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Metal-free cascade reactions of aziridines with arylalkynes and aryldiazoniums: facile access to arylazopyrrolines

Org. Biomol. Chem., 2020, 18,3149-3157
DOI: 10.1039/D0OB00346H, Paper
Jing Rong, Hao Jiang, Sijing Wang, Zhenni Su, Huiyan Wang, Chuanzhou Tao
A novel and facile approach to synthesize arylazopyrroline scaffolds via metal-free cascade reactions of aziridines with arylalkynes and aryldiazoniums has been developed, providing access to a variety of 4-arylazo-2-pyrrolines in a highly concise fashion.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Progress in recent development of stereoselective synthesis of β2-amino acid derivatives from β-nitroacrylate derivatives

Org. Biomol. Chem., 2020, 18,2991-3006
DOI: 10.1039/D0OB00448K, Review Article
Hao-Wei Zeng, Ping-Yu Wu, Hsyueh-Liang Wu
β2-Amino acids: recent advances in the synthesis of β2-amino acids and their derivatives from various stereoselective transformations of β-nitroacrylates are summarized.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Rh(III)-Catalyzed regioselective C4 alkylation of indoles with allylic alcohols: direct access to β-indolyl ketones

Org. Biomol. Chem., 2020, 18,3038-3042
DOI: 10.1039/D0OB00396D, Communication
Changduo Pan, Gao Huang, Yujia Shan, Yiting Li, Jin-Tao Yu
A Rh(III)-catalyzed direct C4 alkylation of indoles with allylic alcohols to access β-indolyl ketones was developed.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Construction of 2,3-disubstituted benzo[b]thieno[2,3-d]thiophenes and benzo[4,5]selenopheno[3,2-b]thiophenes using the Fiesselmann thiophene synthesis

Org. Biomol. Chem., 2020, 18,3164-3168
DOI: 10.1039/D0OB00300J, Paper
Roman A. Irgashev, Nadezhda S. Demina, Gennady L. Rusinov
A number of 2,3-disubstituted benzo[b]thieno[2,3-d]thiophenes and benzo[4,5]selenopheno[3,2-b]thiophenes have been obtained using a convenient approach based on the Fiesselmann thiophene synthesis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Ni(II)-Catalyzed vinylic C–H functionalization of 2-acetamido-3-arylacrylates to access isotetronic acids

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00557F, Paper
Biswajit Roy, Eshani Das, Avijit Roy, Dipakranjan Mal
A ligand-free Ni(II)-catalyzed cascade annulation reaction for the synthesis of 4-aryl-substituted isotetronic acids from 2-acetamido-3-arylacrylates via vinylic C–H functionalization is reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00253D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hadyn L. Parker, Ruben M. F. Tomás, Christopher M. Furze, Collette S. Guy, Elizabeth Fullam
Chemoenzymatic synthesis of azido-functionalised asymmetric trehalose analogues that are resistant to enzymatic degradation to probe carbohydrate processing pathways in mycobacteria.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Acylation of oxindoles using methyl/phenyl esters via mixed Claisen condensation – An access to 3-alkylideneoxindoles

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00789G, Communication
Ramdas Sreedharan, Purushothaman Rajeshwaran, Pradeep Kumar Reddy Panyam, Saurabh Yadav, C. M. Nagaraja, THIRUMANAVELAN GANDHI
Predominantly, aggressive acid chlorides and stoichiometric coupling reagents are employed in the acylating process for synthesizing carbonyl tethered heterocycles. Herein, we report simple acyl sources, viz. methyl and phenyl esters...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Heterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00617C, Communication
Wei Liu, Vinay Gopal Jannu, Zhiwen Liu, Qingbo Zhang, Xiaodong Jiang, Liang Ma, Wenjun Zhang, Changsheng Zhang, Yiguang Zhu
N-Methyltransferase TsnB8 was demonstrated to catalyze successive methyltransfer reactions in the biosynthesis of trichostatin.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Catalyst- and Solvent-Free Efficient Access to N-Alkylated Amines via Reductive Amination using HBPin

