BACKGROUND:Post–COVID-19 syndrome has affected millions of people, with rehabilitation being at the center of non-pharmacologic care. However, numerous published studies show conflicting results due to, among other factors, considerable variation in subject characteristics. Currently, the effects of age, sex, time of implementation, and prior disease severity on the outcomes of a supervised rehabilitation program after COVID-19 remain unknown.METHODS:This was a non-randomized case-control study. Subjects with post–COVID-19 sequelae were enrolled. Among study participants, those who could attend an 8-week, supervised rehabilitation program composed the intervention group, whereas those who couldn’t the control group. Measurements were collected at baseline and 8 weeks thereafter.RESULTS:Study groups (N = 119) had similar baseline measurements. Participation in rehabilitation (n = 47) was associated with clinically important improvements in the 6-min walk test (6MWT) distance, adjusted (for potential confounders) odds ratio (AOR) 4.56 (95% CI 1.95–10.66); 1-min sit-to-stand test, AOR 4.64 (1.88-11.48); Short Physical Performance Battery, AOR 7.93 (2.82–22.26); health-related quality of life (HRQOL) 5-level EuroQol-5D (Visual Analog Scale), AOR 3.12 (1.37–7.08); Montreal Cognitive Assessment, AOR 6.25 (2.16–18.04); International Physical Activity Questionnaire, AOR 3.63 (1.53–8.59); Fatigue Severity Scale, AOR 4.07 (1.51–10.98); Chalder Fatigue Scale (bimodal score), AOR 3.33 (1.45–7.67); Modified Medical Research Council dyspnea scale (mMRC), AOR 4.43 (1.83–10.74); Post–COVID-19 Functional Scale (PCFS), AOR 3.46 (1.51–7.95); and COPD Assessment Test, AOR 7.40 (2.92–18.75). Time from disease onset was marginally associated only with 6MWT distance, AOR 0.99 (0.99–1.00). Prior hospitalization was associated with clinically important improvements in the mMRC dyspnea scale, AOR 3.50 (1.06–11.51); and PCFS, AOR 3.42 (1.16–10.06). Age, sex, and ICU admission were not associated with the results of any of the aforementioned tests/grading scales.CONCLUSIONS:In this non-randomized, case-control study, post–COVID-19 rehabilitation was associated with improvements in physical function, activity, HRQOL, respiratory symptoms, fatigue, and cognitive impairment. These associations were observed independently of timing of rehabilitation, age, sex, prior hospitalization, and ICU admission.

A prefilled syringe (PFS) should be able to be adequately and consistently extruded during injection for optimal safe drug delivery and accurate dosing. To facilitate appropriate break-loose and gliding forces (BLGFs) required during injection, certain primary packaging materials (PPMs) such as the syringe barrel and plunger are usually coated with silicone oil, which acts as a lubricant. Due to its direct contact with drug, silicone oil can increase the number of particles in the syringe, which could lead to adverse interactions. Compliance with regulatory-defined silicone oil quantities in certain drug products, such as ophthalmics, presents a trade-off with the necessity for desirable low and consistent BLGF. In addition to its siliconization, the dimensional accuracy of the PPM has an important role in controlling the BLGF. The dimensions of the PPM are individualized depending on the product and its design and have certain tolerances that must be met during manufacturing. Most studies on ophthalmics focused on the adverse interactions between silicone oil and the drug. To the authors' knowledge, there have been no public studies so far that have investigated the impact of the dimensional variability of the PPM on the BLGF in ophthalmic PFSs. In this study, we applied advanced optical shaft and tactile measuring technologies to investigate this impact. The syringes investigated were first sampled during aseptic production and tested for the BLGF. Subsequently, defined dimensions of the PPM were measured individually. The results showed that the dimensional variability of the PPM can have a negative impact on the BLGF, despite their conformity to specifications, which indicates that the currently available market quality of PPMs is improvable for critical drug products such as ophthalmics. This study could serve as an approach to define product-specific requirements for primary packaging combinations and thus appropriate specifications based on data during the development stage of drug products.

Long noncoding (lnc)RNAs emerge as regulators of genome stability. The nuclear-enriched abundant transcript 1 (NEAT1) is overexpressed in many tumors and is responsive to genotoxic stress. However, the mechanism that links NEAT1 to DNA damage response (DDR) is unclear. Here, we investigate the expression, modification, localization, and structure of NEAT1 in response to DNA double-strand breaks (DSBs). DNA damage increases the levels and N6-methyladenosine (m⁶A) marks on NEAT1, which promotes alterations in NEAT1 structure, accumulation of hypermethylated NEAT1 at promoter-associated DSBs, and DSB signaling. The depletion of NEAT1 impairs DSB focus formation and elevates DNA damage. The genome-protective role of NEAT1 is mediated by the RNA methyltransferase 3 (METTL3) and involves the release of the chromodomain helicase DNA binding protein 4 (CHD4) from NEAT1 to fine-tune histone acetylation at DSBs. Our data suggest a direct role for NEAT1 in DDR.

End-to-end RNA-sequencing methods that capture 5'-sequence content without cumbersome library manipulations are of great interest, particularly for analysis of long RNAs. While template-switching methods have been developed for RNA sequencing by distributive short-read RTs, such as the MMLV RTs used in SMART-Seq methods, they have not been adapted to leverage the power of ultraprocessive RTs, such as those derived from group II introns. To facilitate this transition, we dissected the individual processes that guide the enzymatic specificity and efficiency of the multistep template-switching reaction carried out by RTs, in this case, by MarathonRT. Remarkably, this is the first study of its kind, for any RT. First, we characterized the nucleotide specificity of nontemplated addition (NTA) reaction that occurs when the RT extends past the RNA 5'-terminus. We then evaluated the binding specificity of specialized template-switching oligonucleotides, optimizing their sequences and chemical properties to guide efficient template-switching reaction. Having dissected and optimized these individual steps, we then unified them into a procedure for performing RNA sequencing with MarathonRT enzymes, using a well-characterized RNA reference set. The resulting reads span a six-log range in transcript concentration and accurately represent the input RNA identities in both length and composition. We also performed RNA-seq from total human RNA and poly(A)-enriched RNA, with short- and long-read sequencing demonstrating that MarathonRT enhances the discovery of unseen RNA molecules by conventional RT. Altogether, we have generated a new pipeline for rapid, accurate sequencing of complex RNA libraries containing mixtures of long RNA transcripts.

