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Design, synthesis, and evaluation of novel thiadiazole derivatives as potent VEGFR-2 inhibitors: a comprehensive in vitro and in silico study

RSC Adv., 2024, 14,35505-35519
DOI: 10.1039/D4RA04158E, Paper
Open Access
Ibrahim H. Eissa, Walid E. Elgammal, Hazem A. Mahdy, Susi Zara, Simone Carradori, Dalal Z. Husein, Maymounah N. Alharthi, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Hazem Elkady, Ahmed M. Metwaly
This study aims to investigate the potential of designed 2,3-dihydro-1,3,4-thiadiazole derivatives as anti-proliferative agents targeting VEGFR-2, utilizing a multidimensional approach combining in vitro and in silico analyses.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Design, synthesis, and in vitro and in vivo biological evaluation of triazolopyrimidine hybrids as multitarget directed anticancer agents

RSC Adv., 2024, 14,35239-35254
DOI: 10.1039/D4RA06704E, Paper
Open Access
Heba A. Adawy, Samar S. Tawfik, Abdullah A. Elgazar, Khalid B. Selim, Fatma E. Goda
In response to the urgent need for new anti-proliferative agents, four novel series of triazolopyrimidine compounds (7a–e, 9a–d, 11a–f, and 13a–e) were synthesized and evaluated for in vitro and in vivo anticancer efficacy.
The content of this RSS Feed (c) The Royal Society of Chemistry




valuation

A facile synthesis of iron oxide nanoparticles as a nano-sensor to detect levofloxacin and ciprofloxacin in human blood and evaluation of their biological activities

RSC Adv., 2024, 14,36093-36100
DOI: 10.1039/D4RA05024J, Paper
Open Access
Erum Hasan, Ziana Manzar, Nabeel Haroon, Ali Raza, Syed Nawazish Ali, Mehreen Lateef, Sabira Begum
New bioactive magnetic nanoparticles were synthesized and stabilized by 3-aminobenzoic acid (3-ABA) utilized in detection of levofloxacin and ciprofloxacin.
The content of this RSS Feed (c) The Royal Society of Chemistry




valuation

FPIs withdraw ₹85,790 crore from Indian equities in October on attractive Chinese market valuations

Since June, foreign portfolio investors (FPIs) have consistently bought equities after withdrawing ₹34,252 crore in April-May




valuation

FPIs withdraw record ₹94,000 crore from Indian equities in October on attractive Chinese valuations

Foreign portfolio investors withdrew ₹94,000 crore from Indian stock market in October due to high valuations, shifting focus to Chinese stocks




valuation

Fabrication and evaluation of a flexible antenna device composed of a compatible iron-oxide clay in a PDMS graphene matrix

React. Chem. Eng., 2024, 9,901-909
DOI: 10.1039/D2RE00352J, Paper
Ameen Abdelrahman, Fouad Erchiqui, Mourad Nedil
We create a flexible and robust conductive polymer composite based on iron oxide and a thin film of clay doped with graphene nanoparticles, and test its application as a wearable device for underground workers.
The content of this RSS Feed (c) The Royal Society of Chemistry




valuation

Allergenicity evaluation of an extensively hydrolyzed infant formula based on cow milk protein

Food Funct., 2024, 15,11036-11046
DOI: 10.1039/D4FO03582H, Paper
Hongbo Li, Lin Yang, Jiayi Li, Quan Gao, Tiantian Liu, Yang Zou, Xiaohong Chen, Hongjuan Li, Jinghua Yu
We developed an extensively hydrolyzed infant formula (EHF) with a protein composition similar to breast milk (whey protein-to-casein ratio of 6 : 4) and evaluated its sensitization in vitro and in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




valuation

Particle Surface Engineering at Nano-Micro Scale Interfaces of Metal-Nonmetal Bonded Polymeric Coatings: Experimental and In-Silico Evaluations

Nanoscale, 2024, Accepted Manuscript
DOI: 10.1039/D4NR03431G, Paper
Suman Yadav, Sarvesh Kumar Pandey, Shikha Awasthi
Polyvinyl alcohol (PVA) is a well-known cost-effective synthetic polymer that offers a variety of applications including medical, aerospace, automotive, and construction industries. However, weak bonding with low mechanical and tribological...
The content of this RSS Feed (c) The Royal Society of Chemistry




valuation

IPL valuation dips 10.6% to ₹82,700 crore due to demand-side constraints: D&P Advisory report

Downturn in IPL valuation comes despite the league continuing to attract audiences across TV and digital platforms, says the report




valuation

Perplexity raising new funds at $9 billion valuation, source says

Perplexity is raising new investment that would value the search startup at $9 billion, a source familiar with the matter said on Tuesday




valuation

Evaluation on the recovery of lignin from basic [Ch][Lys] systems using low-cost alcohols as anti-solvents under acid-free conditions

Green Chem., 2024, 26,10950-10959
DOI: 10.1039/D4GC03898C, Paper
Yichen Liu, Wanting Zhao, Qizhen Luo, Jipeng Yan, Jian Sun
An acid-free, high efficiency, and mild method of precipitating and separating lignin from basic ionic liquids (BIL) such as choline lysinate ([Ch][Lys]) by using alchohols (such as tert-butanol) as anti--solvents.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Always open to exit OVO at the right valuation: Lippo Group’s John Riady

If on a risk-adjusted basis, I think it's a good time to get out, then I will get out, he says.

