SiriusPoint appointed Anthony Shapella as Group Chief Underwriting Officer and David Govrin to focus on Global Reinsurance, effective January 1, 2025. A spokesperson said, “SiriusPoint Ltd.  a global specialty insurer and reinsurer, has today announced changes to its Chief Underwriting Office leadership to support plans for further growth and profitability in 2025. “From January 1, […]

Saltus announced the retirement of Board Chair Gil Tucker after 13 years, appointing E. Michael Leverock as his successor and celebrating Tucker’s significant contributions to the school and Bermuda community. A spokesperson said, “After an impressive 13-year tenure as Board Chair and 27 years as a Board Trustee, Saltus is announcing the retirement of Gil […]

The government is expected to announce that a $100 monthly personal allowance to cover the cost of personal care items will be added for people on financial assistance and the Ministry of Transport will reduce the number of vehicle inspections required in the first five years for a new vehicle. In advance of tomorrow’s reading […]

1. Outback Queensland residents spend thousands on flights, grapple with Qantas service changes  ABC News
2. Airlines that love competition: Do you see pigs fly?  Sydney Morning Herald
3. Predictably, domestic airfares surged after the collapse of Rex. There aren’t many good solutions  The Conversation
4. Report finds just how much airfares spiked since end of Rex. One route doubled  The Canberra Times
5. Qantas’ single excuse for fare price hike  news.com.au

Adopting a healthy lifestyle by making positive changes is not always easy. It involves setting realistic goals and making gradual changes that lead to significant achievements. Generally, small positive changes are more sustainable than sudden ones. Therefore, anyone seeking to improve their diet and lifestyle should consider making minor changes that eventually have a significant ... Read more

The post The Power of Nutrition: Small Changes That Make a Big Difference appeared first on Star Two.

eBay Partner Network has moved from rover-based tracking links to a new tracking link format, which complies with industry standards. All former rover-based tracking links have to be replaced with the new tracking links by Wednesday, March 31.  Read more.   We are ready for these changes and have released update for our eBay Feeds […]

The post Important Changes In eBay Feeds Generator appeared first on RSSground.com.

After the recent changes at the Shopify platform we had to make some updates to our Shopify Feeds generator.  Shopify has deprecated its private apps. They were not completely removed, they were replaced by custom apps.   Read more about Shopify custom apps  You can still continue using your existing private apps and its credentials with […]

The post Important Changes in Shopify Feeds Generator appeared first on RSSground.com.

What causes those beautiful reds, oranges, and pinks at sunset?

With Donald Trump's re-election, millions of federal student loan borrowers are left to wonder if this is the end of the road for President Biden's promises of loan relief.

Meta is taking the European Union a little more seriously, as the EU has requested the US-based company to put… Continue reading Meta and the EU butt heads again amid changes to ads

The post Meta and the EU butt heads again amid changes to ads appeared first on ReadWrite.

Americans will only achieve healthy public discourse when we agree on basic principles and start telling the truth. As it stands, however, too many elected officials engage in hypocrisy by […]

The post Dem Lawmaker Says the Quiet Part Out Loud as She Suddenly Changes Her Tune on the Senate Filibuster appeared first on The Western Journal.

Lys234 is one of the residues present in class A β-lactamases that is under selective pressure due to antibiotic use. Located adjacent to proton shuttle residue Ser130, it is suggested to play a role in proton transfer during catalysis of the antibiotics. The mechanism underpinning how substitutions in this position modulate inhibitor efficiency and substrate specificity leading to drug resistance is unclear. The K234R substitution identified in several inhibitor-resistant β-lactamase variants is associated with decreased potency of the inhibitor clavulanic acid, which is used in combination with amoxicillin to overcome β-lactamase–mediated antibiotic resistance. Here we show that for CTX-M-14 β-lactamase, whereas Lys234 is required for hydrolysis of cephalosporins such as cefotaxime, either lysine or arginine is sufficient for hydrolysis of ampicillin. Further, by determining the acylation and deacylation rates for cefotaxime hydrolysis, we show that both rates are fast, and neither is rate-limiting. The K234R substitution causes a 1500-fold decrease in the cefotaxime acylation rate but a 5-fold increase in kcat for ampicillin, suggesting that the K234R enzyme is a good penicillinase but a poor cephalosporinase due to slow acylation. Structural results suggest that the slow acylation by the K234R enzyme is due to a conformational change in Ser130, and this change also leads to decreased inhibition potency of clavulanic acid. Because other inhibitor resistance mutations also act through changes at Ser130 and such changes drastically reduce cephalosporin but not penicillin hydrolysis, we suggest that clavulanic acid paired with an oxyimino-cephalosporin rather than penicillin would impede the evolution of resistance.

