Eric Peterman, Mindaugas Valius, and Rytis Prekeris

During mitotic cell division, the actomyosin cytoskeleton undergoes several dynamic changes that play key roles in progression through mitosis. While the regulators of cytokinetic ring formation and contraction are well-established, proteins that regulate cortical stability during anaphase and telophase have been understudied. Here, we describe a role for CLIC4 in regulating actin and actin-regulators at the cortex and cytokinetic cleavage furrow during cytokinesis. We first describe CLIC4 as a new component of the cytokinetic cleavage furrow that is required for successful completion of mitotic cell division. We also demonstrate that CLIC4 regulates the remodeling of sub-plasma membrane actomyosin network within the furrow by recruiting MST4 kinase and regulating ezrin phosphorylation. This work identifies and characterizes new molecular players involved in regulating cortex stiffness and blebbing during late stages of cytokinetic furrowing.

The number and diversity of tectonic landforms in our solar system “is truly remarkable,” Watters and Schultz write. Photographs of these structures have stimulated a range of scholarly investigations.

The post Book Review: Planetary Tectonics examines otherworldly landforms appeared first on Smithsonian Insider.

The Smithsonian’s National Museum of Natural History recently acquired four remarkable gemstones and jewelry pieces for the Smithsonian’s National Gem Collection in celebration of the 100th anniversary of the museum.

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Images obtained by NASA’s MErcury Surface, Space ENvironment, GEochemistry and Ranging (MESSENGER) spacecraft during the low-altitude orbital phase of the mission have revealed previously undetected […]

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John Ososky, preparator in the Osteology Laboratory at the Smithsonian's National Museum of Natural History in Washington, D.C., explains how skeletons of animal specimens are prepared for exhibtion and for study—with the assistance of nearly 1 million flesh-eating beetles.

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"The Antarctic Treaty Summit: Science-Policy Interactions in International Governance" will be convened at the Smithsonian Institution, National Museum of Natural History in Washington, DC from Nov. 30 to Dec. 3 2009. More information on this event can be found at the Web site: www.atsummit50.aq/

To assess legacy lessons about managing nearly 10% of the Earth "for peaceful purposes only"

Find out how you can be involved:

www.atsummit50.aq

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The post Device at the Smithsonian Environmental Research Center examines how phytoplankton would react if the ozone layer vanished appeared first on Smithsonian Insider.

The post How do paleontologists identify dinosaur teeth? Smithsonian Curator Matthew Carrano identifies Cretaceous dinosaur teeth from the Washington D.C. area. appeared first on Smithsonian Insider.

The Smithsonian has launched an ambitious project to scan millions of items and make them available to the world on a searchable database. CBS reporter […]

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The National Air and Space Museum will reopen the “Boeing Milestones of Flight Hall” July 1 in conjunction with the museum’s 40th anniversary. The two-year […]

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Peter Sefton, D.C. Preservation League trustee, reflects on how Washington, D.C. has changed in recent years. (Anacostia Community Museum video series)  

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White-faced capuchin monkeys in Panama’s Coiba National Park habitually use hammer-and-anvil stones to break hermit crab shells, snail shells, coconuts and other food items, according […]

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The move enhances coordination efforts for the 46-plot research network, which partners with more than 75 institutions in 21 countries.

The post Global forest science research center moves from Harvard to the National Museum of Natural History, Washington, D.C. appeared first on Smithsonian Insider.

On March 26, 1912, a donation from Japan arrived in Washington, D.C.―3,020 ornamental cherry trees, sparking one of the biggest springtime annual attractions in the […]

The post Washington, D.C.’s Cherry Trees are Very Good at Planning for the Future appeared first on Smithsonian Insider.

Muted moans of sadness punctuated the pandemonium that engulfed the Smithsonian’s National Zoo over the weekend as throngs of well-wishing visitors flooded through the Zoo’s […]

The post Bon Voyage Bao Bao! Washington loses its precious treasure appeared first on Smithsonian Insider.

Is it foolish to be optimistic about our environment and its future prospects? Every day, we hear dire warnings about the health of the planet […]

The post The Argument for Environmental Optimism: Opinion by Smithsonian Secretary David J. Skorton appeared first on Smithsonian Insider.

