"America's Funniest Home Videos" will resume the remainder of season 30 the following week at 7:00/6:00c.

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My therapist wants me to start blogging again. Which, okay. I’m a writer, and the way I used to work things out was to write about what was going on. But something happened to me a few years ago that made that outlet impossible to use properly for a few years; it basically broke my […]

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Switchzilla issues a whopping 30+ patches in time for the long UK weekend

Cisco has emitted a fresh round of software updates to address nearly three dozen security holes in its products.…

Date: April 27, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating 50 years of Kids Coding!

Help stop the spread of COVID-19 by following these steps.
 

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Date: April 28, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating Cricket!

Help stop the spread of COVID-19 by following these steps.  
 

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Date: April 29, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating Oskar Fischinger!
 

Help stop the spread of COVID-19 by following these steps.  
 

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Date: April 30, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Clara Rockmore!
 

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Date: May 1, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2018 Doodle game celebrating Garden Gnomes!
 

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Date: May 4, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Wilbur Scoville!
 

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Date: May 5, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2019 Doodle game celebrating Lotería!
 

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Date: May 6, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

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Our 2016 Doodle game celebrating Halloween!
 

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Date: May 7, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

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Our 2017 Doodle game celebrating the birth of Hip Hop!
 

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Date: May 8, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

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Our 2010 Doodle game celebrating PAC-MAN!
 

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Brown and beige adipose tissues contain thermogenic fat cells that can be activated by β3-adrenergic receptor agonists. In rodents, such drugs both diminish obesity and improve glucose homeostasis. In this issue of the JCI, O’Mara et al. and Finlin and Memetimin et al. report that chronic administration of the approved β3 agonist mirabegron to human subjects was without effect on body weight or fat mass, but improved several measures of glucose homeostasis. Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that β3 agonists could have therapeutic utility in disorders of glucose homeostasis.

BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998.

The indie cinema chain is going digital.

The post Studio Coffee Run 5/8/20: Alamo On Demand brings new and old films to your home theater appeared first on The Beat.

Real heroes deserve their own comics/Los héroes reales merecen sus propios comics

The post Heroes always come home in David Rubín’s free COVID-19 SUPERMAN story (version en español incluída) appeared first on The Beat.

If you've only ever had refried beans from a can, this should be the next recipe you cook. Homemade refried beans are a game-changer. Use just the right amount of olive oil to cook well-minced onions along with the beans and plenty of their broth. Smoked paprika adds a hint of smoky depth you can't quite put a finger on, my secret ingredient is a finishing splash of freshly squeezed lemon juice. I think it's the element that helps keep the beans from seeming too heavy, and the acidity counters the starchiness of the beans.

Continue reading Homemade Refried Beans on 101 Cookbooks

Pets at Home, the UK’s leading pet specialist retailer and IBM today announced the launch of Sales Assist, an IBM MobileFirst for iOS app for iPad which will be used across 440 stores nationwide to make it easier and simpler for customers to purchase the products they need.

My first job out of college was teaching biology, chemistry, physics, and vocational agriculture at Triway High School in rural Wooster, Ohio. I lasted for six weeks. The school environment was such a downer, from the smoke-filled teachers’ lounge to my young co-workers who were teaching mainly, it seemed to me, to avoid service in Vietnam. So when a reporting job became available, I jumped on it, leaving Ohio forever. Years later I returned to teaching, this time at Stanford University, where I worked for six years. Now, 37 years after Stanford, I’m teaching my kids at home thanks to COVID-19. You may be teaching your kids, too. This column is my attempt to make your job easier. It’s not that I’m God’s gift to […]






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Are my tools going to be stolen? Is my car going to be stolen? What if she refuses to leave? What if she leaves in the middle of the night? What if she leaves the door open? What if she has lice or bedbugs or hepatitis? What if she locks herself in the bathroom? What if she never wakes up? And I'm sure she worried about me.

IBM is bringing its expertise in sports venue infrastructure design and implementation to the practice field for newly formed Major League Soccer Club, Atlanta United, providing a year-round, state-of-the art technological experience for the players and staff.

IBM annonce aujourd’hui que son nouveau cloud pour les fabricants d’appareils électroniques fournira à la TV connectée de Philips de nouveaux services internet, afin de proposer une gamme de services plus interactifs à des millions de téléspectateurs dans plus de 30 pays en Europe, mais aussi au Brésil et en Argentine.

