Hepatic steatosis, the excess storage of intrahepatic lipids, is a rampant clinical problem associated with the obesity epidemic. Hepatic steatosis is linked to increased risk for insulin resistance, type 2 diabetes, and cardiovascular and advanced liver disease. Accumulating evidence shows that physical activity, exercise, and aerobic capacity have profound effects on regulating intrahepatic lipids and mediating susceptibility for hepatic steatosis. Moreover, exercise can effectively reduce hepatic steatosis independent of changes in body mass. In this perspective, we highlight 1) the relationship between obesity and metabolic pathways putatively driving hepatic steatosis compared with changes induced by exercise; 2) the impact of physical activity, exercise, and aerobic capacity compared with caloric restriction on regulating intrahepatic lipids and steatosis risk; 3) the effects of exercise training (modalities, volume, intensity) for treatment of hepatic steatosis, and 4) evidence for a sustained protection against steatosis induced by exercise. Overall, evidence clearly indicates that exercise powerfully regulates intrahepatic storage of fat and risk for steatosis.

The global COVID-19 spread has gone from bad to worse, with over 3.2 million confirmed cases and close to 250,000 deaths, not only has this pandemic claimed innumerable lives, it has also destabilised economies by freezing trade and other economic...

At age 13, Nadeen Matthews Blair, chief executive officer of the NCB Foundation, challenged the tide to prove to a guidance counsellor at her United States-based school, that black girls can overcome all odds to become powerful leaders. Matthews...

Nicole Stott is an engineer, aquanaut and one of the 220 astronauts to have lived and worked on the International Space Station. In a confined space, under huge pressure, with no way out, it's important that teams maintain healthy dynamics, and individuals can manage their stress adequately, and in this podcast Nicole explains a little about...

The Pentagon announced Tuesday that Sgt. Christopher Wesley Curry died Monday in Iraq in what officials describe as a non-combat-related incident.

A $28.8 million spending bill nearing legislative approval would allocate funding to combat lead in Michigan drinking water systems and investigate sexual assaults by clergy.

Minister of Finance Tito Mboweni has announced a number of "exceptional tax measures as part of the fiscal package outlined by President Cyril Ramaphosa to fight the coronavirus pandemic.

Automated EFT payments enabled by technology from fintech company Ozow may be a secure alternative method to transact than card payments.

Microsoft originally sought to become a 'carbon neutral' company, meaning it could generate carbon emissions as long as it offset them through other means, but "in short, neutral is not enough to address the world's needs," says Microsoft President Brad Smith.

A finance ministry official said some other state governments have also shown interest in borrowing from their respective state CAMPA funds, but refused to name them.

January serves as National Slavery and Human Trafficking Awareness Month, culminating in the annual observation of National Freedom Day on February 1. For many, this month presents an opportunity to refocus efforts to slow, and ultimately stop, human trafficking around the globe, but especially here in the United States. The [...]

The post Analytics can help combat the horrors of human trafficking appeared first on Government Data Connection.

Manufacturers have been told to commence production before July 31, 2020.

The Centre has released Rs 11,092 crore as the first instalment in FY21 to State Disaster Response Mitigation Fund of 28 states.

Recently, Team India captain Virat Kohli had also called upon people to "stay safe and vigilant" in the midst of the coronavirus outbreak.

Voice AI apps can help in prevention, detection and treatment of hundreds of patients at the same time, thus helping mitigate the shortage of doctors

Helyxon’s two solutions—OXY-2 and 98.6 Fever Watch—equipped with geo-fencing tracking alerts, keep a tab on the patient’s vital parameters and inform the medical staff about any aberration.

[News24Wire] Only offenders who committed petty crimes will be eligible to be included in the 19 000 inmates who will be released on parole to combat the spread of Covid-19 in prisons.

The UAE followed Singapore’s swift reaction to combat Covid-19, to preserve the health of its citizens. Now moves are in place to tackle the country’s economic wellbeing.

The Boeing Company is set to design and build a large, military unmanned air vehicle (UAV) in Australia, with the first flight set for 2020. The Australian government will invest A$40 million in the project.

The Reserve Bank of India on Sept. 22, 2011, issued a letter to financial institutions regarding anti-money laundering and the combating of financing of terrorism standards.

The Reserve Bank of India on Sept. 22, 2011, issued a letter to financial institutions regarding anti-money laundering and the combating of financing of terrorism standards.

“The Chinese Communist Party must end its pattern of bullying Southeast Asians out of offshore oil, gas, and fisheries,” said Adm. John Aquilino.

The biggest threat to Brazil's ability to successfully combat the spread of the coronavirus and tackle the unfolding public health crisis is the country's president, Jair Bolsonaro, according to the British medical journal The Lancet.

(MENAFN - Jordan News Agency) Amman, May 9 (Petra) �� Minister of Planning and International Cooperation Wissam Rabadi Saturday discussed with British... ......

(MENAFN - Jordan News Agency) Amman, May 9 (Petra)- Minister of Planning and International Cooperation, Dr. Wissam Rabadi, discussed with the British ... ......

(MENAFN - Khaleej Times) The civic body in Dibba Al Fujairah has ordered the closure of three pharmacies for unreasonably increasing the price of h... ......

As coronavirus pandemic continues, Asian actors, directors and social influencers concerned over increased instances of harassment and racism.

