edi The Small Gods of Editing By blog.chasclifton.com Published On :: Sun, 28 Jul 2024 14:36:19 +0000 This is me, preparing for an evening of copyediting articles for The Pomegranate: The International Journal of Pagan Studies. There is in fact a small shrine within arm’s length of my desktop computer, but I usually don’t have so many … Continue reading → Full Article Uncategorized France Rome shrine
edi Ronald Surtz, ‘eminent Princeton medievalist,’ dies at 75 By www.princeton.edu Published On :: Wed, 02 Feb 2022 10:00:00 -0500 Ronald Surtz, professor of Spanish and Portuguese languages and literatures, emeritus, died peacefully at home in Cranbury, New Jersey, on Nov. 14. He was 75. Full Article
edi Princeton University Concerts Live Music Meditation: Isidore String Quartet By www.princeton.edu Published On :: Wed, 20 Nov 2024 12:30:00 -0500 "When the first notes of [the music] threaded their way into my consciousness, they seemed to come from inside me…music wound its way through me as sound turned pure sensation." —The New York Times on PUC's Live Music Meditation About the Event Breathe in sound and silence through guided meditation as you listen to music more viscerally than ever before, meditating to the playing of the Isidore String Quartet, guided by Matthew Weiner, Associate Dean in the Princeton University Office of Religious Life. This is a FREE, unticketed opportunity to indulge in attentive, focused, and mindful listening. No prior experience with meditation necessary. Capacity is limited, and we advise participants to arrive early—although the event officially begins at 12:30PM, doors to the hall will open and meditation instruction will begin at 12:00PM (noon). The event will conclude by 1:30PM. If desired, attendees may bring floor seating (mat/cushion/etc); seating will be on stage, with chairs provided. For more information about the Live Music Meditation experience, check out this New York Times feature and Performance Today segment. About the Musicians: Winners of a 2023 Avery Fisher Career Grant, and the 14th Banff International String Quartet Competition in 2022, the New York City-based Isidore String Quartet was formed in 2019 with a vision to revisit, rediscover, and reinvigorate the repertory. The quartet is heavily influenced by the Juilliard String Quartet and the idea of ‘approaching the established as if it were brand new, and the new as if it were firmly established.’ The quartet began as an ensemble at the Juilliard School. They are currently completing their final year as Peak Fellowship Ensemble-in-Residence at Southern Methodist University in Dallas. Additional Evening Concerts: The Isidore Quartet will also perform in the evening as part of the Performances Up Close series at 6PM & 9PM, with audience seated onstage. Concert info & tickets This event is presented by Princeton University Concerts. For a full event listing and tickets, please visit this link. Full Article
edi Sound Healing and Mindfulness Meditation By www.princeton.edu Published On :: Thu, 14 Nov 2024 17:30:00 -0500 Ever wanted to try a sound healing meditation? Come join GSG and CPS for a mindfulness hour, guided by a certified sound healer. Full Article
edi ‘Mulan’ Director Tony Bancroft Attached To Direct Toonz Media’s ‘Minibots’ By www.cartoonbrew.com Published On :: Tue, 05 Nov 2024 20:02:36 +0000 The film is being scripted by 'Terminator 3: Rise of Machines' and 'Rugrats' writer Michael Ferris. Full Article Feature Film Evolutionary Films Michael Ferris Minibots Mojo Global Arts Tony Bancroft Toonz Media Group
edi New LinkedIn Pages Posting in RSS Ground By www.rssground.com Published On :: Fri, 16 Nov 2018 12:00:49 +0000 This week LinkedIn has announced a major renovation of its Company Pages feature. You can now refer to them simply as Pages. As they say: “LinkedIn Pages — the next generation of LinkedIn Company Pages. Pages have been rebuilt from the ground up to make it easier for brands, institutions, and organizations, from small […] The post New LinkedIn Pages Posting in RSS Ground appeared first on RSSground.com. Full Article RSS Ground News LinkedIn content marketing LinkedIn management LinkedIn poster
edi LinkedIn Poster issues By www.rssground.com Published On :: Thu, 25 Jul 2019 12:25:18 +0000 Dear RSS Ground users, Due to the recent changes in LinkedIn developers documentation and specifications, some of the remote LinkedIn account management options require a substantial update. For this reason and at this moment RSS Ground LinkedIn Poster can only make posts to your personal feed. Posting to specific company pages is not currently available. However, […] The post LinkedIn Poster issues appeared first on RSSground.com. Full Article RSS Ground News LinkedIn poster
