Clearly visible connecting the dark-purple cephalopods was the white “terminal organ” or penis of the male, extending out through the male’s funnel.

The post First detailed sex video of deep-sea squid resolves long-standing mysteries as to how these animals mate appeared first on Smithsonian Insider.

The inventions of Alexander Graham Bell—most famously the telephone but also methods of recording sound—have allowed people to hear each other’s voices for more than […]

The post “Hear My Voice”: Smithsonian identifies 130-year-old recording as Alexander Graham Bell’s voice appeared first on Smithsonian Insider.

Based on a treasure trove of recent discoveries, astronomers now know that planets are remarkably plentiful in our galaxy and may be common throughout the […]

The post Dust trap around distant star may unlock mystery as to how planets form appeared first on Smithsonian Insider.

Kepler-78b is a planet that shouldn’t exist. This scorching lava world circles its star every eight and a half hours at a distance of less […]

The post Mystery lava world baffles astronomers appeared first on Smithsonian Insider.

Unlocking the mysteries of animal migration through precise, near real-time tracking can solve major conservation challenges and transform wildlife science worldwide. For the past year, […]

The post New project to unlock migration mysteries from air appeared first on Smithsonian Insider.

A research team from the Smithsonian and Arizona State University have developed a new, non-destructive method using spectroscopic analysis to help unravel the complex chemistry […]

The post Feathers yield mysteries of pigment chemistry to spectroscopic analysis appeared first on Smithsonian Insider.

A mysterious X-ray signal has been found in a detailed study of galaxy clusters using NASA’s Chandra X-ray Observatory and ESA’s XMM-Newton. One intriguing possibility […]

The post Mysterious X-ray signal from space appeared first on Smithsonian Insider.

It is related to one of the world’s most destructive invasive species, and possibly the slimiest. Thirty-five pounds of live giant West African snails (Archachatina […]

The post Slimy invaders, giant snails: Q&A with mollusk expert Ellen Strong appeared first on Smithsonian Insider.

Investigators from Rock County, Wisconsin, are one step closer to solving the mystery surrounding the death of an unknown teenager thanks to Smithsonian scientists. Christine […]

The post Smithsonian/Wisconsin police narrow search in 20 year mystery appeared first on Smithsonian Insider.

Over the vast, empty reaches of interstellar space, countless small molecules tumble quietly though the cold vacuum. Forged in the fusion furnaces of ancient stars […]

The post Mysterious molecules in space appeared first on Smithsonian Insider.

Size isn’t the only thing that’s small about the pygmy sloth―its population is too. But scientists at the Smithsonian say things may be looking up […]

The post Study reveals more Pygmy Sloths, But There Still Aren’t Many appeared first on Smithsonian Insider.

When the population of one of the Chesapeake Bay’s most famous residents, the blue crab, went into rapid decline due to overfishing, the Smithsonian stepped […]

The post Waiter, There’s a Tag on My Crab! appeared first on Smithsonian Insider.

Contrary to popular imagery, massive volcanic eruptions or an asteroid impact may not have been the cause of the world’s first mass extinction. Rather, some […]

The post Did mystery worms cause world’s first mass extinction? appeared first on Smithsonian Insider.

President Jimmy Carter, an avid birder, talks about the importance of bird conservation and why birds really matter. Step outside your house in the morning […]

The post Why Birds Really Matter: President Jimmy Carter appeared first on Smithsonian Insider.

Food is scarce in the deep, dark regions of the ocean where barbeled dragonfishes and their relatives dwell. Known as the Stomiidae, some of these […]

The post Odd anatomy: flexible joint between skull and spine allow dragonfish to open wide appeared first on Smithsonian Insider.

A bizarre change occurs in the mouth of a humpback whale during its development in the womb. Several dozen tooth buds sprout in a row […]

The post Paleo-detectives energize great whale mystery: how & when baleen evolved appeared first on Smithsonian Insider.

When fast radio bursts, or FRBs, were first detected in 2001, astronomers had never seen anything like them before. Since then, astronomers have found a […]

The post New study indicates mysterious fast radio bursts occur in universe every second appeared first on Smithsonian Insider.

