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Soft target protection: theoretical basis and practical measures / edited by Ladislav Hofreiter, Viacheslav Berezutskyi, Lucia Figuli and Zuzana Zvaková

Online Resource




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Pakistan violates ceasefire again, targets Indian posts in Rajouri

This is the 19th ceasefire violation by Pakistan in September alone, 97 such incidents this year.




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Pakistan targets civilian areas in Jammu, 3 children among 4 hurt in firing along LoC

This is the ninth ceasefire violation by Pakistani troops in the past four days.




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Pak violates ceasefire, targets Indian posts on LoC

Pakistan has committed ceasefire violations 195 times along the LoC so far this year.




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CPM taken care of, next target is Delhi: Mamata Banerjee



  • DO NOT USE West Bengal
  • India

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Star Wars, 2014: BJP and Congress target each others’ biggies in candidate selection, but not consistently

By fielding one of its vice-presidents – former television soap star Smriti Irani – against Congress’s Rahul Gandhi in Amethi Lok Sabha constituency, BJP has shown it is inclined to take the electoral battle to one of two Gandhi pocket boroughs in Uttar Pradesh.




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Targeted Isolation of Two Disesquiterpenoids Macrocephadiolides A and B from Ainsliaea macrocephala using Molecular Networking-based Dereplication Strategy

Org. Chem. Front., 2020, Accepted Manuscript
DOI: 10.1039/D0QO00030B, Research Article
Yong-Mei Ren, Shuaizhen Zhou, Tian Zhang, Meijia Qian, Rui Zhang, Sheng Yao, Hong Zhu, Chunping Tang, Ligen Lin, Yang Ye
A molecular networking-based dereplication strategy was applied to the phytochemical investigation of Ainsliaea macrocephala, leading to the isolation of two novel disesquiterpenoids macrocephadiolides A (1) and B (2). Their structures,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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[ASAP] Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing

Journal of the American Chemical Society
DOI: 10.1021/jacs.0c00768




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Energy management in plastics processing: strategies, targets, techniques, and tools / Dr. Robin Kent

Online Resource




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A high-throughput and untargeted lipidomics approach reveals new mechanistic insight and the effects of salvianolic acid B on the metabolic profiles in coronary heart disease rats using ultra-performance liquid chromatography with mass spectrometry

RSC Adv., 2020, 10,17101-17113
DOI: 10.1039/D0RA00049C, Paper
Open Access
Ying-peng Li, Cong-ying Wang, Hong-tao Shang, Rui-rui Hu, Hui Fu, Xue-feng Xiao
High-throughput lipidomics provides the possibility for the development of new therapeutic drugs.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Successful project management [electronic resource] : how to complete projects on time, on budget, and on target / Michael S. Dobson

Dobson, Michael Singer, author




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Target opportunity selling [electronic resource] : top sales performers reveal what really works / Nicholas A.C. Read

Read, Nicholas A. C




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Could targeting STING make a universal flu vaccine?

In animal tests, vaccine gives broad protection




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Researchers in China report structure of the novel coronavirus bound to its human target

The structure shows the first steps of SARS-CoV-2 infection, and could help in drug discovery




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Researchers in China report structure of the novel coronavirus bound to its human target

The structure shows the first steps of SARS-CoV-2 infection and could help in drug discovery




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AlloVir and Baylor to make donor-derived T cell therapies that target coronaviruses




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Roche partners with Arrakis on small molecules that target RNA

Arrakis will earn $190 million in its first pharma partnership




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Rgenta Therapeutics launches with $20 million to develop small molecules that target RNA




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Light-controlled guide RNA hones CRISPR targeting

Technique modifies subsets of cells and frees gene editing proteins for potential further improvements




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Inovio targeted by short seller Citron




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Drug targeting [electronic resource] : strategies, principles, and applications / edited by G.E. Francis and Cristina Delgado

Totowa, N.J. : Humana Press, [2000]




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Manu Bhaker gets electronic target installed at home in place of manual machine

Manu Bhaker was sure in her mind that the Olympics will take place next year despite the uncertainty in the world of sports due to the COVID-19 pandemic.




