ca Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00663A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin KrátkýLinking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00601A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza GainaNew meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00558A, Research ArticleLaura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva JúniorThis article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00553H, Research ArticleStefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro CosconatiNon-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00637B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qiang Yang, Yunpeng LiuFc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A practical guide for the assay-dependent characterisation of irreversible inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00707G, Review ArticleLavleen K. Mader, Jessica E. Borean, Jeffrey W. KeillorKinetic evaluations for assay dependent characterization of irreversible inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Case filed against actor Kasthuri over remarks on Telugu community By www.thehindu.com Published On :: Wed, 06 Nov 2024 19:46:03 +0530 Full Article Tiruchirapalli
ca Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:10:58 +0530 About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive Full Article Tiruchirapalli
ca Fishermen seek healthcare and cold storage facilities By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:03:17 +0530 Full Article Tiruchirapalli
ca Small-scale handloom park to come up at Sengunthapuram By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:09:38 +0530 Ministers R. Gandhi and S.S. Sivashankar inspect the 13,205 sq. ft. site belonging to the Tamil Nadu Cotton Corporation at Sengunthapuram Full Article Tiruchirapalli
ca Site identified for small-scale handloom park in Karur By www.thehindu.com Published On :: Sat, 09 Nov 2024 19:30:54 +0530 Full Article Tiruchirapalli
ca Students and agriculture officials grapple with logistical, technical issues during digital crop survey By www.thehindu.com Published On :: Sat, 09 Nov 2024 20:32:48 +0530 Full Article Tiruchirapalli
ca Students cautioned against drug addiction By www.thehindu.com Published On :: Sat, 09 Nov 2024 22:12:06 +0530 Full Article Tiruchirapalli
ca Lack of signboards indicating bus timings at Chathiram Bus Stand in Tiruchi irks passengers By www.thehindu.com Published On :: Mon, 11 Nov 2024 17:08:51 +0530 Passengers also say some buses leave earlier than scheduled or don’t pass certain rural areas, leading to schoolchildren not being able to board on time Full Article Tiruchirapalli
ca 548: Infinite Canvas, Luro + Figma, and Scraping or Crawling By shoptalkshow.com Published On :: Mon, 16 Jan 2023 10:41:42 +0000 What's going to happen to homework with AI? Thoughts on infinite canvas which leads into Luro and Sigma integration, and Chris gets nerdsniped and tries to scrap (or should he crawl?) websites for data. Full Article All Episodes chatgpt infinite canvas Luro
ca 551: PlanetScale with Iheanyi Ekechukwu and Mike Coutermarsh By shoptalkshow.com Published On :: Mon, 06 Feb 2023 19:44:27 +0000 Iheanyi Ekechukwu and Mike Coutermarsh talk about PlanetScale, what Vitess is, if PlanetScale is for both side and big projects, what read only regions are, what schema changes are, and how PlanetScale compares to other projects. Full Article All Episodes database planetscale vitess
ca 560: Oh Biscuits! Cascade Layers, Block Links, Emoji Lists, and more CSS! By shoptalkshow.com Published On :: Mon, 10 Apr 2023 08:53:57 +0000 After a brief visit from Hip Hop Dad Dave, we're talking cascade layers updates, block link practices, search element getting dropped, how to use cite, emoji list accessibility, scrollbar state, and trigonometric functions in CSS. Full Article All Episodes cascade layers cite emoji trigonometric
ca 562: Podcast Apps, Zaraz, Future CSS Thoughts, and Arc By shoptalkshow.com Published On :: Mon, 24 Apr 2023 08:01:44 +0000 What if Taylor Swift lyrics hold the answers to web dev questions? Podcast app thoughts, using Cloudflare Zaraz, what we're excited about with CSS, Arc browser updates, and are we even developers or are we specialized systems whisperers? Full Article All Episodes arc CSS zaraz
ca 581: DevRel, Musical Mics, Social Sharing, and 100 Years of WordPress By shoptalkshow.com Published On :: Mon, 04 Sep 2023 08:25:38 +0000 Dave calls a quick Luro branding meeting, some thoughts on DevRel, Chris tries to figure out musical instrument mics, follow up on WordPress from a previous episode, Chris' journey through the social graph options, 100 year hosting with WordPress, and the introduction of a new segment: Happy Project Share Time. Full Article All Episodes guitar happy project share time Luro social graph Wordpress