edi LinkedIn Company Pages Posting is Resumed By www.rssground.com Published On :: Thu, 03 Oct 2019 15:30:08 +0000 LinkedIn has finally approved our app! After the recent LinkedIn platform updates and long-awaited app review LinkedIn Poster is back to its normal functionality. The post LinkedIn Company Pages Posting is Resumed appeared first on RSSground.com. Full Article RSS Ground News autoposting company pages LinkedIn pages LinkedIn poster
edi Feeds Editing And Better Search By www.rssground.com Published On :: Fri, 25 Oct 2019 13:01:57 +0000 Now in Feeds Box you can change feeds title, add tags to your feeds, and, most remarkable, you can edit feeds' settings. We have also fine-tuned feeds search in your Feeds Box. The post Feeds Editing And Better Search appeared first on RSSground.com. Full Article RSS Ground News change log edit feeds manage feeds private feeds
edi LinkedIn Automated Poster Major Update By www.rssground.com Published On :: Sat, 25 Feb 2023 17:11:53 +0000 We have prepared a major update for one of the most popular automated posters in RSS Ground – LinkedIn Poster. LinkedIn poster can make continuous posts to your LinkedIn personal feed or LinkedIn company pages. And now you can control what content you wish to post. Find a list of new Advanced settings in the […] The post LinkedIn Automated Poster Major Update appeared first on RSSground.com. Full Article RSS Ground News automated posters change log LinkedIn poster service updates
edi The best Edinburgh spa hotels By www.telegraph.co.uk Published On :: Wed, 04 Sep 2024 16:30:00 GMT Full Article topics:places/europe structure:travel/spas structure:travel/hotels topics:places/united-kingdom structure:hotel-guides topics:places/edinburgh structure:travel topics:places/scotland storytype:standard structure:eg-general structure:us-content structure:better-life/better-life-guide structure:better-life/better-life-evergreen
edi Swedish vs. Deep Tissue – Which Massage Will Leave You More Bruised? By www.star2.org Published On :: Fri, 09 Aug 2024 11:38:09 +0000 Imagine slipping into a tranquil space, the soft aroma of essential oils filling the air, as the world outside slowly fades away. For many, this is the sanctuary sought after a long week of work or dealing with chronic pain. In that moment, whether it’s the gentle caress of a Swedish massage or the deep ... Read more The post Swedish vs. Deep Tissue – Which Massage Will Leave You More Bruised? appeared first on Star Two. Full Article Health Deep Tissue Massage Therapy professional massage Swedish massage
edi NASA launches mission to redirect an asteroid—by striking it with a spacecraft By www.pbs.org Published On :: Wed, 24 Nov 2021 15:33:00 +0000 As the first-ever “full-scale planetary defense test” to deflect a space rock, the DART mission aims to show that protecting Earth from a hazardous asteroid is possible. Full Article
edi Astronomers successfully predict an asteroid impact above Iceland By www.pbs.org Published On :: Wed, 16 Mar 2022 23:07:00 +0000 Two hours before asteroid 2022 EB5 entered Earth’s atmosphere, scientists knew exactly when and where the space rock would strike. Full Article
edi How African Indigenous knowledge helped shape modern medicine By www.pbs.org Published On :: Wed, 30 Mar 2022 21:24:00 +0000 In the 1700s, an enslaved man named Onesimus shared a novel way to stave off smallpox during the Boston epidemic. Here’s his little-told story, and how the Atlantic slave trade and Indigenous medicine influenced early modern science. Full Article
edi Repeat Signage Standard v Standalone editions By www.repeatsoftware.com Published On :: Sat, 12 Feb 2022 12:44:20 GMT Two minute video looks at the differences between Repeat Signage Standard edition and the Standalone edition. The former has full features and is ideal for displaying engaging content on any display screen anywhere in the world, whilst the latter is ideal for any application where the Internet is not possible, for example, military, army manoevers, evacuation, outdoor events, etc. Full Article
edi 10 Ignition Media Tactics to Take Your Website to the Next Level By ignitionmedia.com.au Published On :: Tue, 19 Jul 2022 22:00:51 +0000 The website is the foundation of any successful online business. It’s the first impression potential customers have of... The post 10 Ignition Media Tactics to Take Your Website to the Next Level appeared first on Ignition Media. Full Article Website Design
