Veterans are at an increased risk for prostate cancer, a disease with extraordinary clinical and molecular heterogeneity, compared with the general population. However, little is known about the underlying molecular heterogeneity within the veteran population and its impact on patient management and treatment. Using clinical and targeted tumor sequencing data from the National Veterans Affairs health system, we conducted a retrospective cohort study on 45 patients with advanced prostate cancer in the Veterans Precision Oncology Data Commons (VPODC), most of whom were metastatic castration-resistant. We characterized the mutational burden in this cohort and conducted unsupervised clustering analysis to stratify patients by molecular alterations. Veterans with prostate cancer exhibited a mutational landscape broadly similar to prior studies, including KMT2A and NOTCH1 mutations associated with neuroendocrine prostate cancer phenotype, previously reported to be enriched in veterans. We also identified several potential novel mutations in PTEN, MSH6, VHL, SMO, and ABL1. Hierarchical clustering analysis revealed two subgroups containing therapeutically targetable molecular features with novel mutational signatures distinct from those reported in the Catalogue of Somatic Mutations in Cancer database. The clustering approach presented in this study can potentially be used to clinically stratify patients based on their distinct mutational profiles and identify actionable somatic mutations for precision oncology.

Patient expectations of receiving antibiotics for common symptoms can trigger unnecessary use. We conducted a survey (n = 564) between January 2020 to June 2021 in public and private primary care clinics in Texas to study the prevalence and predictors of patients’ antibiotic expectations for common symptoms/illnesses. We surveyed Black patients (33%) and Hispanic/Latine patients (47%), and over 93% expected to receive an antibiotic for at least 1 of the 5 pre-defined symptoms/illnesses. Public clinic patients were nearly twice as likely to expect antibiotics for sore throat, diarrhea, and cold/flu than private clinic patients. Lack of knowledge of potential risks of antibiotic use was associated with increased antibiotic expectations for diarrhea (odds ratio [OR] = 1.6; 95% CI, 1.1-2.4) and cold/flu symptoms (OR = 2.9; 95% CI, 2.0-4.4). Lower education and inadequate health literacy were predictors of antibiotic expectations for diarrhea. Future antibiotic stewardship interventions should tailor patient education materials to include information on antibiotic risks and guidance on appropriate antibiotic indications.

The most impressive aspect of Donald Trump's victory over Vice President Kamala Harris last week was the uniformity of his gains across the electoral landscape.

Day 2 action at the Birmingham Commonwealth Games

Local boy Fraser stars as England retain gymnastics team title

England's Yee wins first gold of Games in men's triathlon

Cyclist Fachie equals Scottish record of five Commonwealth golds

Olympic champion Duffy wins women's triathlon

England's Taylor-Brown second, Scotland's Potter third

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Full schedule and key events to watch out for

English track cyclist knocked unconscious after sickening Commonwealth Games crash

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Track cycling abandoned after riders and fans caught in huge crash

England's Jake Jarman takes gold in the men's all-round gymnastics final while James Hall takes silver

England's Ondine Achampong wins silver in women's all-around

Alice Tai wins gold in the pool just six months after having her leg amputated 

Shock as Peaty finishes out of the medals in the 100m breaststroke as James Wilby wins gold

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Adam Peaty roared back at those writing him off after cruising through his 50 metres breaststroke semi-final – but was later accused of being disrespectful towards Commonwealth Games competitors.

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Adam Peaty is right about Commonwealths not being the pinnacle

Peaty accused of disrespecting Games after roaring into 50m final

British Cycling ‘confident’ they can replace Kenny if she retires

Englishman Jake Jarman wins fourth gymnastics gold medal

Daily Games schedule – plus key events to watch out for

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Geraint Thomas wins bronze after crash proves costly in men's time trial

It is official - England is the world's heptathlon talent factory

Eilish McColgan follows mother's footsteps with thrilling gold medal run at Commonwealth Games

Anna Henderson wins silver in women's time trial

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Commonwealth Games 2022 schedule: Daily guide plus key events to watch out for

Geraint Thomas wins bronze but early crash costs him gold

Andrea Spendolini Sirieix wins diving gold with famous father Fred in crowd

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England beat New Zealand to reach women's hockey final

Australia crush England's hopes of second successive netball gold

Nick Miller wins gold for England in the hammer

India edge England to make T20 cricket final

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England 'swing' brings Commonwealth hockey gold home

Laura Muir bounces back to win 1,500m on a golden night

Delicious Orie hopes to follow in Anthony Johsua's footsteps

Geraint Thomas unable to regain title in final Wales outing

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Oliver Brown on the 'lunacy' of Team Australia's Covid policies

Laura Muir's 1500m gold | England women's hockey gold report

England women stripped of their relay title for lane infringement 

Delicious Orie, gold medal boxer who wants to be the next AJ

Commonwealth Games 2022 medal table: which country came top 

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Loneliness was long thought to cause health conditions ranging from diabetes to cardiovascular disease, but new research paints a more nuanced picture

While startups in highly regulated industries like healthcare and finance are almost certain to face heightened scrutiny, there are controllable factors that can offset these challenges.

