rt

Desert storm: On the T20 Women’s World Cup 

Women’s cricket gets the spotlight as the T20 World Cup gets underway




rt

The other monsoon: On the northeast monsoon

Better modelling of the impact of northeast monsoon is essential




rt

Western front: On the parties and their prospects in the Maharashtra polls

Granular factors can determine the outcome in Maharashtra 




rt

Why Abhishek Missed Aishwarya's Birthday

When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher.




rt

Ananya-Suhana Party Together

Ananya Panday celebrated her birthday with family and the media, but she really wasn't done yet.




rt

Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rt

A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article
Open Access
Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rt

Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rt

Recent advances from computer-aided drug design to artificial intelligence drug design

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00522H, Review Article
Keran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei Wang
CADD and AIDD contribute to the drug discovery.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rt

Advances in antibacterial agents for Mycobacterium fortuitum

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00508B, Review Article
Carlos Roberto Tavolari Jortieke, Angélica Rocha Joaquim, Fernando Fumagalli
This review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rt

meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




rt

Property-based optimisation of PROTACs

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00769G, Opinion
James Scott, Iacovos Michaelides, Markus Schade
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...
The content of this RSS Feed (c) The Royal Society of Chemistry




rt

SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
The content of this RSS Feed (c) The Royal Society of Chemistry




rt

Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi




rt

Property owners block the entrance to Balasubramanya temple in Karur




rt

HR&CE plans to bring properties around the Vennaimalai Temple under tenants list

The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders




rt

Power shutdown in parts of Tiruchi on November 9




rt

Peravurani farmers’ market starts functioning




rt

Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation




rt

Advanced baggage handling system introduced in Tiruchi airport




rt

Art and literary contests lined up for District Central Library’s National Library Week




rt

AIADMK ready to join hands with like-minded parties to defeat DMK: Palaniswami




rt

572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements

Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […]




rt

578: Customer Support, P3 Color, Dave on Productivity, and Mobile vs Desktop

Is Apple's Numbers amazing or the worst? Customer support at various levels of software, Figma and P3 color, imagining a colorspace property in CSS, what's Dave doing for productivity, how has offloading CSS Tricks affected Chris, and should we build different websites for mobile vs desktop?




rt

584: Community, Partnerships, Images, and Astro with Fred K. Schott

Fred K. Schott stops by to talk about building community, open source and sponsorship, building on partnerships in the dev community, WordPress + Astro, view transitions, using Discord for support, and leaking secret Astro Studio details.




rt

597: How Many VS Code Plugins, Poor Charlie’s Almanack, and Where to Start in 2024?

We're closing in on episode 600 and need your help to celebrate! Listen in to learn how to contribute to the episode. We're also talking GitHub desktop apps and code editors, how many VS Code plugins are needed, reading long form like Poor Charlie's Almanack, InVision shutting down, and answering our first Q of the year: how would you approach learning web development in 2024?




rt

603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth

Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web.




rt

608: Can WordPress Kill Your Resume, Fav Parts of Web Dev, Exploring HTMX, and more!

We're opening up the ShopTalk mailbag and answering your questions, including does WordPress on your resume kill your job chances, what are our fav and least fav parts of web dev, our thoughts on HTMX, and what is it like to use pnpm instead of npm.




rt

625: CarTalk, Ownership of A Book Apart, and URL Shorteners

Dave's putting together a platform for his presidential bid and workshops his policies, discussing vehicle options for a family in 2024, Chris and other authors get ownership of their A Book Apart books back, and the ramifications and reasoning behind Google killing a URL shortener.




rt

627: Getting Comfortable with the Struggle and Vibe Driven Development

Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future?




rt

Design water-smart cities

We need an army of people who will ensure the protection of water bodies, and who will strive to create a water-literate community.




rt

Northward bound

Realty developers are aggressively launching projects in north Chennai despite the area’s sluggish growth.




rt

Start green, stay green

A recent CSE study found that many green-certified buildings were not eco-friendly after all. Deepa Sathiaram, executive director, En3 Sustainability Solutions, tells us what exactly goes wrong.




rt

Earth as shelter

Traditionally, people built walls by placing mud mixed with jaggery, grass and such local additives, but today we have scientifically evolved mix with cement and quarry dust.




rt

Smart water solution

A bunch of Chennai students are making Paani Genie, a 90-litre water container that can be rolled along.




rt

The art of dispensing water

Water-ATMs are becoming the rage all over the country. A look at the mechanism.




rt

Say ‘no’ to joints and mortars

It would lead to lesser material consumption, zero wastage, faster construction and better aesthetics




rt

Rammed earth on the roof

There is no dearth of ideas in construction, only of implementation, says Sathya Prakash Varanashi




rt

A sporty knock from India Inc

A growing crop of corporates are making serious investments in sports and beginning to reap the rewards, too




rt

Startups join the party with craft mixers

How non-alcoholic mixers, handcrafted by small players, are edging out sugary soft drinks, sodas in cocktail glasses




rt

Brand expertise and heritage bubbling in a moka pot

Lessons from European brands that have won consumers’ mindspace for long years




rt

Sport against strokes

World Stroke Day — October 29




rt

Galathea Bay: New major port can be game changer

Transshipment port at Galathea Bay is strategically located on the East-West international trade and shipping route




rt

How to report faulty glucose monitors, insulin pumps

UK regulator has a reporting scheme to identify safety concerns in diabetes-care devices




rt

How radio waves can power smart cities 

Practically omnipresent, thanks to human activity, radio frequency is the new area of focus for energy harvesting technology



  • Science and Technology

rt

Fem-tech: Niche and fertile for growth

Offering tech-enabled healthcare solutions exclusively for women, the fem-tech segment is clocking steady growth




rt

How Jio is powering Reliance’s media, entertainment biz

Despite a late entry into telecom, digital services, and media, Reliance has raced to the top




rt

Bengaluru startup develops new tech for battery recycling, begins production

Li-ion battery recycler Metastable Materials launches commercial ops




rt

‘Focused on building a high-conviction portfolio’

How fund house Cactus Partners ensures its capital goes toward growth rather than just keeping operations running




rt

GalaxEye: A multi-sensor peek at earth from outer space

Startup sets out to fill a crucial gap in satellite imagery for real-world applications