‘Proper opportunities would be created for their livelihood’

Rietveld/MEM analysis applied to synchrotron powder X-ray diffraction data of dehydrated CHA zeolites with catalytically active Cu2+ reveals Cu2+ in both the six- and eight-membered rings in the CHA framework, providing the first complete structural model that accounts for all Cu2+. Density functional theory calculations are used to corroborate the experimental structure and to discuss the Cu2+ coordination in terms of the Al distribution in the framework.

Hydrogen is present in almost all of the molecules in living things. It is very reactive and forms bonds with most of the elements, terminating their valences and enhancing their chemistry. X-ray diffraction is the most common method for structure determination. It depends on scattering of X-rays from electron density, which means the single electron of hydrogen is difficult to detect. Generally, neutron diffraction data are used to determine the accurate position of hydrogen atoms. However, the requirement for good quality single crystals, costly maintenance and the limited number of neutron diffraction facilities means that these kind of results are rarely available. Here it is shown that the use of Transferable Aspherical Atom Model (TAAM) instead of Independent Atom Model (IAM) in routine structure refinement with X-ray data is another possible solution which largely improves the precision and accuracy of X—H bond lengths and makes them comparable to averaged neutron bond lengths. TAAM, built from a pseudoatom databank, was used to determine the X—H bond lengths on 75 data sets for organic molecule crystals. TAAM parametrizations available in the modified University of Buffalo Databank (UBDB) of pseudoatoms applied through the DiSCaMB software library were used. The averaged bond lengths determined by TAAM refinements with X-ray diffraction data of atomic resolution (dmin ≤ 0.83 Å) showed very good agreement with neutron data, mostly within one single sample standard deviation, much like Hirshfeld atom refinement (HAR). Atomic displacements for both hydrogen and non-hydrogen atoms obtained from the refinements systematically differed from IAM results. Overall TAAM gave better fits to experimental data of standard resolution compared to IAM. The research was accompanied with development of software aimed at providing user-friendly tools to use aspherical atom models in refinement of organic molecules at speeds comparable to routine refinements based on spherical atom model.

Transferable Aspherical Atom Model (TAAM) instead of Independent Atom Model (IAM) applied through DiSCaMB software library in the structure refinement against X-ray diffraction data largely improves the X—H bond lengths and make them comparable to the averaged neutron bond lengths.

These green crabs have been doing a number on native shellfish. They eat a lot of clams. And they're a very cosmopolitan species—they've now spread all over, to places as far afield as the West Coast of the U.S. and South Africa.

The post Location matters: For invasive aquatic species, it’s better to start upstream appeared first on Smithsonian Insider.

Using echolocation alone the bats found, identified and captured insects perched motionless and silent on the leaves of plants.

The post Common tropical bat uses echolocation with precision previously considered impossible, new experiments reveal appeared first on Smithsonian Insider.

Victor J. F. Kitano, Yoko Ohyama, Chiyomi Hayashida, Junta Ito, Mari Okayasu, Takuya Sato, Toru Ogasawara, Maki Tsujita, Akemi Kakino, Jun Shimada, Tatsuya Sawamura, and Yoshiyuki Hakeda

Osteoporosis is associated with vessel diseases attributed to hyperlipidemia, and bone resorption by multinucleated osteoclasts is related to lipid metabolism. In this study, we generated low-density lipoprotein receptor (LDLR)/lectin-like oxidized LDL receptor-1 (LOX-1) double knockout (dKO) mice. We found that, like LDLR single KO (sKO), LDLR/LOX-1 dKO impaired cell-cell fusion of osteoclast-like cells (OCLs). LDLR/LOX-1 dKO and LDLR sKO preosteoclasts exhibited decreased uptake of LDL. The cell surface cholesterol levels of both LDLR/LOX-1 dKO and LDLR sKO osteoclasts were lower than the levels of wild-type OCLs. Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. Abrogation of the ATP binding cassette G1 (ABCG1) transporter, which transfers PE to the cell surface, caused decreased PE translocation to the cell surface and subsequent cell-cell fusion. The findings of this study indicate the involvement of a novel cascade (LDLR~ABCG1~PE translocation to cell surface~cell-cell fusion) in multinucleation of OCLs.

Faced with financial issues, the Upright Citizens Brigade Theater closed its Chelsea location in 2017.; Credit: Andrew Toth/Getty Images

When the Upright Citizens Brigade announced plans to permanently close its New York bases last week, comedy lost a beloved home. The scrappy, alternative comedy troupe that grew into a school and theater revolutionized improv in New York and beyond with its embrace of "Yes, and ..."

The New York institution incubated the talents of stars such as Kate McKinnon, Aziz Ansari, Chris Gethard, Donald Glover, Aubrey Plaza and many others in the comedy world. A pillar of longform improv, UCB teachings have been brought into countless comedy writers' rooms and are etched into many successful TV shows.

