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Targeted Cancer Therapies

A fact sheet that describes targeted cancer therapies, which are drugs that interfere with specific molecules involved in cancer cell growth and survival.




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Influence of nanomedicine mechanical properties on tumor targeting delivery

Chem. Soc. Rev., 2020, 49,2273-2290
DOI: 10.1039/C9CS00575G, Tutorial Review
Zheng Li, Chen Xiao, Tuying Yong, Zifu Li, Lu Gan, Xiangliang Yang
This tutorial review summarizes the influence of nanomedicine mechanical properties on drug delivery efficiency, antitumor efficacy and safety.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Bhaker gets electronic target installed at home

Bhaker gets electronic target installed at home




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Silica-coated magnetic nanoparticles: an insight into targeted drug delivery and toxicology / Mariela A. Agotegaray, Verónica L. Lassalle

Online Resource




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Sigma receptors: their role in disease and as therapeutic targets / Sylvia B. Smith, Tsung-Ping Su, editors

Online Resource




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Gold(I,III) complexes designed for selective targeting and inhibition of zinc finger proteins Raphael Enoque Ferraz de Paiva

Online Resource




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Surface Modification of Nanoparticles for Targeted Drug Delivery Yashwant V. Pathak, editor

Online Resource




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Current applications for overcoming resistance to targeted therapies / editors, Myron R. Szewczuk, Bessi Qorri and Manpreet Sambi

Online Resource




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Targeted intracellular drug delivery by receptor mediated endocytosis / Padma V. Devarajan, Prajakta Dandekar, Anisha A. D'Souza, editors

Online Resource




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Target scattering mechanism in polarimetric synthetic aperture radar: interpretation and application / Si-Wei Chen, Xue-Song Wang, Shun-Ping Xiao, Motoyuki Sato

Online Resource




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Nitin Desai: On inflation targeting

It is just one element of the new architecture of macroeconomic policy. Much more is required to shore up the economy




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Temporal trends of suspect- and target-per/polyfluoroalkyl substances (PFAS), extractable organic fluorine (EOF) and total fluorine (TF) in pooled serum from first-time mothers in Uppsala, Sweden, 1996–2017

Environ. Sci.: Processes Impacts, 2020, 22,1071-1083
DOI: 10.1039/C9EM00502A, Paper
Open Access
Luc T. Miaz, Merle M. Plassmann, Irina Gyllenhammar, Anders Bignert, Oskar Sandblom, Sanna Lignell, Anders Glynn, Jonathan P. Benskin
Temporal trends (1996–2017) of suspect- and target-per/polyfluoroalkyl substances (PFAS), extractable organic fluorine (EOF) and total fluorine (TF) were determined in first-time mothers from Uppsala, Sweden.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Reactive Polymer Targeting dsRNA as Universal Virus Detection Platform with Enhanced Sensitivity

Biomacromolecules
DOI: 10.1021/acs.biomac.0c00379




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[ASAP] Bottlebrush Glycopolymers from 2-Oxazolines and Acrylamides for Targeting Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin and Mannose-Binding Lectin

Biomacromolecules
DOI: 10.1021/acs.biomac.0c00246




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[ASAP] A6 Peptide-Tagged Core-Disulfide-Cross-Linked Micelles for Targeted Delivery of Proteasome Inhibitor Carfilzomib to Multiple Myeloma In Vivo

Biomacromolecules
DOI: 10.1021/acs.biomac.9b01790




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[ASAP] Two-Stage Strategy for Development of Proteolysis Targeting Chimeras and its Application for Estrogen Receptor Degraders

ACS Chemical Biology
DOI: 10.1021/acschembio.0c00140




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[ASAP] Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

ACS Chemical Biology
DOI: 10.1021/acschembio.0c00285




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[ASAP] Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation

ACS Chemical Biology
DOI: 10.1021/acschembio.0c00104




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[ASAP] <sup>225</sup>Ac-H<sub>4</sub>py4pa for Targeted Alpha Therapy

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00171




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[ASAP] Anionic Polymers Promote Mitochondrial Targeting of Delocalized Lipophilic Cations

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00079




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[ASAP] Supramolecular ß-Sheet Forming Peptide Conjugated with Near-Infrared Chromophore for Selective Targeting, Imaging, and Dysfunction of Mitochondria

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00153




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[ASAP] Noncovalent Indocyanine Green Conjugate of C-Phycocyanin: Preparation and Tumor-Associated Macrophages-Targeted Photothermal Therapeutics

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00139




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[ASAP] An Integrin Alpha 6-Targeted Radiotracer with Improved Receptor Binding Affinity and Tumor Uptake

