A miniprotein receptor electrochemical biosensor chip based on quantum dots
DOI: 10.1039/D3LC01100C, Paper
We developed an on-chip laboratory for biomolecule interactions and kinetics analysis based on the three-electrode and high electron mobility transistor (HEMT) chip platform.
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A microfluidic chip for sustained oxygen gradient formation in the intestine ex vivo
DOI: 10.1039/D3LC00793F, Paper
Here, we have developed a 3D printed microfluidic device capable of oxygen gradient formation within intestinal tissue slices ex vivo. The device is open-welled and compatible with external electrochemical recording during tissue analysis.
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AMF-SporeChip provides new insights into arbuscular mycorrhizal fungal asymbiotic hyphal growth dynamics at the cellular level
DOI: 10.1039/D3LC00859B, Paper
A new microfluidic platform – the AMF-SporeChip – enables immobilisation of arbuscular mycorrhizal fungal spores and confrontation of asymbiotic hyphae with physical obstacles, allowing the identification of various exploration strategies.
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Comparison between dynamic versus static models and real-time monitoring of neuronal dysfunction in an amyloid-β induced neuronal toxic model on a chip platform
DOI: 10.1039/D3LC00507K, Paper
A 3D neural spheroid-based system with an interstitial level of flow for simulating the brain microenvironment toward a dynamic amyloid-β induced neuronal toxic model was established. A real-time impedance recording was used to monitor the neural network formation and disconnection.
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Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism
DOI: 10.1039/D3LC00838J, Paper
Pancreatic in vitro models are crucial for research on diseases such as diabetes mellitus. A novel thermoplastic organ-on-chip with integrated real-time read-outs models the complex microphysiological structure and function of the endocrine pancreas.
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Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies
DOI: 10.1039/D3LC00796K, Perspective
In this perspective article, we present the state of the microfluidic field regarding current limitations and propose future directions and new approaches for the field to advance lab-on-a-chip technologies closer to translation and clinical use.
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Development of a self-contained microfluidic chip and an internet-of-things-based point-of-care device for automated identification of respiratory viruses
DOI: 10.1039/D3LC00933E, Paper
The COVID-19 pandemic greatly impacted the in vitro diagnostic market, leading to the development of new technologies such as point-of-care testing (POCT), multiplex testing, and digital health platforms.
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Evaluating thrombosis risk and patient-specific treatment strategy using an atherothrombosis-on-chip model
DOI: 10.1039/D4LC00131A, Paper
An atherothrombosis-on-chip model to evaluate thrombosis risk and patient-specific treatment strategy.
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Synthesis and photocatalytic property of Au–TiO2 nanocomposites with controlled morphologies in microfluidic chips
DOI: 10.1039/D3LC01053H, Paper
We present an efficient approach for the consecutive synthesis of Au–TiO2 nanocomposites with controlled morphologies in a microfluidic chip.
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High-throughput 3D microfluidic chip for generation of concentration gradients and mixture combinations
DOI: 10.1039/D3LC00822C, Paper
Concentration gradient generation and mixed combinations of multiple solutions are of great value in the field of biomedical research.
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Designing and prototyping a novel biosensor based on a volumetric bar-chart chip for urea detection
DOI: 10.1039/D3LC00730H, Paper
A volumetric bar-chart chip (V-chip) is a microfluidic device based on distance-based quantitative measurement that visualizes analyte concentration without the need for apparatus or data processing.
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Brachytherapy on-a-chip: a clinically-relevant approach for radiotherapy testing in 3d biology
DOI: 10.1039/D4LC00032C, Paper
We introduce the first brachytherapy-on-chip device for in vitro testing of brachytherapy on naturally hypoxic tumor spheroids, for translational research and drug development.
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A microfluidic-based gut-on-a-chip model containing the gut microbiota of patients with depression reveals physiological characteristics similar to depression
DOI: 10.1039/D3LC01052J, Paper
A depression-on-gut-chip (DoGC) is prepared and enables extended co-culture of aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows direct study of interactions between human gut microbiota and depression.
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Multiplex nanozymatic biosensing of Salmonella on a finger-actuated microfluidic chip
DOI: 10.1039/D4LC00291A, Paper
A colorimetric biosensor was elaboratively designed for fast, sensitive and multiplex bacterial detection on a single microfluidic chip using immune magnetic nanobeads for specific bacterial separation, immune gold@platinum palladium nanoparticles...
