reality competition show Sunday night.…

[IMAGE-1] Before smartphones and Instagram, there were influencers, and they could be as shallow, overconfident and pejorative as they are today. This new adaptation of Jane Austen's Emma — the feature debuts of photographer and music-video director Autumn de Wilde and Man Booker Prize-winning novelist turned screenwriter Eleanor Catton — brings that sort of modern frisson to its retelling of the tale of a very rich young woman who amuses herself by interfering in the romantic lives of those around her.…

As COVID-19 fears grew, public officials and sports execs contemplated health risks — and debated a PR message — but let 33,000 fans into a Seattle Sounders soccer match, emails show. By Ken Armstrong, ProPublica, and David Gutman and Lewis Kamb, The Seattle Times On March 6, at 2:43 p.m., the health officer for Public Health — Seattle & King County, the hardest-hit region in the first state to be slammed by COVID-19, sent an email to a half-dozen colleagues, saying, “I want to cancel large group gatherings now.”…

Thirty years into his distinguished career as one of the world's great guitar players, Joe Bonamassa is still finding new ways to showcase his skills, explore new sounds and stretch his artistic horizons.…

Celebrities: They're just like us! Along with everyone else, famous people are self-isolating at home, and some of them have taken to social media to alleviate the stress of the outside world. We don't need to tell you that events everywhere are canceled, so a few big-time musicians are putting on personal concerts for their fans and followers, and a lot of them — save for that cringe-inducing, star-studded cover of "Imagine" that was going around yesterday — are actually pretty good.…

While not every musician has taken to the internet to perform live shows during the (almost) nationwide lockdown, it sure seems that way. At least, it does according to my social media feeds, which lean heavily on bands and solo artists.…

Ask any working musician why they play live, why they lug their equipment to and from bars and restaurants and wine-tasting rooms week after week, and they'll point to the same nebulous thing: It's the connection with an audience.…

You might not know it from the fancy attire they wear on stage at the Fox Theater, but for the musicians in the Spokane Symphony, it's a part-time gig. It's a prestigious gig, to be sure, but like most artists, for the musicians, it's just one piece of a puzzle full of hustle they have to solve to make a living.…

Gonzaga Athletic Director Mike Roth took to the Zoom online meeting app Wednesday for a lengthy chat with members of the school community, fans and media to answer questions about college sports in the era of COVID-19. Like so many things regarding the coronavirus, there are a lot of hopes for a rapid return to normalcy — all of them couched in the reality that none of us really know how the pandemic is going to affect our lives three months from now, or six months down the line.…

By Johnny Diaz The New York Times Company…

[IMAGE-1] It isn't often that you see a local band selling out most of their gigs, but Indian Goat does. The duo of Garrett Zanol and Travis Tveit formed a few years ago and almost immediately struck a chord with Spokane audiences: Their live shows are usually raucous, sweaty, beer-soaked affairs, with rooms crammed full of people rocking out in unison.…

Yesterday, Spokane Mayor Nadine Woodward and other local leaders urged Gov. Jay Inslee to allow Spokane County to open on a different schedule than the rest of the state.  Inslee, however, wouldn't budge.…

When Washington Gov. Jay Inslee solemnly looked into the camera on Friday, May 1, he wasn't ready to declare victory yet.…

The present invention relates to a compound of formula A, wherein R is alkyl. Compound A may be used as an intermediate in the preparation of O-desmethyl venlafaxine or a salt thereof, and the present invention provides such a preparation, as well as a process for preparing the compound of formula A.

A process has been developed for preparing 2-methoxymethyl-1,4-benzenediamine (IV-a), other compounds of formula (IV), and the salts thereof, all of which may be used as primary intermediates in compositions for dyeing keratin fibers.

A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond;where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond;where part (C) is a bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; andwhere part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

Provided is a method for stably and economically producing xylylenediamine with a high yield and long catalyst service life by hydrogenating dicyanobenzene that is obtained by ammoxidating xylene. By bringing an aqueous basic solution into contact with a dicyanobenzene-absorbed liquid, which is obtained by bringing an ammoxidation reaction gas into contact with an organic solvent, under specified temperature conditions, and subjecting a base and a carboxylic acid in the dicyanobenzene-absorbed liquid to a neutralization reaction so as to form an aqueous phase that contains a water-soluble salt, and then subjecting an organic phase and the aqueous phase to liquid-liquid separation so as to remove the aqueous phase, it is possible to remove the carboxylic acid contained in the dicyanobenzene-absorbed liquid with high selectivity while inhibiting loss of the dicyanobenzene. By subjecting the raw material dicyanobenzene, which is obtained by separating low boiling point compounds from the post liquid-liquid separation organic phase by distillation under reduced pressure, to hydrogenation, xylylenediamine is produced with a high yield and the service life of the hydrogenation catalyst is extended.

