motor

to wire multiple horsepower motor

to wire multiple horsepower motor




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to wire a motorcycle headlight

to wire a motorcycle headlight




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Climate-Resilient Connectivity for the Eastern Economic Corridor Project: The Intercity Motorway No. 7 (Extension to Link with U-Tapao International Airport)

The U-Tapao International Airport is the core infrastructure of the EEC and its expansion project is to be implemented via Public-Private Partnership modality. Land transport network connecting the U-Tapao International Airport in the Eastern Economic Corridor (EEC) to the rest of the Pattaya City and country cannot adapt to changing needs as a result of the expansion plan of the airport due to the limitations of the existing land transport network to cope with traffic increase.




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Paramotorists collect rare plant species from Peruvian desert oases

Kew scientists use paramotorists to collect rare plant species from Peruvian desert oases




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Motor made from bacteria parts is one of the smallest ever built

The natural motors that power tail-like appendages in bacteria seem to have a single evolutionary origin, allowing parts from different species to be combined to create a tiny new engine




motor

Sensory-Motor Neuropathy in Mfn2 T105M Knock-in Mice and Its Reversal by a Novel Piperine-Derived Mitofusin Activator [Neuropharmacology]

Mitochondrial dysfunction is a hallmark of many genetic neurodegenerative diseases, but therapeutic options to reverse mitochondrial dysfunction are limited. While recent studies support the possibility of improving mitochondrial fusion/fission dynamics and motility to correct mitochondrial dysfunction and resulting neurodegeneration in Charcot-Marie-Tooth disease (CMT) and other neuropathies, the clinical utility of reported compounds and relevance of preclinical models are uncertain. Here, we describe motor and sensory neuron dysfunction characteristic of clinical CMT type 2 A in a CRISPR/Casp-engineered Mfn2 Thr105Met (T105M) mutant knock-in mouse. We further demonstrate that daily oral treatment with a novel mitofusin activator derived from the natural product piperine can reverse these neurologic phenotypes. Piperine derivative 8015 promoted mitochondrial fusion and motility in Mfn2-deficient cells in a mitofusin-dependent manner and reversed mitochondrial dysfunction in cultured fibroblasts and reprogrammed motor neurons from a human CMT2A patient carrying the MFN2 T105M mutation. Like previous mitofusin activators, 8015 exhibited stereospecific functionality, but the more active stereoisomer, 8015-P2, is unique in that it has subnanomolar potency and undergoes entero-hepatic recirculation which extends its in vivo half-life. Daily administration of 8015-P2 to Mfn2 T105M knock-in mice for 6 weeks normalized neuromuscular and sensory dysfunction and corrected histological/ultrastructural neurodegeneration and neurogenic myoatrophy. These studies describe a more clinically relevant mouse model of CMT2A and an improved mitofusin activator derived from piperine. We posit that 8015-P2 and other piperine derivatives may benefit CMT2A or other neurodegenerative conditions wherein mitochondrial dysdynamism plays a contributory role.

SIGNIFICANCE STATEMENT

Mitochondrial dysfunction is widespread and broadly contributory in neurodegeneration, but difficult to target therapeutically. Here, we describe 8015-P2, a new small molecule mitofusin activator with ~10-fold greater potency and improved in vivo pharmacokinetics versus comparators, and demonstrate its rapid reversal of sensory and motor neuron dysfunction in an Mfn2 T105M knock-in mouse model of Charcot-Marie-Tooth disease type 2 A. These findings further support the therapeutic approach of targeting mitochondrial dysdynamism in neurodegeneration.




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Motorists urged to plan ahead with Kincardine Bridge due to close

Motorists have been urged to plan ahead with a major bridge due to close for work is carried out.  




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Exclusive: Dinosaur Polo Club Interview – CEO Amie Wolken on Mini Metro, Mini Motorways, the Team, Free DLC, Working With Apple, Ports, and More

When thinking about the classics or games I’d recommend people play on mobile, Mini Metro is one of the best …




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F1: Mercedes motorisera Alpine à partir de 2026

C'était une nouvelle attendue.




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Motorists who bought cars on finance could share in billions

The car finance industry is setting aside billions to pay for potential claims after a test case.




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A Wearable to Manage Parkinson’s Motor Symptoms: Interview with Lucy Jung, CEO at Charco Neurotech

Charco Neurotech, a medtech company based in the United Kingdom, has developed CUE1, a non-invasive wearable that is intended to assist those with Parkinson’s disease to manage their motor symptoms. The device is typically affixed to the sternum, and provides vibratory action in a focused region of the body. The technology is based on the […]




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Discovery en Español aumenta la velocidad de sus 'Lunes De Motores' con transformaciones extremas de camiones - Texas Trocas Promo Clip

Conoce a la familia Méndez, pionera en la transformación extrema de camiones. Texas Trocas, nueva serie de Discovery en Español. Estreno 15 de septiembre a las 10PM E/P.




