bil Type 2 diabetes: 5000 patients to test feasibility of “remission service” By feeds.bmj.com Published On :: Friday, November 30, 2018 - 16:21 Full Article
bil Physical activity: a (mobile) call to action By feeds.bmj.com Published On :: Tuesday, January 28, 2020 - 14:40 Full Article
bil Reds hope Roark will bring stability to rotation By mlb.mlb.com Published On :: Fri, 15 Feb 2019 17:45:15 EDT When the Reds overhauled their rotation with three offseason trades, the first deal brought right-hander Tanner Roark from the Nationals for reliever Tanner Rainey. Observers saw Roark as a solid middle-of-the rotation hurler who is steady and dependable while able to rack up innings. Full Article
bil Re-registration process for persons with disabilities cumbersome By jamaica-gleaner.com Published On :: Wed, 06 May 2020 23:05:41 -0500 THE EDITOR, Madam: THE JAMAICA Council for Persons with Disabilities (JCPD) – an agency of the Ministry of Labour... Full Article
bil Major Improvement in Wound Healing Through Pharmacologic Mobilization of Stem Cells in Severely Diabetic Rats By diabetes.diabetesjournals.org Published On :: 2020-03-20T11:50:29-07:00 Current therapeutic strategies for diabetic foot ulcer (DFU) have focused on developing topical healing agents, but few agents have controlled prospective data to support their effectiveness in promoting wound healing. We tested a stem cell mobilizing therapy for DFU using a combination of AMD3100 and low-dose FK506 (tacrolimus) (AF) in streptozocin-induced type 1 diabetic (T1DM) rats and type 2 diabetic Goto-Kakizaki (GK) rats that had developed peripheral artery disease and neuropathy. Here, we show that the time for healing back wounds in T1DM rats was reduced from 27 to 19 days, and the foot wound healing time was reduced from 25 to 20 days by treatment with AF (subcutaneously, every other day). Similarly, in GK rats treated with AF, the healing time on back wounds was reduced from 26 to 21 days. Further, this shortened healing time was accompanied by reduced scar and by regeneration of hair follicles. We found that AF therapy mobilized and recruited bone marrow–derived CD133+ and CD34+ endothelial progenitor cells and Ym1/2+ M2 macrophages into the wound sites, associated with enhanced capillary and hair follicle neogenesis. Moreover, AF therapy improved microcirculation in diabetic and neuropathic feet in GK rats. This study provides a novel systemic therapy for healing DFU. Full Article
bil Valuing Vital Resources in India: Potential for Integrated Approaches to Water, Energy and Agricultural Sustainability By feedproxy.google.com Published On :: Tue, 06 Jan 2015 11:15:01 +0000 Invitation Only Research Event 16 January 2015 - 9:00am to 2:00pm The India Habitat Centre, New Delhi, India Event participants Dr Ashwini Swain, Fellow, CUTS Institute for Regulation and CompetitionGlada Lahn, Senior Research Fellow, Energy, Environment and Resources, Chatham HouseDr Gareth Price, Senior Research Fellow, Asia Programme, Chatham House As part of the international dialogue on Valuing Vital Resources, this seminar will convene policy-makers, scholars, technical practitioners, NGOs, multilateral agencies and the media to discuss recommendations for new policy approaches in India to reorient energy and water use in agriculture. The aim is to gain input to practical policy proposals and identify the work now needed to make them robust. Attendance is by invitation only. Please note this event is held in New Delhi, all times are local. This event is organized together with the CUTS Institute for Regulation & Competition (CIRC). Event attributes External event Department/project Energy, Environment and Resources Programme, Valuing Vital Resources Glada Lahn Senior Research Fellow, Energy, Environment and Resources Programme, Chatham House Email Full Article
bil Chokepoints and Vulnerabilities in Global Food Trade By feedproxy.google.com Published On :: Thu, 15 Jun 2017 09:51:25 +0000 27 June 2017 Policymakers must take action immediately to mitigate the risk of severe disruption at certain ports, maritime straits, and inland transport routes, which could have devastating knock-on effects for global food security. Read online Download PDF Rob Bailey Former Research Director, Energy, Environment and Resources @ClimateRob Laura Wellesley Research Fellow, Energy, Environment and Resources Programme @laurawellesley 2017-06-27-chokepoints.jpg Pedro Miguel locks, Panama Canal. Photo: Gonzalo Azumendi/Getty Images. Trade chokepoints – maritime, coastal and inland – pose an underexplored and growing risk to global food security.Maritime chokepoints will become increasingly integral to