The post Always open to exit OVO at the right valuation: Lippo Group’s John Riady appeared first on DealStreetAsia.





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Hospital to Home: Evaluation report



  • Reports
  • discharge from hospital
  • hospital social work
  • hospital social workers
  • hospitals
  • Institute for Research and Innovation in Social Services (IRISS)

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Purdue basketball enters July evaluation period with 2019 recruiting foundation in place

Purdue coach Matt Painter and staff will explore the July evaluation period over the next three weeks. But the recruiting foundation for 2019 is set.

      




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Is This Working? Assessment and Evaluation Methods Used to Build and Access Language Services in Social Services Agencies In Social Services Agencies

The enactment of President Clinton’s Limited English Proficiency (LEP) Executive Order, issued in 2000, triggered a proliferation of efforts to provide services to individuals who cannot speak, understand, read, or write English fluently. With increased service provision, state and local government agencies have expressed a strong and growing interest in assuring the quality and cost-effectiveness of language access services. This paper attempts to catalog and describe some of those tools and practices.




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RTI Cannot Delay Pupil Evaluations

A response-to-intervention process cannot delay the initial evaluation for special education services of a child suspected of having a disability, federal officials have reminded states.




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3,000 CBSE Schools Open Today For Evaluation Of Board Answer Copies

The Home Ministry has granted permission for opening of 3000 CBSE affiliated schools as assessment centres across India to facilitate evaluation of answer sheets of CBSE Board exams.




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Analyst Corner: Valuations of AIA Engineering will remain rich – IDFC Securities

The production is based on orders received from the customers and hence management is confident that sales despatches would pick up over the next 2-3 quarters, driving an uptick in sales and normalised inventories.




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UK Pensions Speedbrief Public Sector First detail published on employer cost cap and actuarial valuations

? ? ? ?First detail published on employer cost cap and actuarial valuati...




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INDA: The Rupee Devaluation Has Come, More Declines Expected




valuation

Tweet Buster: MSME stimulus & RIL's peanut valuation

Will extra taxes on fuel and alcohol be used to bring relief to the economy?






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Evaluation of Industrial Policy: Methodological Issues and Policy Lessons

While there has been a recent revival of interest in industrial policy around the world, systematic evidence of efficacy is relatively scarce. This report considers recent evidence from the evaluation of industrial policy. It focuses on three specific policy areas: support for R&D, capital market interventions (with a focus on risk capital), and public procurement for innovation.




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Evaluation of the Italian "Start-Up Act" - policy note

As only a tiny proportion of new firms eventually grow, policy makers face two alternatives: target specific firms predicted to be highly innovative in the future, or foster experimentation among firms and streamline both entry and exit. The Italian "Start-Up Act" combines these two approaches with an eclectic mix of policy tools.




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Mortality Risk Valuation in Environment, Health and Transport Policies

This publication presents a major meta-analysis of 'value of a statistical life' (VSL) estimates derived from surveys where people around the world have been asked about their willingness to pay for small reduction in mortality risks.




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National Climate Change Adaptation: Emerging Practices in Monitoring and Evaluation

Developing countries are increasingly moving towards more strategic national policies and plans, the effectiveness of which will depend upon proper assessment of a given country’s vulnerability to climate change. This report draws upon emerging monitoring and evaluation practices across developed and developing countries to identify four tools that countries can draw upon in their own assessment frameworks.




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Are environmental tax policies beneficial? Learning from programme evaluation studies - Environment Working Paper

This paper provides a concrete example of how policy analysts can use empirical programme evaluation studies to perform ex-post assessments of environmentally related tax policies. A number of studies credibly identify causal effects of environmentally related tax policies, but do not necessarily provide all the information needed to fully inform the policy-making process.




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OECD Framework for Regulatory Policy Evaluation

The OECD Framework for Regulatory Policy Evaluation assists countries in systematically evaluating the design and implementation of regulatory policy, against the achievement of strategic regulatory objectives.




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Workshop: Elaboration and evaluation of regulatory impact assessment (RIA) at sub-national level

This workshop provided practical information and learning through case studies, group exercises and presentations from government officials with extensive experience in applying regulatory impact assessment (RIA) systems.




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Workshop on the elaboration and evaluation of regulatory impact assessment, Colombia

The objective of this workshop was to provide basic facts and theory related to RIA and best practices when undertaking RIA.