ca 591: Cascade Layers, CSS Functions, and more CSS with Miriam Suzanne By shoptalkshow.com Published On :: Mon, 13 Nov 2023 10:11:50 +0000 Miriam Suzanne stops by to talk about CSS updates and news on container queries, rolling out cascade layers, !important things to remember, custom properties, exit animations, CSS functions, state queries, and more. Full Article All Episodes cascade layers CSS css functions exit animations
ca 604: VS Code Plugins, Git as a Radical Statement, Tailwind & Arc Drama By shoptalkshow.com Published On :: Mon, 26 Feb 2024 09:43:06 +0000 A follow up on jQuery conversation, Microsoft owning all the things, what VS Code plugins are your ride or die, the ability to Git from wherever you want, Tailwind drama, global design system follow up, Arc Search gets roasted, and Frontend Design Conference is back! Full Article All Episodes global design systems microsoft tailwind vs code
ca 608: Can WordPress Kill Your Resume, Fav Parts of Web Dev, Exploring HTMX, and more! By shoptalkshow.com Published On :: Mon, 25 Mar 2024 07:55:38 +0000 We're opening up the ShopTalk mailbag and answering your questions, including does WordPress on your resume kill your job chances, what are our fav and least fav parts of web dev, our thoughts on HTMX, and what is it like to use pnpm instead of npm. Full Article All Episodes HTMX npm pnpm Wordpress
ca 611: React! TypeScript! Jobification! Drupal! By shoptalkshow.com Published On :: Mon, 15 Apr 2024 08:30:37 +0000 Dave & Chris and thoughts on career advice that worked 3 years ago but isn't as helpful now, marking tests with ChatGPT, is taking a Drupal job in 2024 a good idea, Chris got #gear sniped, P3 color follow up, the confusing File System APIs, and where did all the lightboxes go? Full Article All Episodes Career Advice Drupal File System API p3
ca 623: Assigning Weight Dynamically, CoPilot vs Other AI, and Monorepos By shoptalkshow.com Published On :: Mon, 08 Jul 2024 08:34:45 +0000 We're talking about assigning a weight to items in a layout, differentiating between banger posts and regular blog posts, using social engineering to get PR's accepted, monorepo thoughts, using CoPilot vs other AI programming support bots, has TypeScript benefited from AI, and what happens if you turn off CoPilot? Full Article All Episodes copilot typescript vs code
ca 625: CarTalk, Ownership of A Book Apart, and URL Shorteners By shoptalkshow.com Published On :: Mon, 22 Jul 2024 18:28:00 +0000 Dave's putting together a platform for his presidential bid and workshops his policies, discussing vehicle options for a family in 2024, Chris and other authors get ownership of their A Book Apart books back, and the ramifications and reasoning behind Google killing a URL shortener. Full Article All Episodes books cartalk urls
ca 630: Frostapalooza Recap, Follow Up, and Messy Codebases By shoptalkshow.com Published On :: Mon, 26 Aug 2024 08:22:05 +0000 Chris has a birthday today 🎉, we recap our Frostapalooza experience celebrating Brad Frost's birthday, do all codebases become a mess, Mermaid, TLDraw, and Figjam thoughts, making tiny games, where's the follow up in web and world news, and what's the current state of CMS' on the web? Full Article All Episodes birthday CMS drawing Wordpress
ca Can Chennai change its energy consumption patterns? By www.thehindu.com Published On :: Fri, 05 Dec 2014 17:09:43 +0530 In creating energy-efficient cities, India will do well to model its development on its own age-old techniques, says Durganand Balsavar Full Article Property Plus
ca Webcams & borewells By www.thehindu.com Published On :: Fri, 23 Jan 2015 20:35:02 +0530 A groundwater expert uses a webcam to find out the yield from borewells and identify problems. By Full Article Property Plus
ca Go local is the mantra By www.thehindu.com Published On :: Fri, 06 Mar 2015 14:48:45 +0530 Angela Brady, director, Brady Mallalieu Architects, London, tells Nidhi Adlakha why we need to focus on creating sustainable cities with low carbon footprints Full Article Green Living
ca The commodification of water By www.thehindu.com Published On :: Fri, 10 Apr 2015 21:20:54 +0530 Water purification systems in cities and villages may look attractive but do they actually benefit the needy? Full Article Green Living
ca Chennai’s mega carbon footprint By www.thehindu.com Published On :: Fri, 17 Apr 2015 16:11:27 +0530 Chennai emerges as India’s No. 1 greenhouse gas emitter in a study done among seven major cities. Poor city and building design is the main culprit. Full Article Property Plus