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00170




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[ASAP] The Protein Corona Does Not Influence Receptor-Mediated Targeting of Virus-like Particles

Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.0c00240




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[ASAP] Membrane Fluidity as a New Means to Selectively Target Cancer Cells with Fusogenic Lipid Carriers

Langmuir
DOI: 10.1021/acs.langmuir.0c00262




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Natural allosteric modulators and their biological targets: molecular signatures and mechanisms

Nat. Prod. Rep., 2020, 37,488-514
DOI: 10.1039/C9NP00064J, Review Article
Marjorie Bruder, Gina Polo, Daniela B. B. Trivella
Natural allosteric modulators reported over the last decade are reviewed on a chemical and mechanistic basis, emphasising the importance of natural products as probes for future allosteric drugs.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advanced targeted nanomedicine: a communication engineering solution / Uche Chude-Okonkwo, Reza Malekian, B.T. Maharaj

Online Resource




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Targeting biofilms in translational research, device development, and industrial sectors / Dustin L. Williams, editor

Online Resource




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Mitochondrial DNA targeting and impairment by a dinuclear Ir–Pt complex that overcomes cisplatin resistance

Inorg. Chem. Front., 2020, 7,1864-1871
DOI: 10.1039/D0QI00224K, Research Article
Cheng Zhang, Ruilin Guan, Xinxing Liao, Cheng Ouyang, Jiangping Liu, Liangnian Ji, Hui Chao
A dinuclear complex [(ppy)Ir(tpy)PtCl]2+ (Ir–Pt) can exhibit strong antitumor activity towards cisplatin-resistant cancer cells and induce cell necrosis via mtDNA damage and mitochondrial dysfunction.
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Chemometrics in the Homogeneously Catalyzed Reductive Amination: Combining <italic toggle="yes">In Situ</italic> Fourier-Transform Infrared Spectroscopy and Band-Target Entropy Minimization

Industrial & Engineering Chemistry Research
DOI: 10.1021/acs.iecr.0c01527




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Proceedings of the 28th World Conference of the International Nuclear Target Development Society (INTDS2016): conference date, 13-18 November 2016: location, Stellenbosch, South Africa / editors, Ntombizonke Kheswa and John Greene

Online Resource




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Target Station Optimization for the High-Brilliance Neutron Source HBS: Simulation Studies Based on the Monte Carlo Method / Jan Philipp Dabruck

Online Resource




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Effectiveness of the current temporary skilled visa system in targeting genuine skills shortages / The Senate, Legal and Constitutional Affairs References Committee

Australia. Parliament. Senate. Legal and Constitutional Affairs References Committee




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Credit and hardship : report of the Senate inquiry into credit and financial products targeted at Australians at risk of financial hardship / Economics References Committee

Australia. Parliament. Senate. Economics References Committee, author, issuing body




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Capacitive Sensing of Triglyceride Film Reactions: A Proof-of-Concept Demonstration for Sensing in Simulated Duodenal Contents with Gastrointestinal Targeting Capsule System

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00133C, Paper
George Banis, Luke Beardslee, Justin Stine, Rajendra Mayavan Sathyam, Reza Ghodssi
Ingestible capsule systems continue evolving to overcome drawbacks associated with traditional gastrointestinal (GI) diagnostic and therapeutic processes, such as location restrictions or insufficient sensitivity measures when obtaining information on local...
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Scope of 3D Shape-Based Approaches in Predicting the Macromolecular Targets of Structurally Complex Small Molecules Including Natural Products and Macrocyclic Ligands

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00161




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Heterobimetallic Ru(II)/Fe(II) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets

Metallomics, 2020, 12,547-561
DOI: 10.1039/C9MT00272C, Paper
Adriana Pereira Mundim Guedes, Francyelli Mello-Andrade, Wanessa Carvalho Pires, Maria Alice Montes de Sousa, Paula Francinete Faustino da Silva, Mariana S. de Camargo, Hendryk Gemeiner, Menegário A. Amauri, Clever Gomes Cardoso, Paulo Roberto de Melo Reis, Elisângela de Paula Silveira-Lacerda, Alzir A. Batista
Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(II) complexes attractive for the development of new chemotherapeutic agents for cancer treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selenium deficiency exacerbates LPS-induced necroptosis by regulating miR-16-5p targeting PI3K in chicken tracheal tissue