edi India Abraham: Healing physical and psychological scars through medical tattooing By www.jpost.com Published On :: Sun, 10 Nov 2024 08:41:01 GMT Jerusalemite of the week: India Abraham is a practitioner of medical tattooing who had already helped scores of people before Oct. 7, but her work has taken on even greater significance since then. Full Article health cancer Tattoos Beauty Jerusalemite of the Week
edi 12 of the best Christmas markets in the UK, from Bath to Edinburgh By www.independent.co.uk Published On :: 2024-11-12T11:23:11+00:00 The most Christmassy tree-topping festivities for trinkets, bratwursts and all things mulled this winter Full Article UK Travel
edi Liberal Media: “Minority Racists” Elected Trump By theblacksphere.net Published On :: Tue, 12 Nov 2024 19:50:22 +0000 The following article, Liberal Media: “Minority Racists” Elected Trump, was first published on The Black Sphere. A Message Sent No One Heard Donald Trump is the President-elect for the second time! His will be the second split-presidency incumbent nominee since Grover Cleveland. But last Tuesday night was not just 312-to-226 Electoral College blowout, but with Trump receiving 74,708,855 (and growing) vs Vice President Kamala Harris’ 70,980,347. The former 45th President also … Continue reading Liberal Media: “Minority Racists” Elected Trump ... Full Article Democrats Election of 2024 Featured #DonaldTrump #Trump2024 #Womenvote 2024 election black vote black voters black vs white electoral college Hispanic vote Joe Scarborough Kamala Harris the black vote The View War on Women
edi BREAKING! Supreme Court Decision Used For Immediate Nationwide Block of Border Crisis Rule! (Video) By sonsoflibertymedia.com Published On :: Tue, 12 Nov 2024 19:16:45 +0000 In this video, Armed Scholar expounds on the recent decision by the US Supreme Court concerning our border and the flooding of illegal immigrants, including the Biden administration, through the Department of Homeland Security, concerning programs set up that promised citizenship to illegal aliens. The decision was handed down following the 2024 elections, striking down … Full Article News U.S. News Videos
edi Chief medical officer had nightmares after spy poisoning By www.bbc.com Published On :: Tue, 12 Nov 2024 08:51:52 GMT Dame Sally Davies told the Dawn Sturgess Inquiry she had worried about the disposal of the nerve agent. Full Article
edi The great gene editing debate: can it be safe and ethical? By www.bbc.com Published On :: Tue, 10 Sep 2024 23:17:18 GMT A UK law allowing gene-edited food has been paused and some British scientists fear being overtaken. Full Article
edi Qatar suspends role as mediator between Israel and Hamas By www.bbc.com Published On :: Sat, 09 Nov 2024 21:28:38 GMT The move comes after US officials were quoted saying they would not accept Hamas's presence in Qatar. Full Article
edi Striking image of a whale feeding wins photo award By www.bbc.com Published On :: Fri, 13 Sep 2024 07:32:10 GMT Striking image of a whale feeding wins photo award Full Article
edi Pakistani TikToker Imsha Rehman deactivates social media accounts after explicit video leaked online - Hindustan Times By news.google.com Published On :: Wed, 13 Nov 2024 04:12:28 GMT Pakistani TikToker Imsha Rehman deactivates social media accounts after explicit video leaked online Hindustan TimesPakistani Influencer Imsha Rehman Deactivates Social Media Accounts After Private Video Leaks NDTVNow Pakistani TikToker Imsha Rehman’s alleged obscene video leaked online The Times of IndiaAfter Minahil Malik, another Pakistani TikTok star Imsha Rehman’s X-rated video goes viral; here's how she The Economic TimesImsha Rehman viral video: Why Pakistani TikToker has deactivated her account? What’s there in the ‘explicit’ clip? Mint Full Article
edi Iowa Pediatrician Blistered for Telling Trump Voters that He Hopes Their Children Die By lidblog.com Published On :: Mon, 11 Nov 2024 01:10:17 +0000 A scumbag, left-wing (is there any other kind?) doctor in Iowa is facing an uncertain future at his hospital after he began posting obscene wishes on social media saying that he hopes the children of Trump voters are murdered. The creep is question is one Dr. Mayank Sharma, 35, a pediatric cardiology fellow for the […] The post Iowa Pediatrician Blistered for Telling Trump Voters that He Hopes Their Children Die appeared first on The Lid. Full Article Election 2024 Health
