Proptech refers to the use of technology and software to assist the real estate market with its needs.

Some of Pakistan cricket's legends have criticised the Indian team's refusal to travel across the border for ICC Champions Trophy next year.

On a bright Sunday afternoon, two men walked door to door through a Forsyth County, Georgia, neighborhood on a mission to get out the vote for Democrats.

The Delaware Judiciary, Delaware Department of Justice, Department of Correction and Delaware State Police are warning the public of a phone scam that is apparently targeting probationers. The Delaware State Police have received information about fraudulent callers threatening individuals on probation with re-arrest for allegedly committing new crimes. In at least one case, the caller […]

                Attorney General Kathy Jennings joined a group of 15 state attorneys general calling on Target to support inclusivity and to reject anti-LGBTQ+ hate, intimidation and discrimination.                The letter, sent to national retail chain Target during Pride Month, comes in response to Target’s recent decision to remove certain Pride-related merchandise from its stores and […]

Attorney General Kathy Jennings has joined a coalition of 25 states and territories in filing a letter with the U.S. Treasury Department’s Financial Crimes Enforcement Network (FinCEN) in support of proposed rules entitled “Anti-Money Laundering Regulations for Residential Real Estate Transactions.”     The April 16 letter expresses staunch support for the would-be regulations, which will […]

There's no question that we're all increasingly, and often exclusively, interacting with brands digitally. Consumers are now online through countless mechanisms – from laptops and mobile apps to AI-enabled voice assistants and sensor-based wearables. Engagement is diversifying in fascinating new ways. And when organizations can't see their customers interacting in [...]

SAS Customer Intelligence 360: Behavioral event tracking, targeting & engagement analysis was published on Customer Intelligence Blog.

Eco Equity is one of only a few Europe-based investors in medicinal cannabis from Africa and the Caribbean, an area in which the UK is missing an opportunity, according to CEO Jon-Paul Doran.

The Cadillac Vistiq will serve as the electric XT6 three-row SUV replacement Cadillac Vistiqs are expected to have about 300 miles of EPA-rated range The Vistiq will cost $78,790 when it arrives in 2025. Cadillac on Tuesday confirmed additional details of the Vistiq three-row electric SUV, which remains on track for a launch next year as a 2026...

As of Nov. 11, the Beats Studio Pro headphones are $100 off at Target from their $349.99 list price to $249.99.

Normally, a Target Circle 360 annual membership costs $99. As of Nov. 12, you can save 50% on it, dropping it to just $49 for your first year.

A new AI-powered, imaging-based technology that creates accurate three-dimensional models of tumors, veins and other soft tissue offers a promising new method to help surgeons operate on, and better treat, breast cancers. The technology, from Illinois-based startup SimBioSys, converts routine black-and-white MRI images into spatially accurate, volumetric images of a patient’s breasts. It then illuminates Read Article

A group of young foreign tourists went on a fantastic journey to Sanya, a popular coastal destination in south China’s Hainan Province. The exhilarated youngsters were fascinated by the picturesque scenery,

washington — The U.S. military said Monday that it had carried out strikes against nine targets associated with Iranian groups in Syria.  In a statement, the U.S. military said the strikes were made against two locations in Syria and were a response to several attacks on U.S. personnel in Syria in the past 24 hours.  The U.S. has occasionally carried out strikes against targets linked to Iran in both Iraq and Syria. In February, the U.S. launched airstrikes in Iraq and Syria against more than 85 targets linked to Iran's Islamic Revolutionary Guard Corps and militias it backs, in retaliation for a deadly attack on U.S. troops.  "These strikes will degrade the Iranian backed groups' ability to plan and launch future attacks on U.S. and coalition forces," the U.S. military said after the most recent strikes.  The U.S. has 900 troops in Syria and 2,500 in neighboring Iraq, on a mission to advise and assist local forces trying to prevent a resurgence of Islamic State, which in 2014 seized large swaths of both countries but was later defeated.  The U.S. has sent warships and fighter aircraft to the region since the Israel-Hamas conflict erupted on October 7, 2023, to try to deter Iran and Iran-backed groups from getting involved in the conflict.  U.S. forces have also helped shoot down projectiles that Iran launched toward Israel this year. 

