General framework for distributed ledger technology (DLT)-based invoices

Framework and metrics for digital human application systems

Framework for telemedicine systems using ultra-high definition imaging

Requirements and reference framework for emergency rescue systems

Requirements and reference framework for cloud virtual reality systems

Technical framework for deep neural network model partition and collaborative execution

Framework for audio structuralizing based on deep neural networks

Requirements and framework for feature-based distributed intelligent systems

Collaborative framework for OTTs

Policy framework including principles for digital identity infrastructure

E-waste management framework for countries

Functional requirements and framework of green data centre energy-saving management system

Energy efficiency framework

The measurement framework for the statistical indicators of website traffic

Security framework for voice-over-long-term-evolution (VoLTE) network operation

Security framework for the Internet of things based on the gateway model

Object identifier-based resolution framework for IoT grouped services

Security requirements and framework for big data analytics in mobile Internet services

Client to authenticator protocol/Universal 2-factor framework

Universal authentication framework

Technical framework for countering mobile in-application advertising spam

ITU-T X.1231 - Supplement on technical framework for countering telephone service scams

Security framework and requirements for service function chaining based on software-defined networking

Framework for solutions to combat counterfeit ICT devices

Framework for interconnection between VoLTE-based network and other networks supporting emergency telecommunications service (ETS)

Framework for combating the use of stolen mobile devices

Wireframing is the first and the most crucial step in deciding the fate of an application. The right wireframe can make an excellent app – turning an idea perfectly into an app, while a wrong wireframe can break everything. And to make a wireframe perfect, you need a wireframing tool to solve your design purpose.  […]

The post Most Popular Wireframe tools Small Business Should Consider in 2022 appeared first on Usability Geek

Here's how to ensure these tools can be used in mission-critical applications

The Canon EOS R5 Mark II can main tank both photography and videography tasks just as well. #canon #eosr5markii

AAA United States Inc is hiring in Miami FLAirframe & Powerplant Mechanic positions available. Visit us to learn more about AAA United States Inc and see our job postings on www.avjobs.com Please reference Avjobs when applying. How do you feel about this type of job?

Fairbanks, AK United States - Job Summary Mechanics will perform maintenance on company aircraft for safe and reliable flights. Mechanics will be familiar with and held accountable to the privileges, limitations, and recency of experience requirements listed in 14 CFR Part 65.81(a), 65.81(b),... View

Blitz opens amid a terrifying conflagration on a nighttime city street…

Public service access to TV is to remain at the heart of UK government policy as a new report warns that over a million viewers are at risk of being excluded in the longterm transition to streaming.

Hugh Grant goes against type and scores as a psycho philosopher in the slow burn horror entry “Heretic.” Grant lures a pair of Mormon missionaries into an elaborate trap in his […]

The post Freeze Frame: “Heretic” (R), “The Best Christmas Pageant Ever” (PG), “Absolution” (R), “Small Things Like These” (PG-13) appeared first on KKFI.

He's pushing education forward with #TheBlackManCan.

ESC Limited and Frameworks announced the “successful merger of their operations” which they said “brings together both entities’ strengths, creating a comprehensive and seamless shopping experience. A spokesperson said, “The union of ESC and Frameworks, effective 31 May 2023, is a testament to their shared vision of providing customers with an integrated and comprehensive shopping […]

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Cybersecurity researchers have disclosed six security flaws in the Ollama artificial intelligence (AI) framework that could be exploited by a malicious actor to perform various actions, including denial-of-service, model poisoning, and model theft. "Collectively, the vulnerabilities could allow an attacker to carry out a wide-range of malicious actions with a single HTTP request, including

Tutorial: How to Frame bead Embroidery

Choosing a Frame

Growth is top of mind for most companies, but it can be tricky to get started with developing a growth framework. For one thing, most companies aren’t organized around growth, so thinking about growth requires a lot of collaboration between teams. Additionally, companies often don’t have easy access to all of the data they need to understand growth.

Programmed ribosomal frameshifting (PRF) is a mechanism used by arteriviruses like porcine reproductive and respiratory syndrome virus (PRRSV) to generate multiple proteins from overlapping reading frames within its RNA genome. PRRSV employs −1 PRF directed by RNA secondary and tertiary structures within its viral genome (canonical PRF), as well as a noncanonical −1 and −2 PRF that are stimulated by the interactions of PRRSV nonstructural protein 1β (nsp1β) and host protein poly(C)-binding protein (PCBP) 1 or 2 with the viral genome. Together, nsp1β and one of the PCBPs act as transactivators that bind a C-rich motif near the shift site to stimulate −1 and −2 PRF, thereby enabling the ribosome to generate two frameshift products that are implicated in viral immune evasion. How nsp1β and PCBP associate with the viral RNA genome remains unclear. Here, we describe the purification of the nsp1β:PCBP2:viral RNA complex on a scale sufficient for structural analysis using small-angle X-ray scattering and stochiometric analysis by analytical ultracentrifugation. The proteins associate with the RNA C-rich motif as a 1:1:1 complex. The monomeric form of nsp1β within the complex differs from previously reported homodimer identified by X-ray crystallography. Functional analysis of the complex via mutational analysis combined with RNA-binding assays and cell-based frameshifting reporter assays reveal a number of key residues within nsp1β and PCBP2 that are involved in complex formation and function. Our results suggest that nsp1β and PCBP2 both interact directly with viral RNA during formation of the complex to coordinate this unusual PRF mechanism.