The following is intended to clarify how weight can be controlled when hunger is kept at bay using a reliable, informative tool called the glycemic index.

In response to the global financial crisis in 2008, China rolled out a massive 4 trillion yuan (US$564 billion) stimulus package.With the coronavirus posing an even greater threat to the economy, the outbreak left the top leadership with a decision to make, as the efforts in 2008 also left the nation with a mountain of debt.Before the outbreak, China had already cut the top tier of the value-added tax (VAT) rate to 13 per cent from 16 per cent in April 2019, after a one percentage point cut in…

The Government of Palau will draw down on a $15 million policy-based loan from ADB's Disaster Resilience Program to help finance the country’s response to the novel coronavirus disease (COVID-19) pandemic.

ADB today announced the release of a $6 million grant from its Pacific Disaster Resilience Program (Phase 2) to help finance the Government of the Marshall Islands’ response to the novel coronavirus disease (COVID-19) pandemic.

ADB President Masatsugu Asakawa and Pakistan’s Federal Minister for Economic Affairs and ADB Governor Makhdoom Khusro Bukhtiar today discussed how ADB can scale up its support for the government’s response to the COVID-19...

The Asian Development Bank (ADB) has provided a guarantee for a $25 million trade loan to the State Pharmaceuticals Corporation of Sri Lanka (SPC) to purchase medical supplies as part of the country’s response to the novel ....

A longstanding awareness in generating resistance to common antimicrobial therapies by Gram-negative bacteria has made them a major threat to global health. The application of antimicrobial peptides as a therapeutic agent would be a great opportunity to combat bacterial diseases. Here, we introduce a new antimicrobial peptide (~8.3 kDa) from probiotic strain Lactobacillus acidophilus ATCC 4356, designated acidocin 4356 (ACD). This multifunctional peptide exerts its anti-infective ability against Pseudomonas aeruginosa through an inhibitory action on virulence factors, bacterial killing, and biofilm degradation. Reliable performance over tough physiological conditions and low hemolytic activity confirmed a new hope for the therapeutic setting. Antibacterial kinetic studies using flow cytometry technique showed that the ACD activity is related to the change in permeability of the membrane. The results obtained from molecular dynamic (MD) simulation were perfectly suited to the experimental data of ACD behavior. The structure-function relationship of this natural compound, along with the results of transmission electron microscopy analysis and MD simulation, confirmed the ability of the ACD aimed at enhancing bacterial membrane perturbation. The peptide was effective in the treatment of P. aeruginosa infection in mouse model. The results support the therapeutic potential of ACD for the treatment of Pseudomonas infections.

IMPORTANCE Multidrug-resistant bacteria are a major threat to global health, and the Pseudomonas bacterium with the ability to form biofilms is considered one of the main causative agents of nosocomial infections. Traditional antibiotics have failed because of increased resistance. Thus, finding new biocompatible antibacterial drugs is essential. Antimicrobial peptides are produced by various organisms as a natural defense mechanism against pathogens, inspiring the possible design of the next generation of antibiotics. In this study, a new antimicrobial peptide was isolated from Lactobacillus acidophilus ATCC 4356, counteracting both biofilm and planktonic cells of Pseudomonas aeruginosa. A detailed investigation was then conducted concerning the functional mechanism of this peptide by using fluorescence techniques, electron microscopy, and in silico methods. The antibacterial and antibiofilm properties of this peptide may be important in the treatment of Pseudomonas infections.

Marissa Guale is like all too many Americans right now. Her husband and father of her two children, Raul, is on a ventilator in a hospital on Long Island, fighting for his life while sick with COVID-19. Raul, a 34-year-old nurse, likely caught the disease while working in a nursing home. When the National Institutes of Health announced an emergency use authorization for the experimental antiviral drug remdesivir, Marissa scrambled friends and family on Facebook to figure out how to get access for Raul, emailing hospital administrators, senators, and doctors. They pressed the Guale family’s case for a potentially lifesaving treatment on social media to anyone who would listen.

Her confusion about where and how to get access to the drug isn’t unique. All over the country, families, doctors, and hospitals are wondering how to get the drug and on what basis it’s being distributed. The Trump administration, which is in charge of allocation, hasn’t published any guidance on how it’s making decisions about the scarce supplies of the drug.

So who decides which hospitals get remdesivir? And what’s the most ethical way to prioritize access?

Read more at The Daily Beast.

As cities and states come out of COVID-19 stay-at-home orders, Uber is working on technologies to ensure both drivers and riders have masks in place.

L’UFC s’apprête à reprendre ses combats, à huis clos, samedi à Jacksonville, sept semaines après l’arrêt forcé des compétitions sportives.

Le combattant Ronaldo Souza, qui devait affronter Uriah Hall dimanche lors du gala UFC 249, a reçu un diagnostic positif à la COVID-19, vendredi.

Building upon the successes of earlier efforts, the Department today announced the opening in Bangkok of a regional conference of approximately 100 key law enforcement and industry officials from more than a dozen nations with the goal of strengthening international cooperation in fighting large-scale intellectual property crimes.

The increased efforts and reallocation of personnel recently announced by the Department of Justice builds on the foundation of expertise and experience gained from ongoing efforts to combat Mexican drug cartels in the United States and to help Mexican law enforcement battle cartels in its own country.