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OECD says Swedish progress combatting foreign bribery insufficient to warrant Phase 4 evaluation

The next review of Sweden’s implementation of the OECD Anti-Bribery Convention, which was scheduled for October 2018, has been delayed until 2019. This is due to the fact that Sweden has not yet enacted legislation to urgently address remaining recommendations to reform its laws on corporate liability for the bribery of foreign public officials.




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OECD Reviews of Evaluation and Assessment in Education: Australia

Evaluation and assessment policies are key in Australia’s national school reform agenda. The Australian approach combines the development of goals, monitoring and reporting at national level with local evaluation and assessment practices shaped by jurisdiction-level school improvement frameworks




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OECD Reviews of Evaluation and Assessment in Education: Denmark 2011

This book provides, for Australia, an independent analysis of major issues facing its educational evaluation and assessment framework, current policy initiatives, and possible future approaches.




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OECD Reviews of Evaluation and Assessment in Education: Sweden 2011

This book provides, for Sweden an independent analysis from an international perspective of major issues facing the evaluation and assessment framework in education, along with current policy initiatives and possible future approaches.




valuation

OECD Reviews of Evaluation and Assessment in Education: Norway 2011

This book provides, for Norway, an independent analysis from an international perspective of major issues facing the evaluation and assessment framework in education along with current policy initiatives and possible future approaches.




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OECD Reviews of Evaluation and Assessment in Education: School Evaluation in the Flemish Community of Belgium 2011

This report provides, for the Flemish community of Belgium, an independent analysis of major issues facing the educational evaluation and assessment framework, current policy initiatives, and possible future approaches.




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OECD Reviews of Evaluation and Assessment in Education: Czech Republic

This report for the Czech Republic forms part of the OECD Review on Evaluationand Assessment Frameworks for Improving School Outcomes. The purpose of the Review is to explore how systems of evaluation and assessment can be used to improve the quality, equity and efficiency of school education.




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Strengthen evaluation to improve student learning, says OECD

Education systems around the world are increasingly measuring the performance of teachers and schools as part of their drive to help students do better and improve results. Rising demand for higher education standards and a trend towards greater school autonomy in some countries are among the factors behind this new focus according to the OECD




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Synergies for Better Learning: An International Perspective on Evaluation and Assessment

How can assessment and evaluation policies work together more effectively to improve student outcomes in primary and secondary schools? This report provides an international comparative analysis and policy advice to countries on how evaluation and assessment arrangements can be embedded within a consistent framework to improve the quality, equity and efficiency of school education.




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OECD Reviews of Evaluation and Assessment in Education - Teacher Evaluation in Chile

This book provides, from an international perspective, an independent analysis of major issues facing teacher evaluation, current policy initiatives, and possible future approaches in Chile.




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Evaluation and Assessment Review Netherlands

This review report for the Netherlands provides, from an international perspective, an independent analysis of major issues facing the Dutch evaluation and assessment framework in education, current policy initiatives and possible future approaches. This series forms part of the OECD Review on Evaluation and Assessment Frameworks for Improving School Outcomes.




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Addressing inequities in the Slovak Republic through evaluation and assessment (OECD Education Today Blog)

OECD Education Today - Addressing inequities in the Slovak Republic through evaluation and assessment




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Improving School Leadership and Evaluation in Mexico: A State-level Perspective from Puebla

The education system of Puebla is undergoing a transformation. Ambitious national reforms have provided a new framework to improve teaching and evaluation practices, and ultimately raise student learning outcomes. At the same time, Puebla has also launched promising initiatives to improve the quality of education in the state.




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Physical-Chemical Properties of Nanomaterials: Evaluation of Methods Applied in the OECD-WPMN Testing Programme

This new document focuses on the evaluation of test methods applied to determine the physico-chemical properties of different types of nanomaterials.




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Assessing the economic valuation of the benefits of regulating chemicals - Environment Working Paper

This paper reviews and compares five case studies on quantification and economic valuation of benefits in cost-benefit analyses (CBAs) of regulating phthalates, mercury, PFOA (perfluoro-octanic acid) and its salts, NMP (1 methyl-2-pyrroloidine) and formaldehyde. The case studies had all been carried out as part of the SACAME project, and the purpose of the present paper is to draw out cross-cutting findings from these studies.




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CBSE board examination evaluation to start today




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CBSE evaluation for class 10, 12 board exams to be done at home by teachers

Union HRD minister Ramesh Pokhriyal 'Nishank' on Saturday announced that the evaluation for class 10, 12 board exams will be done by teachers at their homes and 3,000 schools have been identified as exam centres to deliver the answer sheets to them.




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3,000 CBSE Schools Open Today For Evaluation Of Board Answer Copies

The Home Ministry has granted permission for opening of 3000 CBSE affiliated schools as assessment centres across India to facilitate evaluation of answer sheets of CBSE Board exams.