The crystal structures of caesium di­hydrogen arsenate(V) bis­[tri­hydrogen arsen­ate(V)], Cs(H2AsO4)(H3AsO4)2, ammonium di­hydrogen arsenate(V) tri­hydrogen arsenate(V), NH4(H2AsO4)(H3AsO4), and dilithium bis­(di­hydrogen phosphate), Li2(H2PO4)2, were solved from single-crystal X-ray diffraction data. NH4(H2AsO4)(H3AsO4), which was hydro­thermally synthesized (T = 493 K), is homeotypic with Rb(H2AsO4)(H3AsO4), while Cs(H2AsO4)(H3AsO4)2 crystallizes in a novel structure type and Li2(H2PO4)2 represents a new polymorph of this composition. The Cs and Li compounds grew at room temperature from highly acidic aqueous solutions. Li2(H2PO4)2 forms a three-dimensional (3D) framework of PO4 tetra­hedra sharing corners with Li2O6 dimers built of edge-sharing LiO4 groups, which is reinforced by hydrogen bonds. The two arsenate compounds are characterized by a 3D network of AsO4 groups that are connected solely via multiple strong hydrogen bonds. A statistical evaluation of the As—O bond lengths in singly, doubly and triply protonated AsO4 groups gave average values of 1.70 (2) Å for 199 As—OH bonds, 1.728 (19) Å for As—OH bonds in HAsO4 groups, 1.714 (12) Å for As—OH bonds in H2AsO4 groups and 1.694 (16) Å for As—OH bonds in H3AsO4 groups, and a grand mean value of 1.667 (18) Å for As—O bonds to nonprotonated O atoms.

The com­pound poly[2-hy­droxy-N-methyl­ethan-1-aminium [μ3-cyanido-κ3C:C:N-di-μ-cyanido-κ4C:N-dicuprate(I)]], {(C3H10NO)[Cu2(CN)3]}n or [meoenH]Cu2(CN)3, crystallizes in the tetra­gonal space group P43. The structure consists of a three-dimensional (3D) anionic CuICN network with noncoordinated protonated N-methyl­ethano­lamine cations providing charge neutrality. Pairs of cuprophilic Cu atoms are bridged by the C atoms of μ3-cyanide ligands, which link these units into a 43 spiral along the c axis. The spirals are linked together into a 3D anionic network by the two other cyanide groups. The cationic moieties are linked into their own 43 spiral via N—H⋯O and O—H⋯O hydrogen bonds, and the cations inter­act with the 3D network via an unusual pair of N—H⋯N hydrogen bonds to one of the μ2-cyanide groups. Thermogravimetric analysis indicates an initial loss of the base cation and one cyanide as HCN at temperatures in the range 130–250 °C to form CuCN. We show how loss of a specific cyanide group from the 3D CuCN structure could form the linear CuCN structure. Further heating leaves a residue of elemental copper, isolated as the oxide.

If the dilute and dispose approach for disposing of the surplus plutonium in the Waste Isolation Pilot Plant (WIPP) is fully implemented, the U.S. Department of Energy (DOE) should use two independent review teams to develop public trust in and improve its decisions, says a new interim report by the National Academies of Sciences, Engineering, and Medicine.

Most of the alternative technologies to open burning and open detonation (OB/OD) of conventional munitions designated for disposal are mature, including contained burn and contained detonation chambers with pollution control equipment, and many are permitted to replace OB/OD of waste munitions, says a new report by the National Academies of Sciences, Engineering, and Medicine.

The first-ever Nobel Prize Summit, Our Planet, Our Future, will bring together Nobel Laureates and other world-renowned experts and leaders to advance new insights into global sustainable development and explore actions that need to be taken to ensure humanity’s future on a prosperous, stable, and resilient planet.

Autonomous vehicles (AV) took center stage at the Chair’s Luncheon of the Transportation Research Board’s annual meeting today.

The U.S. Department of Energy’s plan to dilute and dispose of 34 metric tons of surplus plutonium in the Waste Isolation Pilot Plant (WIPP) in New Mexico is technically viable, provided that the plan’s implementation challenges and system vulnerabilities are resolved.

Henry E. Huntington in 1907.; Credit: Theo C. Marceau, New York City. The Huntington Library, Art Museum, and Botanical Gardens

One of the most prized treasures of LA County is 100 years old this year.

The Huntington Library is beloved for its lush botanical gardens and fine art.

As KPCC's Brianna Flores reports, you can trace its origins to a pivotal moment in Southern California history.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Brian Dennehy, known for his interpretations of characters created by Eugene O'Neill and Arthur Miller, has died at the age of 81.; Credit: Mike Piscitelli /Dennehy Family

Brian Dennehy could go from viciously intimidating on film to weak and weary on stage. The actor died yesterday of cardiac arrest. His family says his death was not related to COVID-19. He was 81 years old.

