Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to a New England Journal of Medicine editorial published by Matthew Milowsky, MD, FASCO, a bladder cancer expert at UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center.

In a groundbreaking study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases--two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases' underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.

Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to a New England Journal of Medicine editorial published by Matthew Milowsky, MD, FASCO, a bladder cancer expert at UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center.

In a groundbreaking study, researchers at McMaster University have identified a potential treatment for Sandhoff and Tay-Sachs diseases--two rare, often fatal lysosomal storage disorders that cause progressive damage to nerve cells in the brain and spinal cord. After years of investigating the diseases' underlying mechanisms, the research team has identified an existing FDA-approved drug that could significantly improve quality of life for affected patients and their families.

apZme's Dr. David Isaacs Joins National Group of Elite Providers to Offer Oral Appliance Therapy to Veterans Through the VA Community Care Network

Discover AppatMe, the fresh approach to online dating! Using AI, our platform creates deeper, personalized connections for singles across the U.S., moving beyond random matches to deliver tailored, meaningful encounters.

Batman's absence in The Penguin might seem like a glaring issue, but producer Matt Reeves has a pretty logical explanation for why he doesn't show up.

Batman never shows up in The Penguin, just like its creatives claimed. However, he was very nearly added to the show at one point.

Injured Gazan children brought to Lebanon for treatment are again caught up in war

Will we ever understand how life got started on Earth? We’ve learned much about Earth’s long, multi-billion-year history, but a detailed understanding of how the planet’s atmospheric chemistry evolved still eludes us. At one time, Earth was atmospherically hostile, and its transition from that state to a planet teeming with life followed a complex path. …

Continue reading "Lessons From Ancient Earth’s Atmosphere: From Hostile to Hospitable"

The post Lessons From Ancient Earth’s Atmosphere: From Hostile to Hospitable appeared first on Universe Today.

Sharp rise in cases over 30 years compounded by millions of people lacking access to medication, Lancet study finds

More than 800 million adults around the world now have type 1 or type 2 diabetes, a global analysis has estimated—more than four times the number in 1990.Almost six in 10 adults aged over 30 with diabetes, equal to around 445 million people, did not receive treatment in 2022, three and a half times as many as in 1990, research in the Lancet found.1 The study found that while treatment rates had improved in many high income and industrialised nations and some emerging economies, treatment had stagnated at low levels in many low income countries where diabetes has drastically increased.Majid Ezzati, senior author and a professor of global environmental health at Imperial College London, said that the results highlighted “widening global inequalities” in diabetes treatment. “This is especially concerning as people with diabetes tend to be younger in low income countries and, in the absence of effective treatment, are at...

The fireball—one of many decommissioned satellites from SpaceX's internet service—was spotted by dozens of people across at least four states, and many mistook it for a meteor

As some politicians across the province show support for a forced treatment model for people struggling with mental health and addictions, the CEO of Windsor's leading treatment centre says he doesn't support that.

ESPN NBA writer Brian Windhorst criticized the Los Angeles Lakers' plan for Bronny James, who won't be heading on the road with the G League South Bay Lakers.

1. 800 million diabetics worldwide and most aren't getting treatment, finds study  The Times of India
2. India has the highest number of diabetic people in the world, even more than China: Report  The Economic Times
3. Indians account for quarter of world’s adult diabetes patients: Lancet study  Hindustan Times
4. Why have diabetes rates doubled over the past 30 years – and what can be done about it?  The Guardian
5. One-fourth of people living with diabetes globally are in India, study estimates  The Hindu

Wouldn't it be nice if you could go out for a run without fear of being harmed? Technology has a way of making us both safer and at greater risk while out and about, but a new tool from Strava might help with the former. Strava has announced Night Heatmaps, a feature that shows which areas have more activity — or "heat" — between sunset and sunrise. Yes, Heatmaps is the feature that accidentally revealed the location of US military bases. 

The update is a welcome one with sunset getting very early in some areas of the world, while night seems to last late into the morning. It also comes alongside a new Weekly Heatmap, which shows heat levels in an area over the last seven days. Again, this can help you know which paths will have the most people, but at all times of the day. While this added awareness is great for knowing where to go, some people might also purposely choose to avoid the busiest times, for fear of unwanted attention (there's no winning here). 