meeting global food supply as population growth, shifting dietary preferences, bioenergy expansion and slowing improvements in crop yields drive up demand for imported grain.Rising trade volumes, increasing dependence on imports among food-deficit countries, underinvestment, weak governance, climate change and emerging disruptive hazards together make chokepoint disruptions – both small-scale and large-scale – increasingly likely.Climate change will have a compounding effect on chokepoint risk, increasing the probability of both isolated and multiple concurrent weather-induced disturbances.Investment in infrastructure lags demand growth: critical networks in major crop-producing regions are weak and ageing, and extra capacity is urgently needed. RecommendationsIntegrate chokepoint analysis into mainstream risk management and security planning - for example, government agencies should assess exposure and vulnerability to chokepoint risk at the national and subnational levels.Invest in infrastructure to ensure future food security – for example by agreeing on guidelines for climate-compatible infrastructure through an international taskforce established under the G20.Enhance confidence and predictability in global trade - for example, through a process under the World Trade Organization (WTO) to continually reduce the scope for export restrictionsDevelop emergency supply-sharing arrangements and smarter strategic storage, e.g. an emerging response mechanism among major players in the global food trade, modelled in part on that of the International Energy Agency in oil markets and led by the UN Food and Agriculture Organization (FAO), the UN World Food Programme (WFP) or the Agricultural Market Information System (AMIS).Build the evidence base around chokepoint risk - including through the collection of data on real-time food trade and infrastructural capacity to aid in assessing risks to food supply chains.Further ReadingRead more about chokepoints in global food trade at resourcetrade.earthTake a closer look at chokepoints and food security threats in an interview with a report author and experts in related fieldsDiscover the 5 things you need to know about chokepointsExplore what the Qatar crisis tells us about food supply risk (in The New Arab) Department/project Energy, Environment and Resources Programme, Chokepoints and Vulnerabilities in Global Food Trade Full Article
bil Reversibility of 68Ga-FAPI-2 Trapping Might Prove an Asset for PET Quantitative Imaging By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Full Article
bil Conrad George and André Sheckleford | Incorrect layoff procedures can lead to future liability By jamaica-gleaner.com Published On :: Wed, 06 May 2020 00:14:20 -0500 OP-CONTRIBUTION: EMPLOYMENT CONTRACTS The COVID-19 pandemic is hitting businesses and the economy in a manner perhaps not seen since the Second World War. This, of course, has affected the ability of employers to pay their employees. The COVID-19... Full Article
bil LNG complicates light bill savings By jamaica-gleaner.com Published On :: Wed, 06 May 2020 00:05:38 -0500 THE SWITCH towards liquefied natural gas, LNG, as fuel to produce power supplies for Jamaica has a downside for electricity customers, who are largely missing out on the big oil savings. The near two-thirds plunge in oil prices will have limited... Full Article
bil Secrets and Spies: UK Intelligence Accountability By feedproxy.google.com Published On :: Fri, 07 Feb 2020 12:15:01 +0000 Members Event 5 March 2020 - 6:00pm to 7:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Abigail Watson, Research Manager, Oxford Research GroupDr Jamie Gaskarth, Reader in Foreign Policy and International Relations, University of Birmingham; Author, Secrets and Spies: UK Intelligence Accountability After Iraq and SnowdenJo Hare, Ethics CounsellorDr Claudia Hillebrand, Senior Lecturer in International Relations, Cardiff UniversityChair: Professor Sir David Omand GCB, Visiting Professor, King's College London; Security and Intelligence Coordinator, Cabinet Office, UK (2002-05); Director, GCHQ (1996-97) As an important global actor, the UK gathers intelligence material that helps inform decisions on issues such as nuclear proliferation, terrorism, transnational crime and breaches of international humanitarian law. On the flip side, the UK was a major contributor to intelligence failures leading up to the Iraq war in 2003.Using the UK as a case study and drawing on new research and interviews conducted by Dr Jamie Gaskarth, the panel will reflect on UK intelligence accountability in the context of 21st century politics. How can democratic governments hold intelligence