The post The Startup Economy is Turbulent. Here’s How Founders Can Recognize and Avoid Common Pitfalls appeared first on MedCity News.

Dec 14, 2023

The Belfer Center's National Security Fellows (NSFs), as part of the Defense, Emerging Technology, and Strategy (DETS) program, developed and taught the "For the Common Defense" study group throughout the Fall 2023 semester. Each “Common Defense” seminar is an in-depth exploration of a national security or defense-related subject taught by senior defense officials. Over the course of eight seminars, this study group examined key foreign policy topics, including Russia’s invasion of Ukraine and great power competition.

 

Jun 3, 2024

As the climate crisis intensifies, demand is surging for minerals needed to manufacture clean energy technologies. In the race to secure supplies of critical minerals, Africa and the Arctic have taken center stage as companies and governments around the world eye their vast mineral deposits. These seemingly disparate regions now face the same question: how to capitalize on their mineral wealth while maximizing the socioeconomic benefits and minimizing the environmental harms of mining.

The new HomeKit-enabled Onelink by First Alert� Wi-Fi Smoke + Carbon Monoxide (CO) Alarm pairs First Alert�s legacy of safety and innovation with Apple�s revolutionary HomeKit technology.

Broll of pregnant women, doctors, prenatal exam, healthy & sick babies. Antidepressant use among reproductive-aged women is common. If you�re pregnant, or are planning a pregnancy, speak to your doctor right away.

In this article, we shall outline the everyday mistakes made at some stage during the submission of food license documents and guide how to avoid them.

It's National Common Sense Day, minions, but how "common" is it, really? 

 Hmmm?

When your faith in reading comprehension is also (crooked) and (going down).

  Candice asked them to write Skye with an E.

Such a shame the baker didn't have enough room to write out "birthday."

OH WAIT

Kim wanted "2018 Angels" in the center.

Then Lisa asked for a picture of a 20 sided die:

There's something extra special about writing the word "picture" here, don't you think?

And finally, Sharla just wanted her name on the cake.

Oh, the pain.


Thank to Rob M., Candice B., Kim T., Lisa P., & Sharla, for those... fascinating... finds.

*****

And from my other blog, Epbot:

A Swedish study has challenged the widespread use of beta-blockers for all heart attack patients. While these medications are commonly prescribed to regulate

Access to a popular medlinkabortion pill/medlink will continue, as the US Supreme Court has ruled the drug can remain on the market while a lower court lawsuit is underway.

Highlights: Frequent infections and colds are common indicators of low immunity Chronic fatigue can hinder a chi

Many individuals express concerns about the presence of chemicals, contaminants, or microplastics in their food. However, it's lesser-known that many

Scientists have discovered that genes often defy expectations, turning on when they should be off in healthy individuals. The team also identify several mechanisms behind these gene activity errors.

A common ingredient in plastic may cause breaks in DNA strands, leading to egg cells with an abnormal number of chromosomes in roundworms, reveals a new

Men taking either abiraterone or enzalutamide for advanced prostate cancer who had also undergone hormone therapy were at increased risk of serious metabolic

Common heart medications, like beta blockers, could have side effects including triggering depression in heart attack patients.

All of us are familiar with the popular terminology "global warming" which could be found everywhere from school textbooks to huge international summits and conferences.

A gene variant that is associated with the cause of medlinkhypertension/medlink or medlinkhigh blood pressure/medlink has been discovered by researchers (!--ref1--).

Recent research has demonstrated that a widely prescribed hypertension medication, medlinkamlodipine/medlink, is safe for patients. This finding contradicts

Toys can be described as objects designed and created to be used by kids. They are normally made of plastics, boxes, cloths or light metals. Remote control toys are available in different models such as vehicles, airplanes, dolls and...

Composition (per 100 gm) Of 9 Common Vegetables.

Understanding food and...

Venetian blinds is a popular home decor item and can be mostly seen in Indian offices and homes in coastal areas. But then the charm of the blinds has made us to fall in love with them to try and experiment

The procedure for seeking admission to MBA, MCA, and M.E/ M.Tech/ M.Arch./ M.Plan. Degree programs for the academic year 2017-2018 consist of the following two steps: Appearing for the Tamil Nadu Common Entrance Test (TANCET) 2017 in March 2017.  Applying

Leeds : ARC Humanities Press, [2023]

Oakland, CA : PM Press ; Brooklyn, NY : Autonomedia, [2019]

Cambridge : Cambridge University Press, 2023.

Manchester : Manchester University Press, [2018]

'Romil Chaudhary and Deepak Thakur are the most cunning people in the house. If Sreesanth holds his temper, he has the potential to be the winner. Dipika may also be in the finals.'

A companionable book filled with personal advice shared with honesty

I just returned from a holiday on the gorgeous island of Corfu in Greece and spent quite some time taking photos. Instead of releasing those piecemeal on various social media channels, I thought it would be fun to go back to our ways of early social media, and put them all up on Flickr with […]

According to the government the recent 50% hike in prices of eight drugs was sanctioned keeping in mind the larger public interest and to ensure continued availability of drugs