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Ag@S-nitrosothiols core-shell nanoparticles for chemo and photothermal synergistic tumor target therapy

By pubs.rsc.org
Published On ::

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00734J, Paper
Xinlin Yang, Tuanwei Liu, Xiao Li, Jinan Wang, Ping Zhang, Xiaoying Huang, Zhide Zhang, Dian-Shun Guo
Along with development of the controlled delivery systems for target therapy, ‘single-strategy’ therapy often fails to achieve the desired performance in real body internal environment. In such case, it is...
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Molecular targets and therapeutic uses of spices : modern uses for ancient medicine / Bharat B. Aggarwal, Ajaikumar B. Kunnumakkara [editors]

By prospero.murdoch.edu.au
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Chinese News Aggregation App Targets $3 Billion U.S. IPO

By www.rss-specifications.com
Published On :: Wed, 18 Apr 2018 09:51:07 -0400

Qu Toutiao, which means Fun Headlines in Chinese, is reportedly making its own fun headlines these days, telling sources that it is eyeing an initial public offering that could value it as high as $3 billion.

If successful, it would be an extraordinary valuation for a company, a news and video aggregation mobile app popular in mostly rural areas of China, that was launched less than 2 years ago. The company is considering an IPO in New York as soon as early this year, people familiar with the matter told Bloomberg News.

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Product Development for Distant Target Groups: An Experimental Study for the Silver Market / Malte Marvede ; with a foreword by Cornelius Herstatt

By library.mit.edu
Published On :: Sun, 25 Jun 2017 06:20:26 EDT

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[ASAP] Parallel Reaction Monitoring-Mass Spectrometry (PRM-MS)-Based Targeted Proteomic Surrogates for Intrinsic Subtypes in Breast Cancer: Comparative Analysis with Immunohistochemical Phenotypes

By feedproxy.google.com
Published On :: Fri, 22 Nov 2019 05:00:00 GMT

Journal of Proteome Research
DOI: 10.1021/acs.jproteome.9b00490


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[ASAP] Quality Control and Outlier Detection of Targeted Mass Spectrometry Data from Multiplex Protein Panels

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Published On :: Sat, 25 Apr 2020 04:00:00 GMT

Journal of Proteome Research
DOI: 10.1021/acs.jproteome.9b00854


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A high-throughput targeted metabolomics method for the quantification of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolism: application in the study of a CCl4-induced liver injury mouse model

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00385A, Paper
Mengqi Jia, Zhangxiao Peng, Kaige Yang, Changqing Su, Yan Wang, Chao Yan
Experimental workflow of 104 non-polar metabolites in cholesterol, eicosanoid, and phospholipid metabolisms analysis using UPLC-QqQ-MS.
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Target triggered ultrasensitive electrochemical polychlorinated biphenyl aptasensor based on DNA microcapsules and nonlinear hybridization chain reaction

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00065E, Paper
Ting Han, Shaozhen Wang, Feifan Sheng, Sicheng Wang, Tianyue Dai, Xiaojun Zhang, Guangfeng Wang
In this work, we demonstrated an ultrasensitive detection platform for polychlorinated biphenyls (PCBs) based on DNA microcapsules and a nonlinear hybridization chain reaction (NHCR).
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Enzyme-activated anchoring of peptide probes onto plasma membranes for selectively lighting up target cells

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Analyst, 2020, Advance Article
DOI: 10.1039/D0AN00487A, Paper
Julan Xia, Sujuan Sun, Xianhua Wu, Yan Huang, Chunyang Lei, Zhou Nie
Enzyme-activated membrane insertion peptide probes were developed for selectively lighting up target cells.
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[ASAP] Genome-Wide CRISPRi-Based Identification of Targets for Decoupling Growth from Production

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Published On :: Tue, 21 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00143


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[ASAP] A Chemical Switch System to Modulate Chimeric Antigen Receptor T Cell Activity through Proteolysis-Targeting Chimaera Technology

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

ACS Synthetic Biology
DOI: 10.1021/acssynbio.9b00476


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[ASAP] Imidazo[1,2-<italic toggle="yes">a</italic>]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells

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Published On :: Mon, 20 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01910


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[ASAP] Pyridine-Embedded Phenothiazinium Dyes as Lysosome-Targeted Photosensitizers for Highly Efficient Photodynamic Antitumor Therapy

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Published On :: Tue, 21 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00280


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[ASAP] Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02035


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[ASAP] Triazolo-Peptidomimetics: Novel Radiolabeled Minigastrin Analogs for Improved Tumor Targeting

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b01936


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[ASAP] Dual-Target Inhibitors Based on HDACs: Novel Antitumor Agents for Cancer Therapy

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00491


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[ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

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Published On :: Mon, 04 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00339


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[ASAP] Targeting ALK2: An Open Science Approach to Developing Therapeutics for the Treatment of Diffuse Intrinsic Pontine Glioma

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Published On :: Tue, 05 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c00395


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[ASAP] p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators

