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Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination

By pubs.rsc.org
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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00072B, Communication

Dongyu Tang, Yaqing Ma, Jinping Bao, Shushan Gao, Shuli Man, Chengsen Cui
An engineered imine reductase (IRED) was developed specifically for 2-tetralone substrate, and utilized in the total synthesis of rotigotine.
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Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination

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