Six Colorado restaurants and distilleries have been nominated for James Beard awards. Here's what to order from them.

How strong is our economy if it can’t absorb shocks? If growth comes at a great expense to future generations? And where is the scorecard that tells us how we are actually doing?

On Saturday, a host of Denver businesses — from clothing stores to hair salons — will open their doors for the first time in nearly two months as Mayor Michael Hancock’s stay-at-home order expires.

On Saturday, a host of Denver businesses — from clothing stores to hair salons — will open their doors for the first time in nearly two months as Mayor Michael Hancock’s stay-at-home order expires.

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The network gets recognized for its outstanding series.

Kevin gets the big call at a bad time.

Duane is a little salty he got left out.

Kevin’s within reach of an Oscar!

She’s spilling all the tea.

B. Simone breaks down the 2019 BET Awards nominees.

Does Meek Mill have the greatest rap intro of all time?

He also revealed the inspiration behind “Beamer.”

B. Simone breaks down the 2019 BET Awards nominees.

The presidential candidates address the racial wealth gap.

The presidential candidate shares his campaign initiatives.

International BET Breaks hosts share their perspectives.

She also reveals her secret to career-home balance.

TRB’s Airport Cooperative Research Program (ACRP) Conference Proceedings on the Web 23: Economic and Social Sustainability at Airports is a compilation of the presentations and a summary of the ensuing discussions at May 7-8, 2018, forum in Washington, D.C. The meeting brought together individuals from airports, airlines, academia, consulting, local and regional government, general sustainability professionals, and others. The forum included sessions on social sustainability, economic sustainability, key...

TRB’s Airport Cooperative Research Program (ACRP) Conference Proceedings on the Web 23: Economic and Social Sustainability at Airports is a compilation of the presentations and a summary of the ensuing discussions at May 7-8, 2018, forum in Washington, D.C. The meeting brought together individuals from airports, airlines, academia, consulting, local and regional government, general sustainability professionals, and others. The forum included sessions on social sustainability, economic sustainability, key...

The Marine Board of the National Academies of Sciences, Engineering, and Medicine (National Academies) is seeking nominations for new members to be appointed to three-year terms that would commence on November 1, 2020. There will be five (5) vacancies on the Board in 2020 and there is particular interest in candidates with expertise in the following areas: Naval Architecture and Naval Engineering Shipbuilding/Shipyard Operations Vessel Pilotage and Harbor Operations Seaport Administration, Planning, and ...

A new breed of smart telescopes is set to take users past these hurdles, and get them out under the night sky. We recently had a chance to put Vaonis’ Stellina ‘smart telescope’ through its paces, and we’re intrigued at the glimpse it provides at the future of observational astronomy.

The post Our Review of Stellina: a ‘Smart Telescope’ for 21st Century Astronomy appeared first on Universe Today.

[I am happy to turn this space over to my former colleague and (I trust) lifelong friend Romans Pancs, who offers what he describes as a polemical essay. It has no references and no confidence intervals. It has question marks. It makes a narrow point and does not weigh pros and cons. It is an […]

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1.8 million people in the United States drive heavy trucks for a living and are at risk of losing their jobs when trucks become autonomous. That number is from the BLS category heavy and tractor-trailer trucking with 1.8 million employees. A separate category Delivery Truck Drivers and Driver/Sales Workers has 1.3 million workers. The heavy duty truckers are more at risk than the local delivery drivers because it is easier to automate long haul driving on interstates than to automate driving on more complex (cross traffic, pedestrians, parked cars, etc) local roads. Plus, delivery drivers have to run up to houses and businesses to make most deliveries. Building robots to do that work will take longer. Railroad operation is easier...

Uber also made a deal with Volvo to cooperate on self-driving cars. Self-driving cars are an existential threat to Uber if Uber doesn't develop them first. Suppose Ford makes self-driving cars viable a few years before does and rolls them out in many cities. Uber gets wiped out by Ford's ability to charge less for a ride. Uber's big competitive advantage from a large set of recruited drivers could vanish as fast as sufficiently safe autonomous vehicles can get manufactured. Sufficiently safe: that's the challenge. But autonomous vehicle makers who limit themselves to some urban markets can lower the bar for their initial roll-out by just excluding any streets and corners that are too tricky to handle. They'll lose some...

Already we've hit the $1000 genome and faster and cheaper DNA sequencing is on the way. DNA sequencing is going through a speed-up and cost-cutting rate that is similar to that which computer processors have been going through for decades. While the doubling rate of computer power has slowed quite a bit the rate of decrease in DNA sequencing costs has kept up the pace and, in fact, the rate of decline in DNA sequencing costs suddenly accelerated at the end of 2007 has been going down pretty sharply ever since. The cost decline seemed to halt during 2014 only to plunge in 2015. So why should you care? Really cheap massive amounts of DNA sequencing of cancerous cells will...