The SARS-CoV-2 frameshifting element (FSE) has been intensely studied and explored as a therapeutic target for coronavirus diseases, including COVID-19. Besides the intriguing virology, this small RNA is known to adopt many length-dependent conformations, as verified by multiple experimental and computational approaches. However, the role these alternative conformations play in the frameshifting mechanism and how to quantify this structural abundance has been an ongoing challenge. Here, we show by DMS and dual-luciferase functional assays that previously predicted FSE mutants (using the RAG graph theory approach) suppress structural transitions and abolish frameshifting. Furthermore, correlated mutation analysis of DMS data by three programs (DREEM, DRACO, and DANCE-MaP) reveals important differences in their estimation of specific RNA conformations, suggesting caution in the interpretation of such complex conformational landscapes. Overall, the abolished frameshifting in three different mutants confirms that all alternative conformations play a role in the pathways of ribosomal transition.

Extract

It is of utmost importance that medicines are available at all times for our patients. Historically, medication unavailability has typically, if not exclusively, affected low- and middle-income countries [1]. More recently however, drug shortages have also been reported in high-income European countries [2]. Drug shortages have negative health consequences for patients [3], and a profound economic impact, with the need to resort to more expensive alternatives and demands on healthcare professionals’ time to find, prescribe and dispense alternatives [4].

Extract

In cystic fibrosis (CF), Pseudomonas aeruginosa acquisition represents a turning point in disease progression. The presence of chronic P. aeruginosa infection is associated with worsening lung function and increased risk of earlier death, whereas treatment substantially improves lung function and survival [1, 2]. Efforts to diagnose and eradicate early P. aeruginosa provide lasting benefits for children with CF [3, 4]. However, the timing of infection varies considerably between individuals with CF, treatment centres [5, 6], and different birth cohorts of people with the disease [7, 8].

Background

Pseudomonas aeruginosa is a common pathogen that contributes to progressive lung disease in cystic fibrosis (CF). Genetic factors other than CF-causing CFTR (CF transmembrane conductance regulator) variations contribute ~85% of the variation in chronic P. aeruginosa infection age in CF according to twin studies, but the susceptibility loci remain unknown. Our objective is to advance understanding of the genetic basis of host susceptibility to P. aeruginosa infection.

Background

Halm's clinical stability criteria have long guided antibiotic treatment and hospital discharge decisions for patients hospitalised with community-acquired pneumonia (CAP). Originally introduced in 1998, these criteria were established based on a relatively small and select patient population. Consequently, our study aims to reassess their applicability in the management of CAP in a contemporary real-world setting.

Sterol 12α-hydroxylase (CYP8B1) is the unique P450 enzyme with sterol 12-oxidation activity, playing an exclusive role in 12α-hydroxylating intermediates along the bile acid (BA) synthesis pathway. Despite the long history of BA metabolism studies, it is unclear whether CYP8B1 catalyzes 12α-hydroxylation of C₂₇ BAs, the key intermediates shuttling between mitochondria and peroxisomes. This work provides robust in vitro evidence that both microsomal and recombinant CYP8B1 enzymes catalyze the 12α-hydroxylation of dihydroxycoprostanic acid (DHCA) into trihydroxycoprostanic acid (THCA). On the one hand, DHCA 12α-hydroxylation reactivity is conservatively detected in liver microsomes of both human and preclinical animals. The reactivity of human tissue fractions conforms well with the selectivity of CYP8B1 mRNA expression, while the contribution of P450 enzymes other than CYP8B1 is excluded by reaction phenotyping in commercial recombinant enzymes. On the other hand, we prepared functional recombinant human CYP8B1 proteins according to a recently published protocol. Titration of the purified CYP8B1 proteins with either C4 (7α-hydroxy-4-cholesten-3-one) or DHCA yields expected blue shifts of the heme Soret peak (type I binding). The recombinant CYP8B1 proteins efficiently catalyze 12α-hydroxylation of both DHCA and C4, with substrate concentration occupying half of the binding sites of 3.0 and 1.9 μM and k_cat of 3.2 and 2.6 minutes^–1, respectively. In summary, the confirmed role of CYP8B1 in 12α-hydroxylation of C₂₇ BAs has furnished the forgotten passageway in the BA synthesis pathway. The present finding might have opened a new window to consider the biology of CYP8B1 in glucolipid metabolism and to evaluate CYP8B1 inhibition as a therapeutic approach of crucial interest for metabolic diseases.

ABSTRACTTraining health workers is one of the biggest challenges and cost drivers when introducing a new contraceptive method or service delivery innovation. PATH developed a digital training curriculum for family planning providers who are learning to offer subcutaneous DMPA (DMPA-SC), including through self-injection, as an option among a range of contraceptive methods. The DMPA-SC eLearning course for health workers includes 10 lessons with an emphasis on informed choice counseling and training clients to self-inject. In partnership with Ministries of Health in Senegal and Uganda, the course was rolled out in select areas in 2019–2020, including during the COVID-19 pandemic when physical distancing requirements restricted in-person training. We conducted evaluations in both countries to assess the practical application of this digital training approach for contraceptive introduction. The evaluation consisted of a post-training survey, an observational assessment conducted during post-training supportive supervision, and an estimation of training costs.In both countries, a majority (88.6% in Uganda and 64.3% in Senegal) scored above 80% on a DMPA-SC knowledge test following the training. In Senegal, where there was a comparison group of providers trained in person, those providers scored similar on the post-test to eLearners. Providers in both groups and in both countries felt more prepared to administer DMPA-SC or offer self-injection to clients after receiving a supervision visit (93%–98% of eLearners felt very prepared after supervision as compared to 45%–72% prior). The evaluation results suggest that digital approaches offer a number of benefits, can be cost-effective, and are most optimal when blended with in-person training and/or supportive supervision.

