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Publisher Correction: High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble




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COVID-19 assistance needs to target energy insecurity




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Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection




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CRISPR off-target detection with DISCOVER-seq




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Cellular thermal shift assay for the identification of drug–target interactions in the <i>Plasmodium falciparum</i> proteome




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RNAi against therapeutic targets with short interfering ribonucleic neutrals (siRNNs)

siRNNs could enable RNAi knockdown of therapeutic targets in a broader range of cells and tissue types than siRNA.




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In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40




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Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus




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Activation and targeting of ATG8 protein lipidation




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Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke




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Targeting inflammation in AKI by P2Y14 receptor inhibition in mice




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A novel vaccine target for malaria




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Barrichello targets turnaround

Rubens Barrichello hopes that his fourth place in the European Grand Prix will provide a springboard for the team to improve further for the remainder of the season




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Boullier targets title tilt in three years

Renault team principal Eric Boullier is targeting race victories in the next three years and fourth place in the championship next season




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Targeting an Achievement Gap in One of the Country's Most Educated Metropolitan Areas

Over the past two decades, the Puget Sound area’s innovation-driven economy has become a magnet for highly educated people from across the country and around the world. Drawn to the region by some of the nation’s most innovative companies—Microsoft, Boeing, Nintendo, Amazon, Genentech and the Fred Hutchinson Cancer Research Center, to name a few—the Puget Sound region ranks well on measures of educational attainment. Of the nation’s largest 100 metro areas, the Seattle-Tacoma-Bellevue area is 11th in bachelor’s degree holders and 17th in graduate degree attainment.

But for all its brainpower, the region has fallen behind in terms of cultivating homegrown talent, particularly in less affluent school districts located in South Seattle and South King County. Starting from an early age, low-income students and children of color in these communities tend to lag behind on important indicators of educational success. The effects of this achievement gap worsen with time, putting these students at a serious disadvantage that often affects their ability to find jobs and their earning potential. 

In an effort to address this achievement gap, the Community Center for Education Results has teamed up with the city of Seattle, the University of Washington, the Seattle Community Colleges District, the Puget Sound Educational Service District, the Bill & Melinda Gates Foundation and others to form the Road Map Project, a coalition working to double the number of South Seattle and South King County students pursuing a college diploma or career credential by 2020.

What’s innovative about the Road Map Project is its focus on collective action and community engagement. By bringing together key stakeholders to collaborate on shared goals, the project is creating a new model for efforts to reduce inequality in educational attainment. Its cradle-to-college-and-career approach aims to improve student outcomes beginning with access to prenatal care and kindergarten readiness all the way through to elementary and secondary schooling and beyond. Through a combination of community outreach and partnership building, data-driven goal-setting and performance management, the project supports area organizations working to boost student success and close the achievement gap in South Seattle and South King County.

In December, the Project released its baseline report, which provides a detailed snapshot of student achievement in the Road Map region during the 2009-2010 school year. With this initial data in hand, the project will be able to work with area organizations to encourage and track progress on a wide variety of indicators, ranging from birth weight and full-day kindergarten enrollment to proficiency in reading, math, and science, parent engagement to graduation rates and postsecondary enrollment. “Demographics should not determine the destiny of children in this region,” says Mary Jean Ryan, executive director of the Community Center for Education Results. “The children who grow up here deserve as good of an education as the people who show up here.”

Authors

Publication: The Atlantic Cities
     
 
 




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Why the Bank of Canada sticks with 2 percent inflation target

When inflation targeting came to Canada, it was the government not the Bank of Canada that proposed it. Why? Three possible explanations come to mind. First, perhaps the government thought it was a fundamentally good idea. Second, the government was in the process of introducing a new goods and services tax, which would boost headline…

       




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Preventing targeted violence against communities of faith

The right to practice religion free of fear is one of our nation’s most indelible rights. But over the last few years, the United States has experienced a significant increase in mass casualty attacks targeting houses of worship and their congregants. Following a string of attacks on synagogues, temples, churches, and mosques in 2019, the…

       




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Can social media ‘targetcasting’ and democracy coexist?

Speaking recently at Georgetown University, Mark Zuckerberg told an audience “I’ve focused on building services to do two things: give people voice, and bring people together.” He later said “More people being able to share their perspectives has always been necessary to build a more inclusive society.” The speech anointed Facebook as the “Fifth Estate”…

       




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All Medicaid expansions are not created equal: The geography and targeting of the Affordable Care Act

Summary Craig Garthwaite, John Graves, Tal Gross, Zeynal Karaca, Victoria Marone, and Matthew J. Notowidigdo study the effect of the Affordable Care Act Medicaid expansion on hospital services, with a focus on the geographic variations of its impact, finding that it increased Medicaid visits, decreased uninsured visits, and lead the uninsured to consume more hospital…

       




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The optimal inflation target and the natural rate of interest

Summary Philippe Andrade, Jordi Galí, Hervé Le Bihan, and Julien Matheron study how changes in the steady-state natural interest rate affect the optimal inflation target, finding that starting from pre-crisis values, a 1 percentage point decline in the natural rate should be accommodated by an increase in the optimal inflation target of about 0.9 to…

       




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Preventing targeted violence against communities of faith

The right to practice religion free of fear is one of our nation’s most indelible rights. But over the last few years, the United States has experienced a significant increase in mass casualty attacks targeting houses of worship and their congregants. Following a string of attacks on synagogues, temples, churches, and mosques in 2019, the…

       




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Targeted Improvements in Crisis Resolution, Not a New Bretton Woods

The current crisis reveals two major flaws in the world’s crisis-resolution mechanisms: (i) funds available to launch credible rescue operations are insufficient, and (ii) national crisis responses have negative spillovers. One solution is to emulate the EU’s enhanced cooperation solution at the global level, with the IMF ensuring that the rules are respected. Big global…