Little to nothing is known about how and where a small European songbird called the bluethroat spends much of the year. Now, Smithsonian scientists have […]

The post Scientists track a mysterious songbird using tiny backpack locators appeared first on Smithsonian Insider.

Mycoplasma hyopneumoniae is a prokaryotic pathogen that colonizes the respiratory ciliated epithelial cells in swine. Infected animals suffer respiratory lesions, causing major economic losses in the porcine industry. Characterization of the immunodominant membrane-associated proteins from M. hyopneumoniae may be instrumental in the development of new therapeutic approaches. Here, the crystal structure of P46, one of the main surface-antigen proteins, from M. hyopneumoniae is presented and shows N- and C-terminal α/β domains connected by a hinge. The structures solved in this work include a ligand-free open form of P46 (3.1 Å resolution) and two ligand-bound structures of P46 with maltose (2.5 Å resolution) and xylose (3.5 Å resolution) in open and closed conformations, respectively. The ligand-binding site is buried in the cleft between the domains at the hinge region. The two domains of P46 can rotate with respect to each other, giving open or closed alternative conformations. In agreement with this structural information, sequence analyses show similarities to substrate-binding members of the ABC transporter superfamily, with P46 facing the extracellular side as a functional subunit. In the structure with xylose, P46 was also bound to a high-affinity (Kd = 29 nM) Fab fragment from a monoclonal antibody, allowing the characterization of a structural epitope in P46 that exclusively involves residues from the C-terminal domain. The Fab structure in the complex with P46 shows only small conformational rearrangements in the six complementarity-determining regions (CDRs) with respect to the unbound Fab (the structure of which is also determined in this work at 1.95 Å resolution). The structural information that is now available should contribute to a better understanding of sugar nutrient intake by M. hyopneumoniae. This information will also allow the design of protocols and strategies for the generation of new vaccines against this important swine pathogen.

David Guerit, Pauline Marie, Anne Morel, Justine Maurin, Christel Verollet, Brigitte Raynaud-Messina, Serge Urbach, and Anne Blangy

Among hematopoietic cells, osteoclasts (Oc) and immature dendritic cells (Dc) are closely related myeloid cells with distinct functions; Oc participate skeleton maintenance while Dc sample the environment for foreign antigens. Such specificities rely on profound modifications of gene and protein expression during Oc and Dc differentiation. We provide global proteomic and transcriptomic analyses of primary mouse Oc and Dc, based on original SILAC and RNAseq data. We established specific signatures for Oc and Dc including genes and proteins of unknown functions. In particular, we showed that Oc and Dc have the same α and β tubulin isotypes repertoire but that Oc express much more β tubulin isotype Tubb6. In both mouse and human Oc, we demonstrate that elevated expression of Tubb6 in Oc is necessary for correct podosomes organization and thus for the structure of the sealing zone, which sustains the bone resorption apparatus. Hence, lowering Tubb6 expression hindered Oc resorption activity. Overall, we highlight here potential new regulators of Oc and Dc biology and illustrate the functional importance of the tubulin isotype repertoire in the biology of differentiated cells.

Bipasha Dey and Richa Rikhy

Cell shape morphogenesis from spherical to polygonal occurs in epithelial cell formation in metazoan embryogenesis. In syncytial Drosophila embryos, the plasma membrane incompletely surrounds each nucleus and is organized as a polygonal epithelial-like array. Each cortical syncytial division cycle shows circular to polygonal plasma membrane transition along with furrow extension between adjacent nuclei from interphase to metaphase. In this study, we assess the relative contribution of DE-cadherin and Myosin II at the furrow for polygonal shape transition. We show that polygonality initiates during each cortical syncytial division cycle when the furrow extends from 4.75 to 5.75 µm. Polygon plasma membrane organization correlates with increased junctional tension, increased DE-cadherin and decreased Myosin II mobility. DE-cadherin regulates furrow length and polygonality. Decreased Myosin II activity allows for polygonality to occur at a lower length than controls. Increased Myosin II activity leads to loss of lateral furrow formation and complete disruption of polygonal shape transition. Our studies show that DE-cadherin-Myosin II balance regulates an optimal lateral membrane length during each syncytial cycle for polygonal shape transition.