A process for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines comprising (1) providing a mixture of 1,3-cyanocyclohexane carboxaldehyde and/or 1,4-cyanocyclohexane carboxaldehyde; (2) contacting said mixture with a metal carbonate based solid bed or a weak base anion exchange resin bed at a temperature from 15 to 40 ° C. for a period of at least 1 minute; (3) thereby treating said mixture, wherein said treated mixture has a pH in the range of 6 to 9; (4) feeding said treated mixture, hydrogen, and ammonia into a continuous reductive amination reactor system; (6) contacting said treated mixture, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature from 80 ° C. to 160 ° C. and a pressure from 700 to 3500 psig; (7) thereby producing one or more cycloaliphatic diamines is provided.

A branched hetero polyfunctional polyoxyalkylene compound represented by the following formula (1): wherein Z represents a hydroxyl group-removed residue of pentaerythritol or dipentaerythritol, OA1 and OA2 represent an oxyalkylene group having 2 to 4 carbon atoms, L1, L2 and L3 represent an alkylene group or an alkylene group that contains an ester bond, a urethane bond, an amide bond, an ether bond, a carbonate bond, a secondary amino group or a urea bond, X and Y are different from each other and represent a functional group capable of a chemical reaction; m and n are an average number of moles of the oxyalkylene group added, m represents 5 to 1,000, n represents 0 to 1,000, and p, q and r represent 0 or 1; and s1 is an integer of 2 or more and s1+s2=4 or 6.

Provided are an anti-static and anti-microbial surface treatment agent including a quaternary ammonium salt compound as an active ingredient and a method of preventing a polymer fiber from developing static electricity by using the surface treatment agent. The quaternary ammonium salt compound has excellent anti-static and anti-microbial effects for the prevention or improvement of static electricity in a polymer fiber. Accordingly, the quaternary ammonium salt compound is suitable for use as a fabric softener, or an anti-static agent, and also, provides anti-microbial effects to a polymer fiber.

A process for preparing alkylated p-phenylenediamine having the steps of reacting aniline and nitrobenzene in presence of a complex base catalyst to obtain 4-aminodiphenylamine intermediates, hydrogenating the 4-aminodiphenylamine intermediates to 4-aminodiphenylamine in presence of a hydrogenation catalyst, and reductively alkylating the 4-aminodiphenylamine to alkylated p-phenylenediamine.

A process for conversion of aliphatic bicyclic amines to aliphatic diamines including contacting one or more bicyclic amines selected from the group consisting of 3-azabicyclo[3.3.1]nonane and azabicyclo[3.3.1]non-2-ene with ammonia and hydrogen, and alcohols in the presence of heterogeneous metal based catalyst systems, a metal selected from the group consisting of Co, Ni, Ru, Fe, Cu, Re, Pd, and their oxides at a temperature from 140° C. to 200° C. and a pressure from 1540 to 1735 psig for at least one hour reactor systems; forming a product mixture comprising aliphatic diamine(s), bicyclic amine(s), ammonia, hydrogen, and alcohol(s); removing said product mixture from the reactor system; removing at least some of the ammonia, hydrogen, water, alcohols, bicyclic amines from said product mixture; thereby separating the aliphatic diamines from said product mixture.

The invention relates to a method for preparing ring-halogenated N,N-dialkylbenzylamines and intermediates obtainable therefrom for preparing agrochemicals and pharmaceutically active ingredients.

A modeling framework for evaluating the impact of weather conditions on farming and harvest operations applies real-time, field-level weather data and forecasts of meteorological and climatological conditions together with user-provided and/or observed feedback of a present state of a harvest-related condition to agronomic models and to generate a plurality of harvest advisory outputs for precision agriculture. A harvest advisory model simulates and predicts the impacts of this weather information and user-provided and/or observed feedback in one or more physical, empirical, or artificial intelligence models of precision agriculture to analyze crops, plants, soils, and resulting agricultural commodities, and provides harvest advisory outputs to a diagnostic support tool for users to enhance farming and harvest decision-making, whether by providing pre-, post-, or in situ-harvest operations and crop analyzes.

An apparatus for selecting a motion signifying artificial feeling is provided. The apparatus includes: an feeling expression setting unit configured to set probabilities of each feeling expression behavior performed for each expression element of a robot for each predetermined feeling; a behavior combination generation unit configured to generate at least one behavior combination combined by randomly extracting the feeling expression behaviors in each expression element one by one; and a behavior combination selection unit configured to calculate an average for the probabilities of the feeling expression behaviors included in each behavior combination for each feeling of a robot and select behavior combinations in which the average of the probabilities of the feeling expression behaviors most approximates the predetermined feeling value of a robot from each behavior combination.

In embodiments of the present invention improved capabilities are described for a computer program product embodied in a computer readable medium that, when executing on one or more computers, helps determine an unknown user's preferences through the use of internet based social interactive graphical representations on a computer facility by performing the steps of (1) ascertaining preferences of a plurality of users who are part of an internet based social interactive construct, wherein the plurality of users become a plurality of known users; (2) determining the internet based social interactive graphical representation for the plurality of known users; and (3) inferring the preferences of an unknown user present in the internet based social interactive graphical representation of the plurality of known users based on the interrelationships between the unknown user and the plurality of known users within the graphical representation.

