The other monsoon: On the northeast monsoon
Western front: On the parties and their prospects in the Maharashtra polls
Why Abhishek Missed Aishwarya's Birthday
When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher.
Ananya-Suhana Party Together
Ananya Panday celebrated her birthday with family and the media, but she really wasn't done yet.
Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane
DOI: 10.1039/D4MD00257A, Research Article
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
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The content of this RSS Feed (c) The Royal Society of Chemistry
A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy
DOI: 10.1039/D4MD00517A, Research Article
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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The content of this RSS Feed (c) The Royal Society of Chemistry
Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis
DOI: 10.1039/D4MD90044H, Correction
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The content of this RSS Feed (c) The Royal Society of Chemistry
Recent advances from computer-aided drug design to artificial intelligence drug design
DOI: 10.1039/D4MD00522H, Review Article
CADD and AIDD contribute to the drug discovery.
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The content of this RSS Feed (c) The Royal Society of Chemistry
Advances in antibacterial agents for Mycobacterium fortuitum
DOI: 10.1039/D4MD00508B, Review Article
This review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.
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The content of this RSS Feed (c) The Royal Society of Chemistry
meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells
DOI: 10.1039/D4MD00601A, Research Article
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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The content of this RSS Feed (c) The Royal Society of Chemistry
Property-based optimisation of PROTACs
DOI: 10.1039/D4MD00769G, Opinion
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...
The content of this RSS Feed (c) The Royal Society of Chemistry
SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction
DOI: 10.1039/D4MD00722K, Research Article
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
The content of this RSS Feed (c) The Royal Society of Chemistry
HR&CE plans to bring properties around the Vennaimalai Temple under tenants list
The HR&CE department has cleared 34 properties around the Balasubramanyaswamy Temple at Vennaimalai in Karur district as per the High Court orders
Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation
Art and literary contests lined up for District Central Library’s National Library Week
572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements
Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […]
578: Customer Support, P3 Color, Dave on Productivity, and Mobile vs Desktop
Is Apple's Numbers amazing or the worst? Customer support at various levels of software, Figma and P3 color, imagining a colorspace property in CSS, what's Dave doing for productivity, how has offloading CSS Tricks affected Chris, and should we build different websites for mobile vs desktop?
584: Community, Partnerships, Images, and Astro with Fred K. Schott
Fred K. Schott stops by to talk about building community, open source and sponsorship, building on partnerships in the dev community, WordPress + Astro, view transitions, using Discord for support, and leaking secret Astro Studio details.
597: How Many VS Code Plugins, Poor Charlie’s Almanack, and Where to Start in 2024?
We're closing in on episode 600 and need your help to celebrate! Listen in to learn how to contribute to the episode. We're also talking GitHub desktop apps and code editors, how many VS Code plugins are needed, reading long form like Poor Charlie's Almanack, InVision shutting down, and answering our first Q of the year: how would you approach learning web development in 2024?
603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth
Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web.
608: Can WordPress Kill Your Resume, Fav Parts of Web Dev, Exploring HTMX, and more!
We're opening up the ShopTalk mailbag and answering your questions, including does WordPress on your resume kill your job chances, what are our fav and least fav parts of web dev, our thoughts on HTMX, and what is it like to use pnpm instead of npm.
625: CarTalk, Ownership of A Book Apart, and URL Shorteners
Dave's putting together a platform for his presidential bid and workshops his policies, discussing vehicle options for a family in 2024, Chris and other authors get ownership of their A Book Apart books back, and the ramifications and reasoning behind Google killing a URL shortener.
627: Getting Comfortable with the Struggle and Vibe Driven Development
Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future?
Design water-smart cities
We need an army of people who will ensure the protection of water bodies, and who will strive to create a water-literate community.
Northward bound
Realty developers are aggressively launching projects in north Chennai despite the area’s sluggish growth.
Start green, stay green
A recent CSE study found that many green-certified buildings were not eco-friendly after all. Deepa Sathiaram, executive director, En3 Sustainability Solutions, tells us what exactly goes wrong.
Earth as shelter
Traditionally, people built walls by placing mud mixed with jaggery, grass and such local additives, but today we have scientifically evolved mix with cement and quarry dust.
Smart water solution
A bunch of Chennai students are making Paani Genie, a 90-litre water container that can be rolled along.
The art of dispensing water
Say ‘no’ to joints and mortars
It would lead to lesser material consumption, zero wastage, faster construction and better aesthetics
Rammed earth on the roof
There is no dearth of ideas in construction, only of implementation, says Sathya Prakash Varanashi
A sporty knock from India Inc
A growing crop of corporates are making serious investments in sports and beginning to reap the rewards, too
Startups join the party with craft mixers
How non-alcoholic mixers, handcrafted by small players, are edging out sugary soft drinks, sodas in cocktail glasses
Brand expertise and heritage bubbling in a moka pot
Galathea Bay: New major port can be game changer
Transshipment port at Galathea Bay is strategically located on the East-West international trade and shipping route
How to report faulty glucose monitors, insulin pumps
UK regulator has a reporting scheme to identify safety concerns in diabetes-care devices
How radio waves can power smart cities
Practically omnipresent, thanks to human activity, radio frequency is the new area of focus for energy harvesting technology
Fem-tech: Niche and fertile for growth
Offering tech-enabled healthcare solutions exclusively for women, the fem-tech segment is clocking steady growth
How Jio is powering Reliance’s media, entertainment biz
Despite a late entry into telecom, digital services, and media, Reliance has raced to the top
Bengaluru startup develops new tech for battery recycling, begins production
‘Focused on building a high-conviction portfolio’
How fund house Cactus Partners ensures its capital goes toward growth rather than just keeping operations running
GalaxEye: A multi-sensor peek at earth from outer space
Startup sets out to fill a crucial gap in satellite imagery for real-world applications