and security agencies to account when what they do is largely secret? Should intelligence organizations create ethics committees allowing the public more input into intelligence decisions? And what has been the impact of technological and social changes, including the rise of artificial intelligence and social media, on the UK intelligence machinery?This event will be followed by a drinks reception.Secrets and Spies: UK Intelligence Accountability After Iraq and Snowden is part of the Chatham House Insights book series published jointly with the Brookings Institution Press. Secrets and Spies was the result of a project funded by the British Academy (SG151249). COVID-19This event is proceeding as scheduled, as are other Chatham House events, in accordance with the advice from the UK Government, Foreign and Commonwealth Office and Public Health England. However, we are closely monitoring the spread of COVID-19 and will send updates to attendees as the situation warrants. In the meantime, in line with the official advice for returning travellers or visitors to the UK from specified countries and areas (see guidance here), we ask that:If you have travelled from Category 1 countries/areas, you refrain from attending the event even if asymptomatic (i.e. even if you are showing no symptoms);If you have travelled from Category 2 countries/areas, you refrain from attending the event should you develop symptoms.If you fall under one of these affected categories and have any questions, please call +44 (0)207 314 3638 or email lbedford@chathamhouse.org. This event is open to Chatham House Corporate Members only. Not a member? Find out more.For further information on the different types of Chatham House events, visit Our Events Explained. Members Events Team Email Full Article
bil Covid-19: the challenge of patient rehabilitation after intensive care By feeds.bmj.com Published On :: Wednesday, May 6, 2020 - 12:36 Full Article
bil House Bills Would Largely Dismantle Asylum System at U.S.-Mexico Border By www.migrationpolicy.org Published On :: Thu, 14 Jun 2018 15:27:49 -0400 The House is set to vote on two bills that would largely dismantle the U.S. asylum system at the southern border by significantly narrowing grounds to apply for asylum, eliminating protections for the vast majority of unaccompanied minors, and unilaterally declaring Mexico a safe third country. The result would be a sharp reduction in the number of people permitted to seek humanitarian protection, as this commentary explains. Full Article
bil The Unintended Consequences for English Learners of Using the Four-Year Graduation Rate for School Accountability By www.migrationpolicy.org Published On :: Fri, 26 Apr 2019 10:37:37 -0400 High school graduation is a landmark event for students. It also plays an important role in the state accountability systems designed to ensure that schools provide all students a high-quality education. Yet relying on a school's four-year graduation rate for federal accountability purposes can have unintended consequences for English Learners, who may need extra time to graduate. Full Article
bil English Learners in Select States: Demographics, Outcomes, and State Accountability Policies By www.migrationpolicy.org Published On :: Tue, 28 Aug 2018 15:09:23 -0400 States are in the midst of designing new policies to hold schools accountable for the education of English Learner (EL) students, as mandated by the federal Every Student Succeeds Act (ESSA). This series of fact sheets sketches the characteristics of immigrant and EL students in 25 states, the gaps between their educational outcomes and those of their peers, and the accountability policies each state is developing. Full Article
bil No Retreat: Climate Change and Voluntary Immobility in the Pacific Islands By www.migrationpolicy.org Published On :: Mon, 11 Jun 2018 17:23:56 -0400 While media and academic discussions of "climate refugees" paint a picture of mass displacement of millions, in reality many communities vulnerable to climate change may choose to stay as a result of strong cultural, historical, and spiritual attachments to place. This article explores this "voluntary immobility" and its implications in the Pacific Islands. Full Article
bil Achieving Skill Mobility in the ASEAN Economic Community: Challenges, Opportunities, and Policy Implications By www.migrationpolicy.org Published On :: Thu, 11 Feb 2016 10:15:00 -0500 This report by MPI and the Asian Development Bank lays out a realistic roadmap toward freer movement among skilled professionals within the ASEAN Economic Community (AEC), encouraging cooperation among ASEAN Member States in recognizing foreign qualifications and making government investments in training and educations systems that prepare workers in accordance with common standards. Full Article
