(Florida Museum of Natural History) Florida and Georgia archaeologists have discovered the location of Fort San Antón de Carlos, home of one of the first Jesuit missions in North America. The Spanish fort was built in 1566 in the capital of the Calusa, the most powerful Native American tribe in the region, on present-day Mound Key in the center of Estero Bay on Florida's Gulf Coast.

Rationale: Lymphatic tracers can help visualize the lymphatic drainage patterns and sentinel nodes of individual prostate cancer patients. To determine the role of nuclear medicine, in particular the positional guidance of a SPECT/CT-based 3D imaging roadmap, in this process we studied to which extend fluorescence-guidance underestimated the number of target lesions. Methods: SPECT/CT imaging was performed after intraprostatic tracer administration of either ICG-^99mTc-nanocolloid (hybrid tracer group) or ^99mTc-nanocolloid to create a roadmap that depicted all sentinel nodes (SNs). Patients who received ^99mTc-nanocolloid were injected with "free" ICG immediately prior to surgery ("free" ICG group). Before unblinding, fluorescence-guidance was used for intraoperative SN identification. This was followed by extended pelvic lymph node dissection (ePLND). Following unblinding of the SPECT/CT images, the number of missed SN’s were recorded and their resection was pursued when the anatomy allowed. Results: Preoperative SPECT/CT revealed no differences in the SN identification rate between ICG-^99mTc-nanocolloid and ^99mTc-nanocolloid. However, fluorescence-guidance only allowed intraoperative removal of all SNs in 40% of patients in the hybrid tracer group and in 20% of patients in the "free" ICG group. Overall, 75.9% of the intraoperatively resected SNs in the hybrid tracer group and 51.8% of the SNs in the "free" ICG group were removed solely under fluorescence-guidance. During ePLND 22 additional SNs were resected (7 in the hybrid tracer group and 15 in the "free" ICG group). After unblinding 18 remaining SNs were identified (6 in the hybrid group and 12 in the "free" ICG group). In the "free" ICG group, ex vivo evaluation of the excised specimens revealed that 14 SNs removed under ePLND or after unblinding contained radioactivity but no fluorescence. Conclusion: The preoperative imaging roadmap provided by SPECT/CT enhanced the detection of prostate SNs in more ectopic locations in 17 of the 25 patients and the hybrid tracer ICG-^99mTc-nanocolloid was shown to outperform "free" ICG. Overall, fluorescence-guided pelvic nodal surgery underestimated the number of SNs in 60-80% of patients.

Henry J. Pownall
May 1, 2020; 61:595-597
Commentary

Membrane-bound proteins have been proposed to mediate the transport of long-chain FA (LCFA) transport through the plasma membrane (PM). These proposals are based largely on reports that PM transport of LCFAs can be blocked by a number of enzymes and purported inhibitors of LCFA transport. Here, using the ratiometric pH indicator (2',7'-bis-(2-carboxyethyl)-5-(and-6-)-carboxyfluorescein and acrylodated intestinal FA-binding protein-based dual fluorescence assays, we investigated the effects of nine inhibitors of the putative FA transporter protein CD36 on the binding and transmembrane movement of LCFAs. We particularly focused on sulfosuccinimidyl oleate (SSO), reported to be a competitive inhibitor of CD36-mediated LCFA transport. Using these assays in adipocytes and inhibitor-treated protein-free lipid vesicles, we demonstrate that rapid LCFA transport across model and biological membranes remains unchanged in the presence of these purported inhibitors. We have previously shown in live cells that CD36 does not accelerate the transport of unesterified LCFAs across the PM. Our present experiments indicated disruption of LCFA metabolism inside the cell within minutes upon treatment with many of the "inhibitors" previously assumed to inhibit LCFA transport across the PM. Furthermore, using confocal microscopy and a specific anti-SSO antibody, we found that numerous intracellular and PM-bound proteins are SSO-modified in addition to CD36. Our results support the hypothesis that LCFAs diffuse rapidly across biological membranes and do not require an active protein transporter for their transmembrane movement.

ROSEAU, Dominica (CMC): A top West Indies Cricket Umpires Association (WICUA) official says regional umpires have also been heavily impacted by the cessation of cricket, stemming from the outbreak of the COVID-19 pandemic. Vivian Johnson, who...

EJ Kurth-Kraczek
Aug 1, 1999; 48:1667-1671
Articles

Brunn : J.G. Trassler, 1821-1822.

Mohd Arshad, Omer Abdalghani.

Source: Brazilian Journal of Probability and Statistics, Volume 34, Number 1, 167--182.

