Ketel Marte does not lack for confidence when it comes to switching from second base/shortstop to center field, which is where he's expected to see a lot of time this season.

It was the eighth inning of a late September game against the Dodgers when D-backs right-hander Yoan Lopez showed that not only might he have the stuff to be a future closer, but also the moxie of one as well.

In the face of mounting public and political opposition to the war in Iraq, recent reports from the White House suggest that President Bush remains serenely confident.

Fidelity is often seen as a bad word in school, but it doesn't have to be that way. In this guest blog by George Toman, the concept of fidelity is explained and defended.

Laurent Gardes.

Source: Electronic Journal of Statistics, Volume 14, Number 1, 661--701.

Abstract:
The first part of the paper is dedicated to the construction of a $gamma$ - nonparametric confidence interval for a conditional quantile with a level depending on the sample size. When this level tends to 0 or 1 as the sample size increases, the conditional quantile is said to be extreme and is located in the tail of the conditional distribution. The proposed confidence interval is constructed by approximating the distribution of the order statistics selected with a nearest neighbor approach by a Beta distribution. We show that its coverage probability converges to the preselected probability $gamma $ and its accuracy is illustrated on a simulation study. When the dimension of the covariate increases, the coverage probability of the confidence interval can be very different from $gamma $. This is a well known consequence of the data sparsity especially in the tail of the distribution. In a second part, a dimension reduction procedure is proposed in order to select more appropriate nearest neighbors in the right tail of the distribution and in turn to obtain a better coverage probability for extreme conditional quantiles. This procedure is based on the Tail Conditional Independence assumption introduced in (Gardes, Extremes , pp. 57–95, 18(3) , 2018).

Gregory J. Matthews, Ofer Harel

Source: Statist. Surv., Volume 5, 1--29.

Abstract:
There is an ever increasing demand from researchers for access to useful microdata files. However, there are also growing concerns regarding the privacy of the individuals contained in the microdata. Ideally, microdata could be released in such a way that a balance between usefulness of the data and privacy is struck. This paper presents a review of proposed methods of statistical disclosure control and techniques for assessing the privacy of such methods under different definitions of disclosure.

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Matthews, G.J., Harel, O., Aseltine, R.H., 2010b. Examining the robustness of fully synthetic data techniques for data with binary variables. Journal of Statistical Computation and Simulation 80 (6), 609–624.

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Sarathy, R., Muralidhar, K., 2002b. The security of confidential numerical data in databases. Info. Sys. Research 13 (4), 389–403.

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Skinner, C., Shlomo, N., 2008. Assessing identification risk in survey microdata using log-linear models. Journal of the American Statistical Association 103, 989–1001.

Skinner, C.J., Elliot, M.J., 2002. A measure of disclosure risk for microdata. Journal of the Royal Statistical Society. Series B (Statistical Methodology) 64 (4), 855–867.

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Sweeney, L., 1997. Guaranteeing anonymity when sharing medical data, the datafly system. Journal of the American Medical Informatics Association 4, 51–55.

Sweeney, L., 2002a. Achieving k-anonymity privacy protection using generalization and suppression. International Journal of Uncertainty, Fuzziness and Knowledge Based Systems 10 (5), 571–588.

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Willenborg, L., de Waal, T., 2001. Elements of Statistical Disclosure Control. Springer-Verlag.

Woodward, B., 1995. The computer-based patient record and confidentiality. The New England Journal of Medicine, 1419–1422.

Uncertainties in a structure is inevitable, which generally lead to variation in dynamic response predictions. For a complex structure, brute force Monte Carlo simulation for response variation analysis is infeasible since one single run may already be computationally costly. Data driven meta-modeling approaches have thus been explored to facilitate efficient emulation and statistical inference. The performance of a meta-model hinges upon both the quality and quantity of training dataset. In actual practice, however, high-fidelity data acquired from high-dimensional finite element simulation or experiment are generally scarce, which poses significant challenge to meta-model establishment. In this research, we take advantage of the multi-level response prediction opportunity in structural dynamic analysis, i.e., acquiring rapidly a large amount of low-fidelity data from reduced-order modeling, and acquiring accurately a small amount of high-fidelity data from full-scale finite element analysis. Specifically, we formulate a composite neural network fusion approach that can fully utilize the multi-level, heterogeneous datasets obtained. It implicitly identifies the correlation of the low- and high-fidelity datasets, which yields improved accuracy when compared with the state-of-the-art. Comprehensive investigations using frequency response variation characterization as case example are carried out to demonstrate the performance.

François Bachoc, David Preinerstorfer, Lukas Steinberger.

Source: The Annals of Statistics, Volume 48, Number 1, 440--463.

