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Large second harmonic generation and birefringence from extended octupolar π-conjugated structures

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05756B, Edge Article
Open Access
Danyang Dou, Bingbing Zhang, Daqing Yang, Ying Wang
By adopting an extended octupolar π-conjugation strategy, two excellent optical functional materials with a strong SHG response and large birefringence were prepared.
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Three in one: engineering MOF channels via coordinated water arrays for regulated separation of alkanes and alkenes

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05286B, Edge Article
Open Access
Lu-Lu Ma, Pavel N. Zolotarev, Kang Zhou, Xin Zhou, Jiaqi Liu, Jiafeng Miao, Shenfang Li, Guo-Ping Yang, Yao-Yu Wang, Davide M. Proserpio, Jing Li, Hao Wang
Regulated adsorptive separation of alkane/alkenes has been achieved through engineering the coordinated water arrays in MOF channels.
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Simultaneous generation of hydroxyl and hydrogen radicals from H+/OH− pairs caused by water–solid contact electrification

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC06227B, Edge Article
Open Access
Fengjie Chen, Jingde Wu, Dou Wang, Yu Xia, Qingyuan Song, Ying Liang, Pu Wang, Bolei Chen, Yong Liang, Yongguang Yin, Yawei Wang, Maoyong Song, Guibin Jiang
Water–solid contact electrification is a common physical phenomenon involving interfacial electron and ion transfer, recently discovered to trigger unique redox reactions.
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Franklin Templeton India makes a debt fund comeback: Should you invest in its ultra short duration NFO?

The ultra short duration scheme is a new offering from the fund house after a long gap




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PM Modi participates in 200th year celebrations of Shree Swaminarayan Mandir in Gujarat




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New CJI Sanjiv Khanna aims to reduce trial duration




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Real-time monitoring of a 3D blood–brain barrier model maturation and integrity with a sensorized microfluidic device

Lab Chip, 2024, 24,5085-5100
DOI: 10.1039/D4LC00633J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Ceccarelli, Marie Celine Lefevre, Attilio Marino, Francesca Pignatelli, Katarzyna Krukiewicz, Matteo Battaglini, Gianni Ciofani
A new in vitro sensorized model of the blood–brain barrier has been developed and characterized.
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Integrated device for plasma separation and nucleic acid extraction from whole blood toward point-of-care detection of bloodborne pathogens

Lab Chip, 2024, 24,5124-5136
DOI: 10.1039/D4LC00571F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Abigail G. Ayers, Christia M. Victoriano, Samuel K. Sia
This work presents PRECISE, a device that integrates plasma separation and nucleic acid extraction, enabling streamlined sample preparation of whole blood for point-of-care diagnostics without external equipment or electricity.
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Laugh in life: Kochi-based comedians Abhishek and Akshay on their latest show, their inspirations and more

The duo has been performing stand-up comedy for around three years now.




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HC flays police inaction in clearing blockade to Thiruvananthapuram Corporation office




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Decision on extending Warehousing Corporation MD’s tenure soon, govt. tells HC




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Self-declaration for advertisers limited to food, health sectors

I&B Ministry stated that advertisements issued for products related to food and health sectors will be required to upload an annual self-certificate on the Broadcast Seva Portal and Press Council of India portal.  




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Health Ministry directs FSSAI to waive off registration fee for street food vendors

Union Health Minister, Jagat Prakash Nadda also stressed on providing ‘Street Safe’ Rapid Testing Kit to ensure safe food is used by street food vendors and highlighted the need to empower them by enrolling them on food delivery platforms




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Govt issues operational guidelines for under PM-Surya Ghar: Muft Bijli Yojana

A total financial outlay of ₹800 crore has been allocated for this component, providing ₹1 crore per selected model solar village, the Ministry said




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Nitish Kumar skipped NITI Aayog meet over refusal of special category status to Bihar: CPI(ML) Liberation leader

Mehboob Alam, CPI(ML) L leader in the Bihar Assembly, said, “I must say that Kumar skipped the meeting out of embarrassment over the refusal of the Centre to grant special category status to Bihar.”




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Wayanad landslide: More than 1,000 government employees engaged in 24x7 relief operations, says CMO

The government staff are handling the coordination of the search and rescue effort, distribution of relief materials, counselling of landslide victims with medical conditions




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‘Father of Indian chess boom’: The Anand effect that’s shaping a ‘golden generation’

The country swept both the men's and women's gold at the 45th Olympiad in Budapest, Hungary




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Trump rules out former Cabinet members Mike Pompeo, Nikki Haley in his administration

Pompeo served as the CIA Director and Secretary of State in his first term, Haley served as his ambassador to the United Nations in the first two years of Trump’s presidency




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On paper characterisation of droplet and evaporation study using impedance spectroscopy

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00303A, Paper
O. Kare Siva Prakasam, Akashlina Basu, Koel Chaudhury, Soumen Das
A paper chip employs an impedance method to determine the characteristics of the droplet. We compare the traditional evaporation method with the electrical method to study the evaporation of various liquids.
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Simple and convenient preconcentration procedure for the isotopic analysis of uranium in seawater

