Reportedly part of an upcoming Catwoman documentary, the footage also features Zoe Kravitz describing her iteration of the anti-hero in the Matt Reeves-directed movie.

Reportedly part of an upcoming Catwoman documentary, the footage also features Zoe Kravitz describing her iteration of the anti-hero in the Matt Reeves-directed movie.

A Good Hope consultant has won international recognition for leading a new treatment study

Adam Lisagor returns to the show. Topics include the cinematic and presentation style of Apple’s WWDC keynote, some post-production details on The Talk Show’s WWDC episode, the tribulations of producing professional videos during COVID-19, and the new sounds of MacOS 11 Big Sur.

Rene Ritchie returns to the show. Topics include Phil Schiller advancing to Apple Fellow, Microsoft’s simmering spat with Apple over Xbox Game Pass and the App Store’s ban on game streaming services, and Epic’s sizzling spat with Apple over, well, the entire concept of iOS as we know it.

Most Canadians are secure knowing that they benefit from universal health care. All you have to do is walk into a clinic or hospital and you will be treated. For an estimated 500,000 people who live and work among us, it’s a different reality.

The catalyst of creation located in the power of psychic persuasion.

[Written by Stephen Wright] Bermuda triple jumper Jah-Nhai Perinchief said he is settling into life at the Olympic Village in Saint-Denis after arriving in Paris from Arkansas today [July 25]. Perinchief, who does not compete until August 7, will be joined in the French capital by coach Travis Geopfert and mentor Brian Wellman. He told […]

Bermuda Hospitals Board [BHB] is “partnering with Lahey Hospital & Medical Center, Optimum Wellness and the Bermuda College Division of Nursing & Allied Health to offer a free, public panel discussion about the latest treatment options for male and female incontinence.” A spokesperson said, “The free event will take place from 3pm to 5pm on Saturday […]

Examining MicroStrategy’s record-shattering $21bn ATM Roula Khalaf, Editor of the FT, selects her favourite stories in this weekly newsletter. History, they say, doesn’t repeat, but it often rhymes. Bitcoin-hodling MicroStrategy is an excellent example. In early 2000, MicroStrategy embodied the…

Uncanny Valley-$2.59

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The hepatitis E virus protein ORF1 contains a region that scientists have struggled to characterize, making the structure and function of this region the subject of much debate. Now, Princeton scientists show that this region of the protein does not behave as a protease, as has been previously suggested, but instead serves as a molecular scaffold to stabilize the rest of the ORF1 protein.

To combat climate change, scientists are working to remove carbon dioxide from the atmosphere.

(Nov. 9, to kick off Veterans Day weekend)  MOBILE, Alabama — On this Veterans Day, Alabama is roiled by a doozy of a veterans-related controversy. Republican Gov. Kay Ivey last month invoked […]

The post Gov. Ivey’s treatment of Bama veterans is a scandal appeared first on Quin Hillyer.

The Ipswich legend and former Scotland manager says he is feeling optimistic after his initial treatment.

bradders1999 posted a photo:

The MATRIX-Style colour grading version.

Minifigures made, photographed and edited by me.

Conroy Overdose's 'Life of a Star' birthday bash sizzled recently at Cool Breeze Entertainment Complex in Church Pen, St Catherine. Glamorous ladies and dapper gents gathered for a night of high fashion and revelry. The Sharper Lane venue pulsed...

The increasing consumption of high-fat foods combined with a lack of exercise is a major contributor to the burden of obesity in humans. Aerobic exercise such as running is known to provide metabolic benefits, but how the over-consumption of a high fat diet (HFD) and exercise interact is not well characterized at the molecular level. Here, we examined the plasma proteome in mice for the effects of aerobic exercise as both a treatment and as a preventative regime for animals on either HFD or a healthy control diet. This analysis detected large changes in the plasma proteome induced by the HFD, such as increased abundance of SERPINA7, ALDOB, and down-regulation of SERPINA1E, CFD (adipsin). Some of these changes were significantly reverted using exercise as a preventative measure, but not as a treatment regime. To determine if either the intensity, or duration, of exercise influenced the outcome, we compared high-intensity interval training (HIIT) and endurance running. Endurance running slightly out-performed HIIT exercise, but overall, both provided similar reversion in abundance of plasma proteins modulated by the high-fat diet including SERPINA7, APOE, SERPINA1E, and CFD. Finally, we compared the changes induced by over-consumption of HFD to previous data from mice fed an isocaloric high saturated fat (SFA) or polyunsaturated fat (PUFA) diet. This identified several common changes including increased APOC2 and APOE, but also highlighted changes specific for either over-consumption of HFD (ALDOB, SERPINA7, CFD), SFA-based diets (SERPINA1E), or PUFA-based diets (Haptoglobin - Hp). Together, these data highlight the importance of early intervention with exercise to revert HFD-induced phenotypes and suggest some of the molecular mechanisms leading to the changes in the plasma proteome generated by high fat diet consumption. Web-based interactive visualizations are provided for this dataset (larancelab.com/hfd-exercise), which give insight into diet and exercise phenotypic interactions on the plasma proteome.

Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressing role via its interaction with RNF20 (ring finger protein 20) in shaping chromatin landscape and preserving genomic stability. However, the mechanism that mobilizes SMURF2 in response to DNA damage remains unclear. Using biochemical approaches and MS analysis, we show that upon the onset of the DNA-damage response, SMURF2 becomes phosphorylated at Ser384 by ataxia telangiectasia mutated (ATM) serine/threonine kinase, and this phosphorylation is required for its interaction with RNF20. We demonstrate that a SMURF2 mutant with an S384A substitution has reduced capacity to ubiquitinate RNF20 while promoting Smad3 ubiquitination unabatedly. More importantly, mouse embryonic fibroblasts expressing the SMURF2 S384A mutant show a weakened ability to sustain the DSB response compared with those expressing WT SMURF2 following etoposide treatment. These data indicate that SMURF2-mediated RNF20 ubiquitination and degradation controlled by ataxia telangiectasia mutated–induced phosphorylation at Ser384 constitutes a negative feedback loop that regulates DSB repair.

Our objective is to explore quantitative imaging markers for early prediction of treatment response in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) undergoing [¹⁷⁷Lu]Lu-DOTATATE therapy. By doing so, we aim to enable timely switching to more effective therapies in order to prevent time-resource waste and minimize toxicities. Methods: Patients diagnosed with unresectable or metastatic, progressive, well-differentiated, receptor-positive GEP-NETs who received 4 sessions of [¹⁷⁷Lu]Lu-DOTATATE were retrospectively selected. Using SPECT/CT images taken at the end of treatment sessions, we counted all visible tumors and measured their largest diameters to calculate the tumor burden score (TBS). Up to 4 target lesions were selected and semiautomatically segmented. Target lesion peak counts and spleen peak counts were measured, and normalized peak counts were calculated. Changes in TBS (TBS) and changes in normalized peak count (nPC) throughout treatment sessions in relation to the first treatment session were calculated. Treatment responses were evaluated using third-month CT and were binarized as progressive disease (PD) or non-PD. Results: Twenty-seven patients were included (7 PD, 20 non-PD). Significant differences were observed in TBS_second-first, TBS_third-first, and TBS_fourth-first (where second-first, third-first, and fourth-first denote scan number between the second and first, third and first, and fourth and first [¹⁷⁷Lu]Lu-DOTATATE treatment cycles), respectively) between the PD and non-PD groups (median, 0.043 vs. –0.049, 0.08 vs. –0.116, and 0.109 vs. –0.123 [P = 0.023, P = 0.002, and P < 0.001], respectively). nPC_second-first showed significant group differences (mean, –0.107 vs. –0.282; P = 0.033); nPC_third-first and nPC_fourth-first did not reach statistical significance (mean, –0.122 vs. –0.312 and –0.183 vs. –0.405 [P = 0.117 and 0.067], respectively). At the optimal threshold, TBS_fourth-first exhibited an area under the curve (AUC) of 0.957, achieving 100% sensitivity and 80% specificity. TBS_second-first and TBS_third-first reached AUCs of 0.793 and 0.893, sensitivities of 71.4%, and specificities of 85% and 95%, respectively. nPC_second-first, nPC_third-first, and nPC_fourth-first showed AUCs of 0.764, 0.693, and 0.679; sensitivities of 71.4%, 71.4%, and 100%; and specificities of 75%, 70%, and 35%, respectively. Conclusion: TBS and nPC can predict [¹⁷⁷Lu]Lu-DOTATATE response by the second treatment session.

A new technology developed by NASA to predict space weather showed that Hurricane Helene produced "enormous" waves in the Earth's upper atmosphere as it came ashore on Sept. 26, the agency says.