       




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Target Compliance: The Final Frontier of Policy Implementation

Abstract Surprisingly little theoretical attention has been devoted to the final step of the public policy implementation chain: understanding why the targets of public policies do or do not “comply” — that is, behave in ways that are consistent with the objectives of the policy. This paper focuses on why program “targets” frequently fail to…

       




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Target Malware Kingpins

Traditionally, defense in cyberspace has been based on the “Risk equation,” a loosely calculated product of Vulnerability, Asset value and Threat. Vulnerability means the degree to which computing infrastructure is exposed to intruders. Asset value represents the importance of information to an organization and its constituents. Threat is a subjective assessment of the danger posed…

       




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Targeted Killing in U.S. Counterterrorism Strategy and Law

The following is part of the Series on Counterterrorism and American Statutory Law, a joint project of the Brookings Institution, the Georgetown University Law Center, and the Hoover Institution Introduction It is a slight exaggeration to say that Barack Obama is the first president in American history to have run in part on a political…

       




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Target to "Systematically Reduce" PVC Use

Photo credit: What Rhymes with Nicole Target may finally be feeling the heat from consumer, health, and environmental groups such as the Center for Health, Environment and Justice (CHEJ), which has been vociferous in its campaign to get the nation's




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Sears & Kmart Join Wal-Mart, Target In PVC Reduction Programs

Short design-life products made of PVC have been a common, inexpensive, and functional choice for almost 50 years. But, vinyl can also be a risky choice of material for objects often handled by consumers, posing a risk of lead exposure, especially if




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News Corporation Announces New Sustainability Targets for 2015 and Beyond

News Corporation, parent company of Fox, the Wall Street Journal, and most recently of The Daily for the iPad, was the first global media company to commit to and then achieve the goal of becoming carbon neutral.




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Masters of Beef Advocacy Grads Take On Sustainable Food Supporters, Attacking The Wrong Target

If you don't subscribe to the print version of Mother Jones you may have missed what seems to be a really sort of creepy story about how the US beef industry is not so subtly waging war against sustainable and slow




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Forget 2030 or targets; we need to reduce our carbon emissions right now

George Monbiot says you don't set targets in an emergency, you act.




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India may smash its 175 GW renewables target several years early

It's not revising up its official targets, but the government is hinting that it may now achieve 225 GW by 2022.




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Sweden to reach its 2030 renewables target 12 years early!

For those who say it's too difficult...




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US energy maps show energy infrastructure sitting in extreme weather's line of target

If a hurricane is headed your way, you surely have a lot on your mind. Knowing the energy infrastructure risks in your area may be one more thing to throw in there.




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New Low-Cost Desalination System Targets Fracking Wastewater

A new desalination technology company is looking to help clean up and recover some of the trillion gallons of salty wastewater from the oil and gas industry.





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San Francisco targets May 18 for some businesses to resume as California unveils reopening guidelines

Covid-19 has infected 3.7 million people globally, and killed at least 264,111 as of Thursday.




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Target in talks to boost its same-day delivery ambitions by buying pieces of startup Deliv

The aspect of the technology that interests Target is its ability to pool multiple orders and route them to a similar place, NBC News reports.




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China needs a growth target to guide its stimulus measures: Citi

China should still set a growth target this year for the authorities to design a "sensible" stimulus package, says Liu Li-gang, Citigroup's chief economist for China, who adds that the country's unemployment rate risks exceeding 10% without aggressive fiscal stimulus.




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So much money, so little oversight: Coronavirus bailout cash is a big target for fraud

With so much money being issued so quickly, the potential for scams and misuse runs rampant.




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These five stocks are well below their average price targets, but two could catch up

Matt Maley, chief market strategist at Miller Tabak, and Quint Tatro, chief investment officer at Joule Financial, talk top Thanksgiving trades with CNBC's Mike Santoli.




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DuPont doubles cost-savings target, slashes capital expenses

Industrial materials maker DuPont on Tuesday slashed its capital expenditure by about $500 million and raised its annual cost-savings target to counter global trade uncertainties brought on by the coronavirus outbreak.




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Greece's strict fiscal targets will likely be relaxed in 2021 as well, minister says

Greece might be spared from having to hit strict fiscal targets related to previous bailouts next year, a government official told CNBC, given the ongoing health and economic crises.




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San Francisco targets May 18 for some businesses to resume

CNBC's Dominic Chu reports that San Francisco is targeting May 18 to reopen some businesses.




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May Day People's Strike! Target, Amazon, Instacart Workers Demand Safe Conditions & Pandemic Relief

This May Day, an unprecedented coalition of essential workers from Amazon, Instacart, Whole Foods, Walmart, Target and FedEx are calling out sick or walking out during their lunch break to demand better health and safety conditions, along with hazard pay. Others are joining them for May Day actions that include rent strikes, car caravan protests and online organizing calling for a "People's Bailout" and economic recovery plan that prioritizes workers. We speak with Kali Akuno, co-founder and co-director of Cooperation Jackson, which issued a call for a people's strike starting May 1. "The corporations and the government are willing to sacrifice tens of thousands of us," Akuno says. "We have to put people before profits."





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UK sets new target to recruit 18,000 contact tracers by mid-May

The UK government has set a new target of recruiting an army of 18,000 coronavirus contact tracers by the middle of May, to be in place for the launch of the NHS contact tracing app




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Red light could be used to precisely target rheumatoid arthritis drugs

People with rheumatoid arthritis often take medicines that can have damaging side-effects, but a system that uses red light to deliver drugs exactly where they are needed could help




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Coronavirus: Are these seven targets being hit?

Ministers have set targets for testing, medical equipment and hospital beds. Have they delivered?