A century ago, Susan Pringle Frost tirelessly campaigned to save these South Carolina buildings from destruction

From gas stations to public libraries, these celebrity architect-designed buildings are worth a road trip

To preserve Southern Africa’s relative peace in the face of rising challenges and threats, Southern African Development Community (SADC) member states must collectively reinforce its peace and security architecture.

An increasing number of parents have concerns about childhood vaccines. Parents consistently cite their child’s provider as influential in their vaccine decision-making. Little is known about how providers communicate with parents about vaccines and which communication strategies are important.

How providers initiate the vaccine recommendation at health supervision visits appears to be an important determinant of parent resistance. Also, when providers pursue their original vaccine recommendations in the face of parental resistance, many parents subsequently agree to vaccination. (Read the full article)

More than a decade after the Economic Community of Central African States (ECCAS) was requested by the African Union (AU) to give life to a new peace and security architecture, political and security cooperation on the continent is still in need of reinforcement.

The developers contacted him and concluded that no personal information of any user has been proven to be at risk by the ethical hacker.

  I’m Jean-Claude Cottier, a video game industry veteran. I’ve been working in this field for the last 18 years and in 2008, I’ve setup my own solo game studio: Ovogame. Recently,...

  Introduction Mobile games with stunning graphics and realistic physics are now possible due to the increasing compute power now available on mobile devices. Effects such as grenade explosions in sh...

  Cocos2D is a game engine that works with various devices from PCs to smart phones. This engine supports the vast majority of the features needed to make wonderful 2D-based games; it even includes a fu...

  Intro RenderScript is a scripting language on Android. You can use it to write high performance graphics rendering and raw computational code. The RenderScript API includes high performance func...

As the stakes for winning server segment market share grow ever higher an increasing number of companies are seeking to grasp the latest Holy Grail of multi-chip coherence. The approach promises to better enable applications such as machine learning...(read more)

Enhancing System Architecture Implementation for AI Applications, Microchip Delivers its Analog Embedded SuperFlash® Technology

ABSTRACT

The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to the surface of infected red blood cells (RBCs) via membranous organelles, known as the Maurer’s clefts. We developed a method for efficient enrichment of Maurer’s clefts and profiled the protein composition of this trafficking organelle. We identified 13 previously uncharacterized or poorly characterized Maurer’s cleft proteins. We generated transfectants expressing green fluorescent protein (GFP) fusions of 7 proteins and confirmed their Maurer’s cleft location. Using co-immunoprecipitation and mass spectrometry, we generated an interaction map of proteins at the Maurer’s clefts. We identified two key clusters that may function in the loading and unloading of PfEMP1 into and out of the Maurer’s clefts. We focus on a putative PfEMP1 loading complex that includes the protein GEXP07/CX3CL1-binding protein 2 (CBP2). Disruption of GEXP07 causes Maurer’s cleft fragmentation, aberrant knobs, ablation of PfEMP1 surface expression, and loss of the PfEMP1-mediated adhesion. GEXP07 parasites have a growth advantage compared to wild-type parasites, and the infected RBCs are more deformable and more osmotically fragile.

IMPORTANCE The trafficking of the virulence antigen PfEMP1 and its presentation at the knob structures at the surface of parasite-infected RBCs are central to severe adhesion-related pathologies such as cerebral and placental malaria. This work adds to our understanding of how PfEMP1 is trafficked to the RBC membrane by defining the protein-protein interaction networks that function at the Maurer’s clefts controlling PfEMP1 loading and unloading. We characterize a protein needed for virulence protein trafficking and provide new insights into the mechanisms for host cell remodeling, parasite survival within the host, and virulence.

Many complex human traits exhibit differences between sexes. While numerous factors likely contribute to this phenomenon, growing evidence from genome-wide studies suggest a partial explanation: that males and females from the same population possess differing genetic architectures. Despite this, mapping gene-by-sex (GxS) interactions remains a challenge likely because the magnitude of such an interaction is typically and exceedingly small; traditional genome-wide association techniques may be underpowered to detect such events, due partly to the burden of multiple test correction. Here, we developed a local Bayesian regression (LBR) method to estimate sex-specific SNP marker effects after fully accounting for local linkage-disequilibrium (LD) patterns. This enabled us to infer sex-specific effects and GxS interactions either at the single SNP level, or by aggregating the effects of multiple SNPs to make inferences at the level of small LD-based regions. Using simulations in which there was imperfect LD between SNPs and causal variants, we showed that aggregating sex-specific marker effects with LBR provides improved power and resolution to detect GxS interactions over traditional single-SNP-based tests. When using LBR to analyze traits from the UK Biobank, we detected a relatively large GxS interaction impacting bone mineral density within ABO, and replicated many previously detected large-magnitude GxS interactions impacting waist-to-hip ratio. We also discovered many new GxS interactions impacting such traits as height and body mass index (BMI) within regions of the genome where both male- and female-specific effects explain a small proportion of phenotypic variance (R² < 1 x 10^–4), but are enriched in known expression quantitative trait loci.

