Sensible, inclusive regulation of pastoralism that has mitigated tension in parts of the Sahel should be extended to the Democratic Republic of Congo (DRC) and the Central African Republic (CAR), where conflicts have worsened with the southward expansion of pastoralism.

The United Nations Security Council decided on 10 April to deploy a peacekeeping mission in the Central African Republic (CAR) which will take over the mission of the African Union (MISCA), which itself succeeded the mission of the Economic Community of Central African States (MICOPAX).

To stabilise the Central African Republic (CAR), the transitional government and its international partners need to prioritise, alongside security, action to fight corruption and trafficking of natural resources, as well as revive the economy.

In Central African Republic, the conflict between armed groups is now compounded by a conflict between armed communities. The roadmap to end the crisis including elections late 2015 presents only a short-term answer and risks exacerbating existing tensions. The transitional authorities and their international partners must address crucial issues by implementing a comprehensive disarmament policy and reaffirming that Muslims belong within the nation.

En Centrafrique, la course aux élections qui prévoit des scrutins présidentiel et législatif avant la fin de l’année est aussi irréaliste que dangereuse. Alors que le plan initial de la transition a complètement déraillé, l’obstination des internationaux, et plus particulièrement de la France, à faire voter les Centrafricains à l’ombre des groupes armés, avec une administration territoriale squelettique et des haines inter-communautaires tenaces ressemble plus à une fuite en avant qu’à un processus de transition accompli.

Carbapenems are currently the preferred agents for the treatment of serious Acinetobacter infections. However, whether cefepime/cefpirome can be used to treat Acinetobacter bloodstream infection (BSI) if it is active against the causative pathogens is not clear. This study aimed to compare the efficacy of cefepime/cefpirome and carbapenem monotherapy in patients with Acinetobacter BSI. The population included 360 patients with monomicrobial Acinetobacter BSI receiving appropriate antimicrobial therapy admitted to four medical centres in Taiwan in 2012–2017. The predictors of 30-day mortality were determined by Cox regression analysis. The overall 30-day mortality rate in the appropriate antibiotic treatment group was 25.0% (90/360 patients), respectively. The crude 30-day mortality rates for cefepime/cefpirome and carbapenem therapy were 11.5% (7/61 patients) and 26.3% (21/80 patients), respectively. The patients receiving cefepime/cefpirome/carbapenem therapy were infected by Acinetobacter nosocomialis (51.8%), A. baumannii (18.4%) and A. pittii (12.1%). After adjusting for age, Sequential Organ Failure Assessment (SOFA) score, invasive procedures, and underlying diseases, cefepime/cefpirome therapy was not independently associated with a higher or lower 30-day mortality compared to the carbapenem therapy. SOFA score (hazard ratio [HR], 1.324; 95% confidence interval [CI], 1.137–1.543; P < 0.001) and neutropenia (HR, 7.060; 95% CI, 1.607–31.019; P = 0.010) were independent risk factors for 30-day mortality of patients receiving cefepime/cefpirome or carbapenem monotherapy. The incidence density of 30-day mortality for cefepime/cefpirome versus carbapenem therapy was 0.40% versus 1.04%. The therapeutic response of cefepime/cefpirome therapy was comparable to that of carbapenems among patients with Acinetobacter BSI receiving appropriate antimicrobial therapy.

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 patients, mostly children enrolled in a multicentre trial from 10 sites in Africa. A linear relationship described the QTc-prolonging effect of piperaquine, estimating a 5.90ms mean QTc-prolongation per 100ng/mL increase in piperaquine concentration. The effect of piperaquine on absolute QTc-interval estimated a mean maximum QTc-interval of 456ms (EC₅₀=209ng/mL). Simulations from the pharmacokinetic-pharmacodynamic models predicted 1.98-2.46% risk of having QTc-prolongation > 60ms in all treatment settings. Although piperaquine administration resulted in QTc-prolongation, no cardiovascular adverse events were found in these patients. Thus, the use of dihydroartemisinin-piperaquine should not be limited by this concern.

Aspergillus niger, the third species responsible for invasive aspergillosis has been considered as a homogeneous species until DNA-based identification uncovered many cryptic species. These species have been recently reclassified into the Aspergillus section Nigri. However little is yet known among the section Nigri about the species distribution and the antifungal susceptibility pattern of each cryptic species. A total of 112 clinical isolates collected from 5 teaching hospitals in France and phenotypically identified as A. niger were analyzed. Identification to the species level was carried out by nucleotide sequence analysis. The Minimum Inhibitory Concentrations (MICs) of itraconazole, voriconazole, posaconazole, isavuconazole and amphotericin B were determined by both the EUCAST and gradient concentration strips methods. Aspergillus tubingensis (n=51, 45.5%) and A. welwitschiae (n=50, 44.6%) were the most common species while A. niger accounted for only 6.3% (n=7). The MICs of azoles drugs were higher for A. tubingensis than for A. welwitschiae. The MIC of amphotericin B was 2 mg/L or less for all isolates. Importantly, MICs determined by EUCAST showed no correlation with those determined by gradient concentration strips methods, these latter being lower than the former (Spearman's rank correlation tests ranging - depending on the antifungal agent - from 0.01 to 0.25; p>0.4). In conclusion, A. niger should be considered as a minority species in the section Nigri. The differences in MICs between species for different azoles underline the importance of accurate identification. Significant divergences in the determination of MIC between EUCAST and gradient concentration strips methods require further investigation.