The Managing Director of Abuja Electricity Distribution Company (AEDC), Ernest Mupwaya said his company has installed 88,000 meters and would install 120,000 units by December 2017 to tackle complaints on estimated billing. upwaya said this at the opening of a two day workshop on energy theft for judges within the Federal Capital Territory (FCT). He […]

Abuja DisCo meters 88,000 customers, targets 120,000 by December

the hague, netherlands — Dozens of people armed with sticks and firecrackers set a tram on fire in Amsterdam on Monday, police said, while the city is facing tensions following violence last week targeting fans of an Israeli soccer club. Police said the fire was quickly extinguished and riot officers cleared the square. Images online showed people damaging property and setting off firecrackers. Police said it was not clear who started the unrest or whether it was related to what happened last week. But they noted the tense atmosphere since five people were treated in the hospital and dozens detained Thursday following a Maccabi Tel Aviv-Ajax match. Youths on scooters and on foot went in search of Israeli fans, punching and kicking them and then fleeing to evade police, according to Amsterdam’s mayor. Dutch police announced five new arrests Monday in their investigation into that earlier violence. The suspects are men aged 18 to 37 and are from Amsterdam or surrounding cities. Four are still in custody; the fifth has been released but remains a suspect. Earlier, police said that four other men who had been arrested last week would remain in custody while the investigation continued. Two of those are minors, a 16-year-old and a 17-year-old from Amsterdam. The other two men are from Amsterdam and a nearby city. Police said they have identified over 170 witnesses and have taken forensics evidence from dozens. Prime Minister Dick Schoof said they were also examining videos posted to social media. Reports of antisemitic speech, vandalism and violence have been on the rise in Europe since the start of the war in Gaza, and tensions mounted in Amsterdam ahead of Thursday night’s match. Pro-Palestinian demonstrators were banned by local authorities from gathering outside the stadium. Before the match, Maccabi fans also tore a Palestinian flag off a building in Amsterdam and chanted anti-Arab slogans on their way to the stadium. There were also reports of Maccabi fans starting fights. The mayor has banned all demonstrations in the city and declared several parts of Amsterdam risk zones where police can stop and check anyone. Dozens were detained on Sunday for taking part in a pro-Palestinian demonstration in central Amsterdam that had been outlawed. Israeli Foreign Minister Gideon Saar rushed to the Netherlands on Friday and offered Israel’s help in the police investigation. He met on Saturday with the Dutch prime minister and said in a statement that the attacks and demands to show passports “were reminiscent of dark periods in history.”

Demonstrators held flags with Nazi swastikas and reportedly chanted a pro-Donald Trump slogan.

The IDF’s 162nd Division continued its operations in the Jabalya area, where soldiers engaged and neutralized several terrorists and dismantled key structures that were used for weapons storage.

The strikes were in response to attacks on US personnel over the past 24 hours, CENTCOM reported.

While India continues to rely heavily on coal, the south Asian economic giant is also aggressively pushing renewable energy production, especially after the costs of renewable energy production have fallen drastically in recent years around the world. But experts say that India—the world’s third largest emitter of greenhouse gases (GHGs)—has to face many headwinds for […]

So, the worst has happened. American voters have apparently just elected the most chaotic and kleptocratic individual in their country’s political history as their president. (We say ‘apparently’, because these days nothing can be certain about the integrity of the US political or electoral system – as is the case with far too many other […]

SpaceX is preparing for the sixth test flight of Starship, the world's most powerful rocket. Next week's launch – if successful – will be the fastest turnaround yet

Title: In Early Trial, Targeted Therapy Fights Advanced Melanoma
Category: Health News
Created: 8/25/2010 6:10:00 PM
Last Editorial Review: 8/26/2010 12:00:00 AM

Title: Warning Letters Target Illegal Online Sales of Opioid Meds: FDA
Category: Health News
Created: 8/28/2018 12:00:00 AM
Last Editorial Review: 8/29/2018 12:00:00 AM