The divalent anion sodium symporter (DASS) family (SLC13) plays critical roles in metabolic homeostasis, influencing many processes, including fatty acid synthesis, insulin resistance, and adiposity. DASS transporters catalyze the Na+-driven concentrative uptake of Krebs cycle intermediates and sulfate into cells; disrupting their function can protect against age-related metabolic diseases and can extend lifespan. An inward-facing crystal structure and an outward-facing model of a bacterial DASS family member, VcINDY from Vibrio cholerae, predict an elevator-like transport mechanism involving a large rigid body movement of the substrate-binding site. How substrate binding influences the conformational state of VcINDY is currently unknown. Here, we probe the interaction between substrate binding and protein conformation by monitoring substrate-induced solvent accessibility changes of broadly distributed positions in VcINDY using a site-specific alkylation strategy. Our findings reveal that accessibility to all positions tested is modulated by the presence of substrates, with the majority becoming less accessible in the presence of saturating concentrations of both Na+ and succinate. We also observe separable effects of Na+ and succinate binding at several positions suggesting distinct effects of the two substrates. Furthermore, accessibility changes to a solely succinate-sensitive position suggests that substrate binding is a low-affinity, ordered process. Mapping these accessibility changes onto the structures of VcINDY suggests that Na+ binding drives the transporter into an as-yet-unidentified conformational state, involving rearrangement of the substrate-binding site–associated re-entrant hairpin loops. These findings provide insight into the mechanism of VcINDY, which is currently the only structurally characterized representative of the entire DASS family.

Synaptic transmission leading to release of neurotransmitters in the nervous system is a fast and highly dynamic process. Previously, protein interaction and phosphorylation have been thought to be the main regulators of synaptic transmission. Here we show that sialylation of N-linked glycosylation is a novel potential modulator of neurotransmitter release mechanisms by investigating depolarization-dependent changes of formerly sialylated N-linked glycopeptides. We suggest that negatively charged sialic acids can be modulated, similarly to phosphorylation, by the action of sialyltransferases and sialidases thereby changing local structure and function of membrane glycoproteins. We characterized site-specific alteration in sialylation on N-linked glycoproteins in isolated rat nerve terminals after brief depolarization using quantitative sialiomics. We identified 1965 formerly sialylated N-linked glycosites in synaptic proteins and found that the abundances of 430 glycosites changed after 5 s depolarization. We observed changes on essential synaptic proteins such as synaptic vesicle proteins, ion channels and transporters, neurotransmitter receptors and cell adhesion molecules. This study is to our knowledge the first to describe ultra-fast site-specific modulation of the sialiome after brief stimulation of a biological system.

Afonso Dhlakama’s Death Changes the Calculation for Peace Prospects in Mozambique Expert comment sysadmin 4 May 2018

If politicians continue to act in good faith, the death of the opposition leader may be a significant opportunity to finally draw a line under Mozambique’s long war.

The unexpected death of opposition and ex-rebel leader Afonso Dhlakama on 3 May is a game changer for Mozambique’s politics and an almost-completed peace process. The 65-year old Dhlakama, who died of a heart attack, had led Renamo for 38 years and had totally dominated his party. Dhlakama regularly boasted that he was Mozambique’s ‘father of democracy’, despite not allowing competition within his own party, and he leaves a legacy of more than 30 years of struggle, through both armed action and peaceful politics.

A long war

Originally Renamo had been a tool for the white minority regimes of Rhodesia and apartheid South Africa to challenge the socialist Frelimo political party that took power in Mozambique in 1975. But under Dhlakama’s command, by the late 1980s Renamo had become increasingly independent and rooted in Mozambique. After Renamo’s long war with Frelimo ground to a hurting stalemate, a transition led to Mozambique’s first multiparty elections in 1994, and the creation of a new joint army. A ‘pay and scatter’ programme successfully dispersed and reintegrated many thousands of ex-combatants.