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY01381B, Paper
Minami Abe, Noriaki Seko, Hiroyuki Hoshina, Shigeki Wada, Shinya Yamasaki, Keisuke Sueki, Aya Sakaguchi
Amidoxime adsorbent was synthesised by graft polymerisation. The adsorbent was efficient for collection of U in seawater for both the adsorption and desorption steps, thus affording a new strategy for measurement of U isotopes.
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A simple, fast and inexpensive approach to quantify low concentrations of iron in biodiesel by voltammetry after extraction induced by microemulsion breaking

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00342J, Paper
Cristian Henrique Krause, Alexandre Batista Schneider, Leandro Kolling, Lauren Thauani Teixeira Oliveira, Márcia M. Silva
An alternative approach to assay iron (Fe) in biodiesel by differential pulse adsorptive cathodic stripping voltammetry (DPAdCSV) is presented herein. The sample treatment involved a simple, rapid, but effective extraction...
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Direct solid sample analysis of low-cost jewelry using spectroanalytical techniques: exploratory chemical data evaluation and metal migration with synthetic sweat

Anal. Methods, 2024, 16,2286-2291
DOI: 10.1039/D4AY00325J, Paper
Thaila Lorena de Araújo, Fabiola Manhas Verbi Pereira, Edenir Rodrigues Pereira-Filho
Jewelry samples were directly analyzed using LIBS and XRF.
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The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00219A, Paper
Yumin Yang, Daojin Li, Bingqian Liu
Shikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.
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Novel advanced materials and magnetic solid phase extraction as approaches in sample preparation to enhance the analysis of ochratoxin A in peanuts

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00246F, Paper
Bingchen Wang, Yifan Wang, Xiuyuan Zhang, Kuo He
In order to improve the detection efficiency of ochratoxin, a superparamagnetic nano-material was synthesized for solid phase extraction of ochratoxin.
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How mobile data can help rationalise bus routes




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Politicising the laddu: On the Tirupati laddu and its ‘adulteration’

The Tirupati laddu issue should be limited to one of quality control




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Sweet and sour: On the laddu ‘adulteration’ case  

The inquiry into laddu adulteration must not be communalised




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​Allow for deliberation: On the legitimate demands of Ladakh

The lack of a legislature and regional autonomy in Ladakh has led to the current protests




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​Celebration and vigil: On India, kala-azar and trachoma

India must not let its guard down on kala-azar




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SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway

RSC Med. Chem., 2024, 15,3460-3468
DOI: 10.1039/D4MD00405A, Research Article
Xiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli Bi
Schematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.
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Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024)

RSC Med. Chem., 2024, 15,3371-3394
DOI: 10.1039/D4MD00384E, Review Article
Debasis Das, Lingzhi Xie, Jian Hong
Prospects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.
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Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity

RSC Med. Chem., 2024, 15,3609-3615
DOI: 10.1039/D4MD00501E, Research Article
Open Access
Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. Veale
Rationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.
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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
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Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
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Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs

About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive




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Tiruchi Corporation office expansion plan witnesses more delay




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Delhi L-G inspects Gole Market restoration project




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Issue of infiltration in Santhal Pargana was raised, Hemant did not listen: Champai Soren

The longtime JMM-loyalist, who has now switched to the BJP, adds that decisions he had taken as CM — on tribal language education, PESA implementation, and jump-starting state recruitments — have been put on hold now




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2024 Pacificon Inspires Next Generation of Radio Amateurs




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Handbook 101: A New Generation of Amateur Radio




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Desecration of a way of life

A story of how China ripped into the genteel charm of the traditional Buddhist society in Tibet




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In love with operations management

The author brings aesthetics into a field obsessed with quantification




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Of crowds and irrational behaviour

The book unravels how people rationalise facts to fit them into their perceptions




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For people with aspirations

A book that focuses on an oft neglected aspect — soft skills




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First International Dairy Federation Asia-Pacific summit in Kochi from June 26 to 28




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Mangrove restoration in T.N. makes a small but steady progress

The Tamil Nadu Forest Department and non-governmental organisations are working to restore mangroves at various sites of the Ennore-Pulicat wetlands. In the meantime, the National Centre for Coastal Research has identified land available for restoration in Cuddalore, Tiruvarur, Thanjavur, Pudukkottai, Ramanathapuram, and Thoothukudi




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Singapore Arbitration Centre to open office at GIFT City

The Arbitration and Conciliation Act lays down a time frame of 18 months for the disputes to be resolved.




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Nilgiris district administration urges people living downstream of Emerald Dam to take adequate safety measures

The Nilgiris district administration said that owing to work on the new Kundah hydro power house in Kattukuppai, water stored in the Emerald Dam will be released




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Karaikal police round up history-sheeters under ‘Operation Trishul’

Eight long-pending non-bailable warrants were successfully executed, and two arrests made under the Arms Act for possession of dangerous weapons