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Assessee can avail ITC only on tax paid on services for leasing/ renting/ hiring of motor vehicles for women's safety

The AAR, Tamil Nadu in the case of M/s. CMA CGM Global Business Services (India) (P.) Ltd., In Re [Order No. 15/ARA/2024 dated July 15, 2024] ruled that an Assessee is eligible to avail input services in respect of leasing/ renting/ hiring of motor vehicles of motor vehicles to provide transportatio




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Go Motorsport




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Bentley Motors amână planul pentru producția de vehicule electrice

Bentley Motors Ltd. amână planul de a oferi doar vehicule complet electrice (EV – electric vehicles) până în 2030, pentru că vânzările de EV-uri continuă să dezamăgească la nivel de industrie. Compania va extinde termenul pentru strategia de afaceri „Beyond100” – acum denumită „Beyond100+” – cu cinci ani, până în 2035, a declarat președintele și ...

The post Bentley Motors amână planul pentru producția de vehicule electrice appeared first on Forbes Romania.




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4000 ಕುಸಿತ! 50MP ಸೆಲ್ಫಿ ಕ್ಯಾಮೆರಾ.. 125W ಚಾರ್ಜಿಂಗ್.. ಕಡಿಮೆ ಬೆಲೆಗೆ Motorola 5G ಫೋನ್ ಸೇಲ್

ಮೊಟೊರೊಲಾ ಕಂಪನಿಯ ಮೊಬೈಲ್‌ಗಳಿಗೆ ಮಾರುಕಟ್ಟೆಯಲ್ಲಿ ಭಾರೀ ಬೇಡಿಕೆಯಿದೆ. ಸ್ಮಾರ್ಟ್‌ಫೋನ್ ಪ್ರಿಯರು ಸಹ ಈ ಫೋನ್‌ಗಳನ್ನು ಇಷ್ಟಪಟ್ಟು ಖರೀದಿಸುತ್ತಾರೆ. ಅದರಂತೆ, ಕಂಪನಿಯು ಆಗಾಗ್ಗೆ ತನ್ನ ಅಭಿಮಾನಿಗಳಿಗೆ ಬೊಂಬಾಟ್ ಆಫರ್‌ಗಳನ್ನು ನೀಡುತ್ತದೆ. ಇದೀಗ, ಮೊಟೊರೊಲಾ ಎಡ್ಜ್‌ 50 ಪ್ರೊ 5G (Motorola Edge 50 Pro 5G) ಫೋನಿನ ಬೆಲೆ ಇಳಿಕೆ ಮಾಡಿದೆ. ನೀವು, 4 ಸಾವಿರ ರೂ. ರಿಯಾಯಿತಿಯೊಂದಿಗೆ




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Hyundai Motor India Q2 Results: लिस्टिंग के बाद पहली बार आए रिजल्ट्स! मुनाफा घटा, शेयर भी 2% टूटा

Hyundai Motor India Q2 Results: शेयर बाजार में लिस्टेड कंपनियां तिमाही नतीजे जारी कर रही. इस कड़ी में ऑटो सेक्टर की कंपनी हुंडई मोटर इंडिया ने भी सितंबर तिमाही के नतीजे जारी कर दिए हैं. हाल ही में लिस्ट शेयर नतीजों




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BMW Motorrad Unveils Concept F 450 GS Adventure Motorcycle: All Details Here

BMW Motorrad has unveiled the Concept F 450 GS, a new addition to its motorcycle lineup. This concept bike is built on a fresh 450cc platform and features a twin-cylinder engine producing 48 bhp. The design draws inspiration from BMW's larger




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Rolex Monterey Motorsports Reunion 2025 To Feature Historic Race Groups And Formula One Exhibition

Discover the exciting race groups and exhibitions at the Rolex Monterey Motorsports Reunion 2025, celebrating Formula One's 75th Anniversary.




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Hyundai Motor America Secures 2024 Great Place To Work Certification For Employee Satisfaction

Hyundai Motor America earns the Great Place To Work certification for the second consecutive year, reflecting employee satisfaction and workplace culture.




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Motorsport FMSCI | Triple delight for Jaden and Abhay




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MOTORSPORTS | Aditya, Virender seize overall lead in MMSC South India Rally




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Motor racing | Verstappen wants more focus on car, not Red Bull drama

Verstappen, who has won the last three world championships with Red Bull, said the internal strife had no impact on his performance or comfort within the team.