edi News24 | EXPLAINER | COP29: What is a carbon credit? What is Article 6? By www.news24.com Published On :: Tuesday Nov 12 2024 06:21:50 Countries at the UN COP29 climate summit in Azerbaijan will attempt to agree to rules for a global system for trading carbon offset credits. Full Article
edi Where to watch St. Denis Medical: Live stream new series from Superstore creator By www.businessinsider.com Published On :: Tue, 12 Nov 2024 21:45:58 +0000 NBC's newest workplace sitcom is here, and we'll show you where to watch St. Denis Medical if you don't have cable. Full Article Streaming (Reviews) Reviews Entertainment streaming how-to-watch insider-reviews vpn
edi The Efficacy of Digital Media Resources in Improving Children’s Ability to Use Informational Text: An Evaluation of Molly of Denali From PBS KIDS By www.readingrockets.org Published On :: Wed, 31 Aug 2022 14:08:03 EDT Informational text — resources whose purpose is to inform — is essential to daily life and fundamental to literacy. Unfortunately, young children typically have limited exposure to informational text. Two 9-week randomized controlled trials with 263 first-grade children from low-income communities examined whether free educational videos and digital games from the PBS KIDS show “Molly of Denali” supported children’s ability to use informational text to answer real-world questions. Study 1 found significant positive intervention impacts on child outcomes; Study 2 replicated these findings. Full Article
edi Engaging, Explicit, and Elaborated: An Initial Trial of Media-Enhanced Preschool Vocabulary Instruction By www.readingrockets.org Published On :: Fri, 16 Dec 2022 13:12:12 EST Children from backgrounds of poverty often lag behind more advantaged peers in early language skills, including breadth and depth of vocabulary knowledge. We report the results of a pilot study of an explicit and elaborated vocabulary intervention in preschool classrooms serving children from lower-income backgrounds. The intervention used multimodal instruction, including segments from public television children's programs and interactive games, to build children's knowledge of and semantic connections for 128 words across 18 weeks of daily lessons. Full Article
edi The Role of Word-, Sentence-, and Text-Level Variables in Predicting Guided Reading Levels of Kindergarten and First-Grade Texts By www.readingrockets.org Published On :: Tue, 11 Oct 2022 10:54:00 EDT Texts classified according to guided reading levels (GRL) are ubiquitous in U.S. beginning reading classrooms. This study examined features of texts across three grade bands (kindergarten, early first grade, final first grade) and the 10 GRLs within these bands. The 510 texts came from three programs with different functions in beginning reading instruction: core, intervention, and content areas. Full Article
edi As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU By readwrite.com Published On :: Tue, 12 Nov 2024 17:57:33 +0000 Continuing to set records, Pepe Unchained recently achieved a new milestone after reaching $26 million. The project’s presale has now… Continue reading As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU The post As Pepe Unchained Launch Date Nears, Analyst Makes ‘Massive’ Prediction For PEPU appeared first on ReadWrite. Full Article Cryptocurrency
edi News24 Business | South African AI body calls for LinkedIn probe over alleged local user data violations By www.news24.com Published On :: Tuesday Oct 22 2024 05:00:18 The South African Artificial Intelligence Association wants LinkedIn to be investigated, as it claims the social networking platforms new data use practice violates local personal information protection law. Full Article
edi News24 | Wednesday's weather: Severe weather predicted in parts of the country with multiple warnings issued By www.news24.com Published On :: Tuesday Nov 12 2024 18:36:01 The country is set to experience varied weather conditions, with several impact-based warnings issued across various provinces, according to the South African Weather Service. Full Article
edi News24 | SA Jewish Board of Deputies approaches Equality Court with social media hate speech complaint By www.news24.com Published On :: Wednesday Nov 13 2024 08:11:04 The Cape South African Jewish Board of Deputies has asked the Equality Court in Cape Town to declare politician Mehmet Vefa Dag's social media posts about about Jewish people hate speech. Full Article
