witch

This Week in Apps: WWDC goes online, Android 11 delays, Facebook SDK turns into app kill switch

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.




witch

Ever Considered Using Natural Hair Products? Here’s Why You Should Make The Big Switch

Some trends are worth the hype and organic hair products is one such trend. Switching to natural and organic products seems like a gamble that we are not too crazy about. Don't you think that it is high time that you




witch

Andhra government switches to online classes using video-conferencing

The state has been conducting virtual classes using video conferencing platforms such as Skype, Cisco, Google Meet and Microsoft Teams to conduct online classes.




witch

UK to switch ‘Stay At Home’ Covid-19 message to ‘Stay Alert’

The UK is set to modify its Stay At Home social distancing message to curb the spread of coronavirus to Stay Alert as British Prime Minister Boris Joh




witch

Nintendo Servers Down: 2219-2502 Error hits Switch Online and Animal Crossing



Nintendo Servers look to be down this evening with many users receiving a 2219-2502 Error on Nintendo Switch




witch

This Week in Apps: WWDC goes online, Android 11 delays, Facebook SDK turns into app kill switch

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.




witch

Twitch for Musicians - Boost Your Fanbase & Bottom Line

When Karen Allen told us about her book for musicians about the live streaming platform Twitch, she said: “I’ve been working in digital music for 20 years and have never seen anything so effective for artists.” That certainly piqued our interest.

Lo and behold, there is a growing and prospering community of musicians on Twitch using the platform to engage new fans, turn casual fans into super fans, and make some good money doing it. Allen, a veteran of the digital music industry and author of Twitch for Musicians, joins us on today's show to explain Twitch’s evolution and how indie musicians can utilize it to great effect.

This episode is sponsored by Bandzoogle. Try it free for 30 days and use the promo code “CMPOD” to get 15% off the first year of any subscription. https://bandzoogle.com/?pc=cmpod

http://canadianmusician.com




witch

Southeast Asia should switch to a greener growth model, OECD says

Southeast Asia’s over-reliance on natural resources like oil, gas, minerals and wood for economic growth is unsustainable over the long term and is causing environmental damage that will hurt future prosperity if left unchecked, according to a new OECD report.




witch

Southeast Asia should switch to a greener growth model, OECD says

Southeast Asia’s over-reliance on natural resources like oil, gas, minerals and wood for economic growth is unsustainable over the long term and is causing environmental damage that will hurt future prosperity if left unchecked, according to a new OECD report.




witch

This Week in Apps: WWDC goes online, Android 11 delays, Facebook SDK turns into app kill switch

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.




witch

This Week in Apps: WWDC goes online, Android 11 delays, Facebook SDK turns into app kill switch

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.




witch

It's not totally clear why The Worst Witch at the Vaudeville Theatre needed to be a musical

Long before Harry Potter there was Mildred Hubble - a luckless pupil at Miss Cackle's Academy For Witches.




witch

SAD President asks Punjab CM to give incentives to farmers for switching from paddy to other crops




witch

XUV-driven plasma switch for THz: new spatio-temporal overlap tool for XUV–THz pump–probe experiments at FELs

A simple and robust tool for spatio-temporal overlap of THz and XUV pulses in in-vacuum pump–probe experiments is presented. The technique exploits ultrafast changes of the optical properties in semiconductors (i.e. silicon) driven by ultrashort XUV pulses that are probed by THz pulses. This work demonstrates that this tool can be used for a large range of XUV fluences that are significantly lower than when probing by visible and near-infrared pulses. This tool is mainly targeted at emerging X-ray free-electron laser facilities, but can be utilized also at table-top high-harmonics sources.




witch

Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases

Tannerella forsythia is an oral dysbiotic periodontopathogen involved in severe human periodontal disease. As part of its virulence factor armamentarium, at the site of colonization it secretes mirolysin, a metallopeptidase of the unicellular pappalysin family, as a zymogen that is proteolytically auto-activated extracellularly at the Ser54–Arg55 bond. Crystal structures of the catalytically impaired promirolysin point mutant E225A at 1.4 and 1.6 Å revealed that latency is exerted by an N-terminal 34-residue pro-segment that shields the front surface of the 274-residue catalytic domain, thus preventing substrate access. The catalytic domain conforms to the metzincin clan of metallopeptidases and contains a double calcium site, which acts as a calcium switch for activity. The pro-segment traverses the active-site cleft in the opposite direction to the substrate, which precludes its cleavage. It is anchored to the mature enzyme through residue Arg21, which intrudes into the specificity pocket in cleft sub-site S1'. Moreover, residue Cys23 within a conserved cysteine–glycine motif blocks the catalytic zinc ion by a cysteine-switch mechanism, first described for mammalian matrix metallopeptidases. In addition, a 1.5 Å structure was obtained for a complex of mature mirolysin and a tetradecapeptide, which filled the cleft from sub-site S1' to S6'. A citrate molecule in S1 completed a product-complex mimic that unveiled the mechanism of substrate binding and cleavage by mirolysin, the catalytic domain of which was already preformed in the zymogen. These results, including a preference for cleavage before basic residues, are likely to be valid for other unicellular pappalysins derived from archaea, bacteria, cyanobacteria, algae and fungi, including archetypal ulilysin from Methanosarcina acetivorans. They may further apply, at least in part, to the multi-domain orthologues of higher organisms.