Abstract:
We suggest general methods to construct asymptotically uniformly valid confidence intervals post-model-selection. The constructions are based on principles recently proposed by Berk et al. ( Ann. Statist. 41 (2013) 802–837). In particular, the candidate models used can be misspecified, the target of inference is model-specific, and coverage is guaranteed for any data-driven model selection procedure. After developing a general theory, we apply our methods to practically important situations where the candidate set of models, from which a working model is selected, consists of fixed design homoskedastic or heteroskedastic linear models, or of binary regression models with general link functions. In an extensive simulation study, we find that the proposed confidence intervals perform remarkably well, even when compared to existing methods that are tailored only for specific model selection procedures.

Stephen M. S. Lee, Puyudi Yang.

Source: The Annals of Statistics, Volume 48, Number 1, 274--299.

Abstract:
Suppose that a confidence region is desired for a subvector $ heta $ of a multidimensional parameter $xi =( heta ,psi )$, based on an M-estimator $hat{xi }_{n}=(hat{ heta }_{n},hat{psi }_{n})$ calculated from a random sample of size $n$. Under nonstandard conditions $hat{xi }_{n}$ often converges at a nonregular rate $r_{n}$, in which case consistent estimation of the distribution of $r_{n}(hat{ heta }_{n}- heta )$, a pivot commonly chosen for confidence region construction, is most conveniently effected by the $m$ out of $n$ bootstrap. The above choice of pivot has three drawbacks: (i) the shape of the region is either subjectively prescribed or controlled by a computationally intensive depth function; (ii) the region is not transformation equivariant; (iii) $hat{xi }_{n}$ may not be uniquely defined. To resolve the above difficulties, we propose a one-dimensional pivot derived from the criterion function, and prove that its distribution can be consistently estimated by the $m$ out of $n$ bootstrap, or by a modified version of the perturbation bootstrap. This leads to a new method for constructing confidence regions which are transformation equivariant and have shapes driven solely by the criterion function. A subsampling procedure is proposed for selecting $m$ in practice. Empirical performance of the new method is illustrated with examples drawn from different nonstandard M-estimation settings. Extension of our theory to row-wise independent triangular arrays is also explored.

Eduard Belitser, Nurzhan Nurushev.

Source: Bernoulli, Volume 26, Number 1, 191--225.

Abstract:
In the general signal$+$noise (allowing non-normal, non-independent observations) model, we construct an empirical Bayes posterior which we then use for uncertainty quantification for the unknown, possibly sparse, signal. We introduce a novel excessive bias restriction (EBR) condition, which gives rise to a new slicing of the entire space that is suitable for uncertainty quantification. Under EBR and some mild exchangeable exponential moment condition on the noise, we establish the local (oracle) optimality of the proposed confidence ball. Without EBR, we propose another confidence ball of full coverage, but its radius contains an additional $sigma n^{1/4}$-term. In passing, we also get the local optimal results for estimation , posterior contraction problems, and the problem of weak recovery of sparsity structure . Adaptive minimax results (also for the estimation and posterior contraction problems) over various sparsity classes follow from our local results.

The move to middle school can be a rougher adjustment for students who were high achievers at their elementary schools, finds a new study.

Ceftazidime–avibactam and cefiderocol are two of the latest generation β-lactam agents that possess expanded activity against highly drug-resistant bacteria, including carbapenem-resistant Enterobacterales. Here we show that structural changes in AmpC β-lactamases can confer reduced susceptibility to both agents. A multidrug-resistant Enterobacter cloacae clinical strain (Ent385) was found to be resistant to ceftazidime–avibactam and cefiderocol without prior exposure to either agent. The AmpC β-lactamase of Ent385 (AmpC^Ent385) contained an alanine–proline deletion at positions 294–295 (A294_P295del) in the R2 loop. AmpC^Ent385 conferred reduced susceptibility to ceftazidime–avibactam and cefiderocol when cloned into Escherichia coli TOP10. Purified AmpC^Ent385 showed increased hydrolysis of ceftazidime and cefiderocol compared with AmpC^Ent385Rev, in which the deletion was reverted. Comparisons of crystal structures of AmpC^Ent385 and AmpC^P99, the canonical AmpC of E. cloacae, revealed that the two-residue deletion in AmpC^Ent385 induced drastic structural changes of the H-9 and H-10 helices and the R2 loop, which accounted for the increased hydrolysis of ceftazidime and cefiderocol. The potential for a single mutation in ampC to confer reduced susceptibility to both ceftazidime–avibactam and cefiderocol requires close monitoring.