Metallomics, 2020, 12,562-571
DOI: 10.1039/C9MT00302A, Paper
Lanqiao Wang, Xu Shi, Shufang Zheng, Shiwen Xu
Se deficiency can induce necroptosis in tracheal tissue. LPS-induced necroptosis can be exacerbated by Se deficiency. The miR-16-5p-PI3K/AKT pathway participates in the occurrence of necroptosis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A liver-targeting Cu(I) chelator relocates Cu in hepatocytes and promotes Cu excretion in a murine model of Wilson’s disease

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00069H, Paper
Marie Monestier, AnaÏS M. Pujol, Aline Lamboux, Martine Cuillel, Isabelle Pignot-Paintrand, Doris Cassio, Peggy Charbonnier, Khémary Um, Amélie Harel, Sylvain BOHIC, Christelle GATEAU, Vincent Balter, Virginie Brun, Pascale Delangle, Elisabeth Mintz
Copper chelation is the most commonly used therapeutic strategy nowadays to treat Wilson’s disease, a genetic disorder primarily inducing a pathological accumulation of Cu in the liver. The mechanism of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Magnetic Bead-Immobilized Mammalian Cells Are Effective Targets to Enrich Ligand-Displaying Yeast

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00036




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New targets for the world’s biggest atom smasher and wood designed to cool buildings

The Large Hadron Collider (LHC) was built with one big goal in mind: to find the Higgs boson. It did just that in 2012. But the question on many physicists’ minds about the LHC is, “What have you done for me lately?” Host Sarah Crespi talks with Staff Writer Adrian Cho about proposals to look at the showers of particles created by its proton collisions in new ways—from changing which events are recorded, to changing how the data are analyzed, even building more detectors outside of the LHC proper—all in the hopes that strange, longer-lived particles are being generated but missed by the current set up. Also this week, Sarah talks with Tian Li of the University of Maryland in College Park about a modified wood designed to passively cool buildings. Starting from its humble roots in the forest, the wood is given a makeover: First it is bleached white to eliminate pigments that absorb light. Next, it is hot pressed, which adds strength and durability. Most importantly, these processes allow the wood to emit in the middle-infrared range, so that when facing the sky, heat passes through the wood out to the giant heat sink of outer space. This week’s episode was edited by Podigy. Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast




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Evaluation of segmented non-target data acquisition (SWATH/vDIA) in a QToF and QOrbitrap for pesticide residue analysis

Anal. Methods, 2020, 12,2027-2038
DOI: 10.1039/D0AY00290A, Paper
Łukasz Rajski, Iciar Beraza, María José Gómez Ramos, Carmen Ferrer, Amadeo R. Fernández-Alba
Two high-resolution instruments (a QToF and a QOrbitrap) were used to evaluate a segmented non-target MS2 (SWATH/vDIA) acquisition for pesticide residue analysis.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia

Anal. Methods, 2020, Advance Article
DOI: 10.1039/D0AY00305K, Paper
Xiao-fan Wang, You-xi Zhang, Hai-ying Ma
Targeted profiling of amino acid metabolome in serum by LC-MS: application to identify potential markers for diet-induced hyperlipidemia.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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One-step synthesis of mitochondrion-targeted fluorescence carbon dots and fluorescent detection of silver ions

Anal. Methods, 2020, Accepted Manuscript
DOI: 10.1039/D0AY00622J, Paper
Yue Hou, Hanxiao Liu, Zhanxian Li, Hongyan Zhang, Liuhe Wei, Mingming Yu
Silver ions (Ag+) are the most representative harmful ions found in water pollution and widely used in many industries, excessive ingestion of Ag+ in the human body may interact with...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Covid alters India's borrowing plan, target now raised to Rs 12L cr

Govt will borrow Rs 6L cr from the market via gilts through the remaining part of the first half of the year.




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[ASAP] Sulfenic Acid-Mediated on-Site-Specific Immobilization of Mitochondrial-Targeted NIR Fluorescent Probe for Prolonged Tumor Imaging

Analytical Chemistry
DOI: 10.1021/acs.analchem.9b05855




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[ASAP] Capping Ligand Size-Dependent LSPR Property Based on DNA Nanostructure-Mediated Morphological Evolution of Gold Nanorods for Ultrasensitive Visualization of Target DNA

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00321




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[ASAP] Fold-Change Compression: An Unexplored But Correctable Quantitative Bias Caused by Nonlinear Electrospray Ionization Responses in Untargeted Metabolomics

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00246




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[ASAP] In Situ Study of the Drug–Target Protein Interaction in Single Living Cells by Combining Fluorescence Correlation Spectroscopy with Affinity Probes

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00263




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Leadership decapitation: strategic targeting of terrorist organizations / Jenna Jordan

Dewey Library - HV6431.J674 2019