In SAS Life Science Analytics Framework 4.6, group membership removal fails with an exception if a user is set as assignee, a candidate, or a notification recipient in a user task for a Process Flow . The Process

In SAS Merchandise Financial Planning, custom time frame-based data versions do not aggregate correctly when referenced in worksheets with standard hierarchy levels. The data does not aggregate correctly from l

When you log on to the SAS Risk Governance Framework and choose a solution, the web application might fail to load the solution content. When the problem occurs, you continue to see "Loading..." on the screen, an

The development of the HUPO-PSI's (Proteomics Standards Initiative) standard data formats and MIAPE (Minimum Information About a Proteomics Experiment) guidelines should improve proteomics data sharing within the scientific community. Proteomics journals have encouraged the use of these standards and guidelines to improve the quality of experimental reporting and ease the evaluation and publication of manuscripts. However, there is an evident lack of bioinformatics tools specifically designed to create and edit standard file formats and reports, or embed them within proteomics workflows. In this article, we describe a new web-based software suite (The ProteoRed MIAPE web toolkit) that performs several complementary roles related to proteomic data standards. Firstly, it can verify the reports fulfill the minimum information requirements of the corresponding MIAPE modules, highlighting inconsistencies or missing information. Secondly, the toolkit can convert several XML-based data standards directly into human readable MIAPE reports stored within the ProteoRed MIAPE repository. Finally, it can also perform the reverse operation, allowing users to export from MIAPE reports into XML files for computational processing, data sharing or public database submission. The toolkit is thus the first application capable of automatically linking the PSI's MIAPE modules with the corresponding XML data exchange standards, enabling bidirectional conversions. This toolkit is freely available at http://www.proteored.org/MIAPE/.

Online Disinformation and Political Discourse: Applying a Human Rights Framework Research paper sysadmin 5 November 2019

Although some digital platforms now have an impact on more people’s lives than does any one state authority, the international community has been slow to hold to account these platforms’ activities by reference to human rights law.

This paper examines how human rights frameworks should guide digital technology.

Summary

• Online political campaigning techniques are distorting our democratic political processes. These techniques include the creation of disinformation and divisive content; exploiting digital platforms’ algorithms, and using bots, cyborgs and fake accounts to distribute this content; maximizing influence through harnessing emotional responses such as anger and disgust; and micro-targeting on the basis of collated personal data and sophisticated psychological profiling techniques. Some state authorities distort political debate by restricting, filtering, shutting down or censoring online networks.
• Such techniques have outpaced regulatory initiatives and, save in egregious cases such as shutdown of networks, there is no international consensus on how they should be tackled. Digital platforms, driven by their commercial impetus to encourage users to spend as long as possible on them and to attract advertisers, may provide an environment conducive to manipulative techniques.
• International human rights law, with its careful calibrations designed to protect individuals from abuse of power by authority, provides a normative framework that should underpin responses to online disinformation and distortion of political debate. Contrary to popular view, it does not entail that there should be no control of the online environment; rather, controls should balance the interests at stake appropriately.
• The rights to freedom of thought and opinion are critical to delimiting the appropriate boundary between legitimate influence and illegitimate manipulation. When digital platforms exploit decision-making biases in prioritizing bad news and divisive, emotion-arousing information, they may be breaching these rights. States and digital platforms should consider structural changes to digital platforms to ensure that methods of online political discourse respect personal agency and prevent the use of sophisticated manipulative techniques.
• The right to privacy includes a right to choose not to divulge your personal information, and a right to opt out of trading in and profiling on the basis of your personal data. Current practices in collecting, trading and using extensive personal data to ‘micro-target’ voters without their knowledge are not consistent with this right. Significant changes are needed.
• Data protection laws should be implemented robustly, and should not legitimate extensive harvesting of personal data on the basis of either notional ‘consent’ or the data handler’s commercial interests. The right to privacy should be embedded in technological design (such as by allowing the user to access all information held on them at the click of a button); and political parties should be transparent in their collection and use of personal data, and in their targeting of messages. Arguably, the value of personal data should be shared with the individuals from whom it derives.
• The rules on the boundaries of permissible content online should be set by states, and should be consistent with the right to freedom of expression. Digital platforms have had to rapidly develop policies on retention or removal of content, but those policies do not necessarily reflect the right to freedom of expression, and platforms are currently not well placed to take account of the public interest. Platforms should be far more transparent in their content regulation policies and decision-making, and should develop frameworks enabling efficient, fair, consistent internal complaints and content monitoring processes. Expertise on international human rights law should be integral to their systems.
• The right to participate in public affairs and to vote includes the right to engage in public debate. States and digital platforms should ensure an environment in which all can participate in debate online and are not discouraged from standing for election, from participating or from voting by online threats or abuse.

One of the most difficult problems with quantum computing relates to increasing the size of the quantum computer. Researchers globally are seeking to solve this “challenge of scale.” To bring […]

The post Recipe for Scaling: ARQUIN Framework for Simulating a Distributed Quantum Computing System appeared first on HPCwire.

Bilingual individuals demonstrate different personality characteristics when speaking different languages. Marketers making media and language decisions when addressing multilingual markets should add this finding to their list of influencing factors.

The post Cultural Frame Switching: Different Language, Different Personality appeared first on Neuromarketing.

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.