G-quadruplex, assembled from a square array of guanine (G) molecules, is an important structure with crucial biological roles in vivo but also a versatile template for ordered functional materials. Although the understanding of G-quadruplex structures is the focus of numerous studies, little is known regarding the control of G-quartet stacking...

Background

Previous studies showed that Cdc42, a member of the prototypical Rho family of small GTPases and a regulator of the actin cytoskeleton, is critical for the normal development and health of podocytes. However, upstream regulatory mechanisms for Cdc42 activity in podocytes are largely unknown.

The cell surfaces of many bacteria carry filamentous polypeptides termed adhesins that enable binding to both biotic and abiotic surfaces. Surface adherence is facilitated by the exquisite selectivity of the adhesins for their cognate ligands or receptors and is a key step in niche or host colonization and pathogenicity. Streptococcus gordonii is a primary colonizer of the human oral cavity and an opportunistic pathogen, as well as a leading cause of infective endocarditis in humans. The fibrillar adhesin CshA is an important determinant of S. gordonii adherence, forming peritrichous fibrils on its surface that bind host cells and other microorganisms. CshA possesses a distinctive multidomain architecture comprising an N-terminal target-binding region fused to 17 repeat domains (RDs) that are each ∼100 amino acids long. Here, using structural and biophysical methods, we demonstrate that the intact CshA repeat region (CshA_RD1–17, domains 1–17) forms an extended polymeric monomer in solution. We recombinantly produced a subset of CshA RDs and found that they differ in stability and unfolding behavior. The NMR structure of CshA_RD13 revealed a hitherto unreported all β-fold, flanked by disordered interdomain linkers. These findings, in tandem with complementary hydrodynamic studies of CshA_RD1–17, indicate that this polypeptide possesses a highly unusual dynamic transitory structure characterized by alternating regions of order and disorder. This architecture provides flexibility for the adhesive tip of the CshA fibril to maintain bacterial attachment that withstands shear forces within the human host. It may also help mitigate deleterious folding events between neighboring RDs that share significant structural identity without compromising mechanical stability.

Discovery of the Breagh gas field in the Southern North Sea (SNS) has demonstrated the potential that the Lower Carboniferous (Visean, 346.7–330.9 Ma) Farne Group reservoirs have to contribute to the UK's future energy mix. New biostratigraphic correlations provide a basis to compare Asbian and Brigantian sedimentary cores from the Breagh Field and age-equivalent sediments exposed on the Northumberland Coast, which has proved critical in gaining an understanding of exploration and development opportunities. Thirteen facies associations characterize the mixed carbonate–siliciclastic system, grouped into: marine, delta front, delta shoreface, lower delta plain and upper delta plain gross depositional environments. The facies associations are interpreted as depositing in a mixed carbonate and siliciclastic fluvio-deltaic environment, and are arranged into coarsening- and cleaning-upward cycles (parasequences) bounded by flooding surfaces. Most cycles are characterized by mouth bars, distributary channels, interdistributary bays and common braided rivers, interpreted as river-dominated deltaic deposits. Some cycles include rare shoreface and tidally-influenced deposits, interpreted as river-dominated and wave- or tide-influenced deltaic deposits. The depositional processes that formed each cycle have important implications for the reservoir net/gross ratio (where this ratio indicates the proportion of sandstone beds in a cycle), thickness and lateral extent. The deltaic deposits were controlled by a combination of tectonic and eustatic (allocyclic) events and delta avulsion (autocyclic) processes, and are likely to reflect a changing tectonic regime, from extension within elongate fault-bounded basins (synrift) to passive regional thermal subsidence (post-rift). Deep incision by the Base Permian Unconformity across the Breagh Field has removed the Westphalian, Namurian and upper Visean, to leave the more prospective thicker clastic reservoirs within closure.