In either case, the Night and Weekly Heatmaps are only available on subscriber accounts (a membership will cost you $12 monthly or $80 annually). It's also worth noting that Heatmaps pull solely from public activities on Strava, so you're not getting the full story of how many people go where. 

Night and Weekly Heatmaps join the Global Heatmaps (also subscriber exclusive) and your Personal Heatmap. You can access any of them through the Map tab and filter the Heatmap by activity type. 

Highlights: BHB-Phe, a newly discovered molecule, suppresses hunger by activating specific neurons in the brain

Can a new molecule help regulate hunger and body weight? Researchers have discovered BHB-Phe, which targets neurons to suppress appetite and reduce weight!

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The Appellant filed an (offline) RTI application dated 26.05.2023 seeking the following information:

Page 1 of 5

"प्र०1- रामा कृष्णा पुरम, अय्यप्पा मार्ग, चचग रोड की रे ड लाइट से लेकर के केंद्रीय विद्यालय तक दिल्ली नर्र ननर्म की ककतनी तहबाजारी अलॉटमें ट की र्ई है उन सभी का साइड नंबर, स्थान, तथा तहबाजारी धारकों के नाम बताएं?

प्र०2- ज्ञानचंि S/Oअयोध्या प्रसाि साइड नंबर 13 341 अलॉटमें ट कक साइट बताएं तथा यह िक ु ान कहां लर्ी हुई है बताएं ?

प्र०3- राजू साइड नंबर 17076 ककस जर्ह लर्ी हुई है इस तहबाजारी का स्थान बताएं ?

प्र०4- रामा कृष्णा पुरम सेक्टर-1 वििेकानंि माकेट के सामने लाल बत्ती से फायर स्टे शन तक ककतनी तहबाजारी लर्ी हुई है सभी का साइड नंबर, स्थान और तहबाजारी धारक का नाम बताएं?"

A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian function. The combined results of the Tamoxifen and Exemestane Trial and Suppression of Ovarian Function Trial were presented at the 2014 ASCO Annual Meeting in Chicago.

States being given funds on time, and the total funds given under each head was far higher than what the states received earlier, she said

Zerkle, A L; Yin, R; Chen, C; Li, X; Izon, G J; Grasby, S E. Nature Communications vol. 11, issue 1, 1709, 2020 p. 1-9, https://doi.org/10.1038/s41467-020-15495-3
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200064.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200064.jpg" title="Nature Communications vol. 11, issue 1, 1709, 2020 p. 1-9, https://doi.org/10.1038/s41467-020-15495-3" height="150" border="1" /></a>

Sun, R; Grasby, S E; Shen, J; Xiao, J; Yin, R. Chemical Geology vol. 598, 120830, 2022 p. 1-6, https://doi.org/10.1016/j.chemgeo.2022.120830
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220032.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220032.jpg" title="Chemical Geology vol. 598, 120830, 2022 p. 1-6, https://doi.org/10.1016/j.chemgeo.2022.120830" height="150" border="1" /></a>

1. Oncologist stabbed at Chennai govt hospital ‘by 26-year-old whose mother is undergoing cancer treatment’  The Indian Express
2. Video: Chennai man calmly walks away after stabbing doctor, wipes knife  India Today
3. Indian Medical Association condemns brutal attack on doctor in Chennai  The New Indian Express
4. Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock  The Hindu
5. 'No law and order': BJP, AIADMK attack ruling DMK after government doctor stabbed in Chennai  The Times of India

1. Chennai hospital stabbing: IMA demands ‘overhaul of security atmosphere’  Hindustan Times
2. Video: Chennai man calmly walks away after stabbing doctor, wipes knife  India Today
3. Chennai doctor stabbed, raises safety concerns among health workers, Tamil Nadu govt takes action: What happened so far  Mint
4. 'No law and order': BJP, AIADMK attack ruling DMK after government doctor stabbed in Chennai  The Times of India
5. Indian Medical Association condemns brutal attack on doctor in Chennai  The New Indian Express

The Wheel That Changed The World, Mahatma...