witch

Structural insights into conformational switching in latency-associated peptide between transforming growth factor β-1 bound and unbound states

Transforming growth factor β-1 (TGFβ-1) is a secreted signalling protein that directs many cellular processes and is an attractive target for the treatment of several diseases. The primary endogenous activity regulatory mechanism for TGFβ-1 is sequestration by its pro-peptide, latency-associated peptide (LAP), which sterically prohibits receptor binding by caging TGFβ-1. As such, recombinant LAP is promising as a protein-based therapeutic for modulating TGFβ-1 activity; however, the mechanism of binding is incompletely understood. Comparison of the crystal structure of unbound LAP (solved here to 3.5 Å resolution) with that of the bound complex shows that LAP is in a more open and extended conformation when unbound to TGFβ-1. Analysis suggests a mechanism of binding TGFβ-1 through a large-scale conformational change that includes contraction of the inter-monomer interface and caging by the `straight-jacket' domain that may occur in partnership through a loop-to-helix transition in the core jelly-roll fold. This conformational change does not appear to include a repositioning of the integrin-binding motif as previously proposed. X-ray scattering-based modelling supports this mechanism and reveals possible orientations and ensembles in solution. Although native LAP is heavily glycosylated, solution scattering experiments show that the overall folding and flexibility of unbound LAP are not influenced by glycan modification. The combination of crystallography, solution scattering and biochemical experiments reported here provide insight into the mechanism of LAP sequestration of TGFβ-1 that is of fundamental importance for therapeutic development.




witch

As robins disperse, West Nile mosquitoes switch diet to humans: Q&A with Smithsonian ornithologist Peter Marra

A rising spike in West Nile virus is taking health officials across the country by surprise as this year more than 2,600 people in 45 states and the District of Columbia, have been stricken with severe symptoms of this mosquito-transmitted disease.

The post As robins disperse, West Nile mosquitoes switch diet to humans: Q&A with Smithsonian ornithologist Peter Marra appeared first on Smithsonian Insider.




witch

The Power of Touch: Sex-changing snails switch sooner when together

Many animals change sex at some point in their lives, often after reaching a certain size. Snails called slipper limpets begin life as males, and […]

The post The Power of Touch: Sex-changing snails switch sooner when together appeared first on Smithsonian Insider.




witch

Potential biofuel pest, the switchgrass moth, under renewed scrutiny of entomologists

For the first time researchers from the Smithsonian, South Dakota State University and the University of Nebraska described the immature stages of the switchgrass moth, first collected in Denver in 1910.

The post Potential biofuel pest, the switchgrass moth, under renewed scrutiny of entomologists appeared first on Smithsonian Insider.




witch

In San Francisco, one wet winter can switch up Bay’s invasive species

For many Californians, last year’s wet winter triggered a case of whiplash. After five years of drought, rain from October 2016 to February 2017 broke […]

The post In San Francisco, one wet winter can switch up Bay’s invasive species appeared first on Smithsonian Insider.




witch

Rotational switches in the two-dimensional fullerene quasicrystal

One of the essential components of molecular electronic circuits are switching elements that are stable in two different states and can ideally be switched on and off many times. Here, distinct buckminsterfullerenes within a self-assembled monolayer, forming a two-dimensional dodecagonal quasicrystal on a Pt-terminated Pt3Ti(111) surface, are identified to form well separated molecular rotational switching elements. Employing scanning tunneling microscopy, the molecular-orbital appearance of the fullerenes in the quasicrystalline monolayer is resolved. Thus, fullerenes adsorbed on the 36 vertex configuration are identified to exhibit a distinctly increased mobility. In addition, this finding is verified by differential conductance measurements. The rotation of these mobile fullerenes can be triggered frequently by applied voltage pulses, while keeping the neighboring molecules immobile. An extensive analysis reveals that crystallographic and energetic constraints at the molecule/metal interface induce an inequality of the local potentials for the 36 and 32.4.3.4 vertex sites and this accounts for the switching ability of fullerenes on the 36 vertex sites. Consequently, a local area of the 8/3 approximant in the two-dimensional fullerene quasicrystal consists of single rotational switching fullerenes embedded in a matrix of inert molecules. Furthermore, it is deduced that optimization of the intermolecular interactions between neighboring fullerenes hinders the realization of translational periodicity in the fullerene monolayer on the Pt-terminated Pt3Ti(111) surface.