Dennehy had a vast and varied body of work. On screen he was known for his roles in First Blood, Cocoon, and Tommy Boy. In theater, he earned wide acclaim for his depiction of the beleagured Willy Loman in the 1999 Broadway revival of Arthur Miller's Death of a Salesman. That performance earned him one of his two Best Actor Tony Awards. He earned the other in 2003 for his portrayal of family patriarch James Tyrone in Eugene O'Neill's Long Days Journey into Night.

Brian Manion Dennehy was born in Bridgeport, Connecticut, on July 9, 1938, and grew up on Long Island, New York. He was tall and broad-chested and played football in high school, but was also in love with theater. As an Irish Catholic, he didn't see much of a future for himself in acting until he saw Marlon Brando in On the Waterfront. "For the first time when I saw that picture, I realized there were people in the business who looked like me, and who sounded like me. And who came from places I came from" he said in an interview with WHYY's Fresh Air in 1999. "Before that time, acting was like ballet — something I could appreciate but never consider myself a part of."

On stage, Dennehy was a revered actor, particularly in the Chicago theater scene. His two Tony-award winning performances began at the famed Goodman Theatre, where he also performed in Samuel Beckett's Krapp's Last Tape. On Broadway, his credits include Translations, Love Letters, and Inherit the Wind.

Earlier in his career, Dennehy wasn't picky about his roles — and he wasn't shy about it either. "I had kids," he said in the Fresh Air interview. "I had kids who were ready to go to college, and I knew I had the responsibility — which I did not resent — to make sure they had good educations." Dennhey said his wide range of roles on television, where he acted in everything from Dynasty to M*A*S*H to Just Shoot Me, helped him become a more efficient actor. Dennehy worked all throughout his life, most recently appearing in the television series The Blacklist, as well the upcoming independent film Driveways.

This content is from Southern California Public Radio. View the original story at SCPR.org.

There are still a couple dozen tickets left for one of the most interestingly-cast performances of H.G. Wells, Orson Welles and Howard Koch's "War of the Worlds." On Saturday, Jan. 17,  generations of Star Trek actors will take on the world's most famous radio show.

The cast — directed by Jim Fall — features: René Auberjonois (“Star Trek: Deep Space Nine”), Michael Dorn (“Star Trek: TNG”), Dean Haglund (“The X-Files”), Walter Koenig ("Star Trek"), Linda Park ("Star Trek: Enterprise"), Jason Ritter (“The Event”), Tim Russ (“Star Trek: Voyager”), Armin Shimerman (“Star Trek: Deep Space Nine”) and Wil Wheaton, playing... Orson Welles.

The performance is a fundraiser for Sci-Fest LA, the new annual science fiction play festival, so tickets aren't cheap — but they're scarce, and this looks like a memorable night.

KPCC and "Off-Ramp" celebrated the 75th anniversary of the broadcast last year by distributing the original 1938 performance, and a new documentary, internationally... introduced by George Takei, another original Trek actor you might have heard of.

War of the Worlds: Sat., Jan. 17,  8 PM; The Acme Theatre, 135 North La Brea Ave. LA CA 90036

This content is from Southern California Public Radio. View the original story at SCPR.org.

New entrance at The Huntington Library, Art Collections, and Botanical Gardens. ; Credit: Tim Street-Porter/The Huntington

For years, I’d feared the worst. Behind that intrusive belt of chain link and green canvas fence, with all the hidden noise of power digging machines, smashing jackhammers and growling tractors going on behind it, and heaps of dirt piled high, I dreaded that something terrible was going on in the dark, hidden heart of our dear old Huntington.

We were promised a new visitor center, a new store, a new cafe and restaurant. I imagined the Disney-fied worst: Henry Huntington’s Roller Coaster Red Car Ride; Pinky’s Pinkberry Parlor. The Blue Boy Fashion Center. Maybe even a giant Rem Koolhaas-LACMA style amoeba of purple reinforced concrete sprawling all over the lawns between the library and the old gallery.

My fears were groundless. The $68 million (not much more than the Getty paid for its new Manet) 52,000 square foot Education and Visitor Center addition is in perfect harmony with the early 20th Century original library and art gallery, perhaps more so than some previous increments, such as the nearby and blankly imposing Munger Research Center. 

The addition is named after outgoing Huntington chief Steven S. Koblik, who engineered much of the funding and planning for the facility. He’s got something to be proud of in his retirement: a new garden-centered segment of new facilities that founder, pioneer transit tycoon Henry Huntington, would probably have enthused over.