Importance Ceftazidime–avibactam and cefiderocol are newly approved β-lactam agents that possess broad spectrum activity against multidrug-resistant (MDR) Gram-negative bacteria. We show here that a two amino-acid deletion in the chromosomal AmpC β-lactamase, identified in a clinical strain of Enterobacter cloacae, confers reduced susceptibility to both agents. By crystallographic studies of free and drug-bound forms of enzyme, we demonstrate that this deletion in AmpC induces slanting of the H-9 helix that is directly connected with the R2 loop, and disappearance of the H-10 helix, is directly responsible for increased hydrolysis of ceftazidime and cefiderocol. These findings provide novel insights into how MDR Gram-negative bacteria may evolve their β-lactamases to survive selective pressure from these newly developed β-lactam agents.

Unearthing cartels by invoking applicant confidence: Lesser penalty regulations, 2009

Learn how continuous monitoring of suppliers can flag issues and help prevent supply chain disruptions.

Know your supplier: How to confidently choose trustworthy suppliers was published on SAS Voices by Ellen Joyner-Roberson

"I cannot say much about the intelligence we have collected with respect to this. But we know enough now to be confident of this," he said in an interview to Fox News.

Google likes its ambitions sky high. This time, it has gone a little further...

[Daily Maverick] Pension fund fraudster, J Arthur Brown, is one of around 19,000 low-risk prison inmates set to be released as part of President Cyril Ramaphosa's Special Covid-19 parole dispensation.

The Obama administration has taken a lot of heat for creating climate change rules that bypass Congress. But recent court decisions are bolstering the president’s clean air agenda – and they come at a crucial time.

This session will cover how legal privilege can be used to keep documents and communications confidential and how and when to use without prejudice. An essential guide to confidentiality and avoiding some of the pitfalls in real estate disputes. ...

As originally published on CoStar on 07 November 2019 In the first of a regular series, leading real estate lawyer Bruce Dear talks to a senior player in real estate over ...

“To obtain an inheritance which is imperishable and undefiled and will not fade away, reserved in heaven for you” (1 Peter 1:4).

We can rejoice after enduring a trial because our hope in Heaven will be renewed.

The joy a Christian experiences as a result of trials can be the best kind he will ever know. But so often we allow the everyday stress and strain of financial difficulties, health problems, unrealized goals, and many other trials to rob us of our joy in Christ. True joy stems from spiritual realities that are much greater than temporal circumstances.

In today’s verse Peter gives us one strong reason for rejoicing—the confident hope that as Christians we have inherited a place in Heaven. This confidence can be so powerful that Peter, who was writing to believers suffering persecution, describes it as a truth we ought to “greatly rejoice” in (v. 6). This expressive, intense word is always used in the New Testament in relation to the joy of knowing God, never of shallow, temporal relationships.

Jesus’ disciples had a difficult time seeing that trials could be related to the certainty of going to Heaven. In teaching them about His upcoming death, Christ told the Twelve, “Therefore you, too, now have sorrow; but I will see you again, and your heart will rejoice, and no one takes your joy away from you” (John 16:22). And that is exactly what happened when they saw the risen Savior and understood the impact of His work.

We can have two responses to trials, just like passengers riding a train through the mountains. We can look to the left and see the dark mountainside and be depressed. Or we can look to the right and be uplifted by the beautiful view of natural scenery stretching into the distance. Some believers even compound their sadness by continuing to look to the mountain shadows of their trial after life’s train has moved away from the threatening peaks. But they would not forfeit their joy if they simply looked ahead to the brightness and certainty of their eternal inheritance.

Nothing in life can take away the wonderful promise of Heaven’s glory: it was reserved by God, bought by Christ, and guaranteed by the Spirit (see Eph. 1:11-13).

Suggestions for Prayer

Ask the Lord to help you meditate today on the glories promised for you in the future.

For Further Study

Read Revelation 21 and note the primary living conditions that will be true of Heaven.

From Strength for Today by John MacArthur Copyright © 1997. Used by permission of Crossway Books, a division of Good News Publishers, Wheaton, IL 60187, www.crossway.com.

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Across the banking sector, the Bank of England and the Financial Conduct Authority predict that firms’ utilisation of artificial intelligence (AI) solutions will triple in the next three years (BoE and FCA Joint Report on Machine Learning in U...

Malaysia’s politics took another dramatic turn on Friday ahead of its first parliamentary sitting in months as the speaker of the house accepted a motion by former prime minister Mahathir Mohamad to launch a no-confidence vote against his replacement, Muhyiddin Yassin.Mahathir, however, has conceded that he does not believe he has the numbers required to command the majority support of parliament, claiming that Muhyiddin had won over supporters by giving them government roles. “Maybe we will…