Four of the company's founding members, known as the "UCB4" — Amy Poehler, Matt Besser, Matt Walsh and Ian Roberts — told staff in an email on April 21 that the organization couldn't afford to renew its leases on the group's two Manhattan locations: the UCB theater in Hell's Kitchen and a training center in the Garment District.

UCB also has two locations in Los Angeles where operations have been temporarily halted during the coronavirus outbreak, but there are currently no plans to close them.

Obits followed, marking the exit of UCB's physical presence in the city where it took off in the '90s, when the group turned a former strip club into its first theater.

"The guys that I came up with in New York at the UCB Theater — we made our bones there basically," said Rob Corddry, who went on to be a Daily Show correspondent and star in comedy films including Hot Tub Time Machine. "It's really sad. Sort of the end of an era."

The news comes a month after layoffs were announced at the group's New York and Los Angeles facilities in response to the coronavirus. A small number of staff were kept at training centers on both coasts.

But UCB was under financial strain long before the pandemic. Many UCBers cast the move as an example of an opaque, top-down decision-making that, over the years, they say has sowed distrust in UCB leadership among its members.

"The biggest issue with UCB was the lack of communication of the company and the owners to their employees," said Paris Adkins, a New York performer who was laid off from her administrative job with the company last month.

A previous round of layoffs took place at the end of 2018, mostly of New York employees. Adkins said the pandemic "is just the extenuating circumstance that put things over the edge."

As for the most recent closures, UCB's founders admitted to falling short of expectations.

"Look, we heard the community when they said, 'We're scared, too, and we want better communication,' " Amy Poehler told The Hollywood Reporter in an interview with the UCB4 after the announcement. "I think we did make mistakes, and we're trying to do better."

UCB has not responded to NPR's attempts to contact the organization.

Chris Renfro, an LA-based performer and show producer who relied on UCB as his main source of income, said that learning in March via a mass email that his 3-year career there had come to an end struck him as a betrayal of the values the UCB4 claimed to live by.

"UCB is about a community, it's about having each other's backs," he said, referencing the improv tradition UCB students learn of literally patting each other's backs and saying "Got your back."

"It felt like they had turned their backs on this massive community they had built up around them," he said. "So now there's a weird taste in a lot of peoples' mouths because of that."

According to a letter sent to staff addressing the layoffs, Poehler said she would pay for an additional month of health care for former full-time staff.

Much of the company's operations run on part-time staff, according to Adkins. She estimated that UCB cut a total of 45 New York-based employees across the city since last month.

Despite the community's frustrations, when the indefinite shutdown of the New York outposts turned definite, the tributes rolled in online.

Stephen Colbert, who studied at the peer improv hub Second City in Chicago before moving to New York, tweeted "I'll always be grateful" for the times he was roped in to perform with UCB during the '90s in the acclaimed sketch show mainstay Asssscat.

Daily Show correspondent Jordan Klepper added, "When I left Chicago, the people at UCB NY welcomed me, challenged me, and embodied the NY spirit of full commitment today because tomorrow you could run out of cash and life ships you back home."

Other dispatches on social media were less endearing.

Former students, many of whom shelled out several hundred dollars for improv classes, wrote about negative experiences and wasted money. Some revived longstanding criticism of the theater's policy to not pay its performers, unlike many of its improv peers.

Despite its problems, many felt a sense of community at UCB, Adkins said.

"I think people are grieving," she said. "It's pretty much my only community in New York and I think a lot of people feel that way. You don't get the support of a community like you do at UCB."

In an effort to financially support herself and her peers following the layoffs, Adkins started a GoFundMe page to raise money for New York staff. To date, the account has raised nearly $60,000. She's splitting the funds between staff members, who will receive a month's worth of pay. The rest will be divided among teachers who are in need, Adkins said.

In the THR interview, Amy Poehler assured the UCB community, "We're not leaving New York."

At least for the short-term, the company has moved both LA and New York classes online. For the long-term in New York, leadership has floated plans to return to the old days of renting other independent spaces to hold classes and performances.

Still, even some of its youngest members see the now-shuttered hubs as a piece of history.

"But that's replaceable and people are not," said former training center staff member Maicy Jo Schwartz, who began her UCB NY career in 2014.

Schwartz sees a silver lining.

"I wouldn't be surprised if in the future some people branch off and start their own theaters or their own training centers or their own underground improv and sketch, because New York is a perfect place to do that," she said. "And I do hope that the UCB4 — Amy, Matt, Matt and Ian — can be part of that and support that when there are future endeavors that their alumni take on."

NPR's Elizabeth Blair contributed to this story.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Invasions of alien species are rising at an alarming rate, largely due to growing global trade and transport routes. Preventing the successful establishment of alien species by better understanding the factors determining success is a step toward limiting the threat of future biological invasions. Statistical modelling using observed bird invasion data — including location, event and species-level factors showed which factors were key to successful establishment by the alien species.