Aparna Sherlekar, Gayatri Mundhe, Prachi Richa, Bipasha Dey, Swati Sharma, and Richa Rikhy

Branched actin networks driven by Arp2/3 collaborate with actomyosin filaments in processes such as cell migration. The syncytial Drosophila blastoderm embryo also shows expansion of apical caps by Arp2/3 driven actin polymerization in interphase and buckling at contact edges by MyosinII to form furrows in metaphase. Here we study the role of Syndapin (Synd), an F-BAR domain containing protein in apical cap remodelling prior to furrow extension. synd depletion showed larger apical caps. STED super-resolution and TIRF microscopy showed long apical actin protrusions in caps in interphase and short protrusions in metaphase in control embryos. synd depletion led to sustained long protrusions even in metaphase. Loss of Arp2/3 function in synd mutants partly reverted defects in apical cap expansion and protrusion remodelling. MyosinII levels were decreased in synd mutants and MyosinII mutant embryos have been previously reported to have expanded caps. We propose that Syndapin function limits branching activity during cap expansion and affects MyosinII distribution in order to shift actin remodeling from apical cap expansion to favor lateral furrow extension.

Forget what you thought you knew about geology. Some minerals can roll up like flaky Belgian piroulines. For the last several decades, mining operations in […]

The post Rolled-Up Mystery Mineral may cause Craving for Piroulines appeared first on Smithsonian Insider.

A mysterious nocturnal animal was leaving its tracks on the delicate mirrors of the telescopes at the Smithsonian's Whipple Observatory in Arizona. With a little ingenuity and a live trap, the mystery was solved. The visitor proved to be a ringtail cat, a member of the raccoon family.

The post Astronomers solve mystery of dusty foot trails crossing telescope mirrors appeared first on Smithsonian Insider.

The post 3-D laser scanning is helping solve ancient mysteries at the Smithsonian appeared first on Smithsonian Insider.

myVolcano is a crowd-sourcing app that enables you to share your photographs and descriptions of volcanic hazards, as well as collecting samples and measurements of […]

The post New: myVolcano crowd-sourcing app appeared first on Smithsonian Insider.

Each year, a mysterious group of night herons flock to Smithsonian’s National Zoo. Then, they vanish. In episode three of our series, we go behind […]

The post The great night heron mystery at the National Zoo appeared first on Smithsonian Insider.

Meet Amy Homma, the Director of Digital Learning at Art Lab+. Learn how Smithsonian’s Hirshhorn Museum and Sculpture Garden has created a dynamic program to […]

The post An Active Environment With Smithsonian Educator: Amy Homma appeared first on Smithsonian Insider.

Scientists at the Smithsonian Conservation Biology Institute (SCBI) have found that poaching is an emerging crisis for Asian elephants in Myanmar. Researchers first became aware […]

The post Elephant poaching crisis in Myanmar appeared first on Smithsonian Insider.

When talk turns to the economy, it's clear that LA brings out the best and the worst.

Steve Julian: Business analyst Mark Lacter, where do you see the best of it here?

Mark Lacter: You see the best of the economy, Steve, with all kinds of startup activity - much of it tech-related - and you also see the large number of auto sales, the improved housing market, and the record number of people visiting Southern California - all indications of a growing economy.  But then, you have the other L.A. economy, with large numbers of families struggling to make ends meet, and seeing very little sign of recovery.  You know, the government has been releasing income data covering the last few years, and what you see is that the disparity between the richest 1 percent and the other 99 percent is at its widest point since the 1920s.  You especially see that kind of bifurcated economy in Southern California, which has some of the wealthiest people in the country, and also some of the poorest.

Julian: Now, the split between rich and poor has been happening for a good long time, hasn't it?

Lacter: Yes, but L.A. is in a special class because there are so many immigrants with limited job skills - in fact, a new study by the UCLA Anderson Forecast says it's a much higher percentage than immigrants living in Miami, San Francisco, and New York.  What's interesting is that 20 years ago the job skills among immigrants were significantly higher in L.A.  Limited job skills mean there's very little opportunity to move up the income ladder.  That factors into buying homes, sending your kids to college - really becoming part of the middle class.