But early post-election gains did not translate to lasting peace. Disarmament was a time-limited, technical process, and devoted declining resources and attention to clusters of ex-combatants that failed to disperse. In addition, Dhlakama was allowed to maintain an armed militia under the guise of a presidential guard.

Mounting economic inequality, notably in opposition strongholds such as central Mozambique, saw Renamo made political gains and Dhlakama nearly won the 1999 presidential elections. (Some believe he did.) The result focused Frelimo’s attention on the threat that Renamo posed and, ultimately, a strategy of pursuing total Frelimo domination across the country, culminating in a crushing Frelimo victory at the 2009 elections.

This humiliated and marginalized former Renamo rebels, resulting in Dhlakama ordering their return to targeted armed violence in 2013. Frelimo’s new leader, President Filipe Nyusi, took power in 2015 and sought direct dialogue with Dhlakama. Five rounds of internationally mediated peace talks took place from July to December. Finally, in late December 2016, Dhlakama announced a unilateral truce, which was extended twice and subsequently made indefinite.

New peace talks also started and, in August 2017 and February 2018, President Nyusi and Dhlakama showed the courage to meet in person, near Renamo’s base in central Mozambique, to build up mutual trust and discuss the details of the emerging peace deal – including the demobilization or integration into government security forces for Renamo’s now mostly middle-aged gunmen.

Dhlakama the ‘Big Man’

Dhlakama’s sudden death has fundamentally changed the negotiation dynamics. He never allowed for any serious succession planning, and ensured all key decisions were his and his alone. Renamo had already decided that he would be its presidential candidate for the 2019 national elections.

His party is significantly weakened by his death and unlikely able to fully recover – but needs to try and reach consensus quickly on a successor, as it will also compete in municipal elections in October and was expecting significant gains. There will be a number of contenders to succeed him including from the parliamentary wing, led by his niece Ivone Soares, its secretary general, Manuel Bissopo, and a few others.

But Renamo’s key leverage for now remains some 1,000 middle-aged gunmen in central Mozambique who have been stoically loyal to Dhlakama since the 1980s and who have little respect for the younger generation of professional politicians based in Maputo. Some may be bought off by government offers, others integrated into localised organized crime groups and others into internal Renamo sectarianism. The risk of fragmentation is real.

Renamo’s weakness could also embolden Frelimo hardliners to seek a return to unilateral domination of Mozambique’s political landscape, and to undermine the peace process. That would be a serious tactical mistake by Frelimo, as a lasting deal is close and the death of Dhlakama could actually assist in making this settlement lasting. Dhlakama was quixotic and prone to changing his mind, often influenced by the last person he spoke to – his death potentially introduces greater predictability in negotiations and in any post-deal implementation.

President Nyusi is clearly aware of this as he hailed on state television TVM that Dhlakama was ‘a citizen who has always worked for Mozambique’ and said he was distraught at the news of his death. He stated, ‘I hope that we as Mozambicans can continue to do everything so things do not go down.’ He also addressed Renamo’s support base by saying that ‘[Dhlakama] did everything so that there would be peace. The last time he spoke to me, he said he was not going to miss out anything in peace negotiations.’

Renamo’s gunmen are fatigued and want to retire with dignity but are vulnerable to manipulation and political miscalculation by Mozambican’s positioning politicians. International partners and investors can engage, by emphasizing that sustainable peace is the only pathway to poverty reduction and inclusive economic development.

This includes assisting development and reconciliation projects in areas impacted by the renewed conflict since 2013. Long-term investment for development in Renamo’s key constituencies could help avoid fragmentation at a critical time – faith groups and NGOs may also have a key role to play.

If Mozambique’s politicians continue to act in good faith, the death of Dhlakama may constitute a significant opportunity to finally draw a line under Mozambique’s long war.

Private schools in New York soon will be required to report suspected sexual abuse of students in their schools to law enforcement, bringing the independent schools under the same rules as public schools.

Mary Jackson's story is among those depicted in the book "Hidden Figures," which focused on the lives of black women who worked as mathematicians and engineers for NASA during the Space Race. Before landing there, Jackson worked as a math teacher in Maryland.

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Rome, 2 December 2014 – The Ministers of Agriculture of the European Union and of other Mediterranean countries welcomed FAO’s transformational changes implemented in the last two years, and underlined [...]