ca Typecasting eco-ideas By www.thehindu.com Published On :: Fri, 20 Nov 2015 14:26:08 +0530 Important public buildings ignore the time-tested lessons of sustainability found in local architecture. By SATHYA PRAKASH VARANASHI Full Article Green Living
ca How ‘priority sector’ status can rev up Jan Dhan banking By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 21:31:00 +0530 How regulation can nudge private banks to promote financial inclusion Full Article Current Account
ca The delicate balance in doctor-patient interaction By www.thehindubusinessline.com Published On :: Sun, 06 Oct 2024 22:06:15 +0530 How clear communication and accountability in healthcare can significantly improve patient outcomes Full Article Pulse
ca As India’s installed solar capacity crosses 90GW, a look at the journey By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 Sun-sational growth: In September, India’s installed solar power capacity reached 90,762 MW. Given the current rate of monthly capacity additions, there is little doubt that installed capacity will exceed 100 GW in 2024-25. Full Article Clean Tech
ca Carbon credits to boost incomes of Jharkhand village farmers By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 The Birsa Harit Gram project serves as a potential model for agro-forestry, which is gaining ground because the buyers of carbon credits prefer — pay a premium — for credits based on Nature Based Solution, as opposed to offsetting projects like renewable energy or projects like carbon capture. Full Article Clean Tech
ca Flat organisation believers: Can you imagine a world without managers? By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:24:36 +0530 What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important? Full Article Corporate File
ca Cargo companies upsize for new business By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 19:43:00 +0530 Booming demand for ecommerce delivery spurs freight handlers to open more centres, digitise for efficiency Full Article Logistics
ca Galathea Bay: New major port can be game changer By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 19:56:00 +0530 Transshipment port at Galathea Bay is strategically located on the East-West international trade and shipping route Full Article Logistics
ca How radio waves can power smart cities By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 21:40:29 +0530 Practically omnipresent, thanks to human activity, radio frequency is the new area of focus for energy harvesting technology Full Article Science and Technology
ca Catalysing Indian IP creation By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 21:48:42 +0530 How policy support and monetisation can rev up India’s innovation ecosystem Full Article Science and Technology
ca Indo National plans battery of home-care launches By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:00:42 +0530 The maker of Nippo batteries plans to innovate in its core business and get into LED bulbs Full Article Corporate File
ca Getting the gig economy to care for its backbone By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:25:45 +0530 Why startups in India cannot afford to take a hands-off approach towards the armies of gig workers they have created Full Article Emerging Entrepreneurs
ca CEA plans 613 GW RE transmission capacity By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 18:36:40 +0530 Higher generation of renewable energy challenges grid stability Full Article Clean Tech
ca Making medicines at the point of patient care By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 18:52:12 +0530 UK readies law allowing preparation of medicines near hospital setting to reach patients safely, quickly Full Article Pulse
ca Navigating the flood of healthcare information, with a little help from AI By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 19:35:44 +0530 A global survey maps how willing, and equipped clinicians are in using artificial intelligence to support their work Full Article Pulse
ca Trump presidency casts long shadow over climate summit By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 19:27:32 +0530 The return of the climate denier as head of the world’s biggest greenhouse gas emitter threatens to throw net-zero negotiations into disarray once again Full Article Clean Tech
ca Can we escape the gas chamber we have walked into? By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 20:10:58 +0530 All countries are falling short of their promise to do their mite for climate action Full Article Clean Tech
ca Jamiat cautions NDA partners, says ‘crutches’ cannot escape responsibility for Waqf Bill By www.thehindu.com Published On :: Mon, 04 Nov 2024 21:07:19 +0530 The Jamiat Ulama-i-Hind urged NDA partners TDP and JD(U) to heed Muslim sentiments on the contentious issue surrounding the Waqf (Amendment) Bill, 2024 Full Article India