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile acids generates bile flow and facilitates biliary secretion of lipids, endogenous metabolites, and xenobiotics. In intestine, bile acids facilitate the digestion and absorption of dietary lipids and fat-soluble vitamins. Through activation of nuclear receptors and G protein-coupled receptors and interaction with gut microbiome, bile acids critically regulate host metabolism and innate and adaptive immunity and are involved in the pathogenesis of cholestasis, metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, type-2 diabetes, and inflammatory bowel diseases. Bile acids and their derivatives have been developed as potential therapeutic agents for treating chronic metabolic and inflammatory liver diseases and gastrointestinal disorders.

BACKGROUND AND PURPOSE:

Patients with brain tumors have high intersubject variation in putative language regions, which may limit the utility of straightforward application of healthy subject brain atlases in clinical scenarios. The purpose of this study was to develop a probabilistic functional brain atlas that consolidates language functional activations of sentence completion and Silent Word Generation language paradigms using a large sample of patients with brain tumors.

BACKGROUND AND PURPOSE:

Prediction of aneurysm instability is crucial to guide treatment decisions and to select appropriate patients with unruptured intracranial aneurysms (IAs) for preventive treatment. High-resolution 4D MR flow imaging and 3D quantification of aneurysm morphology could offer insights and new imaging markers for aneurysm instability. In this cross-sectional study, we aim to identify 4D MR flow imaging markers for aneurysm instability by relating hemodynamics in the aneurysm sac to 3D morphologic proxy parameters for aneurysm instability.

We present a unique case of a single patient presenting with two mutationally distinct, PD-L1⁺ diffuse large B-cell lymphomas (DLBCLs). One of these DLBCLs demonstrated exceptionally high mutational burden (eight disease-associated variants and 41 variants of undetermined significance) with microsatellite instability (MSI) and an acquired PMS2 mutation with loss of PMS2 protein expression, detected postchemotherapy. This report, while highlighting the extent of possible tumor heterogeneity across separate clonal expansions as well as possible syndromic B-cell neoplasia, supports the notion that, although rare, PD-L1 expression and associated states permissive of high mutational burden (such as mismatch repair gene loss of function/MSI) should be more routinely considered in DLBCLs. Appropriate testing may be predictive of outcome and inform the utility of targeted therapy in these genetically diverse and historically treatment-refractory malignancies.

Billionaire Bill Ackman spent days after the ABC presidential debate promoting false claims that a network “whistleblower” had allegedly uncovered collusion between ABC and Kamala Harris’ campaign. Now, a month and multiple denials later, he sees the claims differently.

“It seems pretty clear that the alleged @abc whistleblower debate story claiming that @KamalaHarris was given questions in advance and other advantages was a fake,” Ackman posted on X alongside a blog post by Megyn Kelly discussing the dubious claims.

What Ackman, CEO of Pershing Square Capital Management, did not acknowledge, however, is that he was one of falsehood’s early boosters. After an X account named “Black Insurrectionist” claimed it had been in touch with a whistleblower who alleged the Harris campaign had been given debate topics ahead of the showdown with Donald Trump and had demanded Trump—and Trump alone—be fact-checked.

Read more at The Daily Beast.

My strongest and most enduring memory of Grand Theft Auto will always be creasing into complete hysterics watching my mate pile into a crumpled police officer with a wooden baseball bat in GTA 3 after school one time. Young’uns these days just don’t appreciate how revolutionary it was to be able to hit a cop with a thing after he’d already fallen over. Suffice it to say I’ve got good memories of the open world series’ nascent forays into 3D, though never enough to tempt me into revisiting them, especially given the poor reception to Grand Theft Auto: The Trilogy - The Definitive Edition. I can sympathise. I’m annoyed just having to type a semicolon and a dash in the same game name.

If you’re in a similarly non-fussed position (I will never not be annoyed that ‘nonplussed’ doesn’t mean what it sounds like it should mean) I can’t imagine a lighting update that’s been available on the mobile versions for a while is enough to tempt you back. But what is a reporter's job if not pathetically treading water between chunklets of Grand Theft Auto news, upon the publishing of which Graham presses the button to release the nutritious pellets on which we all wholly subsist? I hope he doesn’t read that last sentence. I don’t get my pellet if the syntax becomes too convoluted. Moving swiftly on.

Read more

Secretary of State was questioned on Good Morning Britain over the pledge - with host asking 'how much will it have gone up by then?'

The energy bill support has been described as a "crucial lifeline" for certain individuals who are often "overlooked".

A Labour minister confirmed that the application process for Personal Independence Payment is being 'kept under review'

A 6000-kilogram spacecraft will embark on a six-year journey to Jupiter to explore whether its icy moon Europa has the conditions to support life

Devices that let people with paralysis walk and talk are rapidly improving. Some see a future in which we alter memories and download skills – but major challenges remain

In What's Next? Bill Gates digs into AI, climate, inequality, malaria and more. But the man looms too large for alternative solutions to emerge, says Bethan Ackerley

Video Friday is your weekly selection of awesome robotics videos, collected by your friends at IEEE Spectrum robotics. We also post a weekly calendar of upcoming robotics events for the next few months. Please send us your events for inclusion.

ROSCon 2024: 21–23 October 2024, ODENSE, DENMARK

ICSR 2024: 23–26 October 2024, ODENSE, DENMARK

Cybathlon 2024: 25–27 October 2024, ZURICH

Humanoids 2024: 22–24 November 2024, NANCY, FRANCE

Enjoy today’s videos!

One of the most venerable (and recognizable) mobile robots ever made, the Husky, has just gotten a major upgrade.