edi New York feeding rats tasty birth control By boingboing.net Published On :: Tue, 01 Oct 2024 20:30:00 +0000 The tales of New York City's rats are legendary. NY Rats are big and smart, and they have lots of babies. The city has a rat czar and recently held a rat summit to discuss the issue. Mayor Eric Adams was undoubtedly happy to talk about the rat problem rather than his own issues. — Read the rest The post New York feeding rats tasty birth control appeared first on Boing Boing. Full Article Post birth control new york city rats Science
edi IVT MediaPlatform 4.1 Sets New Standard for Enterprise Video Communications By communicationtransformation.blogspot.com Published On :: Wed, 06 May 2009 20:22:00 +0000 IVT released its latest upgrades to its MediaPlatform software.Click to view the announcement. Full Article
edi MediaPlatform Debuts WebCaster By communicationtransformation.blogspot.com Published On :: Wed, 12 May 2010 00:59:00 +0000 MediaPlatform Debuts WebCaster, a Fusion of Performance and UsabilityNew Addition to Webcasting Software Lineup Leverages Cloud Platform for Productivity and Connectivity NEW YORK - STREAMING MEDIA EAST - May 11, 2010 -MediaPlatform, Inc. (formerly IVT) today unveiled its latest product offering, MediaPlatform WebCaster, cloud-based webcasting software that packs leading edge event management, event customization, and production capabilities into a simple user experience. WebCaster has been built to serve the needs of demanding webcast production professionals as well as non-technical users"WebCaster is a heavyweight performer with a flyweight price and impact on corporate IT," said Jim McGovern, Chief Executive Officer of MediaPlatform. "Our team has worked hard for over a year to exceed client expectations in virtually every aspect of the webcasting experience."WebCaster offers a unique mix of best-in-class features, ranging from an intuitive, browser-based user interface and sophisticated reporting to multiple remote presenters and flexible producing teams. WebCaster also offers rich templates with options to customize, total operating system and browser independence, telephony to Flash® Audio input, and iPhone support."We went into the development process with a goal of enabling presentations from 'anywhere to anyone,'" said Greg Pulier, Founder and CTO of MediaPlatform, and head of WebCaster's development. "For every feature we considered, our constant question was, 'Will this provide the best possible experience for users at every step of the webcasting process? I am very proud of the work everyone has contributed to this outstanding offering."With WebCaster, MediaPlatform is further establishing itself as the preferred provider for digital media producers. As the business of producing webcasts for lead generation, training, and conferences continues to expand, MediaPlatform is serving a growing number of top tier digital media production firms. WebCaster is designed to provide producers with a webcasting toolset they can rely upon as they build their production businesses. WebCaster is the newest addition to MediaPlatform's growing portfolio of media production and management offerings.It complements the company's high-end webcasting product, now known as IVT MediaPlatform, as well as PrimeTime, MediaPlatform's video portal.About MediaPlatform, Inc. MediaPlatform, Inc. (formerly IVT) delivers best-in-class webcasting and media management technology to global enterprises and digital media producers. MediaPlatform's webcasting software enables high-impact presentations for lead generation, corporate communications and training. The company offers organizations the ability to take advantage of scalable cloud-based computing, as well as on-premises deployment, to present and manage rich media. With media management tools built on its platform, the company helps clients derive long term archive value from their investment in media content. Full Article
edi Amazon Enables MediaPlatform Migration to the Cloud By communicationtransformation.blogspot.com Published On :: Wed, 01 Dec 2010 21:58:00 +0000 Here is a link to the case study Amazon prepared about MediaPlatform's use of the Amazon Elastic Compute Cloud (EC2) and Simple Storage Solution (S3). http://aws.amazon.com/solutions/case-studies/mediaplatform/ MediaPlatform is the only streaming software solution that allows clients to access the obvious benefits of cloud computing while retaining the ability to maintain security, achieve integrations with Active Directory/LDAP, control remote encoders, etc. Combined with its groundbreaking approaches to multicasting Flash and leveraging the native caching abilities of WAN acceleration devices to stream HTTP, MediaPlatform's cloud offering represents the most innovative approach to enterprise webcasting available on the market today. Full Article