Date: May 1, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2018 Doodle game celebrating Garden Gnomes!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

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BACKGROUND Neurofibroma/schwannoma hybrid nerve sheath tumors (N/S HNSTs) are neoplasms associated with larger nerves that occur sporadically and in the context of schwannomatosis or neurofibromatosis type 2 or 1. Clinical management of N/S HNSTs is challenging, especially for large tumors, and established systemic treatments are lacking.METHODS We used next-generation sequencing and array-based DNA methylation profiling to determine the clinically actionable genomic and epigenomic landscapes of N/S HNSTs.RESULTS Whole-exome sequencing within a precision oncology program identified an activating mutation (p.Asp769Tyr) in the catalytic domain of the ERBB2 receptor tyrosine kinase in a patient with schwannomatosis-associated N/S HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic and metabolic response. Analysis of a multicenter validation cohort revealed recurrent ERBB2 mutations (p.Leu755Ser, p.Asp769Tyr, p.Val777Leu) in N/S HNSTs occurring in patients who met diagnostic criteria for sporadic schwannomatosis (3 of 7 patients), but not in N/S HNSTs arising in the context of neurofibromatosis (6 patients) or outside a tumor syndrome (1 patient), and showed that ERBB2-mutant N/S HNSTs cluster in a distinct subgroup of peripheral nerve sheath tumors based on genome-wide DNA methylation patterns.CONCLUSION These findings uncover a key biological feature of N/S HNSTs that may have important diagnostic and therapeutic implications.FUNDING This work was supported by grant H021 from DKFZ-HIPO, the University Cancer Center Frankfurt, and the Frankfurt Research Funding Clinician Scientist Program.

Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD.

THE AMERICAN PEOPLE IN THIS PARTICULAR MOMENT IN OUR HISTORY MUST MAKE A VERY FUNDAMENTAL DECISION, AND THAT DECISION IS DO WE CONTINUE THE STATUS QUO WHICH INCLUDES A 40-YEAR DECLINE OF OUR MIDDLE CLASS AND A HUGE AND GROWING GAP BETWEEN THE VERY, VERY RICH AND EVERYONE ELSE, OR DO WE FIGHT FOR A BOLD AND MEANINGFUL ECONOMIC AGENDA THAT CREATES JOBS, RAISES WAGES, PROTECTS OUR ENVIRONMENT AND PROVIDES HEALTH CARE FOR EVERY AMERICAN Continue reading →

Sen. Bernie Sanders (I-Vt.) warns not to underestimate him in the 2016 Democratic race for the White House. Sanders, who is formally launching his campaign Tuesday, said he has a strong message. Continue reading →

“Thank you all very much for being here and for all the support that you have given me over the years: as the mayor of this great city, as Vermont’s only congressman and now as a U.S. senator. Thanks also … Continue reading →

Donald Trump sold out his supporters and the 99% by selecting Wall Streeters and war mongers for his top cabinet positions. Continue reading →

IBM today announced that Vancouver-based company Fusion Genomics selected IBM’s cloud capabilities to help advance Fusion’s ability to detect pandemics before they happen. Fusion Genomics has developed disruptive DNA and RNA technology that it believes can positively identify infectious diseases and enhance the surveillance of emerging pathogens like MERS, SARS, avian flu, and swine flu.

Hace posible el cifrado en tiempo real sobre todas las transacciones móviles a escala. Primer sistema mainframe con análisis integrado que proporciona conocimientos de transacciones en tiempo real, 17 veces más rápido en comparación a sistemas competidores en una fracción del costo.

Unitec today announced that the number of people employed in two Delivery Centres at its Mount Albert campus now exceeds 500, and continue to drive benefits for Unitec students and the Auckland economy.

IBM Research has announced a research agreement with MoleMap New Zealand to help further advance the identification of melanoma using cognitive technology. It builds on planned research with Melanoma Institute Australia. IBM Research plans to analyse dermatological images of skin lesions to help identify specific clinical patterns in the early stages of melanoma. The New Zealand and Australian research aims to help reduce unnecessary biopsies and help clinicians more accurately understand skin cancer, which could help to improve patient care.

IBM México anunció hoy el nombramiento de Eduardo Gutiérrez como Presidente y Gerente General de la compañía en el país. El directivo mexicano sucederá a Antonio Martins, quien ha sido nombrado Presidente de IBM Brasil.

IBM today announced the findings of a major new study of over 1,900 Chief Financial Officers (CFOs) and senior finance executives from 81 countries and 35 industries worldwide, which reveals that more than 60 percent of CFOs plan major changes to respond to the new economic climate.