Anidulafungin and micafungin were quantified in cerebrospinal fluid (CSF) of critically ill adults and in cerebral cortex of deceased patients. In CSF, anidulafungin levels (<0.01-0.66 μg/ml) and micafungin levels (<0.01-0.16 μg/ml) were lower than the simultaneous plasma concentrations (0.77-5.07 μg/ml and 1.21-8.70 μg/ml, respectively). In cerebral cortex, anidulafungin and micafungin levels were 0.21-2.34 μg/g and 0.18-2.88 μg/g, respectively. Thus, MIC values of several pathogenic Candida strains exceed concentrations in CSF and in brain.

Treatment of exacerbations of chronic Pseudomonas aeruginosa infections in patients with cystic fibrosis (CF) is highly challenging due to hypermutability, biofilm formation and an increased risk of resistance emergence. We evaluated the impact of ciprofloxacin and meropenem as monotherapy and in combination in the dynamic in vitro CDC biofilm reactor (CBR). Two hypermutable P. aeruginosa strains, PAOmutS (MIC_{ciprofloxacin} 0.25 mg/L, MIC_meropenem 2 mg/L) and CW44 (MIC_{ciprofloxacin} 0.5 mg/L, MIC_meropenem 4 mg/L), were investigated for 120h. Concentration-time profiles achievable in epithelial lining fluid (ELF) following FDA-approved doses were simulated in the CBR. Treatments were ciprofloxacin 0.4g every 8h as 1h-infusions (80% ELF penetration), meropenem 6 g/day as continuous infusion (CI; 30% and 60% ELF penetration) and their combinations. Counts of total and less-susceptible planktonic and biofilm bacteria and MICs were determined. Antibiotic concentrations were quantified by UHPLC-PDA. For both strains, all monotherapies failed with substantial regrowth and resistance of planktonic (≥8log₁₀ CFU/mL) and biofilm (>8log₁₀ CFU/cm²) bacteria at 120h (MIC_{ciprofloxacin} up to 8 mg/L, MIC_meropenem up to 64 mg/L). Both combination treatments demonstrated synergistic bacterial killing of planktonic and biofilm bacteria of both strains from ~48h onwards and suppressed regrowth to ≤4log₁₀ CFU/mL and ≤6log₁₀ CFU/cm² at 120h. Overall, both combination treatments suppressed amplification of resistance of planktonic bacteria for both strains, and biofilm bacteria for CW44. The combination with meropenem at 60% ELF penetration also suppressed amplification of resistance of biofilm bacteria for PAOmutS. Thus, combination treatment demonstrated synergistic bacterial killing and resistance suppression against difficult-to-treat hypermutable P. aeruginosa strains.

Given that GoDaddy's GoCentral Online Store is an add-on service to its web hosting product, you'll find its features a little more limited than much of the competition. But if you're a GoDaddy customer, then it's a great way to start quickly.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Thanks to its compact, fanless design, the Lenovo ThinkCentre M90n Nano IoT is a tiny and silent mini PC with enough power for basic office and media-streaming tasks, as well as vertical-market and digital-signage use.

Lenovo's IdeaCentre 510A is an unassuming budget desktop in every sense. It'll perform basic tasks without hurting your wallet, but some alternatives do it better at this price point.

Yong Y. Han
Dec 1, 2005; 116:1506-1512
ARTICLES

When people can’t leave their houses to attend an event, you bring the event to them. With residents across Pennsylvania sheltering in place during the COVID-19 pandemic, Penn State Dickinson Law’s Business Law Society is converting two upcoming entrepreneur pop-up clinics to virtual sessions, allowing people to participate from their homes.

The intercollege minor in entrepreneurship and innovation (ENTI) continues to spread its influence as it graduates its largest number of students this spring with 153 across eight clusters.

Penn State Brandywine is offering a complimentary virtual seminar on Practical Social Media Tactics for the Busy Entrepreneur from 11:30 a.m. to 1:30 p.m. May 18, through Zoom video conferencing.

A rising Penn State senior has submitted a video to a national contest promoting the 2020 Census, which includes several other Penn State students and University President Eric Barron.