Julian: I imagine that's particularly true for factory work…

Lacter: Yes, some of the same jobs that newly-arrived immigrants in previous generations would gravitate to.  Today, many of those jobs are gone, and they're being replaced by positions that require greater skill that's borne out of greater education.  And that, of course, is another problem: a sizable percentage of recently-arrived immigrants never finished high school, much less college, and that makes it even less likely that they'll be able to move up.

Julian: Related, or unrelated, to the recession?

Lacter: Actually, L.A. had serious income inequality in December of 2006, before the recession, when the county's unemployment rate was just 4.3 percent - a stunningly low rate when you consider that as of July, the jobless rate was almost 10 percent.  This points out that the division of haves and have-nots can happen even when the economy is doing well.

Julian: And it seems the last C-17 to be built for Air Force is a reminder of wage gap.

Lacter: That's right - it'll be up to foreign customers to keep the program in Long Beach alive.  Boeing currently has an order from India for 10 of the cargo planes, which will keep the line moving through the third quarter of next year.  Frankly, the only reason the C-17 has lasted this long is heavy political pressure by congressional lawmakers whose districts have an economic stake in the program.  At one time, as many as 16,000 people may have worked on the C-17 in Long Beach, but that number has fallen sharply over the years.

Julian: Still, this is the last airplane manufacturing plant in Southern California.

Lacter: And that, of course, speaks volumes about the state of the aerospace business, which had been one of the main economic drivers back in the days leading up to World War II.  Aerospace continued to be very important until the end of the Cold War, when you had a huge industry consolidation that resulted in the loss of tens of thousands of local jobs throughout the 1990s.  There's still quite a bit of aerospace activity locally that involves missiles, satellites, and electronics - both for the major defense contractors like Boeing and Northrop, and for smaller contractors and sub-subcontractors that still get a piece of the military pie.

Julian: But most of them require high skill levels…

Lacter: Yes, and that gets us back to the folks who are stuck in low-paying jobs with little prospect for moving up.  This is what the L.A. economy is all about, the good and the bad.

Mark Lacter writes for Los Angeles Magazine and pens the business blog at LA Observed.com.

This content is from Southern California Public Radio. View the original story at SCPR.org.

The Weeping Goldsmith, written as a first-person narrative, follows Botanist John Kress through nine years as he surveys Myanmar’s teak forests, bamboo thickets, timber plantations, rivers and mangroves to document its incredible botanical biodiversity.

The post Smithsonian botanist writes book on his discoveries in the secret land of Myanmar appeared first on Smithsonian Insider.

On crime scene investigation shows, forensic scientists use remnants of genetic material to solve mysteries in a matter of hours. Researchers at the Smithsonian Environmental […]

The post Environmental “Forensics” Pieces Together Mysterious Plant Invasion appeared first on Smithsonian Insider.

In the dark recesses of an underground fungus garden, a Panamanian leaf-cutting ant plucks a tuft of mycelia, the wispy part of the basidiomycete fungus […]

The post Mystery solved? Ants Protect Young From Infection By Cocooning Them in Fungus appeared first on Smithsonian Insider.

At the approach of a hungry parrot snake, a tree frog egg transforms from a haven to a prison. With no parent to offer protection, […]

The post Mystery solved: frogs use snout glands in emergency jail break appeared first on Smithsonian Insider.

What might lure someone away from the sunny beaches and lush forests of Brazil to the concrete jungle of Washington, D.C.? For wood anatomist Marcelo […]

The post Rigid yet flexible: Anatomy of woody vines has its grip on botanist Marcelo Pace appeared first on Smithsonian Insider.

Smithsonian scientists have discovered two new gecko species—the Lenya banded bent-toed gecko (Cyrtodactylus lenya) and Tenasserim Mountain bent-toed gecko (C. payarhtanesnsis)—in the little-studied lowland forests […]

The post Smithsonian Scientists Discover Two New Gecko Species in Vanishing Myanmar Rainforest appeared first on Smithsonian Insider.

Each year from summer into fall, ornamental crape myrtle trees in the southern and central U.S. lay out a visual feast of vibrant flowers in […]

The post Crape myrtle trees aren’t native to the US, but hungry native birds still find them tasty appeared first on Smithsonian Insider.