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Published On :: Tue, 05 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.9b02038


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[ASAP] Therapeutic Potential of Targeted Nanoparticles and Perspective on Nanotherapies

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00075


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[ASAP] Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface

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Published On :: Tue, 07 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00111


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[ASAP] Selective Covalent Targeting of Mutated EGFR(T790M) with Chlorofluoroacetamide-Pyrimidines

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00574


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[ASAP] Complete Regression of Carcinoma via Combined C-RAF and EGFR Targeted Therapy

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Published On :: Tue, 14 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00159


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[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00192


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[ASAP] De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits

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Published On :: Tue, 05 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.0c00022


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Simultaneous co-assembly of fenofibrate and ketoprofen peptide for the dual-targeted treatment of nonalcoholic fatty liver disease (NAFLD)

By feeds.rsc.org
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Chem. Commun., 2020, 56,4922-4925
DOI: 10.1039/D0CC00513D, Communication
Zhongyan Wang, Chuanrui Ma, Yuna Shang, Lijun Yang, Jing Zhang, Cuihong Yang, Chunhua Ren, Jinjian Liu, Guanwei Fan, Jianfeng Liu
An ingenious co-assembled nanosystem based on fenofibrate and ketoprofen peptide for the dual-targeted treatment of NAFLD by reducing hepatic lipid accumulation and inflammatory responses.
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Wettability read-out strategy for aptamer target binding based on a recognition/hydrophobic bilayer surface

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Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01936D, Communication
Yunfei Fan, Yahang Xie, Zhen Zhao, Yang Zhao, Rui Yu, Xiang-yang Liu, Youhui Lin, Changxu Lin
A wettability read-out strategy for an aptasensor is setup with a bilayer surface. It targets on methamphetamine and uses hydrophobicity reduction as the signal induced by recognition by the supporting aptamer layer.
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A combined viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization

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Chem. Commun., 2020, Accepted Manuscript
DOI: 10.1039/D0CC02943B, Communication
Le Yu, Jun Feng Zhang, Mingle Li, Dewei Jiang, Ying Zhou, Peter Verwilst, Jong Seung Kim
We report a novel fluorescent molecular conjugate V-M1 enabling an accurate visualization of tumor tissues. The emission wavelength of V-M1 exceeds 650 nm, well within the near-infrared therapeutic window. Tumor...
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A two-photon AIE fluorophore as a photosensitizer for highly efficient mitochondria-targeted photodynamic therapy

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New J. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0NJ00822B, Paper
Qunshou Kong, Boxuan Ma, Tao Yu, Cheng Hu, Gaocan Li, Qing Jiang, Yunbing Wang
Nowadays, photodynamic therapy (PDT) has become an effective way for cancer therapy. However, there are still some drawbacks for common photosensitizers including poor photostability, nonspecific targeting, poor penetration depth of...
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[ASAP] Pyrimidine Analogues as a New Class of Gram-Positive Antibiotics, Mainly Targeting Thymineless-Death Related Proteins

By dx.doi.org
Published On :: Tue, 08 Oct 2019 04:00:00 GMT

ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.9b00305


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[ASAP] Multitarget Approaches against Multiresistant Superbugs

By dx.doi.org
Published On :: Thu, 19 Mar 2020 04:00:00 GMT

ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.0c00001


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[ASAP] Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase

By dx.doi.org
Published On :: Tue, 14 Apr 2020 04:00:00 GMT

ACS Infectious Diseases
DOI: 10.1021/acsinfecdis.0c00024


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Modi targets Nitish,says Bihar govt was partying during Patna serial blasts

By indianexpress.com
Published On :: Fri, 08 Nov 2013 10:05:04 +0000


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Violent protests erupt over killing of two constables; SP blames media for targetting Akhilesh govt

By indianexpress.com
Published On :: Mon, 16 Jun 2014 11:55:54 +0000


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In Rae Bareli, Sonia Gandhi targets Modi over price rise

By indianexpress.com
Published On :: Mon, 01 Sep 2014 20:01:57 +0000


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Sonia Gandhi hails Akhilesh govt, targets Centre as she visits her constituency

By indianexpress.com
Published On :: Thu, 28 May 2015 11:04:18 +0000


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Targeted crystal growth of uranium gallophosphates via the systematic exploration of the UF4–GaPO4–ACl (A = Cs, Rb) phase space

By feeds.rsc.org
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CrystEngComm, 2020, 22,3020-3032
DOI: 10.1039/D0CE00343C, Paper
Christian A. Juillerat, Vladislav V. Klepov, Mark D. Smith, Hans-Conrad zur Loye
The flux synthesis of a uranium gallophosphate and a uranium gallate, Cs4[UO2Ga2(PO4)4] and Cs2UO2Ga2O5, and 4 uranium phosphates, [Rb2Rb3.93Cl0.93][(UO2)5(PO4)5], Rb11[(UO2)8(PO4)9], Rb7.6[(UO2)8O8.6F0.4(PO4)2], and Rb6[(UO2)5O2(PO4)4], is reported.
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Carbon nanotubes for targeted drug delivery / Md Saquib Hasnain, Amit Kumar Nayak

By library.mit.edu
Published On :: Sun, 22 Dec 2019 06:23:55 EST

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Buy Tata Motors for target of Rs 765-775:Karvy

By economictimes.indiatimes.com
Published On :: 2010-06-03T12:29:47+05:30

Karvy Stock Broking has advised traders to buy Tata Motors for target of Rs 765-775.


