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Diuretic Treatment of Hypertension

Ehud Grossman
May 1, 2011; 34:S313-S319
Hypertension




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Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: A Joint Statement by International Diabetes Organizations

Francesco Rubino
Jun 1, 2016; 39:861-877
Metabolic Surgery and the Changing Landscape for Diabetes Care




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Treatment of Type 2 Diabetes: From "Guidelines" to "Position Statements" and Back: Recommendations of the Israel National Diabetes Council

Ofri Mosenzon
Aug 1, 2016; 39:S146-S153
II. Diabetes Treatment Options




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A Multinational, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy of Cyclical Topical Wound Oxygen (TWO2) Therapy in the Treatment of Chronic Diabetic Foot Ulcers: The TWO2 Study

OBJECTIVE

Topical oxygen has been used for the treatment of chronic wounds for more than 50 years. Its effectiveness remains disputed due to the limited number of robust high-quality investigations. The aim of this study was to assess the efficacy of multimodality cyclical pressure Topical Wound Oxygen (TWO2) home care therapy in healing refractory diabetic foot ulcers (DFUs) that had failed to heal with standard of care (SOC) alone.

RESEARCH DESIGN AND METHODS

Patients with diabetes and chronic DFUs were randomized (double-blind) to either active TWO2 therapy or sham control therapy—both in addition to optimal SOC. The primary outcome was the percentage of ulcers in each group achieving 100% healing at 12 weeks. A group sequential design was used for the study with three predetermined analyses and hard stopping rules once 73, 146, and ultimately 220 patients completed the 12-week treatment phase.

RESULTS

At the first analysis point, the active TWO2 arm was found to be superior to the sham arm, with a closure rate of 41.7% compared with 13.5%. This difference in outcome produced an odds ratio (OR) of 4.57 (97.8% CI 1.19, 17.57), P = 0.010. After adjustment for University of Texas Classification (UTC) ulcer grade, the OR increased to 6.00 (97.8% CI 1.44, 24.93), P = 0.004. Cox proportional hazards modeling, also after adjustment for UTC grade, demonstrated >4.5 times the likelihood to heal DFUs over 12 weeks compared with the sham arm with a hazard ratio of 4.66 (97.8% CI 1.36, 15.98), P = 0.004. At 12 months postenrollment, 56% of active arm ulcers were closed compared with 27% of the sham arm ulcers (P = 0.013).

CONCLUSIONS

This sham-controlled, double-blind randomized controlled trial demonstrates that, at both 12 weeks and 12 months, adjunctive cyclical pressurized TWO2 therapy was superior in healing chronic DFUs compared with optimal SOC alone.




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Arizona Mission of Mercy event provides treatment to over 1,700

The Central Arizona Dental Society hosted a Mission of Mercy event Dec. 13-14 at the Arizona State Fairgrounds in Phoenix, providing treatment to 1,785 patients totaling just over $2 million in free dental service.




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ADA urges CDC to provide ‘immediate guidance’ on protecting dental patients, staff from COVID-19 during emergency treatments

The American Dental Association is urging the Centers for Disease Control and Prevention to provide immediate guidance on the best way to protect dental patients and staff from the transmission of COVID-19 during emergency and urgent care situations.




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North Carolina interactive map launches to help public find emergency dental treatment during pandemic

A North Carolina oral health coalition, in collaboration with multiple state partners, has developed an interactive map to help guide the public to sites where emergency dental services are available throughout the Tar Heel State both during and after the COVID-19 outbreak.




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UCLA dental school researchers create nanoparticle that could improve bone defect treatment

A team of researchers at the University of California, Los Angeles School of Dentistry has developed a nanoparticle that could improve treatment for bone defects.




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Cancer patients on Medicaid might not benefit from experimental treatments, study finds

Cancer patients on Medicaid or who don't have insurance benefit less from experimental treatments, even if they get into clinical trials, a study published Thursday by JAMA Network Open has found.




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Johns Hopkins to launch trials of blood plasma treatment for COVID-19

Johns Hopkins University will start two clinical trials of convalescent blood plasma for treatment of COVID-19, the disease caused by the new coronavirus.




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Screening and Treatment Outcomes in Adults and Children With Type 1 Diabetes and Asymptomatic Celiac Disease: The CD-DIET Study

OBJECTIVE

To describe celiac disease (CD) screening rates and glycemic outcomes of a gluten-free diet (GFD) in patients with type 1 diabetes who are asymptomatic for CD.

RESEARCH DESIGN AND METHODS

Asymptomatic patients (8–45 years) were screened for CD. Biopsy-confirmed CD participants were randomized to GFD or gluten-containing diet (GCD) to assess changes in HbA1c and continuous glucose monitoring over 12 months.