(The Huntington Store at The Huntington Library, Art Collections, and Botanical Gardens. Photo: Tim Porter-Street/The Huntington)

With its mighty $400 million endowment and the muscular fundraising power that enticed squillionaire Charlie Munger to donate hugely to this project (not to mention that research center), the venerable Huntington institution could have easily erected something expensively and grandiloquently modern.  

But its directorate and patrons seem to understand an important fact about the place: Most visitors don’t go there to be dazzled. We go there to be enthralled, even comforted by the century-old institution’s enduring and deeply reassuring ambiance that we are privileged to inhabit during our visits to its galleries of great art, its acreage of exquisite gardens and Arcadian vistas.

The Huntington possesses what designer Sheryl Barton, who co-created the new landscaping with the Huntington’s Jim Folsom, spoke of at the opening press conference as “the choreography of experience.”

That experience includes the new California-Mediterranean groves and gardens and the low-lying new structure that includes an expanded store, new classrooms, courts, cafes and an auditorium. With its simple, Tuscan-columned loggias and red-tiled roofs (and, oh, yes, even that showy glass dome on the Rose Hills Foundation Garden Court), it all effortlessly blends into the traditional whole.

Although the Huntington doesn’t seem to be planning on a new influx of visitors, it’s hard to see this new, more user-friendly front office isn’t going to attract more people to its San Marino location than the current 600,000 per year.

Particularly considering how regional museum attendance in general has boomed over recent decades. Will this abate the quiet private experience many of us Huntington fans have shared and treasured over the years?

(The Huntington will be installing this Alexander Calder sculpture, the  Jerusalem Stabile, this spring. Here, it's seen at the Rijksmuseum, Amsterdam. Calder Foundation; gift of the Philip & Muriel Berman Foundation to the Calder Foundation. Copyright © 2015 Calder Foundation /Artists Rights Society (ARS) Used with permission of The Huntington)

Probably. But there will also be important new things to see — like  Alexander Calder’s 12-by-20-foot Jerusalem Stabile, which beckons you into the new addition, and two powerful, newly acquired murals by the great 20th Century California artists Millard Sheets and Doyle Lane. Plus a new and glorious vista from the cafe’s terrace over to the original old Huntington villa — now gallery — where all this began, over a century ago.

This content is from Southern California Public Radio. View the original story at SCPR.org.

On Monday, California State University, Fullerton announced it was planning to begin the fall 2020 semester online, making it one of the first colleges to disclose contingency plans for prolonged coronavirus disruptions.

"Our plan is to enter [the fall] virtually," said Pamella Oliver, the schools provost, at a virtual town hall. "Of course that could change depending on the situation, depending on what happens with COVID-19. But at this point that's what we're thinking."

The public institution in Southern California also said it hopes to resume in-person learning when it's safe to do so.

Oliver asked faculty to start planning for fall virtual classes now, citing the pain felt this spring when the university was forced to transition to online classes. "Having to jump quickly, without having in-depth plans," she said, "added to the difficulty."

Colleges and universities moved spring classes online, and many also closed campuses in response to the coronavirus pandemic. Schools are now grappling with how long the disruptions will last, and what the fall semester will look like, but many have been hesitant to announce their fall plans publicly.

College enrollment was already on a downward trend before the pandemic, making it a competitive field for college recruiters — every student they sign up counts. The big question is: Will students still enroll if college is all online? And will colleges that were already in dire financial straits survive the outbreak?

This content is from Southern California Public Radio. View the original story at SCPR.org.

Patt Morrison models a headdress from the movie "The Lone Ranger."; Credit: Michelle Lanz/KPCC

Trust me – you’re going to be seeing a lot of these between now and Halloween.

I went to “The Lone Ranger” premiere last month, and outside the theater, Disneyland began selling a version of the Tonto headdress dreamed up by Johnny Depp and his folks for his role in the film, which I found to be a rollicking, ironic version of the classic action adventure with some very sober scenes evoking Native Americans’ tragic history.

The inspiration, Depp says, was artist Kirby Sattler’s interpretive 2006 painting “I Am Crow.”

Depp himself has claimed Native American ancestry, and the bird atop his bean plays a substantial if silent role in the proceedings. It is an interpretive painting, as I said, not a literal rendering of any tribal makeup. In the Sattler painting, the bird is flying above the figure’s head, not perched on it.

But the movie’s invested in storytelling, not the fine points of accuracy. If it had been, it wouldn’t have made the historical solecisms of relocating both Monument Valley and the transcontinental railroad to … Texas.

This content is from Southern California Public Radio. View the original story at SCPR.org.