Shipping early next year.

[ Clearpath Robotics ]

MAB Robotics is developing legged robots for the inspection and maintenance of industrial infrastructure. One of the initial areas for deploying this technology is underground infrastructure, such as water and sewer canals. In these environments, resistance to factors like high humidity and working underwater is essential. To address these challenges, the MAB team has built a walking robot capable of operating fully submerged, based on exceptional self-developed robotics actuators. This innovation overcomes the limitations of current technologies, offering MAB’s first clients a unique service for trenchless inspection and maintenance tasks.

[ MAB Robotics ]

Thanks, Jakub!

The G1 robot can perform a standing long jump of up to 1.4 meters, possibly the longest jump ever achieved by a humanoid robot of its size in the world, standing only 1.32 meters tall.

[ Unitree Robotics ]

Apparently, you can print out a functional four-fingered hand on an inkjet.

[ UC Berkeley ]

We present SDS (``See it. Do it. Sorted’), a novel pipeline for intuitive quadrupedal skill learning from a single demonstration video leveraging the visual capabilities of GPT-4o. We validate our method on the Unitree Go1 robot, demonstrating its ability to execute variable skills such as trotting, bounding, pacing, and hopping, achieving high imitation fidelity and locomotion stability.

[ Robot Perception Lab, University College London ]

You had me at “3D desk octopus.”

[ UIST 2024 ACM Symposium on User Interface Software and Technology ]

Top-notch swag from Dusty Robotics

[ Dusty Robotics ]

I’m not sure how serious this shoes-versus-no-shoes test is, but it’s an interesting result nonetheless.

[ Robot Era ]

Thanks, Ni Tao!

Introducing TRON 1, the first multimodal biped robot! With its innovative “Three-in-One” modular design, TRON 1 can easily switch among Point-Foot, Sole, and Wheeled foot ends.

[ LimX Dynamics ]

Recent works in the robot-learning community have successfully introduced generalist models capable of controlling various robot embodiments across a wide range of tasks, such as navigation and locomotion. However, achieving agile control, which pushes the limits of robotic performance, still relies on specialist models that require extensive parameter tuning. To leverage generalist-model adaptability and flexibility while achieving specialist-level agility, we propose AnyCar, a transformer-based generalist dynamics model designed for agile control of various wheeled robots.

[ AnyCar ]

Discover the future of aerial manipulation with our untethered soft robotic platform with onboard perception stack! Presented at the 2024 Conference on Robot Learning, in Munich, this platform introduces autonomous aerial manipulation that works in both indoor and outdoor environments—without relying on costly off-board tracking systems.

[ Paper ] via [ ETH Zurich Soft Robotics Laboratory ]

Deploying perception modules for human-robot handovers is challenging because they require a high degree of reactivity, generalizability, and robustness to work reliably for diverse cases. Here, we show hardware handover experiments using our efficient and object-agnostic real-time tracking framework, specifically designed for human-to-robot handover tasks with legged manipulators.

[ Paper ] via [ ETH Zurich Robotic Systems Lab ]

Azi and Ameca are killing time, but Azi struggles being the new kid around. Engineered Arts desktop robots feature 32 actuators, 27 for facial control alone, and 5 for the neck. They include AI conversational ability including GPT-4o support, which makes them great robotic companions, even to each other. The robots are following a script for this video, using one of their many voices.

[ Engineered Arts ]

Plato automates carrying and transporting, giving your staff more time to focus on what really matters, improving their quality of life. With a straightforward setup that requires no markers or additional hardware, Plato is incredibly intuitive to use—no programming skills needed.

[ Aldebaran ]

This UPenn GRASP Lab seminar is from Antonio Loquercio, on “Simulation: What made us intelligent will make our robots intelligent.”

Simulation-to-reality transfer is an emerging approach that enables robots to develop skills in simulated environments before applying them in the real world. This method has catalyzed numerous advancements in robotic learning, from locomotion to agile flight. In this talk, I will explore simulation-to-reality transfer through the lens of evolutionary biology, drawing intriguing parallels with the function of the mammalian neocortex. By reframing this technique in the context of biological evolution, we can uncover novel research questions and explore how simulation-to-reality transfer can evolve from an empirically driven process to a scientific discipline.

[ University of Pennsylvania ]

If rumours are true and this one should be, I started it, we have a special edition of the Weekend show where we talk about the evolution of the role of the CIO with two incredible CIOs as the CIO Association of Canada turns 20. Don’t miss it.  MUSIC UP Can HP make you love […]

Politics and pinball do sometimes have a lot in common. Both can produce surprising and unexpected results. Those lights and metal balls that pinball was known for before the digital age sometimes would make you an unexpected winner. Politics may do that for all those who want to revive the Farm Bill. Politics... Continue Reading

Along the country road that leads to ATL4, a giant data center going up east of Atlanta, dozens of parked cars and pickups lean tenuously on the narrow dirt shoulders. The many out-of-state plates are typical of the phalanx of tradespeople who muster for these massive construction jobs. With tech giants, utilities, and governments budgeting upwards of US $1 trillion for capital expansion to join the global battle for AI dominance, data centers are the bunkers, factories, and skunkworks—and concrete and electricity are the fuel and ammunition.

To the casual observer, the data industry can seem incorporeal, its products conjured out of weightless bits. But as I stand beside the busy construction site for DataBank’s ATL4, what impresses me most is the gargantuan amount of material—mostly concrete—that gives shape to the goliath that will house, secure, power, and cool the hardware of AI. Big data is big concrete. And that poses a big problem.

Concrete is not just a major ingredient in data centers and the power plants being built to energize them. As the world’s most widely manufactured material, concrete—and especially the cement within it—is also a major contributor to climate change, accounting for around 6 percent of global greenhouse gas emissions. Data centers use so much concrete that the construction boom is wrecking tech giants’ commitments to eliminate their carbon emissions. Even though Google, Meta, and Microsoft have touted goals to be carbon neutral or negative by 2030, and Amazon by 2040, the industry is now moving in the wrong direction.