edi Interactive Media Strategies believes Microsoft could win big with Skype By communicationtransformation.blogspot.com Published On :: Fri, 13 May 2011 22:01:00 +0000 Interactive Media Strategies (IMS) is a market research firm that follows streaming media. They discuss the news of Microsoft’s $8.5 billion acquisition of Skype, and the prospects for Skype to emerge as a viable platform for business video communications. Their research compares usage levels for a range of social media and communications applications, including Skype, YouTube and Facebook. Here is a link to the video. They report that personal use of Facebook and YouTube is relatively high but that has not yet translated into comparable levels of corporate use. They believe this raises the question of whether YouTube and Facebook will be able to outgrow their focus on the consumer side of the business to compete in the enterprise market. Usage levels for Skype are significantly lower overall, but Skype’s penetration in business communications is higher than they see for other communications apps online among young users most likely to experiment with emerging technologies. IMS puts forth the opinion that if Microsoft could make it easier for technology laggards to embrace Skype - i.e. integrate Skype with the Microsoft Office suite - then Skype could achieve significant enterprise adoption. Full Article
edi Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights By conservativefiringline.com Published On :: Sun, 10 Nov 2024 04:15:48 +0000 The following article, Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights, was first published on Conservative Firing Line. (Natural News) Liberals have been working hard to portray Trump as a misogynist, and it worked on a lot of women – with some of them buying into the false narrative that he will work against women so wholeheartedly that they are now having very public meltdowns over his victory. Revolver put together some of the … Continue reading Unhinged Liberal Women Cry On Social Media Over Trump’s Victory And Falsely Claim They’ve Lost All Their Rights ... Full Article Politics democrats election liberals rights Trump unhinged victory women
edi Video: Merlin's Time & Attention Talk (Improvised Rutgers Edition) By www.43folders.com Published On :: Tue, 27 Apr 2010 19:57:09 +0000 Video: Merlin Mann - "Time & Attention Talk (improvised)" Audio (mp3): "Merlin Mann - 'Rutgers Time & Attention Talk'" This is a talk I did at Rutgers earlier this month. I kinda like it, but for a weird reason. Something something, perfect storm of technology Ragnarok, and yadda yadda, I had to start the talk 20 minutes late with no slides. Nothing. So, I riffed. And, I ended up talking about a lot of the new stuff you can expect to see in the Inbox Zero book—work culture, managing expectations, the 3 deadly qualities of email, and one surprising reason email's not as much fun as Project Runway. Some people liked it. I think. I liked it. I hope you do, too. Here's the slides I would have shown. ;-) Who Moved My Brain? Revaluing Time & Attention Many thanks, again, to my great pal, Dr. Donald Schaffner, for bringing me in for this visit. I had a great time and met some fantastic, passionate people. Much appreciated. Hey—know anybody who should hear this talk? Hmmm? I’ll bet. Lucky you, you can hire me to deliver this or any of my other talks to the time- and attention-addled people you work with as well. Current topics include email, meetings, social media, and future-proofing your passion. Drop a note if you have an upcoming event where you think we two might be a good fit. update 2010-04-27_13-50-00 Apologies—my friends at Rutgers (inexplicably) have placed this video under lock and key. Fortunately, I have a lock-picker called Firefox. Samizdat video available soon... update 2010-04-27_14-42-24 Yay, fixed! Many thanks to my hero, Jesse Schibilia. ”Video: Merlin's Time & Attention Talk (Improvised Rutgers Edition)” was written by Merlin Mann for 43Folders.com and was originally posted on April 27, 2010. Except as noted, it's ©2010 Merlin Mann and licensed for reuse under CC BY-NC-ND 3.0. "Why a footer?" Full Article Time and Attention Videos world of work