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Manu gets electronic target installed at home

Boost to ace shooter’s basic training




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[ASAP] Cell Type-Dependent Specificity and Anti-Inflammatory Effects of Charge-Reversible MSNs-COS-CMC for Targeted Drug Delivery in Cervical Carcinoma

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00004




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[ASAP] Targeted Delivery of Anti-inflammatory and Imaging Agents to Microglial Cells with Polymeric Nanoparticles

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.9b00489




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[ASAP] Lyoprotectant Optimization for the Freeze-Drying of Receptor-Targeted Trojan Horse Liposomes for Plasmid DNA Delivery

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00310




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[ASAP] Targeting CNS Related Protist Pathogens: Calcium Ion Dependency in the Brain-Eating Amoebae

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00635




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[ASAP] Mesenchymal Stem Cells Could Be Considered as a Candidate for Further Studies in Cell-Based Therapy of Alzheimer’s Disease via Targeting the Signaling Pathways

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00052




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‘Activists are often targets of cyberbullying’

The JNU Students’ Union (JNUSU) on Friday condemned the trend of targeting activists through cyberbullying, saying it has been proven time and again t




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[ASAP] Targeted Delivery of Adamantylated Peptidoglycan Immunomodulators in Lipid Nanocarriers: NMR Shows That Cargo Fragments Are Available on the Surface

The Journal of Physical Chemistry B
DOI: 10.1021/acs.jpcb.0c00029




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Why is Sanjay Leela Bhansali being targeted?

'The film industry will remain soft targets and continue to be picked upon with no respite, with no choice but to give in due to personal safety and financial compulsions,' says director Suparn Verma.




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Untargeted metabolomics revealed therapeutic mechanisms of icariin on low bone mineral density in older caged laying hens

Food Funct., 2020, 11,3201-3212
DOI: 10.1039/C9FO02882J, Paper
Jie Huang, Yanping Hu, Xiaofeng Tong, Lei Zhang, Zhengwang Yu, Zhongxin Zhou
Untargeted metabolomics revealed the therapeutic effects and mechanisms of icariin on low bone mineral density in older caged laying hens.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Targets and Underlying Mechanisms for Sedative and Hypnotic Activities of Saponins from Semen Ziziphus jujube

Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00098A, Paper
Chun-Yan Shen, Lin Wan, Jing-Jing Zhu, Jian-Guo Jiang
Semen Ziziphus jujube (SZJ) has been widely consumed as edible resources in China to treat insomnia disorders. However, the underlying mechanisms and potential therapeutic targets remained obscure. SZJ-I and SZJ-II...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Covid-19 crisis: Pharma sector misses $22 billion export target

Covid-19 crisis: Pharma sector misses $22 billion export target




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Govt very transparent in setting new fiscal deficit target: FM Sitharaman

She further said that many people have been speculating that the fiscal deficit would cross 4%




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Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs

Interview with Mark G. Kris, MD, author of Using Multiplexed Assays of Oncogenic Drivers in Lung Cancers to Select Targeted Drugs




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[ASAP] Collagen-Targeted Theranostic Nanosponges for Delivery of the Matrix Metalloproteinase 14 Inhibitor Naphthofluorescein

Chemistry of Materials
DOI: 10.1021/acs.chemmater.9b02840




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Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery

Biomater. Sci., 2020, 8,2274-2282
DOI: 10.1039/C9BM02036E, Paper
Yue Cai, Zhuomin Xu, Qi Shuai, Fangtao Zhu, Jiao Xu, Xin Gao, Xuanrong Sun
PEG-PLA micelles are modified with F3 peptides, thus endowing the micelles with active-targeting ability due to the nucleolin-binding ability of the F3 peptides.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry

Biomater. Sci., 2020, 8,2283-2288
DOI: 10.1039/D0BM00088D, Paper
Guihong Lu, Liping Zuo, Jinfeng Zhang, Houshun Zhu, Wanru Zhuang, Wei Wei, Hai-Yan Xie
A highly efficient two-step targeting strategy integrating metabolic lipid-engineering with in situ click chemistry is developed, thus significantly improved the tumor theranostic performance of the red blood cells ghosts based drug delivery.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Delivery of dual miRNA through CD44-targeted mesoporous silica nanoparticles for enhanced and effective triple-negative breast cancer therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00015A, Paper
Manisha Ahir, Priyanka Upadhyay, Avijit Ghosh, Sushmita Sarker, Saurav Bhattacharya, Payal Gupta, Swatilekha Ghosh, Sreya Chattopadhyay, Arghya Adhikary
Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual miRNA loading, efficient delivery and significantly inhibited tumor growth as well as retarded metastasis in triple-negative breast cancer.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A photothermal-hypoxia sequentially activatable phase-change nanoagent for mitochondria-targeting tumor synergistic therapy

Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00003E, Paper
Jia Qu, Dengke Teng, Guoqing Sui, Shihui Guan, Yang Wang, Qimeihui Wang, Yuanqiang Lin, Haitao Ran, Zhigang Wang, Hui Wang
The advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring by PA and FL imaging.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Disulfiram-Gold-Nanorod Integrate for Effective Tumor Targeting and Photothermal-Chemical Synergistic Therapy

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00062K, Paper
Chaoli Xu, Ting Zhang, Guangming Lu, Kun Chen, Jun Tao, Yunlei Zhang, Zhaogang Teng, Bin Yang
Herein, we successfully constructed a combined therapeutic nanoplatform with high tumor targeting for cancer treatment by integrating gold nanorods with disulfiram (denoted Au-DSF). The Au-DSF integrates possess a uniform length...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Trastuzumab targeted micellar delivery of docetaxel using dendron–polymer conjugates

Biomater. Sci., 2020, 8,2600-2610
DOI: 10.1039/C9BM01764J, Paper
Burcu Sumer Bolu, Bianka Golba, Amitav Sanyal, Rana Sanyal
Incorporation of a therapeutic antibody into nanosized drug delivery systems can improve their target specificity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging

Biomater. Sci., 2020, 8,2590-2599
DOI: 10.1039/D0BM00314J, Paper
Julie Tzu-Wen Wang, Umberto Martino, Rehan Khan, Maasoomeh Bazzar, Paul Southern, Dönüş Tuncel, Khuloud T. Al-Jamal
Self-red-emitting magnetic PLGA-PEG nanocapsules for optical imaging and magnetic tumour targeting.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper–tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer

Biomater. Sci., 2020, 8,2420-2433
DOI: 10.1039/C9BM01905G, Paper
Vera L. Silva, Abdessamad Kaassis, Ashkan Dehsorkhi, Cédrik-Roland Koffi, Maja Severic, Moustafa Abdelhamid, Duuamene Nyimanu, Christopher J. Morris, Wafa’ T. Al-Jamal
Cu(TPZ)2 complex as a promising hypoxia selective cytotoxin in prostate cancer.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection

Biomater. Sci., 2020, 8,2682-2693
DOI: 10.1039/D0BM00162G, Paper
Yuanbiao Tu, Ji Tao, Fang Wang, Peifei Liu, Zhihao Han, Zhaolun Li, Yi Ma, Yueqing Gu
The designed novel peptide GB-6 with targeted GRPR-binding possesses more favorable pharmacokinetic properties and metabolic stability, as well as superior tumor-targeting ability in pancreatic cancer models, relative to BBN7–14.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A biomimetic orally targeted delivery of Bindarit for immunotherapy of atherosclerosis

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00418A, Paper
Luqi Yin, Cuiping Peng, Yue Tang, Yuchuan Yuan, Jiaxing Liu, Tingting Xiang, Feila Liu, Zhou Xing, Xiaohui Li
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the development of atherosclerosis. However, the application of bindarit (a specific synthetic inhibitor of MCP-1) in atherosclerosis has not been confirmed...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting CD44v6 receptor in colon cancer cells

Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00556H, Paper
Ana Baião, Flávia Sousa, Ana Oliveira, Carla Oliveira, Bruno Sarmento
Colorectal cancer (CRC) is one of the most incident and mortal cancers in the world, mainly due to its metastatic and metabolic ability. CD44 receptor isoform containing exon 6 (CD44v6)...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide

Toxicol. Res., 2019, 8,850-861
DOI: 10.1039/C9TX00067D, Paper
Wei Huang, Chuanxin Liu, Lijuan Xie, Yuming Wang, Yanyan Xu, Yubo Li
Integrated network pharmacology and targeted metabolomics to reveal the nephrotoxicity mechanism of triptolide.
The content of this RSS Feed (c) The Royal Society of Chemistry




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miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway

Toxicol. Res., 2019, 8,875-884
DOI: 10.1039/C9TX00100J, Paper
Xuan-Ying Chen, Wei-Lin Huang, Xiao-Ping Peng, Yan-Ni Lv, Jun-He Li, Jian-Ping Xiong
Bevacizumab (BVZ) is a widely investigated angiogenesis inhibitor in cancer patients. Although the anti-tumor effects has been verified, cardiotoxicity may be the most serious side-effect for BVZ.
The content of this RSS Feed (c) The Royal Society of Chemistry