Abstract:
Suppose that $pi_{1},pi_{2},ldots ,pi_{k}$ be $k(geq2)$ independent exponential populations having unknown location parameters $mu_{1},mu_{2},ldots,mu_{k}$ and known scale parameters $sigma_{1},ldots,sigma_{k}$. Let $mu_{[k]}=max {mu_{1},ldots,mu_{k}}$. For selecting the population associated with $mu_{[k]}$, a class of selection rules (proposed by Arshad and Misra [ Statistical Papers 57 (2016) 605–621]) is considered. We consider the problem of estimating the location parameter $mu_{S}$ of the selected population under the criterion of the LINEX loss function. We consider three natural estimators $delta_{N,1},delta_{N,2}$ and $delta_{N,3}$ of $mu_{S}$, based on the maximum likelihood estimators, uniformly minimum variance unbiased estimator (UMVUE) and minimum risk equivariant estimator (MREE) of $mu_{i}$’s, respectively. The uniformly minimum risk unbiased estimator (UMRUE) and the generalized Bayes estimator of $mu_{S}$ are derived. Under the LINEX loss function, a general result for improving a location-equivariant estimator of $mu_{S}$ is derived. Using this result, estimator better than the natural estimator $delta_{N,1}$ is obtained. We also shown that the estimator $delta_{N,1}$ is dominated by the natural estimator $delta_{N,3}$. Finally, we perform a simulation study to evaluate and compare risk functions among various competing estimators of $mu_{S}$.

Yong-Chao Zhang, Na Zhang.

Source: Brazilian Journal of Probability and Statistics, Volume 33, Number 1, 184--191.

Abstract:
We investigate the equivalence of dynamic and static asset allocations in the case where the price process of a risky asset is driven by a Poisson process. Under some mild conditions, we obtain a necessary and sufficient condition for the equivalence of dynamic and static asset allocations. In addition, we provide a simple sufficient condition for the equivalence.

This paper deals with robust marginal estimation under a general regression model when missing data occur in the response and also in some of covariates. The target is a marginal location parameter which is given through an $M-$functional. To obtain robust Fisher--consistent estimators, properly defined marginal distribution function estimators are considered. These estimators avoid the bias due to missing values by assuming a missing at random condition. Three methods are considered to estimate the marginal distribution function which allows to obtain the $M-$location of interest: the well-known inverse probability weighting, a convolution--based method that makes use of the regression model and an augmented inverse probability weighting procedure that prevents against misspecification. The robust proposed estimators and the classical ones are compared through a numerical study under different missing models including clean and contaminated samples. We illustrate the estimators behaviour under a nonlinear model. A real data set is also analysed.

Jared D. Fisher, Davide Pettenuzzo, Carlos M. Carvalho.

Source: The Annals of Applied Statistics, Volume 14, Number 1, 299--338.

Abstract:
We introduce a fast, closed-form, simulation-free method to model and forecast multiple asset returns and employ it to investigate the optimal ensemble of features to include when jointly predicting monthly stock and bond excess returns. Our approach builds on the Bayesian dynamic linear models of West and Harrison ( Bayesian Forecasting and Dynamic Models (1997) Springer), and it can objectively determine, through a fully automated procedure, both the optimal set of regressors to include in the predictive system and the degree to which the model coefficients, volatilities and covariances should vary over time. When applied to a portfolio of five stock and bond returns, we find that our method leads to large forecast gains, both in statistical and economic terms. In particular, we find that relative to a standard no-predictability benchmark, the optimal combination of predictors, stochastic volatility and time-varying covariances increases the annualized certainty equivalent returns of a leverage-constrained power utility investor by more than 500 basis points.

Take a bus tour to the sites of movies and TV shows. Your guide will entertain you as you visit over 30 locations used in West Wing, The Exorcist and more

The locational banking statistics provide quarterly data on the outstanding claims and liabilities of internationally active banks located in reporting countries against counterparties residing in more than 200 countries. They capture the currency composition of banks' balance sheets and the geographical breakdown of their counterparties.

St Kilda

Little is known about the epidemiology and pathogenicity of Clostridium difficile infection among children, particularly those aged ≤3 years in whom colonization is common and pathogenicity uncertain.

Young children, 1 to 3 years of age, had the highest Clostridium difficile infection incidence. Considering that clinical presentation, outcomes, and disease severity were similar across age groups, C difficile infection in the youngest age group likely represents true disease and not asymptomatic colonization. (Read the full article)

Recent concussion research has examined the role of impact location (ie, the area on the head to which impact occurred); however, no studies exist regarding impact location’s association with concussion outcomes (eg, symptomatology, symptom resolution time, return to play).

This study is the first to examine the association of impact location and concussion outcomes in young athletes. Our findings suggest that impact location, as assessed by sideline observers/player report, is likely of little use in predicting clinical outcomes. (Read the full article)

Uptake of rotavirus vaccines has increased steadily since introduction. Despite their demonstrated impact, rotavirus vaccine coverage is lower than for other vaccines recommended in infancy and disease continues to occur.