The surge of hungry four-legged visitors to Belushya Guba is part of a larger trend

The City of Winnipeg is advising residents of alternative options to access several city-run services that could be disrupted by the end of this week in the event of a work stoppage at Canada Post. 

The third developer beta of iOS 18.2 is now available for all compatible iPhone models, as Apple Intelligence testing continues. Here's everything you need to know about the update.

OM Madagascar uses sport as tool for reaching youth with the gospel and relationship building.

OM Pakistan encourages believing communities by helping them understand God’s message to His Church.

An OM team in Pakistan regularly visits families to share God’s Word and pray for them, and sometimes they witness God change the families’ lives.

OM worker is amazed to see God change lives, as he peers over his book table on a busy Muslim street in Australia.

Inadequate monitoring and a lack of qualified staff left the bureau unable to ensure that thousands of special education students received the services they were due under federal law, a Government Accountability Office reports finds.

Inadequate monitoring and a lack of qualified staff left the bureau unable to ensure that thousands of special education students received the services they were due under federal law, a Government Accountability Office reports finds.

A newly married couple in the Arabian Peninsula finds fresh opportunity to share their story with local friends.

As schools apply more scrutiny to the methods and materials they use to teach early reading, educators and parents in some states have started to form new advocacy efforts—trying to pressure states and districts to adopt new approaches to teacher training and evaluating materials.

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Ariela left Argentina to serve Rohingya refugees in Bangladesh and ended up going on a journey she never could have imagined.

Dover, Del.—Secretary of State Jeff Bullock announced on Friday that Jordan Schulties, Director of the Division of Small Business, and Tim Slavin, Director of the Division of Historical and Cultural Affairs, will depart from their roles to embark on new journeys at the Delaware Department of Technology and Information (DTI) and Fort Dupont Redevelopment & […]

Secretary of State Jeff Bullock on Friday announced that Regina Mitchell will lead the Delaware Division of Small Business as its next Director. Mitchell most recently served as the Acting Director of the Division of Small Business. “Regina has the work ethic, experience, and leadership skills to lead the Division through the challenges and opportunities […]

Attorney General Kathy Jennings applauded several policy changes implemented by the Criminal Justice Council as part of its ongoing efforts to strengthen rights for survivors of sexual assault. The new policies establish timelines for the collection, documentation, processing and investigation of assault evidence “kits.” This policy is a result of funding received from the U.S. […]

Attorney General Kathy Jennings announced Tuesday that A.J. Roop will serve as the DOJ’s next Chief of Staff. A seven-year veteran of the DOJ, Roop has served as State Prosecutor throughout AG Jennings’ term, leading the DOJ’s largest Division, maintaining the Department’s high conviction rate in gun cases, and guiding the Criminal Division through a […]

Attorney General Kathy Jennings announced Monday that Elmer Setting will serve as the DOJ’s next Chief of Staff. Setting served as Deputy State Court Administrator and Acting State Court Administrator, where he managed security and operations for all six Delaware Courts. He is a former Chief of New Castle County Police (2012-2017), whose leadership and innovation […]

THE NEW YEAR BRINGS LEADERSHIP CHANGES TO THE DELAWARE DEPARTMENT OF LABOR   WILMINGTON, DE (February 23, 2021) – The Delaware Department of Labor has announced leadership changes for the organization. Karryl Hubbard will now serve as the new Delaware Secretary of Labor, Rachel Turney will serve as the incoming Deputy Cabinet Secretary, and Richard […]

The Food and Drug Administration (FDA) published a proposed rule change on December 6, 2021, to amend the agricultural water requirements of the Produce Safety Rule. In response to the proposed change, the Delaware Department of Agriculture and University of Delaware Cooperative Extension will host two outreach sessions on January 21, 2022, to engage farmers and other stakeholders.

NEW CASTLE (Jan. 25, 2022) – Department of Health and Social Services (DHSS) Secretary Molly Magarik today announced three leadership changes for the agency involving one division and one of the Department’s Deputy Secretary positions. The changes: Daniel Walker, who has served in leadership roles with the Wilmington City Council and a Wilmington-based nonprofit education […]

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NEW CASTLE (Nov. 2, 2022) – The Division of Child Support Services’ (DCSS) today announced a new partnership with TD Bank. As of Nov. 14, 2022, Division of Child Support Services paper checks will no longer be drawn on PNC Bank. On Thursday, Oct. 20, DCSS sent letters to all state child support agencies, all […]