One of Australia’s leading digital banks taps cognitive technology to simplify the home loan application process with innovative virtual assistan

nevver:

Nobody home, Alyssa Miserendino

20aliens:

Home of Architect Colin St. John Wilson, Cambridge, England 1972. 

約45分程の心地好い時間が流れる佑、健吾君、絢斗とシネフィルが集まっているのに皆知らないフリして名作をそっと撫でている事に映画愛に感じたまんまと『ラブソング』が観たくなり今まさに観ているそう言った様々な映画への導きが作り手と視聴者とをタイムリーに繋ぐ希有で新たな映画の生まれ方を観た気がするそしてAFROさんは俳優としても魅力的な事が世の中にバレたので収束したら俳優業でも忙しくなるのだろうなhttps://www.youtube.com/channel/UCGEWtIp6qF..

Bring the galaxy home on May the 4th.

On March 31, the volunteer computing part of SETI@home will stop distributing work and will go into hibernation.

We're doing this for two reasons:

1) Scientifically, we're at the point of diminishing returns; basically, we've analyzed all the data we need for now.

2) It's a lot of work for us to manage the distributed processing of data. We need to focus on completing the back-end analysis of the results we already have, and writing this up in a scientific journal paper.

However, SETI@home is not disappearing. The web site and the message boards will continue to operate. We hope that other UC Berkeley astronomers will find uses for the huge computing capabilities of SETI@home for SETI or related areas like cosmology and pulsar research. If this happens, SETI@home will start distributing work again. We'll keep you posted about this.

If you're currently running SETI@home on your computer, we encourage you to attach to other BOINC-based projects as well. Or use Science United and sign up to do astronomy. You can stay attached to SETI@home, of course, but you won't get any jobs until we find new applications.

We're extremely grateful to all of our volunteers for supporting us in many ways during the past 20 years. Without you there would be no SETI@home. We're excited to finish up our original science project, and we look forward to what comes next.

SETI@home will stop distributing tasks soon, but we encourage you to continue donate computing power to science research - in particular, research on the COVID-19 virus. The best way to do this is to join Science United and check the "Biology and Medicine" box.

Well! I have really neglected to update since the last time I posted, I was headed off to Japan! As it turned out, our flight landed in Japan exactly one minute before the earthquake occurred. We were taxi-ing along the runway when the plane began to rock severely. The long and the short of the whole story is that Narita Airport was closed so they couldn't get us through customs and after a 14 hour flight from the US they then kept us on the plane for about another 10 hours on the ground before we could file into the airport where we then spent the night sleeping on the floor among thousands of others. After a long ordeal, we finally made it to our hotel and were able to see some of Tokyo, but the city was not itself. We really loved Japan, though, and I hope we can go back again sometime!

During all of that, the dogs were well taken care of back at home! They loved staying at Canine Crews in Chicago and made these paw paintings for St Patrick's Day.

As the coronavirus pandemic has forced us to break out of our normal sports and fitness routines, these innovators -- and professional athletes -- are making the most of their time at home with creative takes on the games and workouts we know and love.

Místo zájezdu nové brýle a namísto pravidelné masáže konzultace s lékařem na dálku. Vládní opatření proti koronaviru změnila také čerpání zaměstnaneckých benefitů. Na rozdíl od výplat je však firmy nekrátí.

Kvůli koronavirové pandemii pracují z domova tisíce lidí. Home office má však určitý pracovně-právní rámec, což tuší málokdo. Jaká jsou práva a povinnosti zaměstnanců a co musí zaměstnavatel udělat, aby neporušil zákoník práce? Ve spolupráci s právníky Bořivojem Líbalem a Markem Poloni přinášíme praktický servis rad pro zaměstnance a zaměstnavatele.

Práci z domova u zaměstnanců soukromých firem nelze jednostranně nařídit, vzniká jen na základě dohody obou stran. U pedagogických pracovníků a zaměstnanců škol však platí trochu jiná pravidla. Ve spolupráci s právníky Bořivojem Líbalem a Markem Polonim přinášíme odpovědi na nejčastější dotazy pedagogů.

I have to say, I think Anand is learning more at home being unschooled than he was in school, and is much happier. Which isn’t to say that he isn’t missing some things that could use more disciplined teaching, and I’m hoping Kevin and I will have more time to do that this summer after the semester’s … Continue reading "Learning From Home"