Last year, Microsoft’s carbon emissions jumped by over 30 percent, primarily due to the materials in its new data centers. Google’s greenhouse emissions are up by nearly 50 percent over the past five years. As data centers proliferate worldwide, Morgan Stanley projects that data centers will release about 2.5 billion tonnes of CO₂ each year by 2030—or about 40 percent of what the United States currently emits from all sources.

But even as innovations in AI and the big-data construction boom are boosting emissions for the tech industry’s hyperscalers, the reinvention of concrete could also play a big part in solving the problem. Over the last decade, there’s been a wave of innovation, some of it profit-driven, some of it from academic labs, aimed at fixing concrete’s carbon problem. Pilot plants are being fielded to capture CO ₂ from cement plants and sock it safely away. Other projects are cooking up climate-friendlier recipes for cements. And AI and other computational tools are illuminating ways to drastically cut carbon by using less cement in concrete and less concrete in data centers, power plants, and other structures.

Demand for green concrete is clearly growing. Amazon, Google, Meta, and Microsoft recently joined an initiative led by the Open Compute Project Foundation to accelerate testing and deployment of low-carbon concrete in data centers, for example. Supply is increasing, too—though it’s still minuscule compared to humanity’s enormous appetite for moldable rock. But if the green goals of big tech can jump-start innovation in low-carbon concrete and create a robust market for it as well, the boom in big data could eventually become a boon for the planet.

Hyperscaler Data Centers: So Much Concrete

At the construction site for ATL4, I’m met by Tony Qorri, the company’s big, friendly, straight-talking head of construction. He says that this giant building and four others DataBank has recently built or is planning in the Atlanta area will together add 133,000 square meters (1.44 million square feet) of floor space.

They all follow a universal template that Qorri developed to optimize the construction of the company’s ever-larger centers. At each site, trucks haul in more than a thousand prefabricated concrete pieces: wall panels, columns, and other structural elements. Workers quickly assemble the precision-measured parts. Hundreds of electricians swarm the building to wire it up in just a few days. Speed is crucial when construction delays can mean losing ground in the AI battle.

The ATL4 data center outside Atlanta is one of five being built by DataBank. Together they will add over 130,000 square meters of floor space.DataBank

That battle can be measured in new data centers and floor space. The United States is home to more than 5,000 data centers today, and the Department of Commerce forecasts that number to grow by around 450 a year through 2030. Worldwide, the number of data centers now exceeds 10,000, and analysts project another 26.5 million m² of floor space over the next five years. Here in metro Atlanta, developers broke ground last year on projects that will triple the region’s data-center capacity. Microsoft, for instance, is planning a 186,000-m² complex; big enough to house around 100,000 rack-mounted servers, it will consume 324 megawatts of electricity.

The velocity of the data-center boom means that no one is pausing to await greener cement. For now, the industry’s mantra is “Build, baby, build.”

“There’s no good substitute for concrete in these projects,” says Aaron Grubbs, a structural engineer at ATL4. The latest processors going on the racks are bigger, heavier, hotter, and far more power hungry than previous generations. As a result, “you add a lot of columns,” Grubbs says.

1,000 Companies Working on Green Concrete

Concrete may not seem an obvious star in the story of how electricity and electronics have permeated modern life. Other materials—copper and silicon, aluminum and lithium—get higher billing. But concrete provides the literal, indispensable foundation for the world’s electrical workings. It is the solid, stable, durable, fire-resistant stuff that makes power generation and distribution possible. It undergirds nearly all advanced manufacturing and telecommunications. What was true in the rapid build-out of the power industry a century ago remains true today for the data industry: Technological progress begets more growth—and more concrete. Although each generation of processor and memory squeezes more computing onto each chip, and advances in superconducting microcircuitry raise the tantalizing prospect of slashing the data center’s footprint, Qorri doesn’t think his buildings will shrink to the size of a shoebox anytime soon. “I’ve been through that kind of change before, and it seems the need for space just grows with it,” he says.

By weight, concrete is not a particularly carbon-intensive material. Creating a kilogram of steel, for instance, releases about 2.4 times as much CO₂ as a kilogram of cement does. But the global construction industry consumes about 35 billion tonnes of concrete a year. That’s about 4 tonnes for every person on the planet and twice as much as all other building materials combined. It’s that massive scale—and the associated cost and sheer number of producers—that creates both a threat to the climate and inertia that resists change.

At its Edmonton, Alberta, plant [above], Heidelberg Materials is adding systems to capture carbon dioxide produced by the manufacture of Portland cement.Heidelberg Materials North America

Yet change is afoot. When I visited the innovation center operated by the Swiss materials giant Holcim, in Lyon, France, research executives told me about the database they’ve assembled of nearly 1,000 companies working to decarbonize cement and concrete. None yet has enough traction to measurably reduce global concrete emissions. But the innovators hope that the boom in data centers—and in associated infrastructure such as new nuclear reactors and offshore wind farms, where each turbine foundation can use up to 7,500 cubic meters of concrete—may finally push green cement and concrete beyond labs, startups, and pilot plants.

Why cement production emits so much carbon

Though the terms “cement” and “concrete” are often conflated, they are not the same thing. A popular analogy in the industry is that cement is the egg in the concrete cake. Here’s the basic recipe: Blend cement with larger amounts of sand and other aggregates. Then add water, to trigger a chemical reaction with the cement. Wait a while for the cement to form a matrix that pulls all the components together. Let sit as it cures into a rock-solid mass.

Portland cement, the key binder in most of the world’s concrete, was serendipitously invented in England by William Aspdin, while he was tinkering with earlier mortars that his father, Joseph, had patented in 1824. More than a century of science has revealed the essential chemistry of how cement works in concrete, but new findings are still leading to important innovations, as well as insights into how concrete absorbs atmospheric carbon as it ages.