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Target hasty TMC ordinances, short sessions in Prez speech

By archive.indianexpress.com
Published On :: Fri, 06 Dec 2013 22:38:57 GMT

President said Ordinances should be normally promulgated only in the event of immediate need.


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Fiscal deficit target of 5.3% achievable: Eco Survey

By www.business-standard.com
Published On :: Wed, 27 Feb 2013 16:20:00 +0530

The Economic Survey today said slippage on fiscal deficit will be restricted to 0.2 percentage point this year as expenditure measures could offset the shortfall in revenue collections


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Assam looks at boro rice to beat floods, achieve target

By archive.indianexpress.com
Published On :: Fri, 23 Apr 2010 17:51:00 GMT

Assam is counting on boro rice to achieve the target of 46.7 lakh-metric tonnes that it has set for the crop this year.


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Surplus in rice, Assam sets 10 million MT target

By archive.indianexpress.com
Published On :: Thu, 23 Feb 2012 21:57:41 GMT

Fighting odds of floods, small landholdings and depleting agricultural land, state plans to introduce high-yielding, submergence-tolerant paddy varieties, double-cropping


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Nanotechnology-based targeted drug delivery systems for lung cancer / edited by Prashant Kesharwani

By library.mit.edu
Published On :: Sun, 30 Jun 2019 06:40:10 EDT

Barker Library - T174.7.N37347 2019


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Protein labeling approach to improve lysosomal targeting and efficacy of antibody–drug conjugates

By feeds.rsc.org
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Org. Biomol. Chem., 2020, 18,3229-3233
DOI: 10.1039/D0OB00265H, Communication
Ying Han, Yifan Da, Mingjia Yu, Yaping Cheng, Xin Wang, Jiale Xiong, Guoying Guo, Yan Li, Xianxing Jiang, Xiaoqing Cai
An anti-EGFR nanobody was labeled at the C-terminus with a lysosome-sorting NPGY (Asn-Pro-Gly-Tyr) motif via sortase-mediated ligation to enhance the clathrin-mediated endocytosis.
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Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic–inorganic inhibitors

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Org. Biomol. Chem., 2020, 18,3288-3296
DOI: 10.1039/C9OB02682G, Paper
Matthew B. Minus, Haopei Wang, Jaime O. Munoz, Alexandra M. Stevens, Alicia E. Mangubat-Medina, Michael J. Krueger, Wei Liu, Moses M. Kasembeli, Julian C. Cooper, Mikhail I. Kolosov, David J. Tweardy, Michele S. Redell, Zachary T. Ball
Recurrence and drug resistance are major challenges in the treatment of acute myeloid leukemia (AML) that spur efforts to identify new clinical targets and active agents.
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Enhancing the chemotherapeutic efficacy of platinum prodrug nanoparticles and inhibiting cancer metastasis by targeting iron homeostasis

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Nanoscale Horiz., 2020, Advance Article
DOI: 10.1039/D0NH00148A, Communication
Fang Ding, Lingpu Zhang, Hao Chen, Haiqin Song, Shiguo Chen, Haihua Xiao
Combination of cisplatin prodrug nanoparticles and Dp44mT results in enhanced anticancer and anti-metastatic efficiencies.
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Efficient near-infrared photosensitizer with aggregation-induced emission characteristics for mitochondria-targeted and image-guided photodynamic cancer therapy

By pubs.rsc.org
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Mater. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QM00170H, Research Article
Hanxiao Yang, Jiabao Zhuang, Nan Li, Yue Li, Shiyu Zhu, Jiaxin Hao, Jiayao Xin, Na Zhao
A highly efficient near-infrared photosensitizer with aggregation-induced emission characteristics was developed for mitochondria-targeted and image-guided photodynamic cancer therapy.
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[ASAP] Revealing Acquired Resistance Mechanisms of Kinase-Targeted Drugs Using an on-the-Fly, Function-Site Interaction Fingerprint Approach

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Chemical Theory and Computation
DOI: 10.1021/acs.jctc.9b01134


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Indian pharma exports miss target, stand at $20.58 bn in FY' 20

By economictimes.indiatimes.com
Published On :: 2020-05-08T15:34:35+05:30

​​Though the exports started doing well in 2019-20 and it has been a good year for the first three quarters with cumulative growth rate of 11.5 per cent during April-December 2019, the growth rate in February and March has gone down recording 7.7 per cent and -23.24 per cent respectively, resulting in the negative growth of - 2.97 per cent in the fourth quarter.


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