ca A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00146J, PaperDumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan DingA fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Detection of Free DNA Based on Metal-Enhanced Fluorescence Triggered by CRISPR-Cas12a and Colorimetric Analysis By pubs.rsc.org Published On :: Anal. Methods, 2024, Accepted ManuscriptDOI: 10.1039/D4AY00149D, PaperMing-Qiu Zheng, Yuyao Li, Liling Zhang, Cheng-Yu Li, Menghan Liu, Hongwu TangThe CRISPR-Cas system has been found to be extremely sensitive and there is an urgent demand to extend its potential in bioassay. Herein, we developed a novel nanobiosensor to detect...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A simple and rapid colorimetric detection of Staphylococcus Aureus relied on the distance-dependent optical properties of silver nanoparticles By pubs.rsc.org Published On :: Anal. Methods, 2024, Accepted ManuscriptDOI: 10.1039/D3AY02189K, PaperNgoc Anh Thu Phan, Hoang Men Nguyen, Cam Duyen Thi Vo, Toi Vo Van, Phuoc Long TruongThe quick and accurate diagnosis of pathogens has appeared as a pressing issue in clinical diagnostics, environmental monitoring, and food safety. The current assays are suffering from limited capacities in...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A reaction based carbazole–indolium conjugate probe for the selective detection of environmentally toxic ions By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00301B, PaperJayasudha Palanisamy, Mansour K. Gatasheh, Ashraf Atef HatamlehCarbazole–indolium based colorimetric probe was designed for detecting cyanide ions in various water samples. An outstanding response was shown by paper test strips prepared using the probe for the easy detection of cyanide in real time.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Electroanalysis overview: additive manufactured biosensors using fused filament fabrication By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00278D, Minireview Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Robert D. Crapnell, Craig E. BanksAdditive manufacturing (3D-printing), in particular fused filament fabrication, presents a paradigm shift in the way electrochemical based biosensing platforms are produced, giving rise to a new generation of personalized and on-demand biosensors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00264D, PaperMariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia DossFabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00219A, PaperYumin Yang, Daojin Li, Bingqian LiuShikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Α simplified lateral flow immunosensor for the assay of carcinoembryonic antigen in low-resource settings By pubs.rsc.org Published On :: Anal. Methods, 2024, Accepted ManuscriptDOI: 10.1039/D4AY00381K, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ioanna Tsogka, Electra Mermiga, Varvara Pagkali, Christos Kokkinos, Anastasios EconomouCarcinoembryonic antigen (CEA) is a glycoprotein widely used as a tumor marker. In this work, a colorimetric lateral flow immunosensor is developed for rapid and low-cost quantification of CEA in...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Three-dimensional hotspot structures constructed from nanoporous gold with a V-cavity and gold nanoparticles for surface-enhanced Raman scattering By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00348A, PaperYang Xu, Yan Wu, Jianjun Wei, Yuanyu Zhao, Peili XueA nanoporous gold V-shaped resonant cavity (NPGVRC) structure constructed with plasmonic resonance coupling effect. The NPGVRC has excellent SERS performance and 3D hotspot properties.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Monolith stationary phases prepared via cyclic anhydride ring-opening polymerization as tunable platforms for chromatographic applications By pubs.rsc.org Published On :: Anal. Methods, 2024, Accepted ManuscriptDOI: 10.1039/D4AY00251B, PaperAhmad Aqel, Ayman Ghafr, A. Yacine Badjah-Hadj-Ahmed, Zeid Abdullah ALOthmanPolymer monolithic stationary phases were prepared based on a cyclic anhydride as a reactive and tunable platform via ring-opening post-polymerization using primary amines; octadecylamine and benzylamine. The characterization techniques indicated...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis By pubs.rsc.org Published On :: Anal. Methods, 2024, Accepted ManuscriptDOI: 10.1039/D3AY02200E, PaperQiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan GaoTuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A Review of ipwhois.io for Reliable Geolocation Data By www.impressivewebs.com Published On :: Mon, 07 Feb 2022 11:00:00 +0000 [Sponsored] If you’re building an app that requires delivering a dynamic experience based on the user’s location or other location-related data, a fast and easy-to-use Geolocation API will certainly come in handy. One such option is ipwhois.io. The service, which is free for small non-commercial projects that need fewer than 10,000 requests per month, is easy to integrate with your tech stack. As usual, it’s always best to look at a few examples so you can see it in action. Their documentation is short and easy to follow, so I’ll demonstrate using the following example request: The post A Review of ipwhois.io for Reliable Geolocation Data appeared first on Impressive Webs. Full Article Sponsored
ca Meet capella star Alaa Wardi By www.thehindubusinessline.com Published On :: Mon, 22 Apr 2013 12:31:39 +0530 Full Article R Dinakaran
ca How mobile data can help rationalise bus routes By www.thehindubusinessline.com Published On :: Wed, 01 May 2013 16:35:55 +0530 Full Article R Dinakaran
ca Location tracking - do you need it? By www.thehindubusinessline.com Published On :: Sat, 17 Aug 2013 16:31:13 +0530 Full Article R Dinakaran
ca It is an offence: On Supreme Court clarification on online content on child sex abuse By www.thehindu.com Published On :: Wed, 25 Sep 2024 00:10:00 +0530 Court has done well to clarify law on online content showing child sex abuse Full Article Editorial
ca Delay and bail: On former Tamil Nadu Minister V. Senthilbalaji’s case By www.thehindu.com Published On :: Sat, 28 Sep 2024 00:20:00 +0530 Senthilbalaji’s release on bail was overdue, but he should not be made a Minister Full Article Editorial