David Rolf, International Vice President of the Service Employees International Union, stands in his downtown Seattle office. Rolf led the campaign to bring a $15 minimum wage to Seatac, Washington in 2013.; Credit: Ben Bergman/KPCC

As Los Angeles mulls a law that would raise the minimum wage above the current California minimum of $9 an hour, it's the latest city to jump on a trend that started as the by-product of a failed labor negotiation in the state of Washington.

The first city to enact a $15-per-hour minimum wage was SeaTac, Wash., — a tiny airport town outside Seattle. "SeaTac will be viewed someday as the vanguard, as the place where the fight started," the lead organizer of SeaTac's $15 campaign, David Rolf, told supporters in November 2013 after a ballot measure there barely passed.

Rolf never set out to raise SeaTac’s minimum wage, much less start a national movement. Speaking from a sparse corner office in downtown Seattle at the Service Employees International Union 775, which he founded in 2002, Rolf told KPCC that his original goal in 2010 was to unionize workers at SeaTac airport.

When employers – led by Alaska Airlines — played hardball, Rolf put the $15 minimum wage on the ballot as leverage. “We had some polling in SeaTac that it could pass, but it was not at all definitive,” Rolf said.

That proved prescient: In a city of just 12,108 registered voters, Rolf's staff signed up around 1,000 new voters, many of them immigrants who had never cast a ballot. The measure won by just 77 votes.

It's an irony that the new law doesn't apply to workers at the center of the minimum wage campaign: The airport workers at SeaTac. That's because the Port of Seattle, which oversees the airport, challenged the initiative, arguing that the city's new minimum wage should not apply to the nearly 5,000 workers at the airport. A county judge agreed. Supporters of the $15 wage have appealed.

Still, Rolf said, "I think people are proud that that’s what happening. There are leaders of the movement in Seattle, including our mayor, that said shortly after the victory, 'Now we have to take it everywhere else.'"

The $15 minimum wage spread to Seattle last June and to San Francisco in November. 

Why $15 an hour?

The $15 figure first came to people’s attention in a series of strikes by fast food workers that started two years ago in New York. 

“I think it’s aspirational, and it provides a clean and easy-to-understand number," Rolf said. "You can debate whether it ought to really be $14.89 or $17.12, and based upon the cost of living in different cities, you could have a different answer. But in the late 19th and early 20th century, American workers didn’t rally for 7.9 or 8.1 hour working day. They rallied for an eight-hour day.”

“What’s really remarkable about social protest movements in American history is that the radical ideas of one group are often the common sense ideas of another group in a matter of a few years," said Peter Dreier, professor of politics at Occidental College.

Rolf is hopeful the $15 minimum wage can spread to every state. But Nelson Lichtenstein, Director of the Center for the Study of Work, Labor and Democracy at the University of California, Santa Barbara, is skeptical.

“I don’t think having high wages in a few cities will mean it will spread to red state America,” he said. 

Lichtenstein said cities like L.A. have become more labor friendly, thanks largely to an influx of immigrants, but that’s not the case in the South. Oklahoma recently banned any city from setting its own minimum wage, joining at least 12 other states with similar laws, according to Paul Sonn, general counsel and program director at the National Employment Law Project.

In November, voters in four Republican-leaning states — Alaska, Arkansas, South Dakota, and Nebraska — approved higher minimum wages, but they weren’t close to $15.

A $15 dollar wage would have a much greater impact in Los Angeles than Seattle or San Francisco because the average income here is much lower than in those cities. Post-recession, income inequality has become much more of a concern for voters, which has made $15 more palatable, Sonn said.

This fall, the Los Angeles City Council enacted a $15.37 minimum wage for hotel workers that takes effect next year. A similar law has been in effect around LAX since 2007. 

But even though California cities have been allowed to set their own minimum wages for more than a decade, L.A. has never come close to doing so.

Until now.

This content is from Southern California Public Radio. View the original story at SCPR.org.

How to transition to a remote workforce in a safe manner – How to protect yourself from COVID-19 scams – Stantinko's miner caught using new obfuscation techniques

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What COVID-19 may mean for privacy rights – Managing supply-chain risks – Two Windows zero-days remain unpatched

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Staying safe from coronavirus-themed scams – Securing remote desktop connections – The security risks of videoconferencing

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What to know about passwords in Zoom - What to do if your phone goes missing - Email provider hacked

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Sextortion-meets-coronavirus scams - The financial loss from coronavirus-themed fraud in America - Is the time ripe for one global set of data privacy rules?

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ESET research into vulnerabilities in smart home hubs – Discovering and disrupting a botnet in Latin America – Digital assistants in the work-from-home era

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