One of the giants of the literacy world is grappling with the recent push for the "science of reading"—and responding to critics who say her early reading program doesn't align to evidence-based practice.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

Next-generation sequencing has revolutionized the diagnostic process, making broadscale testing affordable and applicable to almost all specialties; however, there remain several challenges in its widespread implementation. Barriers such as lack of infrastructure or expertise within local health systems and complex result interpretation or counseling make it harder for frontline clinicians to incorporate genomic testing in their existing workflow. The general population is more informed and interested in pursuing genetic testing, and this has been coupled with the increasing accessibility of direct-to-consumer testing. As a result of these changes, primary care physicians and nongenetics specialty providers find themselves seeing patients for whom genetic testing would be beneficial but managing genetic test results that are out of their scope of practice. In this report, we present a practical and centralized approach to providing genomic services through an independent, enterprise-wide clinical service model. We present 4 years of clinical experience, with >3400 referrals, toward designing and implementing the clinical service, maximizing resources, identifying barriers, and improving patient care. We provide a framework that can be implemented at other institutions to support and integrate genomic services across the enterprise.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

The 64 entrants are confirmed, 32 in the UEFA Champions League path and 32 in the domestic champions path to be drawn on Tuesday.

This week’s episode of #EntrepreneurCorner features Antoinette Prophy, who talks about starting her own business at the age of 26, and the benefits of surrounding yourself with smart employees.

Jose, an Argentinian worker serving in Southeast Asia, tells of how he entered overseas service and what he has seen God do through his not-so-typical ministry.

The economic meltdown has seen the world's leading central bankers including the South African Reserve Bank come under pressure to bail out their respective economies in the form of interest rate cuts. They've been urged to fund governments, an idea that central bank governor, Lesetja Kganyago, says is tantamount to a client instructing their banker to do the same.

DOVER — Two Delaware families are becoming homeowners in central Dover with the purchase of single-family homes constructed by NCALL as part of the Restoring Central Dover initiative. NCALL, the Delaware State Housing Authority, elected officials and other partners and supporters celebrated the project today, part of a multi-pronged approach to homeownership and economic development […]

The Great Valley LaunchBox, funded by Invent Penn State, will provide mentoring services, office hours, workshops, speakers series and more to the local entrepreneurial community.

A total of 57 clubs have entered the rebranded competition and will be in the preliminary and main round draws at 14:15CET on Thursday 5 July.

A total of 57 clubs will be in the preliminary and main round draws, streamed at 14:00CET on Thursday.

Through propensity score analysis, we examine the effect of living in a segregated area on the development of neonatal IVH, stratified by maternal race.

An app of praise and worship songs is allowing Central Asian believers to share and access music in their heart languages.

Central Asians experienced God’s transformation in their own lives. Now they mobilise others to the least reached in their region.

Books played an important role in Aslan's salvation. Now he provides literature to other Central Asians.

A small team share stories and spread hope among least-reached Muslims in Central Asia.

The Delaware Libraries Inspiration Space announces a new initiative to enable small business owners to expand their knowledge with the latest ideas from the business world’s thought leaders. A Book Club for Entrepreneurs will launch at the Lewes Public Library on Tuesday, January 9, 2018 at noon. Small business owners will have the opportunity to […]

Smart and connected television sets have been around for some years now but the large-scale proliferation will have huge impact on the entertainment and video ecosystem.

Any brand, in order to become stronger, has to constantly connect with its consumers. The entire theory of stimulus-response works on the principle of brands sending a stimulus for consumers to respond.

The Supreme Court came down hard on Centre and states over the issue of pollution in the national capital. Citing examples of developed nations, the Court questioned why Delhi is choking every year. "Delhi is choking every year and we are not able to do anything.Every year this is

New Delhi: The Supreme Court came down hard on Centre and states over the issue of pollution in the national capital. Citing examples of developed nations, the Court questioned why Delhi is choking every year. "Delhi is choking every year and we are not able to do anything.Every year

Ms Sitharaman also said that about three crore farmers with agri loans totaling Rs 4,22,113 crore availed the benefit of the 3-month loan moratorium.

An Indian-origin man has pleaded guilty to an arson attack on a commercial centre in UK's Leicester in central England and is scheduled to get sentenced for the crime at a hearing in June.

Senior Congress leader P Chidambaram today welcomed the Centre's decision to borrow additional 4.2 lakh crore and said it should be used to provide relief to the poor and re-start the economy.

The Congress on Saturday said there was "confusion" within the central government in its fight against the novel coronavirus and wondered how the country will tackle the pandemic if officials...

Coronavirus India Live Updates:Over 3,000 people tested positive for novel coronavirus or COVID-19 in India in 24 hours, taking the total to 59,662 cases, the Union Health Ministry said this morning....

The Union health Ministry will send central teams to 10 states with surging coronavirus cases, the ministry said in a statement.