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Rocking- and diffusion-based culture of tumor spheroids-on-a-chip
DOI: 10.1039/D3LC01116J, Paper
Tumor spheroids are cultured in hydrogel microwells with a gravity driven medium flow underneath the membrane on-a-chip. The rocking system is pumpless, powered with a rechargeable battery, and programmable with a built-in microprocess.
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High-resolution low-cost LCD 3D printing for microfluidic and organ-on-a-chip devices
DOI: 10.1039/D3LC01125A, Paper
The fabrication of microfluidic devices has progressed from cleanroom manufacturing to replica molding in polymers, and more recently to direct manufacturing by subtractive (e.g., laser machining) and additive (e.g., 3D...
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Effects of external light in the magnetic field-modulated photocatalytic reactions in a microfluidic chip reactor
DOI: 10.1039/D4RA00415A, Paper
Mutual enhancement of plasmonic photocatalytic reaction by both magnetic field and plasmonic enhancement was presented through Au–TiO2 nanoparticles.
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Where technology yields not microchips but sun-dried chips
The Women’s Technology Park in Salem is turning rural women into entrepreneurs, through sustainable schemes
Generation, manipulation, detection and biomedical applications of magnetic droplets in microfluidic chips
DOI: 10.1039/D4AN01175A, Minireview
This review discusses the formation and manipulation of magnetic droplets on microfluidic chips and classifies related detection techniques. Applications in biomedicine were reviewed. Future development of this emerging field is provided.
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Supporting the Philippines in Kickstarting the Comprehensive Archipelagic Defense Concept (CADC): The Role of the US-Australian Alliance
Supporting the Philippines in Kickstarting the Comprehensive Archipelagic Defense Concept (CADC): The Role of the US-Australian Alliance Supporting the Philippines in Kickstarting the Comprehensive Archipelagic Defense Concept (CADC): The Role of the US-Australian Alliance
Samsung Electronics shares hit 4-year lows on Trump risks, AI chips
Shares in Samsung Electronics fell on Wednesday to their lowest level in more than four years amid worries about the impact of U.S. tariffs under a new Donald Trump administration, analysts said
Tessolve to acquire German chip design company for up to ₹400 crore
It will expand Tessolve’s European operations by adding four delivery locations across Germany and the Netherlands, including a specialized ADAS and imaging centre-of-excellence lab
OpenAI builds first chip with Broadcom and TSMC, scales back foundry ambition
OpenAI is working with Broadcom and TSMC to build its first in-house chip designed to support its artificial intelligence systems, per sources
Anusha’s impressive Kuchipudi
Apple rolls out new AirPods, Mac chips, MacBook pros
Apple introduced two chips -the M1 Pro and the M1 Max in the new MacBook Pro 14 and 16-inch models
The Science Behind Elon Musk’s Neuralink Brain Chip
Neuralink, Elon Musk’s brain chip, recently pushed back on claims that they violated animal welfare laws a few years ago, while testing on monkeys. This year, the company plans to test on human subjects. What does this mean for brain implant science?
IIT Madras partners with SilTerra Malaysia for silicon photonic processor chips
These chips will be utilised for quantum computing and high-speed secured communication systems
Biden stresses case for computer chips before crucial Senate vote
President Joe Biden is asking Congress to send him a bipartisan bill designed to boost the country’s computer chips industry
Why maternal nutrition is blue-chip investment
Guaranteed maternal nutrition can break the cycle of malnutrition passed from one generation to the next
Exploring cancer-associated fibroblast-induced resistance to tyrosine kinase inhibitors in hepatoma cells using a liver-on-a-chip model
DOI: 10.1039/D4LC00624K, Paper
3D liver-on-a-chip reveals AHSG and CLEC3B to mediate cancer-associated fibroblast-induced resistance to TKIs in hepatoma cells.
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Rapid low-cost assembly of modular microvessel-on-a-chip with benchtop xurography
DOI: 10.1039/D4LC00565A, Paper
Our study is a novel implementation of xurography for multi-layer microfluidic device fabrication. We demonstrate the versatility of this approach by presenting several modular 3D vessel-matrix arrangements.