We observed higher rotavirus detection rates among patients from provider locations with lower rotavirus vaccine coverage; providers who do not offer rotavirus vaccine to age-eligible children may create pockets of susceptible children that serve as reservoirs of ongoing disease transmission. (Read the full article)

  FOR IMMEDIATE RELEASE September 9, 2019                                                     MEDIA ADVISORY WHAT:  Delaware Insurance Commissioner Trinidad Navarro will be hosting a ribbon cutting and ceremony to commemorate the opening of the […]

As currently funded, $278 million project would unfairly burden electric ratepayers on Delmarva WILMINGTON, Del. – Delaware Governor John Carney and Maryland Governor Larry Hogan on Tuesday sent a letter to members of the Federal Energy Regulatory Commission, urging commissioners to expedite their review of the $278 million Artificial Island transmission line project and consider a […]

Eleven Lenapé-themed programs to be presented at three downtown Dover locations.

Programs explore the importance of railroads to America’s economy and way of life, and their impact on Delaware.

Delaware will hold its 16th Drug Take-Back Day on Saturday, April 28, 2018, to help reduce the risk of prescription medications being diverted for misuse. Delawareans can discard their expired or unused medications at 24 locations statewide between 10 a.m. and 2 p.m.

Newport --

Location: Route 141 southbound to Commons Boulevard, Newport.

Dates and Times: 5:00 a.m. on Tuesday, April 14, 2020 until 3:00 p.m. on Saturday, April 25, 2020.

Traffic Information: DelDOT's contractor will be closing the right-turn lane on Route 141 southbound for gas line relocation. [More]

Wilmington --

The Delaware Department of Transportation (DelDOT) and the City of Wilmington are collaborating on a water line relocation project beginning Friday, May 8, 2020 and will require travel lane changes on I-95 for the next several weeks. Three drinking water transmission mains servicing City residents and businesses will be relocated from underneath the 10^th Street Bridge which spans the interstate to an underground trench that will be dug under I-95.

This work will impact both the northbound and southbound lanes. [More]

Stick to asset allocation matrix, take regular profits and go for bottom fishing in select stocks/ MF schemes in these turbulent times

The objective of a good asset allocation plan is to develop an investment portfolio that helps you reach your financial goals with the degree of risk you find comfortable

Ranked as Counterpoint’s top location and mapping platform in the world

Multi-asset funds of mutual funds can be a good option for asset allocation mix even as gold is a good diversifIer. Also, do keep emergency funds in debt funds & fixed deposits

The year 2020 is not going to be a year to forget. Understanding the nuances and re-learning the basics is a good thing to do.

Recently, an expert committee had recommended for a decentralised development by having three capital cities for legislature, executive and judiciary and putting available resources for balanced regional growth.

Ontario immigration is seeking an enhanced allocation of provincial immigrants from the Canadian federal government it receives every year. It wants the allocation in the Ontario Immigrant Nominee Program at 13,300 by 2021, and it is 7,000 in this year. Reasons…

Hi,

I wanted to find the location of a pin in the design using skill program. pin_dbids = axlDBGetDesign()->pins, this gives me all the dbids of the pins that are present in my design. But when im entering that dbid, pad = axlDBGetPad("000001EA8FD8B9F8" "package geometry/assembly_top" "regular") it is throwing an error stating "This dbid is not user defined. Please enter the user defined". So please provide me a snippet so that I can get the exact pin location in the design using skill script.

Hi 

I'm trying to find the location of the assembly line in the design automatically without using "Show Element". And also I want to find the end points of that line. The line exists in "Package Geometry/Assembly_Top" Layer. So is there any code snippet to find the location of assembly line?

Hi everybody,

I've created a symbol with custom pad shapes. Everything looks correct in the symbol editor.

And the 3d view looks correct (upside down to show placement)

But when I try to place it on the pcb the 2 "T" shaped pads aren't in the correct location.

I have the pad shape centered on the pad...

with no offset on the padstack editor.

Does anybody know how to fix this?

Thank you!

London has been named fDi’s inaugural Fintech Location of the Future for 2019/20, followed by Singapore and Belfast. 

Australia tops the FDI Strategy category of fDi's Tourism Locations of the Future 2019/20 rankings, followed by Costa Rica and Azerbaijan.

The UK is the top country, but Dublin is leading city, for foreign companies setting up headquarters in Europe, according to fDi’s ranking.

Last week India finally held its national solar auction, the first in two years, seen as the least risky of several national and state-level solar auctions held over the past few years.

Nigeria (Blank NEWS Online) –:  The people of Ugborodo Community in Warri South West Local Government Area of Delta State have said that they are satisfied with the current  location […]