As in the Aspdins’ day, the process to make Portland cement still begins with limestone, a sedimentary mineral made from crystalline forms of calcium carbonate. Most of the limestone quarried for cement originated hundreds of millions of years ago, when ocean creatures mineralized calcium and carbonate in seawater to make shells, bones, corals, and other hard bits.

Cement producers often build their large plants next to limestone quarries that can supply decades’ worth of stone. The stone is crushed and then heated in stages as it is combined with lesser amounts of other minerals that typically include calcium, silicon, aluminum, and iron. What emerges from the mixing and cooking are small, hard nodules called clinker. A bit more processing, grinding, and mixing turns those pellets into powdered Portland cement, which accounts for about 90 percent of the CO₂ emitted by the production of conventional concrete [see infographic, “Roads to Cleaner Concrete”].

Karen Scrivener, shown in her lab at EPFL, has developed concrete recipes that reduce emissions by 30 to 40 percent.Stefan Wermuth/Bloomberg/Getty Images

Decarbonizing Portland cement is often called heavy industry’s “hard problem” because of two processes fundamental to its manufacture. The first process is combustion: To coax limestone’s chemical transformation into clinker, large heaters and kilns must sustain temperatures around 1,500 °C. Currently that means burning coal, coke, fuel oil, or natural gas, often along with waste plastics and tires. The exhaust from those fires generates 35 to 50 percent of the cement industry’s emissions. Most of the remaining emissions result from gaseous CO ₂ liberated by the chemical transformation of the calcium carbonate (CaCO₃) into calcium oxide (CaO), a process called calcination. That gas also usually heads straight into the atmosphere.

Concrete production, in contrast, is mainly a business of mixing cement powder with other ingredients and then delivering the slurry speedily to its destination before it sets. Most concrete in the United States is prepared to order at batch plants—souped-up materials depots where the ingredients are combined, dosed out from hoppers into special mixer trucks, and then driven to job sites. Because concrete grows too stiff to work after about 90 minutes, concrete production is highly local. There are more ready-mix batch plants in the United States than there are Burger King restaurants.

Batch plants can offer thousands of potential mixes, customized to fit the demands of different jobs. Concrete in a hundred-story building differs from that in a swimming pool. With flexibility to vary the quality of sand and the size of the stone—and to add a wide variety of chemicals—batch plants have more tricks for lowering carbon emissions than any cement plant does.

Cement plants that capture carbon

China accounts for more than half of the concrete produced and used in the world, but companies there are hard to track. Outside of China, the top three multinational cement producers—Holcim, Heidelberg Materials in Germany, and Cemex in Mexico—have launched pilot programs to snare CO₂ emissions before they escape and then bury the waste deep underground. To do that, they’re taking carbon capture and storage (CCS) technology already used in the oil and gas industry and bolting it onto their cement plants.

These pilot programs will need to scale up without eating profits—something that eluded the coal industry when it tried CCS decades ago. Tough questions also remain about where exactly to store billions of tonnes of CO ₂ safely, year after year.

The appeal of CCS for cement producers is that they can continue using existing plants while still making progress toward carbon neutrality, which trade associations have committed to reach by 2050. But with well over 3,000 plants around the world, adding CCS to all of them would take enormous investment. Currently less than 1 percent of the global supply is low-emission cement. Accenture, a consultancy, estimates that outfitting the whole industry for carbon capture could cost up to $900 billion.

“The economics of carbon capture is a monster,” says Rick Chalaturnyk, a professor of geotechnical engineering at the University of Alberta, in Edmonton, Canada, who studies carbon capture in the petroleum and power industries. He sees incentives for the early movers on CCS, however. “If Heidelberg, for example, wins the race to the lowest carbon, it will be the first [cement] company able to supply those customers that demand low-carbon products”—customers such as hyperscalers.

Though cement companies seem unlikely to invest their own billions in CCS, generous government subsidies have enticed several to begin pilot projects. Heidelberg has announced plans to start capturing CO₂ from its Edmonton operations in late 2026, transforming it into what the company claims would be “the world’s first full-scale net-zero cement plant.” Exhaust gas will run through stations that purify the CO₂ and compress it into a liquid, which will then be transported to chemical plants to turn it into products or to depleted oil and gas reservoirs for injection underground, where hopefully it will stay put for an epoch or two.

Chalaturnyk says that the scale of the Edmonton plant, which aims to capture a million tonnes of CO₂ a year, is big enough to give CCS technology a reasonable test. Proving the economics is another matter. Half the $1 billion cost for the Edmonton project is being paid by the governments of Canada and Alberta.

ROADS TO CLEANER CONCRETE

As the big-data construction boom boosts the tech industry’s emissions, the reinvention of concrete could play a major role in solving the problem.

• CONCRETE TODAY Most of the greenhouse emissions from concrete come from the production of Portland cement, which requires high heat and releases carbon dioxide (CO₂) directly into the air.

• CONCRETE TOMORROW At each stage of cement and concrete production, advances in ingredients, energy supplies, and uses of concrete promise to reduce waste and pollution.

The U.S. Department of Energy has similarly offered Heidelberg up to $500 million to help cover the cost of attaching CCS to its Mitchell, Ind., plant and burying up to 2 million tonnes of CO₂ per year below the plant. And the European Union has gone even bigger, allocating nearly €1.5 billion ($1.6 billion) from its Innovation Fund to support carbon capture at cement plants in seven of its member nations.

These tests are encouraging, but they are all happening in rich countries, where demand for concrete peaked decades ago. Even in China, concrete production has started to flatten. All the growth in global demand through 2040 is expected to come from less-affluent countries, where populations are still growing and quickly urbanizing. According to projections by the Rhodium Group, cement production in those regions is likely to rise from around 30 percent of the world’s supply today to 50 percent by 2050 and 80 percent before the end of the century.

So will rich-world CCS technology translate to the rest of the world? I asked Juan Esteban Calle Restrepo, the CEO of Cementos Argos, the leading cement producer in Colombia, about that when I sat down with him recently at his office in Medellín. He was frank. “Carbon capture may work for the U.S. or Europe, but countries like ours cannot afford that,” he said.