Title: COVID Boosters Targeted to Latest Variants Could Be Ready After Labor Day
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM

As a major type of structural variants, tandem duplication plays a critical role in tumorigenesis by increasing oncogene dosage. Recent work has revealed that noncoding enhancers are also affected by duplications leading to the activation of oncogenes that are inside or outside of the duplicated regions. However, the prevalence of enhancer duplication and the identity of their target genes remains largely unknown in the cancer genome. Here, by analyzing whole-genome sequencing data in a non-gene-centric manner, we identify 881 duplication hotspots in 13 major cancer types, most of which do not contain protein-coding genes. We show that the hotspots are enriched with distal enhancer elements and are highly lineage-specific. We develop a HiChIP-based methodology that navigates enhancer–promoter contact maps to prioritize the target genes for the duplication hotspots harboring enhancer elements. The methodology identifies many novel enhancer duplication events activating oncogenes such as ESR1, FOXA1, GATA3, GATA6, TP63, and VEGFA, as well as potentially novel oncogenes such as GRHL2, IRF2BP2, and CREB3L1. In particular, we identify a duplication hotspot on Chromosome 10p15 harboring a cluster of enhancers, which skips over two genes, through a long-range chromatin interaction, to activate an oncogenic isoform of the NET1 gene to promote migration of gastric cancer cells. Focusing on tandem duplications, our study substantially extends the catalog of noncoding driver alterations in multiple cancer types, revealing attractive targets for functional characterization and therapeutic intervention.

The human major histocompatibility complex (MHC) is a ~4 Mb genomic segment on Chromosome 6 that plays a pivotal role in the immune response. Despite its importance in various traits and diseases, its complex nature makes it challenging to accurately characterize on a routine basis. We present a novel approach allowing targeted sequencing and de novo haplotypic assembly of the MHC region in heterozygous samples, using long-read sequencing technologies. Our approach is validated using two reference samples, two family trios, and an African-American sample. We achieved excellent coverage (96.6%–99.9% with at least 30x depth) and high accuracy (99.89%–99.99%) for the different haplotypes. This methodology offers a reliable and cost-effective method for sequencing and fully characterizing the MHC without the need for whole-genome sequencing, facilitating broader studies on this important genomic segment and having significant implications in immunology, genetics, and medicine.

Optimal patient management protocols for metastatic castration-resistant prostate cancer (mCRPC) are poorly defined and even further complexified with new therapy approvals, such as radiopharmaceuticals. The prostate-specific membrane antigen (PSMA)–targeted agent ¹⁷⁷Lu vipivotide tetraxetan ([¹⁷⁷Lu]Lu-PSMA-617), approved after the phase III VISION study, presents physicians with additional aspects of patient management, including specific adverse event (AE) monitoring and management, as well as radiation safety. Drawing on our experience as VISION study investigators, here we provide guidance on best practices for delivering PSMA-targeted radiopharmaceutical therapy (RPT) to patients with mCRPC. After a comprehensive review of published evidence and guidelines on RPT management in prostate cancer, we identified educational gaps in managing the radiation safety and AEs associated with [¹⁷⁷Lu]Lu-PSMA-617. Our results showed that providing sufficient education on AEs (e.g., fatigue and dry mouth) and radiation safety principles is key to effective delivery and management of patient expectations. Patient counseling by health care professionals, across disciplines, is a cornerstone of optimal patient management during PSMA-targeted RPT. Multidisciplinary collaboration is crucial, and physicians must adhere to radiation safety protocols and counsel patients on radiation safety considerations. Treatment with [¹⁷⁷Lu]Lu-PSMA-617 is generally well tolerated; however, additional interventions may be required, such as dosing modification, medications, or transfusions. Urinary incontinence can be challenging in the context of radiation safety. Multidisciplinary collaboration between medical oncologists and nuclear medicine teams ensures that patients are monitored and managed safely and efficiently. In clinical practice, the benefit-to-risk ratio should always be evaluated on a case-by-case basis.