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00740D, Communication
ARNAB RIT, Vipin Kumar Pandey, Somnath Bauri
A sustainable approach which works under catalyst- and solvent-free conditions for the synthesis of structurally diverse secondary amines has been uncovered. This one-pot protocol works efficiently at room temperature and...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Recent Progress on Transition Metal-catalysed Regioselective C–H Transformations Based on Noncovalent Interactions

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00703J, Review Article
Yoichiro Kuninobu, Takeru Torigoe
Transition metal-catalysed C–H transformations are powerful tools to obtain functionalised organic molecules from simple starting materials. To control regioselectivity is one of the most important issues in C–H transformations. Since...
The content of this RSS Feed (c) The Royal Society of Chemistry




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A Selectfluor-promoted oxidative reaction of disulfides and amines: access to sulfinamides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00720J, Paper
Haibo Mei, Jiang Liu, Romana Pajkert, Gerd-Volker Röschenthaler, Jianlin Han
An unprecedented metal-free oxidative reaction of disulfides and amines with Selectfluor as a mild oxidant under aerobic conditions was developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Aspiring actor-cum-model arrested for killing IT professional

A 20-year-old aspiring actor- cum-model was arrested in the national capital for allegedly murdering a young woman IT professional a week ago after she refused to heed to his demand for money.




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Progress measures must include nature — think beyond GDP: Rachel Kyte

As India debates environmental health versus economic growth, Rachel Kyte, vice-president and special envoy for climate change at the World Bank Group, feels it is vital to think beyond basic GDP.




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Plea on metro card-address proof linking declined




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Fact Check: Fake news regarding WhatsApp ticks, govt action on messages being circulated

The fake message was fact-checked by the PIB which said in a tweet that the "Government is doing no such thing."







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'I never think of my films as mindless'

'I do drama with the same intensity as any comedy.'






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Do we need a loneliness minister?

One of the many ironies of modern living is that while technology is bringing people closer, the sense of loneliness is growing. That’s because a text message can never replace a hug, and virtual Siri a real friend. ​




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Message from Bihar: ‘Finished’ netas can win

There is one big message from the recent by-elections that comes ringing in from Bihar. It has tactical implications for the politics that will unfold in the run-up to 2019: hypothetically, if there are any plans afoot to “finish off” another politician (perhaps someone from a neighbouring state) by sending her or him to jail or encircling her or him in corruption and income tax cases, it will only be counter-productive and may end up evoking sympathy for that individual.




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Resistance of concrete to chloride ingress: testing and modelling / Tang Luping, Lars-Olof Nilsson, and P.A. Muhammed Basheer

Barker Library - TA445.T36 2011




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Progress in polymers in concrete: selected, peer reviewed papers from the 14th International Congress on Polymers in Concrete (ICPIC 2013), April 17-20, 2013, Shanghai, China / edited by Ru Wang and Zhenghong Yang

Barker Library - TA443.P58 I57 2013




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Structures Congress 2013: bridging your passion with your profession: proceedings of the 2013 Structures Congress: May 2-4, 2013, Pittsburgh, Pennsylvania / sponsored by the Structural Engineering Institute (SEI) of the American Society of Civil Engineer

Barker Library - TA440.S87 2013




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Self-sensing concrete in smart structures / Baoguo Han, professor, School of Civil Engineering Dalian University of Technology Dalian, China, Xun Yu, associate professor, Mechanical and Energy Engineering, University of North Texas, Denton, TX. USA, Jinp

Barker Library - TA440.H26 2014




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Thermal stresses and temperature control of mass concrete / Zhu Bofang, China Institute of Water Resources and Hydropower Research, and Chinese Academy of Engineering

Barker Library - TA440.Z485 2014




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Successful women ceramic and glass scientists and engineers: 100 inspirational profiles / Lynnette D. Madsen, Ph.D.