Local context may have more influence over public acceptance of restrictive policies, such as road tolls and parking fees, than factors such as age, gender or education, a new study suggests. The researchers analysed public reaction to Norwegian policies used to reduce car use and found that there were three aspects of local context that were particularly important: local urban development policies, sense of local identity, and public understanding of the problems.

Both the companies said privacy and preventing governments from using the system to compile data on citizens was a primary goal

Richer countries have more resources for gathering biodiversity information, creating a biased view of the worlds' species and their distribution. However, a new study argues that there are other reasons why some countries are underrepresented in global biodiversity databases, with low numbers of English speakers, large distances from the database host and low security acting as key barriers to data collection.

The value of moving animals or plants from a stable population into one that is endangered or even extinct has been questioned, with some suggesting that it will mean that the new population is not well adapted to its environment. However, research on an endangered toad has shown that even when individuals were translocated from great distances, the population was able to genetically adapt to local conditions within a few generations.

The value of moving animals or plants from a stable population into one that is endangered or even extinct has been questioned, with some suggesting that it will mean that the new population is not well adapted to its environment. However, research on an endangered toad has shown that even when individuals were translocated from great distances, the population was able to genetically adapt to local conditions within a few generations.

SUFFOLK – VDOT Hampton Roads employees celebrated a major address change today with a ribbon-cutting at their new north Suffolk headquarters. The...

The Virginia Department of Transportation will hold a Location and Design public hearing concerning improvements to Route 11 (South Valley Pike) and Route 704 (Cecil Wampler Road) in Rockingham County.  The meeting will take place from 4 to 7 p.m., Thursday, December 6, 2018 at Bridgewater Town Hall, 201 Green Street, Bridgewater, Virginia  22812.  The inclement weather date is Thursday, December 13, 2018, same time and location.

New network will enable coast-to-coast electric rides and 20-minute charges. CEO Elon Musk is ramping up the timetable.

Fair Trade USA has just released an app that allows users to upload the location of fair trade products that they find for sale. No smartphone? No problem. Use

A giant flood of Arctic meltwater may have triggered an ancient 1,200-year-long chill nicknamed the "Big Freeze," the last major cold age on Earth, a new study

At a single Starbuck location, a whooping 378 people bought coffee for the person behind them.

How can businesses handle relocation with their employees? Peter Done explains how to orchestrate a successful office move

Investing is not a competitive event, ever. You don't need to beat the market. You need to accomplish a set of personalized goals. Avoid what the crowd is doing and shun investment products. Consumers buy products; Investors buy securities.

As Squamish, on B.C.'s busy west coast, cements its reputation as the Outdoor Capital of Canada, it opens up a challenge, what do you do if you can't or don't want to do extreme sports?

Clients of iLoveKickboxing-Sandy get ready to start the 2nd annual 45 day transformation contest this week.

We are pleased to announce the opening of our second location in the Inland Empire. We look forward to building relationships with new clients by helping them negotiate settlements, overcome emotional damages and other financial obligations.

Offering truck drivers another option for fast oil changes on our Southern border.

Global Coworking Space to Further Expand into Several Cities in the Lehigh Valley

Yellen Partners Has Been Hired to Conduct Liquidation of 60-Year Old Family Business

Coming Late 2017

Texas Expansion Continues for Rapidly Growing Global Coworking Space

Founder, Brian Bullman, expresses his enthusiasm for the company's growth.

Top Divorce Law Firm explains the Pet Custody laws.

Teltech Communications LLC (dba Teltech Group) Wins Award to Provide Solar Power Plants for Rio Blanco County in Colorado

Eigen received AS 9100 D certification for Peenya Location.

With addition of St. Louis office, the firm now serves the entire state of Missouri.

The seventh MedPost location in the area is set to open in spring 2020

"It brings me great pleasure to announce the expansion of my franchise located at 1881 South Hampton Rd Suite E, Atlanta, GA 30349 open 7 days a week. All customers are welcomed to book your appointment online." - Rico London

B+E, the first brokerage and technology platform for net lease real estate, announced the listing of the Tesla San Antonio Service Center located at 23011 IH-10 W for $4,750,000.

In order to cater to the diverse schedules of its clients, Car Sell Zone will now be open Saturday to Thursday from 10 a.m. to 9 p.m. Customers who would like to sell their cars in the UAE are now welcome to enjoy Car Sell Zone services.

Cowtown Tanning Now Open at 2613 Wiesenberger Street, Suite 164, Fort Worth 76109

Using Air Quality and Temperature data to answer critical questions.

North Fort Worth Music Lesson Studio Temporarily Moves Lessons Online in Response to Coronavirus

Restaurateur and serial entrepreneur Lino Joseph is proud to announce the Opening of his second SPICE HOUSE restaurant location at 2617 Panola Rd in Lithonia, GA (formerly known as The Blue Room).

Watauga and Colleyville Chef Point Restaurants Take Added Measures to Protect Diners and Employees