Over 4 decades of research support the link between Alzheimer disease (AD) and somatostatin [somatotropin-releasing inhibitory factor (SRIF)]. SRIF and SRIF-expressing neurons play an essential role in brain function, modulating hippocampal activity and memory formation. Loss of SRIF and SRIF-expressing neurons in the brain rests at the center of a series of interdependent pathological events driven by amyloid-β peptide (Aβ), culminating in cognitive decline and dementia. The connection between the SRIF and AD further extends to the neuropsychiatric symptoms, seizure activity, and inflammation, whereas preclinical AD investigations show SRIF or SRIF receptor agonist administration capable of enhancing cognition. SRIF receptor subtype-4 activation in particular presents unique attributes, with the potential to mitigate learning and memory decline, reduce comorbid symptoms, and enhance enzymatic degradation of Aβ in the brain. Here, we review the links between SRIF and AD along with the therapeutic implications.

Both preclinical and clinical studies implicate functional impairments of several neuroactive metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential amino acid tryptophan in mammals, in the pathophysiology of neurologic and psychiatric diseases. A number of KP enzymes, such as tryptophan 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenases (IDO1 and IDO2), kynurenine aminotransferases (KATs), kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilic acid oxygenase (3-HAO), and quinolinic acid phosphoribosyltransferase (QPRT), control brain KP metabolism in health and disease and are therefore increasingly considered to be promising targets for the treatment of disorders of the nervous system. Understanding the distribution, cellular expression, and regulation of KP enzymes and KP metabolites in the brain is therefore critical for the conceptualization and implementation of successful therapeutic strategies.

SpaceX is preparing for the sixth test flight of Starship, the world's most powerful rocket. Next week's launch – if successful – will be the fastest turnaround yet

Shameless scammers trick veterans into giving personal info or cash. Tech expert Kurt “CyberGuy" Knutsson explores five common scams.

In an interview with IT World Canada, consulting giant Deloitte highlighted the importance of an ecosystem-based approach to tackle issues around digital equity in Canada and service delivery challenges in the public sector. “Our strong view is that the people of Canada benefit when there’s effective collaboration between public and private organizations, including on critical […]

A beam of radioactive carbon ions has been used to destroy cancer cells in mice, demonstrating a therapy that may cause less collateral damage than current techniques

RSI said single-player Star Citizen campaign was "feature complete" a year ago.

AFTER suffering an NBA Finals defeat to ruin the best regular season in history, Golden State’s owner promised to be “very aggressive”.

Growth Unlocked: Closing the Strategy-to-Execution Gap

As Latino voters are a key voting bloc in the 2024 presidential election in battleground states like Nevada, Arizona and Pennsylvania, they have been targeted by a rise in Spanish-language misinformation. Most of the false messaging disparages Kamala Harris and supports Donald Trump, says Pulitzer Prize-winning journalist Maria Hinojosa, host of Latino USA, which investigated the phenomenon in a new episode called “The Misinformation Web.” She interviewed some of the content creators in this “blob” of online vitriol and says there is almost no effective content moderation online, nor many reliable fact-checking sources in Spanish to counter the lies.

In a major boost to the Micro, Small, and Medium Enterprises (MSME) sector, the government has outlined ambitious credit growth targets, mandating scheduled commercial banks and Non-Banking Financial Companies (NBFCs) to extend additional credit of R...

SpaceX is preparing for the sixth test flight of Starship, the world's most powerful rocket. Next week's launch – if successful – will be the fastest turnaround yet

The PM insists the government will not "tell people how to live their lives" in achieving the aim.

GB Paralympic swimming hopefuls have their last chance to qualify for London 2012 at this weekend's trials in Sheffield.

Showjumper Tim Stockdale is setting his sights on competing at the Rio Olympic Games of 2016 at the age of 52.

UK Athletics head coach Charles van Commenee insists his squad can hit his target of eight medals at the London Olympics.

Highlights: Several viral diseases are transmitted via mosquitoes that act as transmitters or vectors which transfe