ca Changes at the top: On the Tamil Nadu cabinet reshuffle By www.thehindu.com Published On :: Wed, 02 Oct 2024 00:10:00 +0530 Ministers must infuse confidence in the people they serve Full Article Editorial
ca Inflection point: On the escalation in the multi-party West Asia conflict By www.thehindu.com Published On :: Thu, 03 Oct 2024 00:20:00 +0530 West Asia needs the intervention of major world powers for peace Full Article Editorial
ca Caste in jail: On discrimination in prisons By www.thehindu.com Published On :: Sat, 05 Oct 2024 00:10:40 +0530 Time for State governments to end systemic discrimination in prisons Full Article Editorial
ca Sweet and sour: On the laddu ‘adulteration’ case By www.thehindu.com Published On :: Thu, 10 Oct 2024 00:10:00 +0530 The inquiry into laddu adulteration must not be communalised Full Article Editorial
ca Canadian frostbite: On the India-Canada diplomatic war By www.thehindu.com Published On :: Thu, 17 Oct 2024 00:20:00 +0530 India must consider the impact of its next steps on its diplomacy and image Full Article Editorial
ca Complicit: On India and the U.S and Canada cases By www.thehindu.com Published On :: Mon, 21 Oct 2024 00:30:00 +0530 India must come clean on its stance on transnational killings Full Article Editorial
ca Fair trade: On the 29th COP and India’s carbon market By www.thehindu.com Published On :: Sat, 26 Oct 2024 00:20:00 +0530 India must develop a transparent carbon trade policy Full Article Editorial
ca Beyond intoxication: On alcohol regulation, judicial verdict By www.thehindu.com Published On :: Mon, 28 Oct 2024 00:20:00 +0530 Batting for States, the Supreme Court of India holds federal balance on regulating alcohol Full Article Editorial
ca Escalation ladder: On conflict between Israel and Iran By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:00 +0530 Iran should show strategic restraint; and the world should rein in Israel Full Article Editorial
ca The Raj & DK Line-Up You Cannot Miss By www.rediff.com Published On :: Sukanya Verma looks at their eclectic career of over two decades as their latest offering Citadel: Honey Bunny, the Indian leg of the Russo Brothers globetrotting spy universe series, drops on Amazon Prime Video on November 7. Full Article
ca Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3507-3528DOI: 10.1039/D4MD00417E, Research ArticleYuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan PanIn continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3469-3476DOI: 10.1039/D4MD00422A, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim NenckaSARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3418-3432DOI: 10.1039/D4MD00170B, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van TranMadecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3345-3370DOI: 10.1039/D4MD00317A, Review ArticleMeghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep KumarSemisynthetic phytochemicals in cancer treatment.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3444-3459DOI: 10.1039/D4MD00318G, Research ArticleAnuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar MaitiNiloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3433-3443DOI: 10.1039/D4MD00468J, Research ArticleMeijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing LiA synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3529-3557DOI: 10.1039/D4MD00481G, Research ArticleMohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai AdelDiscovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3460-3468DOI: 10.1039/D4MD00405A, Research ArticleXiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli BiSchematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3485-3494DOI: 10.1039/D4MD00246F, Research ArticleShouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng XuA novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3477-3484DOI: 10.1039/D4MD00266K, Research ArticleRaitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps JaudzemsThe aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024) By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3371-3394DOI: 10.1039/D4MD00384E, Review ArticleDebasis Das, Lingzhi Xie, Jian HongProspects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam. By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3558-3575DOI: 10.1039/D4MD00391H, Research ArticlePothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar MaitiMalabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3597-3608DOI: 10.1039/D4MD00378K, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. JenkinsIn silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00517A, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca ReA novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00471J, Research ArticlePoorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar ShrivastavaScreening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00297K, Research ArticleBranislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea NikolićIn this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00594E, Research ArticleNagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza ElrayessOne benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD90044H, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki FujiiTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00617H, Research ArticleAida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü BeydemirIn this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00632A, Review ArticleAshish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder KumarThe present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00579A, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-BrocetaA ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00623B, Research ArticleOjaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi YaddanapudiA series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ca Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00614C, Research ArticleVijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip BanerjiThe development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