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My Nintendo Switch just broke




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What influences motorists’ intentions to switch to electric vehicles?

What drives people to behave in more environmentally friendly ways? A new study explores factors that affect Dutch motorists’ intentions to switch to electric vehicles. The authors found that they could reliably predict the intention to switch by applying a theoretical framework—Protection Motivation Theory—based on perceptions of the threat of environmental damage.




witch

SWITCH – new tool to help sustainable urban water management

Planning future sustainable water management in cities is a challenge. A recent study describes a new computer tool that enables quick comparisons of different water management options in cities, to help develop future strategies for effective integrated urban water management.




witch

Switching to LED street lighting could alter urban bat behaviour

The effect on bats of the replacement of mercury lamps with light-emitting diodes (LEDs) in street lighting has been investigated in a recent study. Artificial light affects bat species differently and the activity of species normally more sensitive to light were affected less by the new LED street lamps than by traditional mercury lamps. Use of LEDs may, therefore, help to reduce the impacts of outdoor lighting on light-sensitive bats, if used at an appropriate level.




witch

Petrobras Switches Gears on Production Cuts

Plans are also underway for initiatives that expand oil export capacity.




witch

Spellbanned: Etsy policy change invokes ire of witches

Metaphysical services are disappearing from the online marketplace faster than you can say 'I bind you, Etsy, from doing harm ...'



  • Arts & Culture

witch

Puerto Rico plots out total switch to green energy by 2050

Although a recent renewable energy bill stalled, the hurricane-ravaged territory isn't giving up on its fossil fuel-free aspirations.




witch

5 reasons you should switch to beeswax candles

Did you know you could be polluting the air in your house by burning candles? Learn more here.




witch

What happens when you switch to only organic foods?

A family ate organically for 2 weeks, reducing pesticides in their bodies big-time. Here's why it matters.




witch

Water witchery: Is it hocus-pocus or science?

Modern-day dowsers are helping drought-stricken California wineries and farms find water for their crops.




witch

What is switchgrass?

Ethanol from switchgrass, a perennial plant traditionally used for foraging and decoration, promises to be among the next big biofuel breakthroughs marketed as




witch

Bumblebees can switch to 'economy mode' when their nectar load gets extra heavy

Scientists have learned out how much energy bees use to fly when carrying heavy and light loads, and they learned about a new ability along the way.




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We have introduced Guard Lock Safety-door Switch D4SL-N.

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We have introduced Switch Mode Power Supply S8EX.

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witch

Guard Lock Safety-door Switch/D4SL-N-mounting Slide Key

World's smallest Class 6-contact Guard Lock Safety-door Switch(D4SL-N, D4SL-NSK10-LK[])




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Switch Mode Power Supply (15/30/60/120/240/480-W Models)

Reliable and Easy Operation-Worldwide Power Supply. Resistant in tough environments. Easy and fast installation. The most compact class on the market.(S8VK-G)




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We have introduced Switch Mode Power Supply S8EA.

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witch

We have introduced Switch Mode Power Supply S8VK-G.

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We have introduced Switch Mode Power Supply S8VK-C.

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witch

Switch Mode Power Supply (60/120/240/480-W Models)

Cost-effective Single Phase Power Supply Universal input and Safety standards for worldwide applications Space-saving Compact Design(S8VK-C)




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Lighted Pushbutton Switch (Square) Ultra Bright LED Type

Large Square-bodied Lighted Pushbutton Switches New models added with Ultra LEDs.(A3P (Super Luminosity Type))




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Lighted Pushbutton Switch (Square) Ultra Bright LED Type

Pushbutton Switch Series with Square 40-mm Body. New models added with Ultra LEDs.(A3S (Super Luminosity Type))




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We have introduced Lighted Pushbutton Switch (Square) Ultra Bright LED Type A3[].

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Guard Lock Safety Key Selector Switch

The guard lock prevents accidental mode changes.(A22LK)




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We have introduced Two-circuit Limit Switch WL-N.

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Two-circuit Limit Switch

Two-circuit limit switches that can be selected to match the operating environment and application(WL-N / WL)




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We have introduced Switch Mode Power Supply S8VK-T.

Product Information




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Switch Mode Power Supply (120/240/480/960 W Models)

Worldwide 3-phase Power Supply Resistant in tough environments Easy and fast installation The most compact class on the market(S8VK-T)




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Small Enclosed Switches

Small, Lightweight Enclosed Switches(VE)