Thematic collection: This article is part of the Under-explored plays and frontier basins of the UK continental shelf collection available at: https://www.lyellcollection.org/cc/under-explored-plays-and-frontier-basins-of-the-uk-continental-shelf

Genome-wide association studies have implicated thousands of noncoding variants across common human phenotypes. However, they cannot directly inform the cellular context in which disease-associated variants act. Here, we use open chromatin profiles from discrete mouse cell populations to address this challenge. We applied stratified linkage disequilibrium score regression and evaluated heritability enrichment in 64 genome-wide association studies, emphasizing schizophrenia. We provide evidence that mouse-derived human open chromatin profiles can serve as powerful proxies for difficult to obtain human cell populations, facilitating the illumination of common disease heritability enrichment across an array of human phenotypes. We demonstrate that signatures from discrete subpopulations of cortical excitatory and inhibitory neurons are significantly enriched for schizophrenia heritability with maximal enrichment in cortical layer V excitatory neurons. We also show that differences between schizophrenia and bipolar disorder are concentrated in excitatory neurons in cortical layers II-III, IV, and V, as well as the dentate gyrus. Finally, we leverage these data to fine-map variants in 177 schizophrenia loci nominating variants in 104/177. We integrate these data with transcription factor binding site, chromatin interaction, and validated enhancer data, placing variants in the cellular context where they may modulate risk.

Unlike replicative senescence, oncogene-induced senescence caused heterochromatin-body formation.

Researchers have used synchrotron light to study what happens to the nerves in diabetes. The technique shows the 3D-structure of nerve fibers in very high resolution.

The International Telecommunication Union (ITU) is a United Nations Organization agency commissioned to regulate international telecommunications between different operating administrations and businesses. Pursuant to specific recommendations by this organization, on 1 July, standard Y.3172, an architecture for machine learning in future networks (5G and beyond), was approved for telecommunications networks.

The Red Sea has fast become the subject of new geopolitical intrigue, as unprecedented engagement between Gulf states and the Horn of Africa reframes politics, economics, and security astride one of the world’s most heavily trafficked waterways. Friends and foes have converged in this increasingly crowded neighborhood as the Red Sea and its environs are…

On May 2, the Center on the United States and Europe at Brookings (CUSE) hosted a discussion with former U.S. National Security Advisor Zbigniew Brzezinski. In his remarks, Brzezinski offered perspectives from his new book, Strategic Vision: America and the Crisis of Global Power (Basic Books, 2012), on how the United States and Europe can…

From a $50,000 portable recycled house to a tiny green egg house for Chinese students, TreeHugger has already offered plenty of posts that prove that green living doesn't have to mean high-end LEED certified luxury.

Referencing traditional terraced agriculture, this modern house with terraces has an integrated rainwater collection and irrigation system that would allow it to grow greenery.

You are not just buying a box but a full service design/build package. Could this take container architecture mainstream?

Aedas designs a railway station like a hill you can walk on.

This digitally fabricated project revives a traditional material with new building technologies.

A new proposal for Hong Kong tries to fit people into pipes.

Because shipping containers are designed to move and these ones might have to.

It's partially built out of Cross Laminated Timber; it "immerses students in this relatively new product."

Pop-up gardens, urban farms, guerrilla bike lanes, examples of crowdsourced city planning, and other urban interventions will be the focus of the official U.S. Pavilion at the world's most prestigious architecture event.

The U.S. Pavilion is spotlighting grassroots efforts to make cities and neighborhoods greener, safer, and happier places to live.

There is a shipping container building revolution coming, but it won't look like a bunch of silly boxes.

Mike Eliason, an American architect working in Germany, explains.

Green roofs, living walls, vertical farms are all part of a new living architecture.

Strange things happen when roofs touch the ground.

Jean-Philippe Pargade designs a school where the green roof IS the building, defining its whole look and feel

Kate Stohr, the co-founder of Architecture for Humanity, dropped me a note suggesting that I have a look at their Year in Review of their work in Haiti. I did, and couldn't help but come to the conclusion that it was really boring.. I mean really,

It's wonderful to see architects take small interventions for housing for the homeless so seriously.

Building "combines affordable housing with wood construction and the promotion of new technologies."

It's the country's biggest architectural award and quite a few are TreeHugger friendly

They deserve an award for putting on such a terrific award program.

What can you do at a music festival in four days with 75 volunteers and lots of salvaged materials? Build some amazing performance stages, that's what. Last year we reported on the Roots Architecture project at the WOMAD

The ones we have left should be preserved; they don't make them like they used to.

This company creates modern, energy-efficient versions of the backyard 'granny flat'.