RESULTS

Adults had higher CD-seropositivity rates than children (6.8% [95% CI 4.9–8.2%, N = 1,298] vs. 4.7% [95% CI 3.4–5.9%, N = 1,089], P = 0.035) with lower rates of prior CD screening (6.9% vs. 44.2%, P < 0.0001). Fifty-one participants were randomized to a GFD (N = 27) or GCD (N = 24). No HbA1c differences were seen between the groups (+0.14%, 1.5 mmol/mol; 95% CI –0.79 to 1.08; P = 0.76), although greater postprandial glucose increases (4-h +1.5 mmol/L; 95% CI 0.4–2.7; P = 0.014) emerged with a GFD.

CONCLUSIONS

CD is frequently observed in asymptomatic patients with type 1 diabetes, and clinical vigilance is warranted with initiation of a GFD.




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Continuous Positive Airway Pressure Treatment, Glycemia, and Diabetes Risk in Obstructive Sleep Apnea and Comorbid Cardiovascular Disease

OBJECTIVE

Despite evidence of a relationship among obstructive sleep apnea (OSA), metabolic dysregulation, and diabetes, it is uncertain whether OSA treatment can improve metabolic parameters. We sought to determine effects of long-term continuous positive airway pressure (CPAP) treatment on glycemic control and diabetes risk in patients with cardiovascular disease (CVD) and OSA.

RESEARCH DESIGN AND METHODS

Blood, medical history, and personal data were collected in a substudy of 888 participants in the Sleep Apnea Cardiovascular End Points (SAVE) trial in which patients with OSA and stable CVD were randomized to receive CPAP plus usual care, or usual care alone. Serum glucose and glycated hemoglobin A1c (HbA1c) were measured at baseline, 6 months, and 2 and 4 years and incident diabetes diagnoses recorded.

RESULTS

Median follow-up was 4.3 years. In those with preexisting diabetes (n = 274), there was no significant difference between the CPAP and usual care groups in serum glucose, HbA1c, or antidiabetic medications during follow-up. There were also no significant between-group differences in participants with prediabetes (n = 452) or in new diagnoses of diabetes. Interaction testing suggested that women with diabetes did poorly in the usual care group, while their counterparts on CPAP therapy remained stable.

CONCLUSIONS

Among patients with established CVD and OSA, we found no evidence that CPAP therapy over several years affects glycemic control in those with diabetes or prediabetes or diabetes risk over standard-of-care treatment. The potential differential effect according to sex deserves further investigation.




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Five Types of Research, Underexplored until Recently, Could Produce Alzheimer's Treatments

Research into the brain’s protein-disposal systems, electrical activity and three other areas looks promising

-- Read more on ScientificAmerican.com




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A Harder Look at Alzheimer's Causes and Treatments

Amyloid, the leading target for dementia therapy, faces skepticism after drug failures

-- Read more on ScientificAmerican.com




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Mahatma Breakfast - Ayurvedic turmeric, rolled rice porridge

This deliciously warming Ayurvedic gluten-free breakfast idea came from my good friend Brenda when she owned Mondo Organics in Brisbane. I've tweaked it a little to suit what was in my pantry today. The perfect brekky after Sunday morning yoga and a great way to start your surfing day. Rolled rice is available at most good food stores and organic outlets. Best to use fresh turmeric for its antioxidant properties and up to you whether you want yoghurt too. I prefer mine with a squeeze of lime. Om Shanti.




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Barriers to COVID-19 Testing and Treatment: Immigrants without Health Coverage in the United States

As millions of U.S. workers lose jobs and the health insurance associated with them, Medicaid and similar programs are increasingly important for people seeking COVID-19 testing and treatment. Yet many low-income uninsured noncitizens, including green-card holders, are excluded from such programs because of their immigration status, as this fact sheet explores.




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Perspectives in Gestational Diabetes Mellitus: A Review of Screening, Diagnosis, and Treatment

Jennifer M. Perkins
Apr 1, 2007; 25:57-62
Feature Articles




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How visualizing inferential uncertainty can mislead readers about treatment effects in scientific results

STANDARD ERRORS VS STANDARD DEVIATIONS Click to enlarge There’s an ancient haiku that goes: People confuse a well-estimated mean with a certain outcome Ok, that’s not true. But Jake Hofman, Dan Goldstein, and Jessica Hullman have a new paper (recently accepted at CHI 2020) about this. They bet you’ll think the results of their paper […]

The post How visualizing inferential uncertainty can mislead readers about treatment effects in scientific results appeared first on Decision Science News.




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Treatment of post separation contributions / presented by Meredith Dickson, Elizabeth Evatt Chambers.




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Indiana Superintendent Who Used Her Insurance to Help Sick Student Get Treatment Resigns

Casey Smitherman, the superintendent of the Elwood school district, cited the "negative attention" from the incident, according to the Indianapolis Star.