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Self-actuated microfluidic chiplet for two-stage multiplex nucleic acid amplification assay
DOI: 10.1039/D4LC00752B, Paper
Self-actuated chiplet for Penn-RAMP assay.
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Correction: Deciphering hepatoma cell resistance to tyrosine kinase inhibitors: insights from a Liver-on-a-Chip model unveiling tumor endothelial cell mechanisms
DOI: 10.1039/D4LC90093F, Correction
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A gravity-driven tissue chip to study the efficacy and toxicity of cancer therapeutics
DOI: 10.1039/D4LC00404C, Paper
A 96-well plate format, fully-automated multi-organ tissue chip array with gravity-driven flow for cancer research.
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Impact of microchannel width on axons for brain-on-chip applications
DOI: 10.1039/D4LC00440J, Paper
Axon growth is influenced by the width and number of microchannels, with growth cone adaptability reaching its limit for constraints smaller than 350 nm. Tradeoffs between axon growth and control need to be made for neurofluidic devices.
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Observing root growth and signalling responses to stress gradients and pathogens using the bi-directional dual-flow RootChip
DOI: 10.1039/D4LC00659C, Paper
Using a bi-directional dual-flow RootChip with integrated force sensing micropillars, root growth and signalling responses to stress gradients and pathogens were studied in Arabidopsis thaliana, Nicotiana benthamiana and Solanum lycopersicum.
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SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat
DOI: 10.1039/D4LC00858H, Paper
Cortisol, known as the "stress hormone," is secreted by the adrenal cortex. Measuring cortisol levels in body fluids is essential for evaluating stress levels, adrenal function, hormone imbalances, and psychological...
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Government may approve fresh applications for chip facilities in India
New projects could be announced in the upcoming Semicon India between September 11 and 13
The application of a self-designed microfluidic lung chip in the assessment of different inhalable aerosols
DOI: 10.1039/D4AY00017J, Paper
Microfluidic-based assessment platforms have recently attracted considerable attention and have been widely used for evaluating in vitro toxic effects.
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The selective extraction of dietary polyamines from chicken breast using the application of a lab-on-a-chip electromembrane and dispersive liquid–liquid microextraction followed by gas chromatography-mass spectrometry
DOI: 10.1039/D3AY02172F, Paper
Excessive dietary polyamines (PAs), including putrescine (PUT), spermine (SPM), and spermidine (SPD), have become a worldwide concern due to their carcinogenicity and reduced shelf life.
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On-chip light sheet illumination for nanoparticle tracking in microfluidic channels
DOI: 10.1039/D3AY02290K, Communication
A simple and inexpensive method is presented to efficiently integrate light sheet illumination in a microfluidic chip for dark-field microscopic tracking and sizing of nanoparticles.
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Markets rebound in early trade amid buying in blue-chip stocks
Equity market indices rebound with blue-chip stocks, fund inflows; Sensex climbs 239.33 points, Nifty up by 72.95 points
U.S. faces shortage of IV fluids, India alerts domestic firms to chip in
The drug exporters body of India has asked Indian drug makers who have approvalsz, to express their willingness to supply to the U.S., where Hurricane Helene has caused damage to a manufacturing facility
Development of an automated platform for monitoring microfluidic reactors through multi-reactor integration and online (chip-)LC/MS-detection
DOI: 10.1039/D4RE00004H, Paper
Biocatalysis with packed-bed microreactors: a novel method combining microreactor technology, multi-reactor integration, and online (chip-)LC/MS analysis in a sequential automated workflow.
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MLAs chip in to improve the bus stops in Tambaram Corporation
Tambaram MLA S.R. Raja allotted ₹15 lakh under the MLA Constituency Development Scheme for building a concrete bus shelter at Sanatorium on GST Road. Pallavaram MLA E. Karunanidhi allotted funds for building a new concrete bus shelter at Chromepet
Optimization of hair follicle spheroids for hair-on-a-chip
DOI: 10.1039/D3BM02012F, Paper
We report spheroids prepared by injecting LEF1 and Wnt1 into DPCs via transfection and then adding KCs and HUVECs. Through SEM, we observed a part extending outward from the TK and TKH surfaces, as indicated by white arrows.
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Neuroinflammatory response on a newly combinatorial cell–cell interaction chip
DOI: 10.1039/D4BM00125G, Paper
Neuroinflammatory response on a novel combinatorial cell–cell interaction chip.
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