Hydrogen sulfide (H₂S), a plant gasotransmitter, functions in the plant response to cadmium (Cd) stress, implying a role for cysteine desulfhydrase in producing H₂S in this process. Whether d-CYSTEINE DESULFHYDRASE (DCD) acts in the plant Cd response remains to be identified, and if it does, how DCD is regulated in this process is also unknown. Here, we report that DCD-mediated H₂S production enhances plant Cd tolerance in Arabidopsis (Arabidopsis thaliana). When subjected to Cd stress, a dcd mutant accumulated more Cd and reactive oxygen species and showed increased Cd sensitivity, whereas transgenic lines overexpressing DCD had decreased Cd and reactive oxygen species levels and were more tolerant to Cd stress compared with wild-type plants. Furthermore, the expression of DCD was stimulated by Cd stress, and this up-regulation was mediated by a Cd-induced transcription factor, WRKY13, which bound to the DCD promoter. Consistently, the higher Cd sensitivity of the wrky13-3 mutant was rescued by the overexpression of DCD. Together, our results demonstrate that Cd-induced WRKY13 activates DCD expression to increase the production of H₂S, leading to higher Cd tolerance in plants.

Cefiderocol inhibited 97.5% of 478 Gram-negative isolates from cancer patients at ≤4 mg/liter. It had potent activity against extended-spectrum β-lactamase-positive Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae (CRE), and nonfermenting Gram-negative bacilli, including Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species isolates. Amikacin, ceftazidime-avibactam, and meropenem had appreciable activity against non-CRE Enterobacteriaceae. No comparators were active against multidrug-resistant P. aeruginosa isolates. Only trimethoprim-sulfamethoxazole had appreciable activity against S. maltophilia isolates. Overall, cefiderocol was associated with the lowest level of resistance.

People with type 1 diabetes may receive a significant portion of their care from primary care providers (PCPs). To understand the involvement of PCPs in delivering type 1 diabetes care, we performed surveys in California and Florida, two of the most populous and diverse states in the United States. PCPs fill insulin prescriptions but report low confidence in providing type 1 diabetes care and difficulty accessing specialty referrals to endocrinologists.

In 1966, the Eliza program couldn’t say much—but it was enough

More than 55 million viewers tuned into last week’s three-day NFL Draft and you better believe Marcus Sayles was one of them. He saw the Minnesota Vikings draft three cornerbacks in ...

The Government's testing tsar has said he is "confident" that the 100,000 daily target for coronavirus tests will be met on Thursday.

"It is the collective wisdom of the marketplace that there is action and we will move with speed. That improves the confidence level of industry."

Arsenal and Manchester United have been linked with a move for Bayern Munich star Corentin Tolisso, but it is the Gunners who may have the transfer edge.

Former Barcelona star Cesc Fabregas says he is "fully confident" that Lionel Messi will see out the rest of his career at the Nou Camp.

David, who was born in Nigeria but has a British passport, owns two companies and also shares a CBD (cannabidiol) business with former heavyweight boxing champion Mike Tyson.

Crystal Palace are confident that manager Roy Hodgson will face no issues attending games when football finally resumes.

A new survey by GfK found there was a slight overall improvement in mood but fears for the future remain.

Solid rainfall has boosted farmer confidence this season and, while uncertainty hangs over the global economy, many remain optimistic that agriculture will weather the storm.

The coronavirus pandemic is understandably weighing heavily on the business sector, but there are early signs of green shoots as one state begins to open up.

Rugby Australia is prepared to hold crisis talks with a group of disgruntled retired Wallabies captains, who have penned a letter to the governing body claiming the game has "lost its way", while demanding a change in leadership.

A third individual pleaded guilty today to illegally accessing numerous confidential passport application files. Gerald R. Lueders, 65, of Woodbridge, Va., pleaded guilty before U.S. Magistrate Judge Alan Kay in U.S. District Court for the District of Columbia to a one-count criminal information charging him with unauthorized computer access.

A former State Department employee was sentenced today to 12 months of probation and ordered to perform 100 hours of community service for illegally accessing more than 150 confidential passport application files. Dwayne F. Cross, 41, of Upper Marlboro, Md., was sentenced by U.S. Magistrate Judge John M. Facciola in Washington, D.C.

A former State Department employee was sentenced today to one year of probation and ordered to pay a $5,000 fine for illegally accessing more than 50 confidential passport application files.

A fourth individual pleaded guilty today to illegally accessing numerous confidential passport application files.

A fifth individual pleaded guilty today to illegally accessing numerous confidential passport application files. Kevin M. Young, 42, of Temple Hills, Md., pleaded guilty before U.S. Magistrate Judge Alan Kay in the District of Columbia to a one-count criminal information charging him with unauthorized computer access. Young is scheduled to be sentenced on Dec. 9, 2009.

A sixth individual pleaded guilty today to illegally accessing numerous confidential passport application files. Karal Busch, 28, of District Heights, Md., pleaded guilty before U.S. Magistrate Judge Alan Kay in the District of Columbia to a one-count criminal information charging her with unauthorized computer access.