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Description of an apparatus intended to facilitate the treatment of fractures of the lower extremity / by T.M. Greenhow.

London : S. Highley, 1833.




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Diabetes : its causes, symptoms, and treatment / by Charles W. Purdy.

London : Philadelphia, 1890.




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Diabetes : its various forms and different treatments / by George Harley.

London : Walton & Maberly, 1866.




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Diabetes mellitus : its pathological chemistry and treatment / by Carl von Noorden; translated by Florence Buchanan and I. Walker Hall.

Bristol : Wright, 1907.




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The diagnosis and treatment of diseases of the kidney, amenable to direct surgical interference / by W. Bruce Clarke.

London : H.K. Lewis, 1886.




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The diagnosis, prevention, & treatment of diseases of the heart, and of aneurism : with observations on rheumatism / by J.J. Furnivall.

London : J. Churchill, 1845.




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Diarrhoea and dysentery : modern views of their pathology and treatment / by Alonzo B. Palmer.

Detroit, Mich. : G.S. Davis, 1887.




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Die Anstaltsbehandlung der Tuberkulose der Atmungswege / von Gustav Besold.

Berlin : Reimer, 1902.




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Diet and cholera : showing the vital importance of wholesome diet, and that its impurities and deficiencies are the chief cause of cholera, with its premonitory symptoms and treatment : in a series of letters, originally intended for insertion in the &quo

London : S. Highley, 1848.




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A digest of facts relating to the treatment and utilization of sewage / by W.H. Corfield.

London : Macmillan, 1870.




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Diphtheria : its nature and treatment, varieties and local expressions / by Morell MacKenzie.

London : J. & A. Churchill, 1879.




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Diphtheria : its nature and treatment : with special reference to the operation, after-treatment, and complications of tracheotomy / by Robert William Parker.

London : H.K. Lewis, 1891.




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Discussion on the varieties and treatment of asthma / by G. A. Gibson.

London : British Medical Association, 1911.




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Diseases and injuries of the eye : their medical and surgical treatment / by George Lawson.

London : H. Renshaw, 1885.




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Diseases of the mouth, throat, and nose : including rhinoscopy and methods of local treatment / by Philip Schech ; translated by R.H. Blaikie.

Edinburgh : Young J. Pentland, 1886.




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Diseases of the skin : their description, pathology, diagnosis, and treatment / by H. Radcliffe Crocker.

London : H.K. Lewis, 1903.




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Diseases of the veins, more especially of venosity, varicocele, haemorrhoids, and varicose veins, and their treatment by medicines / by J. Compton Burnett.

London : James Epps & Co., Limited, 1894.




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Diseases of the womb : uterine catarrh frequently the cause of sterility : new treatment / by H.E. Gantillon.

London : J. Churchill, [1868]




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Diseases of women : a clinical guide to their diagnosis and treatment / by George Ernest Herman.

London : Cassell, 1898.




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Diseases of women : a clinical guide to their diagnosis and treatment / by George Ernest Herman.

London : Cassell, 1902.




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Diseases of women, including their pathology, causation, symptoms, diagnosis and treatment : a manual for students and practitioners / by Arthur W. Edis.

London : Smith, Elder, 1881.




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Domestic medicine : plain and brief directions for the treatment requisite before advice can be obtained / by Offley Bohun Shore.

Edinburgh : W.P. Nimmo, [1867]




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Ectopic pregnancy : its etiology, classification, embryology, diagnosis and treatment / by J. Clarence Webster.

Edinburgh : Young J. Pentland, 1895.




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Elements of obstetric medicine : with the description and treatment of some of the principal diseases of children / by David D. Davis.

London : Taylor and Walton, 1841.




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Enteric fever : its prevalence and modifications, aetiology, pathology and treatment as illustrated by Army data at home and abroad / by Francis H. Welch.

London : H.K. Lewis, 1883.




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Epilepsy : its pathology and treatment : being an essay to which was awarded a prize of four thousand francs by the Academie Royale de Médécine de Belgique, December 31, 1889 / by Hobart Amory Hare.

London : Philadelphia, 1890.




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Epilepsy : its symptoms, treatment, and relation to other chronic convulsive diseases / by J. Russell Reynolds.

London : J. Churchill, 1861.




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Eruptions of the face, head, and hands : with the latest improvements in the treatment of diseases of the skin / by T.H. Burgess.

London : H. Renshaw, 1849.




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First report of the British Association Committee on the treatment and utilization of sewage : drawn up at the request of the Committee / by Dr. Benjamin H. Paul.

London : Longmans, Green, Reader and Dyer, 1870.




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Report of the Committee on the treatment and utilization of sewage : reappointed at Exeter, 1869.

London : [Published not identified], 1871.