Better cement through chemistry

As long as cement plants run limestone through fossil-fueled kilns, they will generate excessive amounts of carbon dioxide. But there may be ways to ditch the limestone—and the kilns. Labs and startups have been finding replacements for limestone, such as calcined kaolin clay and fly ash, that don’t release CO ₂ when heated. Kaolin clays are abundant around the world and have been used for centuries in Chinese porcelain and more recently in cosmetics and paper. Fly ash—a messy, toxic by-product of coal-fired power plants—is cheap and still widely available, even as coal power dwindles in many regions.

At the Swiss Federal Institute of Technology Lausanne (EPFL), Karen Scrivener and colleagues developed cements that blend calcined kaolin clay and ground limestone with a small portion of clinker. Calcining clay can be done at temperatures low enough that electricity from renewable sources can do the job. Various studies have found that the blend, known as LC3, can reduce overall emissions by 30 to 40 percent compared to those of Portland cement.

LC3 is also cheaper to make than Portland cement and performs as well for nearly all common uses. As a result, calcined clay plants have popped up across Africa, Europe, and Latin America. In Colombia, Cementos Argos is already producing more than 2 million tonnes of the stuff annually. The World Economic Forum’s Centre for Energy and Materials counts LC3 among the best hopes for the decarbonization of concrete. Wide adoption by the cement industry, the centre reckons, “can help prevent up to 500 million tonnes of CO₂ emissions by 2030.”

In a win-win for the environment, fly ash can also be used as a building block for low- and even zero-emission concrete, and the high heat of processing neutralizes many of the toxins it contains. Ancient Romans used volcanic ash to make slow-setting but durable concrete: The Pantheon, built nearly two millennia ago with ash-based cement, is still in great shape.

Coal fly ash is a cost-effective ingredient that has reactive properties similar to those of Roman cement and Portland cement. Many concrete plants already add fresh fly ash to their concrete mixes, replacing 15 to 35 percent of the cement. The ash improves the workability of the concrete, and though the resulting concrete is not as strong for the first few months, it grows stronger than regular concrete as it ages, like the Pantheon.

University labs have tested concretes made entirely with fly ash and found that some actually outperform the standard variety. More than 15 years ago, researchers at Montana State University used concrete made with 100 percent fly ash in the floors and walls of a credit union and a transportation research center. But performance depends greatly on the chemical makeup of the ash, which varies from one coal plant to the next, and on following a tricky recipe. The decommissioning of coal-fired plants has also been making fresh fly ash scarcer and more expensive.

At Sublime Systems’ pilot plant in Massachusetts, the company is using electrochemistry instead of heat to produce lime silicate cements that can replace Portland cement.Tony Luong

That has spurred new methods to treat and use fly ash that’s been buried in landfills or dumped into ponds. Such industrial burial grounds hold enough fly ash to make concrete for decades, even after every coal plant shuts down. Utah-based Eco Material Technologies is now producing cements that include both fresh and recovered fly ash as ingredients. The company claims it can replace up to 60 percent of the Portland cement in concrete—and that a new variety, suitable for 3D printing, can substitute entirely for Portland cement.

Hive 3D Builders, a Houston-based startup, has been feeding that low-emissions concrete into robots that are printing houses in several Texas developments. “We are 100 percent Portland cement–free,” says Timothy Lankau, Hive 3D’s CEO. “We want our homes to last 1,000 years.”

Sublime Systems, a startup spun out of MIT by battery scientists, uses electrochemistry rather than heat to make low-carbon cement from rocks that don’t contain carbon. Similar to a battery, Sublime’s process uses a voltage between an electrode and a cathode to create a pH gradient that isolates silicates and reactive calcium, in the form of lime (CaO). The company mixes those ingredients together to make a cement with no fugitive carbon, no kilns or furnaces, and binding power comparable to that of Portland cement. With the help of $87 million from the U.S. Department of Energy, Sublime is building a plant in Holyoke, Mass., that will be powered almost entirely by hydroelectricity. Recently the company was tapped to provide concrete for a major offshore wind farm planned off the coast of Martha’s Vineyard.

Software takes on the hard problem of concrete

It is unlikely that any one innovation will allow the cement industry to hit its target of carbon neutrality before 2050. New technologies take time to mature, scale up, and become cost-competitive. In the meantime, says Philippe Block, a structural engineer at ETH Zurich, smart engineering can reduce carbon emissions through the leaner use of materials.

His research group has developed digital design tools that make clever use of geometry to maximize the strength of concrete structures while minimizing their mass. The team’s designs start with the soaring architectural elements of ancient temples, cathedrals, and mosques—in particular, vaults and arches—which they miniaturize and flatten and then 3D print or mold inside concrete floors and ceilings. The lightweight slabs, suitable for the upper stories of apartment and office buildings, use much less concrete and steel reinforcement and have a CO₂ footprint that’s reduced by 80 percent.

There’s hidden magic in such lean design. In multistory buildings, much of the mass of concrete is needed just to hold the weight of the material above it. The carbon savings of Block’s lighter slabs thus compound, because the size, cost, and emissions of a building’s conventional-concrete elements are slashed.

Vaulted, a Swiss startup, uses digital design tools to minimize the concrete in floors and ceilings, cutting their CO₂ footprint by 80 percent.Vaulted

In Dübendorf, Switzerland, a wildly shaped experimental building has floors, roofs, and ceilings created by Block’s structural system. Vaulted, a startup spun out of ETH, is engineering and fabricating the lighter floors of a 10-story office building under construction in Zug, Switzerland.

That country has also been a leader in smart ways to recycle and reuse concrete, rather than simply landfilling demolition rubble. This is easier said than done—concrete is tough stuff, riddled with rebar. But there’s an economic incentive: Raw materials such as sand and limestone are becoming scarcer and more costly. Some jurisdictions in Europe now require that new buildings be made from recycled and reused materials. The new addition of the Kunsthaus Zürich museum, a showcase of exquisite Modernist architecture, uses recycled material for all but 2 percent of its concrete.