Alzheimer's disease (AD) and Alzheimer's disease-related dementias (ADRDs) are broad-impact multifactorial neurodegenerative diseases. Their complexity presents unique challenges for developing effective therapies. This review highlights research presented at the 2024 Society for Neuroscience meeting which emphasized the gut microbiome's role in AD pathogenesis by influencing brain function and neurodegeneration through the microbiota–gut–brain axis. This emerging evidence underscores the potential for targeting the gut microbiota to treat AD/ADRD.

Scientists converted the patient’s own cells into blood sugar-regulating cell clusters before injecting them back into her abdomen—and one year later, she still doesn't need insulin injections

Across Canada, there’s a growing number of political leaders proposing to force people into treatment for drug addiction, despite inconclusive evidence about its effectiveness.

An OM short-term team worships God and engages in conversations about God in the public square of a city with an Arab majority in Israel.

Active-duty service members and veterans experiencing PTSD have additional opportunities for treatment to support them, along with their partners, after the Department of Defense awarded a $3 million grant to Steffany Fredman, associate professor of human development and family studies, and colleagues in the STRONG STAR Consortium.

Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta 1a, and remdesivir, have shown that these compounds lack an impact on the COVID-19 course. Although the phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its antiviral activity was 27.5-fold more potent than that of remdesivir (K. M. White, R. Rosales, S. Yildiz, T. Kehrer, et al., Science, 2021, https://science.sciencemag.org/content/early/2021/01/22/science.abf4058). Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. Plitidepsin has shown efficacy in animal models and phase I/II human trials. Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.

Discovery Health Medical Scheme's (DHMS) 2023 cancer claims payouts were almost 19% higher than the previous year though the scheme says screening rates in South Africa have mostly returned to pre-pandemic levels.

On September 26, NASA’s Atmospheric Waves Experiment (AWE) captured atmospheric gravity waves caused by Hurricane Helene’s powerful landfall along Florida’s Gulf Coast. These waves, observed as concentric ripples extending from Florida, highlight NASA’s efforts to understand how terrestrial weather can impact space weather and disrupt communication systems. AWE’s observations offer a critical step in decoding the effects of severe storms on the upper atmosphere.

DOVER – Revenue from a new opioid impact fee created by the Delaware General Assembly in 2019 will be used to prevent overdose deaths and provide new services to those seeking treatment for their substance use disorder, the Delaware Department of Health and Social Services (DHSS) and Sen. Stephanie Hansen announced Wednesday. DHSS Secretary Molly […]

DOVER, Del. (March 17, 2023) -  The Delaware Division of Public Health (DPH) saw a decrease in case rates and hospitalizations from COVID-19 over the past month and urges residents to remain vigilant and use the tools proven successful in the fight against the virus to continue these trends. While rates are down from the […]

DOVER, Del. – Governor John Carney on Wednesday issued the following statement on the Senate’s vote to confirm the Governor’s nominations of Josette Manning to serve as Cabinet Secretary of the Delaware Department of Health and Social Services; Steven Yeatman to serve as Cabinet Secretary of the Delaware Department of Children, Youth, and Their Families; and Robert […]

Read the in depth Review of Batman: Arkham Origins Gaming. Know detailed info about Batman: Arkham Origins configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Read the in depth Review of Zebronics Juke bar 9700 Pro Dolby Atmos Audio Video. Know detailed info about Zebronics Juke bar 9700 Pro Dolby Atmos configuration, design and performance quality along with pros & cons, Digit rating, verdict based on user opinions/feedback.

Man accused of stealing car and taking money from a shrine placed under two-year treatment order by a court

Male pattern baldness could soon be a thing of the past, with new hair loss treatments beginning to show tantalising results

We're finally pinning down the mechanisms that drive obsessive-compulsive disorder, revealing a complex combination of imbalanced brain networks, the immune system and even gut microbes

The stratosphere seems to be full of aluminium particles and other metals that come from spacecraft burning up in the atmosphere, and those particles could mess up polar clouds

Millions of tonnes of water vapour have been lingering in the atmosphere since the Hunga Tonga-Hunga Ha’apai volcano erupted in 2022– possibly contributing to global warming

This claustrophobia-inducing image is taken from photographer Martin Broen's new book Light in the Underworld, a collection of shots from the Yucatán’s cenotes, or sinkholes

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