Hayden Library - TP805.M33 2016




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Durability of concrete: design and construction / Mark Alexander, Arnon Bentur, and Sidney Mindess

Barker Library - TA440.A44 2017




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Biodefense in the age of synthetic biology / Committee on Strategies for Identifying and Addressing Potential Biodenfense Vulnerabilities Posed by Synthetic Biology, Board on Chemical Sciences and Technology, Board on Life Sciences, Division on Earth and

Online Resource




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How scientific progress occurs: incrementalism and the life sciences / Elof Axel Carlson

Hayden Library - QH315.C2885 2018




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Impressionable biologies: from the archaeology of plasticity to the sociology of epigenetics / Maurizio Meloni

Hayden Library - QH450.M45 2019




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Bioethics, public health, and the social sciences for the medical professions: an integrated, case-based approach / Amy E. Caruso Brown, Travis R. Hobart, Cynthia B. Morrow, editors

Online Resource




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Biophysics for beginners: a journey through the cell nucleus / Helmut Schiessel

Online Resource




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Essays on life, science and society: the world through the eyes of a life scientist / Shaw M. Akula

Online Resource




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Essential cell biology / Bruce Alberts [and six others]

Barker Library - QH581.2.E78 2019




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Everything flows: towards a processual philosophy of biology / edited by Daniel J. Nicholson and John Dupré

Dewey Library - QH331.E85 2018




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Mathematical models in developmental biology / Jerome K. Percus, Courant Institute of Mathematical Sciences and Department of Physics, New York University, Stephen Childress, Courant Institute of Mathematical Sciences

Online Resource




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Essential current concepts in stem cell biology Beate Brand-Saberi, editor

Online Resource




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Understand your DNA: a guide / Lasse Folkersen, Sankt Hans Hospital, Denmark ; foreword by professor Pak Sham

Barker Library - QH431.F65 2019




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The cartoon guide to biology / Larry Gonick & Dave Wessner

Dewey Library - QH309.G676 2019




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An Event Apart: Designing Progressive Web Apps

In his The Case for Progressive Web Apps presentation at An Event Apart in Chicago, Jason Grigsby walked through the process of building Progressive Web Apps for your Web experiences and how to go about it. Here's my notes from his talk:

  • Progressive Web Apps (PWAs) are getting a lot of attention and positive stories about their impact are coming out. PWA Stats tracks many of these case studies. These sorts of examples are getting noticed by CEOs who demand teams build PWAs today.
  • A PWA is a set of technologies designed to make faster, more capable Web sites. They load fast, are available online, are secure, can be accessed from your home screen, have push notifications, and more.
  • But how can we define Progressive Web Apps? PWAs are Web sites enhanced by three things: https, service worker, and a manifest file.
  • HTTPS is increasingly required for browsers and APIs. Eventually Chrome will highlight sites that are not on https as "insecure".
  • Service Workers allow Web sites to declare how network requests and the cache are handled. This ability to cache things allows us to build sites that are much faster. With service workers we can deliver near instant and offline experiences.
  • A Web manifest is a JSON file that delivers some attributes about a Web site. Browsers use these files to make decisions on what to do with your site (like add to home page).
  • Are PWAs any different than well-built Web sites? Not really, but the term helps get people excited and build toward best practices on the Web.
  • PWAs are often trojan horses for performance. They help enforce fast experiences.

Feels Like a Native App

  • Does your organization have a Web site? Do you make money off your Web site? If so, you probably need a Progressive Web Site.
  • Not every customer will have your native app installed. A better Web experience will help you reach people who don't. For many people this will be their first experience with your company, so you should make it as good as possible.
  • Getting people to install and keep using native apps is difficult. App stores can also change their policies and interfaces which could negatively impact your native app.
  • The Web can do much more than we think, the Web has APIs to access location, do fast payments using fingerprint identification, push notifications, and more.
  • What should we use to design PWAs? Native app styles or Web styles? How much does your design match the platform? You can set up PWAs to use different system fonts for iOS and Android, should you? For now, we should define our own design and be consistent across different OSs.
  • What impact does going "chrome-less" have on our PWAs? You loose back buttons, menu controls, system controls. Browsers provide us with a lot of useful features and adding them back is difficult. Especially navigation via the back button is complex. So in most cases, you should avoid going full screen.
  • While not every person will add your PWA to their home screen, every person will "install" your PWA via the service worker.
  • An app shell model allows you put your common UI (header, footer, nav, etc.) into the app cache. This makes the first loading experience feel a lot faster. Should you app shell or not? If you have architected as a single page app, this is possible but otherwise might not be worth the effort.
  • Animating transitions can help with way-finding and polish on the Web. This gives Web sites even more personality.