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MOTORSPORTS | Young Indian racers excited for Formula 4 Indian championship




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Chennai’s night street race a shot in the arm for Indian motorsports

The initiative reflects Tamil Nadu’s commitment to cultivate a vibrant racing culture and inspire the NextGen racing drivers, engineers and race mechanics




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A humdinger looms in the three-day Indian National Motorcycle Racing Championship

The contenders across all categories are closely bunched as the fourth round of the INMRC gets under way on September 6




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Indian National Motorcycle Racing Championship | Chiranth Vishwanath secures two pole positions




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A unique approach to nurturing Indian motorsport engineers — the L.I.M.E. way

United Motorsports Academy — founded by former Red Bull engineer Sangodkar, and Rane — provides a two-week course to qualify for an internship in the IRL and F4 series as part of a scholarship called Launchpad for Indian Motorsports Engineers; students learn about the basics and intricacies of the sport which gives them an opening into the world of fast-paced action




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National Motorcycle Racing Championship set for grand climax at MIC

Over 100 entrants, representing 19 teams, will vie for top honours across 19 races at MRF MMSC FMSCI Indian National Motorcycle Racing Championship in Chennai on October 4




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Everything you need to know about India’s first high-voltage e-motorcycle Raptee.HV T30

This Chennai-based startup has introduced the country’s first high-voltage electric two-wheeler, a machine that merges electric car technology with motorcycle performance




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Honda Motorcycle and Scooter India unveils India’s first 300cc flex-fuel bike 

Honda Motorcycle &and Scooter India has launched the new CB300F Flex-Fuel, marking a notable step towards environmentally friendly mobility solutions in India. The motorcycle is India’s first 300cc flex-fuel vehicle and aligns with the country’s broader goals of promoting greener technologies. 




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A motor that cuts import of Chinese raw material

Chennai startup Viridian Ingni Propulsion develops low-cost motor that works with magnets free of rare earth materials




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These motorcyclists at the India Bike Week shatter myths about ‘women bikers’

Maral Yazarloo-Pattrick, Sameera Dahiya, and Urvashi Patole smash stereotypes about female bikers in India




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Tamil Nadu aims to position Chennai as the heart of motorsport, chess, and sailing

State allocates ₹30 crore to support the IRF 2024 event, with an additional ₹12 crore dedicated to publiciszing it




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Bajaj Auto motorcycle sales marginally up in August




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Tata Motors to acquire Ford India's Sanand plant to expand production capacity

Tata Motors said with its manufacturing capacity nearing saturation, the acquisition is timely and a win-win for all stakeholders




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Vauxhall Motors Ltd. MarketLine Company Profile [electronic journal].

Marketline




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Frequent traffic snarls pose hardship to motorists in Tiruchi

It is common to see vehicles lining up for a long distance from the traffic signal near Cauvery bridge to Anna Statue.




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Tata Motors signs MoU with ASDC for skill development




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Hyundai Motor India's ₹27,870 crore IPO subscribed 9% so far on Day 1

This is the largest IPO in India, surpassing LIC's initial share sale of ₹21,000 crore.




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Hyundai Motor India's record ₹27,870 crore IPO fully subscribed

The ₹27,870 crore initial share sale got bids for 14,07,68,187 shares against 9,97,69,810 shares on offer, translating into 1.41 times the subscription, as per NSE data till 13:21 hours




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Hyundai Motor India’s IPO sees muted response from retail investors, issue subscribed 2.37 times

The IPO received lowest retail subscription among some of the big IPOs that had hit the Indian capital markets




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Hyundai Motor India debuts at BSE at a discount of 1.48%, falls nearly 6% post listing

This is the biggest ever IPO to have ever hit in the Indian capital markets




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Hyundai Motor India shares jump 6%

Hyundai shares climbed 5.91% to ₹1,928.15 from the previous close on the BSE. At the NSE, the stock surged 6% to ₹1,928.90




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Individual Closed-Loop Control of Micromotors by Selective Light Actuation

Soft Matter, 2024, Accepted Manuscript
DOI: 10.1039/D4SM00810C, Communication
Open Access
David Rivas, Max Sokolich, Sambeeta Das
Control of individual micromotors within a group would allow for improved efficiency, greater ability to accomplish complex tasks, higher throughput, and increased adaptability. However, independent control of micromotors remains a...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Man arrested and 20 stolen motorcycles worth ₹15 lakh recovered in Nandyal




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Anantapur enforcement dirve: police register over 3,000 cases against violators of Motor Vehicle Act

In the drive conducted over one week, police register 12 cases against gambling dens, arrest 59 persons and seize more than ₹1.91 lakh cash, says SP P. Jagadeesh




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Norton Motorcycles announces top level changes




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Tata Motors Q2 consolidated net profit declines 11% to ₹3,343 crore

The company had posted a consolidated net profit of ₹3,832 crore in the same quarter of the last fiscal, Tata Motors said in a regulatory filing.




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Maruti, Hyundai, Tata Motors report decline in wholesales in September

Mahindra & Mahindra said its SUV wholesales in the domestic market increased 24% to 51,062 units in September compared to the same month of last year