As new policies goose demand for recycled materials and threaten to restrict future use of Portland cement across Europe, Holcim has begun building recycling plants that can reclaim cement clinker from old concrete. It recently turned the demolition rubble from some 1960s apartment buildings outside Paris into part of a 220-unit housing complex—touted as the first building made from 100 percent recycled concrete. The company says it plans to build concrete recycling centers in every major metro area in Europe and, by 2030, to include 30 percent recycled material in all of its cement.

Further innovations in low-carbon concrete are certain to come, particularly as the powers of machine learning are applied to the problem. Over the past decade, the number of research papers reporting on computational tools to explore the vast space of possible concrete mixes has grown exponentially. Much as AI is being used to accelerate drug discovery, the tools learn from huge databases of proven cement mixes and then apply their inferences to evaluate untested mixes.

Researchers from the University of Illinois and Chicago-based Ozinga, one of the largest private concrete producers in the United States, recently worked with Meta to feed 1,030 known concrete mixes into an AI. The project yielded a novel mix that will be used for sections of a data-center complex in DeKalb, Ill. The AI-derived concrete has a carbon footprint 40 percent lower than the conventional concrete used on the rest of the site. Ryan Cialdella, Ozinga’s vice president of innovation, smiles as he notes the virtuous circle: AI systems that live in data centers can now help cut emissions from the concrete that houses them.

A sustainable foundation for the information age

Cheap, durable, and abundant yet unsustainable, concrete made with Portland cement has been one of modern technology’s Faustian bargains. The built world is on track to double in floor space by 2060, adding 230,000 km ², or more than half the area of California. Much of that will house the 2 billion more people we are likely to add to our numbers. As global transportation, telecom, energy, and computing networks grow, their new appendages will rest upon concrete. But if concrete doesn’t change, we will perversely be forced to produce even more concrete to protect ourselves from the coming climate chaos, with its rising seas, fires, and extreme weather.

The AI-driven boom in data centers is a strange bargain of its own. In the future, AI may help us live even more prosperously, or it may undermine our freedoms, civilities, employment opportunities, and environment. But solutions to the bad climate bargain that AI’s data centers foist on the planet are at hand, if there’s a will to deploy them. Hyperscalers and governments are among the few organizations with the clout to rapidly change what kinds of cement and concrete the world uses, and how those are made. With a pivot to sustainability, concrete’s unique scale makes it one of the few materials that could do most to protect the world’s natural systems. We can’t live without concrete—but with some ambitious reinvention, we can thrive with it.

This article was updated on 04 November 2024.

Waiting for each part of a 3D-printed project to finish, taking it out of the printer, and then installing it on location can be tedious for multi-part projects. What if there was a way for your printer to print its creation exactly where you needed it? That’s the promise of MobiPrint, a new 3D printing robot that can move around a room, printing designs directly onto the floor.

MobiPrint, designed by Daniel Campos Zamora at the University of Washington, consists of a modified off-the-shelf 3D printer atop a home vacuum robot. First it autonomously maps its space—be it a room, a hallway, or an entire floor of a house. Users can then choose from a prebuilt library or upload their own design to be printed anywhere in the mapped area. The robot then traverses the room and prints the design.

It’s “a new system that combines robotics and 3D printing that could actually go and print in the real world,” Campos Zamora says. He presented MobiPrint on 15 October at the ACM Symposium on User Interface Software and Technology.

Campos Zamora and his team started with a Roborock S5 vacuum robot and installed firmware that allowed it to communicate with the open source program Valetudo. Valetudo disconnects personal robots from their manufacturer’s cloud, connecting them to a local server instead. Data collected by the robot, such as environmental mapping, movement tracking, and path planning, can all be observed locally, enabling users to see the robot’s LIDAR-created map.

Campos Zamora built a layer of software that connects the robot’s perception of its environment to the 3D printer’s print commands. The printer, a modified Prusa Mini+, can print on carpet, hardwood, and vinyl, with maximum printing dimensions of 180 by 180 by 65 millimeters. The robot has printed pet food bowls, signage, and accessibility markers as sample objects.

MakeabilityLab/YouTube

Currently, MobiPrint can only “park and print.” The robot base cannot move during printing to make large objects, like a mobility ramp. Printing designs larger than the robot is one of Campos Zamora’s goals in the future. To learn more about the team’s vision for MobiPrint, Campos Zamora answered a few questions from IEEE Spectrum.

What was the inspiration for creating your mobile 3D printer?

Daniel Campos Zamora: My lab is focused on building systems with an eye towards accessibility. One of the things that really inspired this project was looking at the tactile surface indicators that help blind and low vision users find their way around a space. And so we were like, what if we made something that could automatically go and deploy these things? Especially in indoor environments, which are generally a little trickier and change more frequently over time.

We had to step back and build this entirely different thing, using the environment as a design element. We asked: how do you integrate the real world environment into the design process, and then what kind of things can you print out in the world? That’s how this printer was born.

What were some surprising moments in your design process?

Campos Zamora: When I was testing the robot on different surfaces, I was not expecting the 3D printed designs to stick extremely well to the carpet. It stuck way too well. Like, you know, just completely bonded down there.

I think there’s also just a lot of joy in seeing this printer move. When I was doing a demonstration of it at this conference last week, it almost seemed like the robot had a personality. A vacuum robot can seem to have a personality, but this printer can actually make objects in my environment, so I feel a different relationship to the machine.

Where do you hope to take MobiPrint in the future?

Campos Zamora: There’s several directions I think we could go. Instead of controlling the robot remotely, we could have it follow someone around and print accessibility markers along a path they walk. Or we could integrate an AI system that recommends objects be printed in different locations. I also want to explore having the robot remove and recycle the objects it prints.

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