Installation and Discovery

  • Using a Web manifest file, allows you specify a number of declarations for your app. In addition to name, icon, and even theme colors.
  • Once you have a PWA built and a manifest file, browsers will being prompting people to install your Web site. Some Browsers have subtle "add" actions. Other use more explicit banner prompts. "Add to home screen" banners are only displayed when they make sense (certain level of use).
  • Developers can request these banners to come up when appropriate. You'll want to trigger these where people are mostly likely to install. (like checkout)
  • Microsoft is putting (explicitly and implicitly) PWAs within their app store. Search results may also start highlighting PWAs.
  • You can use Trusted Web Activity or PhoneGap to wrap native shells around your PWA to put them into Android and iOS app stores.

Offline Mode

  • Your Web site would benefit from offline support. Service Workers enable you to cache assets on your device to load PWAs quickly and to decide what should be available offline.
  • You can develop offline pages and/or cache pages people viewed before.
  • If you do cache pages, make it clear what data hasn't been updated because it is not available offline.
  • You can give people control over what gets cached and what doesn't. So they can decide what they want available for offline viewing.
  • If you enable offline interactions, be explicit what interactivity is available and what isn't.

Push Notifications

  • Push notifications can help you increase engagement. You can send notifications via a Web browser using PWAs.
  • Personal push notifications work best but are difficult to do right. Generic notifications won't be as effective.
  • Don't immediately ask people for push notification permissions. Find the right time and place to ask people to turn them on. Make sure you give people control, if you'd don't they can kill them using browser controls.
  • In the next version of Chrome, Google will make push notification dialogs blocking (can't be dismissed) so people have to decide if they want notifications on or off. This also requires you to ask for permissions at the right time.

Beyond Progressive Web Apps

  • Auto-login with credential management APIs allows you to sign into a site using stored credentials. This streamlines the login process.
  • Apple Pay on the Web converged with the Web Payment API so there's one way to use stored payment info on the Web.
  • These next gen capabilities are not part of PWAs but make sense within PWAs.

How to Implement PWAs

  • Building PWAs is a progressive process, it can be a series of incremental updates that all make sense on their own. As a result, you can have an iterative roadmap.
  • Benchmark and measure your improvements so you can use that data to get buy-in for further projects.
  • Assess your current Web site's technology. If things aren't reasonably fast to begin with, you need to address that first. If your site is not usable on mobile, start there first.
  • Begin by building a baseline PWA (manifest, https, etc.) and then add front-end additions and larger initiatives like payment request and credential api later.
  • Every step on the path toward a PWAS make sense on their own. You should encrypt your Web sites. You should make your Web site fast. These are all just steps along the way.




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‘The borderless Republic’: Sheffield celebrates migration

Britain’s largest festival about refugees and sanctuary is more relevant than ever, writes Lydia Noon.




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‘We feel stronger’: meet those fighting the sand-dredging business in Cambodia

A source of corruption and environmental degradation. Rod Harbinson reports.




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Civil war, mental illness, poverty, gang violence: the many roots of homelessness

We talked to homeless in different countries and they revealed housing insecurity's different causes around the world.




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Eat less, feed the world : Rice tells India and China

And she has blamed the 'growing Indian and Chinese appetite in contributing to the global food crisis'. The US Secretary of State is technically correct since both the countries dominate the world food consumption. But analysts feel she is morally and socially wrong.




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American Express quarterly profit plunges 76% on $1.7 bn reserve build

Shares of the company were up nearly 2%, as it kept a tight lid on costs to weather the impact of the pandemic on its business




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RIL's Q4 PBT falls 33% to Rs 9,223 cr due to pressure in petrochemicals biz

The company looks to raise Rs 53,125 crore through this rights issue, which will be the first by RIL in three decades




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Best WordPress Theme Clubs for Unlimited Sites

Review and comparison of the best Wordpress theme clubs for unlimited domains.