edi 'Warrior for Truth': Trump Has Chosen His Next CIA Director, Crediting Pick for 'Exposing Russian Collusion' Hoax By www.westernjournal.com Published On :: Tue, 12 Nov 2024 23:40:01 +0000 President-elect Donald Trump has chosen the next director of the CIA. Trump tapped former Texas congressman and director of national intelligence John Ratcliffe for the job. According to a statement […] The post 'Warrior for Truth': Trump Has Chosen His Next CIA Director, Crediting Pick for 'Exposing Russian Collusion' Hoax appeared first on The Western Journal. Full Article News 2024 election CIA Donald Trump Russia Trump administration U.S. News
edi Report Shows New Front-Runner for Trump's Press Secretary Spot: The Media Should Be Terrified By www.westernjournal.com Published On :: Wed, 13 Nov 2024 00:01:27 +0000 President-elect Donald Trump is reportedly considering lawyer Alina Habba to be the White House press secretary. Habba often spoke to the media while she was on the legal team representing […] The post Report Shows New Front-Runner for Trump's Press Secretary Spot: The Media Should Be Terrified appeared first on The Western Journal. Full Article Commentary 2024 election Donald Trump Kayleigh McEnany Trump administration White House
edi Sport | More to Bok prodigy Moodie after turbulence with Duhan and Co in Edinburgh By www.news24.com Published On :: Tuesday Nov 12 2024 06:12:02 Canan Moodie used his start against Scotland to show that he is about far more than just pace out wide and aerial ability. Full Article
edi [4Fe-4S] cluster trafficking mediated by Arabidopsis mitochondrial ISCA and NFU proteins [Enzymology] By www.jbc.org Published On :: 2020-12-25T00:06:31-08:00 Numerous iron-sulfur (Fe-S) proteins with diverse functions are present in the matrix and respiratory chain complexes of mitochondria. Although [4Fe-4S] clusters are the most common type of Fe-S cluster in mitochondria, the molecular mechanism of [4Fe-4S] cluster assembly and insertion into target proteins by the mitochondrial iron-sulfur cluster (ISC) maturation system is not well-understood. Here we report a detailed characterization of two late-acting Fe-S cluster-carrier proteins from Arabidopsis thaliana, NFU4 and NFU5. Yeast two-hybrid and bimolecular fluorescence complementation studies demonstrated interaction of both the NFU4 and NFU5 proteins with the ISCA class of Fe-S carrier proteins. Recombinant NFU4 and NFU5 were purified as apo-proteins after expression in Escherichia coli. In vitro Fe-S cluster reconstitution led to the insertion of one [4Fe-4S]2+ cluster per homodimer as determined by UV-visible absorption/CD, resonance Raman and EPR spectroscopy, and analytical studies. Cluster transfer reactions, monitored by UV-visible absorption and CD spectroscopy, showed that a [4Fe-4S]2+ cluster-bound ISCA1a/2 heterodimer is effective in transferring [4Fe-4S]2+ clusters to both NFU4 and NFU5 with negligible back reaction. In addition, [4Fe-4S]2+ cluster-bound ISCA1a/2, NFU4, and NFU5 were all found to be effective [4Fe-4S]2+ cluster donors for maturation of the mitochondrial apo-aconitase 2 as assessed by enzyme activity measurements. The results demonstrate rapid, unidirectional, and quantitative [4Fe-4S]2+ cluster transfer from ISCA1a/2 to NFU4 or NFU5 that further delineates their respective positions in the plant ISC machinery and their contributions to the maturation of client [4Fe-4S] cluster-containing proteins. Full Article
edi Calpain activation mediates microgravity-induced myocardial abnormalities in mice via p38 and ERK1/2 MAPK pathways [Molecular Bases of Disease] By www.jbc.org Published On :: 2020-12-04T00:06:06-08:00 The human cardiovascular system has adapted to function optimally in Earth's 1G gravity, and microgravity conditions cause myocardial abnormalities, including atrophy and dysfunction. However, the underlying mechanisms linking microgravity and cardiac anomalies are incompletely understood. In this study, we investigated whether and how calpain activation promotes myocardial abnormalities under simulated microgravity conditions. Simulated microgravity was induced by tail suspension in mice with cardiomyocyte-specific deletion of Capns1, which disrupts activity and stability of calpain-1 and calpain-2, and their WT littermates. Tail suspension time-dependently reduced cardiomyocyte size, heart weight, and myocardial function in WT mice, and these changes were accompanied by calpain activation, NADPH oxidase activation, and oxidative stress in heart tissues. The effects of tail suspension were attenuated by deletion of Capns1. Notably, the protective effects of Capns1 deletion were associated with the prevention of phosphorylation of Ser-345 on p47phox and attenuation of ERK1/2 and p38 activation in hearts of tail-suspended mice. Using a rotary cell culture system, we simulated microgravity in cultured neonatal