Systems and methods for recommending media content items are provided. In some implementations, a method includes, identifying a first set of media items selected by a first plurality of users; causing a second set of media items to be displayed to a second user not included in the first plurality of users in accordance with the first set of media items. The first set of media items and the second set of media items are associated with a same media item category. In some implementations, the method optionally includes, identifying the second set of media items without regard to media content item selection history associated with the second user. In some implementations, the first and second sets of media items are news items.

To provide a latent variable model estimation apparatus capable of implementing the model selection at high speed even if the number of model candidates increases exponentially as the latent state number and the kind of the observation probability increase. A variational probability calculating unit 71 calculates a variational probability by maximizing a reference value that is defined as a lower bound of an approximation amount, in which Laplace approximation of a marginalized log likelihood function is performed with respect to an estimator for a complete variable. A model estimation unit 72 estimates an optimum latent variable model by estimating the kind and a parameter of the observation probability with respect to each latent state. A convergence determination unit 73 determines whether a reference value, which is used by the variational probability calculating unit 71 to calculate the variational probability, converges.

In one embodiment, a system includes a data collection system configured to collect a data from a control system by using an offline mode of operations. The system further includes a configuration management system configured to manage a hardware configuration and a software configuration for the control system based on the data. The system additionally includes a rule engine configured to use the data as input and to output a health assessment by using a rule database, and a report generator configured to provide a health assessment for the control system.

Methods of separating renewable materials, such as lipids, from microorganisms, such as oleaginous yeasts, may include conditioning cell walls of the microorganisms to form, open or enlarge pores, and removing at least a portion of the renewable material through the pores. These methods may result in delipidated microorganisms with cell walls that are substantially intact and with mesopores. These delipidated microorganisms may be used to produce biofuels.

The invention relates to polyglycol ether-free, polyglycerol partial ester-based sulphosuccinates, the preparation thereof, and the use of these in cosmetic formulations and also in cleaning compositions in the industrial and domestic sector and formulations comprising these sulphosuccinates.

Disclosed is a process for reducing the amount of sterol in a sterol-containing microbial oil composition, including distilling, under short path distillation conditions, a sterol-containing microbial oil wherein said distillation produces a distillate fraction containing the sterol and a triacylglycerol-containing fraction having a reduced amount of the sterol when compared to the amount of sterol in the sterol-containing microbial oil composition that has not been subjected to short path distillation.

Disclosed embodiments provide pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also disclosed are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.

Provided are triazine compounds for inhibiting of Syk kinase, intermediates used in making such compounds, methods for their preparation, pharmaceutical compositions thereof, methods for inhibiting Syk kinase activity, and methods for treating conditions mediated at least in part by Syk kinase activity.

A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y3—NH2; of formula (IIa) 0=C═N—Y0 and/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V).

The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.

This invention relates to novel 5-[(hydroxymethyl)aryl]-substituted pyrrolo[2,1-f][1,2,4]triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.

The presently-disclosed subject matter relates to compounds of the formula: and methods for use thereof. The presently-disclosed subject matter relates methods of selectively differentiating a stem cell, and methods of screening for compounds useful for enhancing terminal differentiation of committed cardiac progenitor cells.

The object of the present invention is to provide an intermediate film for laminated glass which prevents reductions of transparency and appearance property caused by permeation of moisture and water. The above object is attained by the present invention, i.e., a composition for forming an intermediate film for a laminated glass which comprises ethylene-vinyl acetate copolymer and a compound having alkyleneoxy group. The composition of the present invention enables the formation of an intermediate film for a laminated glass that restrains white spots from occurring by the permeation of moisture and water.

Polyamide molding materials for transparent molding parts. The materials comprise transparent copolyamides that contain: (A) 40 to 100 wt % of at least one transparent copolyamide with a glass transition temperature (Tg) of at least 80° C. and not more than 150° C., composed of at least two diamines that are different from each other, wherein the at least two diamines are a mixture of (a) 50 to 90 mol % bis-(4-amino-3-methylcyclohexyl)methane (MACM) and/or bis-(4-amino-3-ethylcyclohexyl)methane (EACM) and/or bis-(4-amino-3,5-dimethylcyclohexyl)methane (TMACM) and b) 10 to 50 mol % aliphatic diamine having 9 to 14 carbon atoms, in particular decandiamine, particularly preferably at least 20 mol % decandiamine, each relative to the total amount of diamines, and of one or more aliphatic dicarboxylic acids, having 6 to 36 carbon atoms, (B) 0 to 60 wt % of at least one further polymer, (C) 0 to 10 wt % of additives, the sum of the components (A), (B) and (C) totaling 100% by weight.

Composite material that contain epoxy resin which is toughened and strengthened with thermoplastic materials and a blend of insoluble particles. The uncured matrix resins include an epoxy resin component, a soluble thermoplastic component, a curing agent and an insoluble particulate component composed of elastic particles and rigid particles. The uncured resin matrix is combined with a fibrous reinforcement and cured/molded to form composite materials that may be used for structural applications, such as primary structures in aircraft.