mouse cardiomyocytes and observed decreased total protein/DNA ratio and induced calpain activation, phosphorylation of Ser-345 on p47phox, and activation of ERK1/2 and p38, all of which were prevented by calpain inhibitor-III. Furthermore, inhibition of ERK1/2 or p38 attenuated phosphorylation of Ser-345 on p47phox in cardiomyocytes under simulated microgravity. This study demonstrates for the first time that calpain promotes NADPH oxidase activation and myocardial abnormalities under microgravity by facilitating p47phox phosphorylation via ERK1/2 and p38 pathways. Thus, calpain inhibition may be an effective therapeutic approach to reduce microgravity-induced myocardial abnormalities. Full Article
edi Reply to Sysel et al.: Comment on the importance of using nitric oxide gas in the synthesis of nitrosylcobalamin and ICH-validated methods to assess purity and stability [Letters to the Editor] By www.jbc.org Published On :: 2020-10-23T00:06:00-07:00 In their comment (1) on our publication (2), the authors make two points: (i) they raise concerns about the possible effect of residual NONOate in our study, and (ii) they promote nitrosylcobalamin (NOCbl) supplied by their own company. Both points lack merit for the following reasons. The authors make the astonishing claim that the spectra of nitric oxide (NO•) and cobalamins overlap. Unlike NO•, cobalamin absorbs in the visible region, permitting unequivocal spectral assignment of NOCbl as reported (3). We demonstrated that whereas NOCbl is highly unstable in solution, it is stabilized by the B12 trafficking protein CblC. So even if present, residual NONOate (which is unstable at neutral pH and is removed during the work-up (3)) could not account for the observed difference.The authors then misrepresent our synthetic method, claiming that anaerobic conditions were used to generate nitrocobalamin (NO2Cbl), which results in the transient formation of NOCbl. We synthesized NO2Cbl aerobically using nitrite as described (4); NOCbl is not an intermediate in this ligand exchange reaction. The aerobic instability of NOCbl has been rigorously described by inorganic chemists (3, 5) and raises obvious questions about its purported biological effects as exemplified by the authors' own 2003 JBC publication, which was later withdrawn.As to promoting NOCbl from their company, the authors refer to a synthetic route from a mixture of NO• gas and aquocobalamin. The authors' method (6) has been described as “dubious” by chemists (5). Whereas DEAE NONOate used in our method is widely known as an NO• donor,... Full Article
edi Comment on the importance of using nitric oxide gas in the synthesis of nitrosylcobalamin and ICH-validated methods to assess purity and stability [Letters to the Editor] By www.jbc.org Published On :: 2020-10-23T00:06:00-07:00 After a thorough read of this paper (1), we wish to clarify that the authors' anaerobic method of synthesis for the production of nitrocobalamin results in the transient formation of nitrosylcobalamin, an unstable intermediate upon exposure to air. We concur that the authors' method results in the production of nitrocobalamin based on the UV-visible data as shown. The authors' adapted anaerobic method consists of mixing hydroxocobalamin hydrochloride with diethylamine NONOate diethylammonium salt in aqueous solution. Of concern, the UV spectrum of nitric oxide overlaps that of all cobalamin species under anaerobic conditions, making any assignments of the binding of nitric oxide to hydroxocobalamin suspect (2). Additionally, the use of acetone to precipitate the authors' product causes precipitation of diethylamine NONOate, resulting in an impure product. As a result, its utility for drawing experimental conclusions is faulty.The product from the authors' anaerobic synthetic method has not been assessed for purity, and the synthetic method itself has not been validated using a stability-indicating method as required by the International Conference on Harmonization (ICH) (ICH Q2B, Validation of Analytical Procedures) methodology, which is a hallmark for analytical characterization. Our nitrosylcobalamin synthesis involves reacting nitric oxide gas with hydroxocobalamin acetate as a heterogeneous mixture in a non-electron-donating solvent followed by rotary evaporation. Our nitrosylcobalamin product is stable in air, releases nitric oxide gas in situ (3), and meets ICH stability guidelines (4). Additionally, our nitrosylcobalamin product demonstrates biological activity, which has not been observed for nitrocobalamin (3, 5). Full Article