bil Intellectual Disability in KATP Channel Neonatal Diabetes By care.diabetesjournals.org Published On :: 2020-02-20T11:55:29-08:00 OBJECTIVE Neonatal diabetes has been shown to be associated with high neuropsychiatric morbidity in a genotype-phenotype–dependent manner. However, the specific impact of different mutations on intellectual functioning is still insufficiently characterized. Specifically, only a small number of subjects with developmental delay have been comprehensively assessed, creating a knowledge gap about patients carrying the heaviest burden. RESEARCH DESIGN AND METHODS We assessed the intellectual functioning and mental health of the complete Norwegian population with KATP channel neonatal diabetes. Eight sulfonylurea-treated children (five with the p.V59M genotype [KCNJ11]) were assessed using age-matched control subjects with type 1 diabetes. The investigations included a physical and motor developmental examination, cerebral MRI, psychometrical examination, and questionnaires assessing intellectual capabilities and psychiatric morbidity. RESULTS A strong genotype-phenotype correlation was found, revealing the p.V59M genotype as highly associated with substantial intellectual disability, with no significant correlation with the time of sulfonylurea initiation. Consistent with previous studies, other genotypes were associated with minor cognitive impairment. Cerebral MRI verified normal brain anatomy in all but one child. CONCLUSIONS We here presented a comprehensive assessment of intellectual functioning in the largest cohort of p.V59M subjects to date. The level of intellectual disability revealed not only changes the interpretation of other psychological measures but downplays a strong protective effect of sulfonylurea. Within the scope of this study, we could not find evidence supporting an early treatment start to be beneficial, although a weaker effect cannot be ruled out. Full Article
bil Glucosamine Use, Inflammation, and Genetic Susceptibility, and Incidence of Type 2 Diabetes: A Prospective Study in UK Biobank By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Glucosamine is a widely used supplement typically taken for osteoarthritis and joint pain. Emerging evidence suggests potential links of glucosamine with glucose metabolism, inflammation, and cardiometabolic risk. We prospectively analyzed the association of habitual glucosamine use with risk of type 2 diabetes (T2D) and assessed whether genetic susceptibility and inflammation status might modify the association. RESEARCH DESIGN AND METHODS This study analyzed 404,508 participants from the UK Biobank who were free of diabetes, cancer, or cardiovascular disease at baseline and completed the questionnaire on supplement use. Cox proportional hazards models were used to evaluate the association between habitual use of glucosamine and risk of incident T2D. RESULTS During a median of 8.1 years of follow-up, 7,228 incident cases of T2D were documented. Glucosamine use was associated with a significantly lower risk of T2D (hazard ratio 0.83, 95% CI 0.78–0.89) after adjustment for age, sex, BMI, race, center, Townsend deprivation index, lifestyle factors, history of disease, and other supplement use. This inverse association was more pronounced in participants with a higher blood level of baseline C-reactive protein than in those with a lower level of this inflammation marker (P-interaction = 0.02). A genetic risk score for T2D did not modify this association (P-interaction = 0.99). CONCLUSIONS Our findings indicate that glucosamine use is associated with a lower risk of incident T2D. Full Article
bil Michigan coach Jim Harbaugh proposes major changes to NFL Draft eligibility rules By www.upi.com Published On :: Thu, 07 May 2020 19:41:19 -0400 Michigan coach Jim Harbaugh is urging the NFL and NCAA to amend their rules and provide flexibility to college football players who consider making the jump to the next level. Full Article
bil Planet already seeing temps beyond human tolerability By www.upi.com Published On :: Sat, 09 May 2020 04:42:06 -0400 Researchers have predicted that if climate change goes unabated, the planet will experience intolerable heat in several decades. But a new study has found that in certain global hot spots, it's already happening. Full Article
bil Feasibility of Outpatient Fully Integrated Closed-Loop Control: First studies of wearable artificial pancreas By care.diabetesjournals.org Published On :: 2013-07-01 Boris P. KovatchevJul 1, 2013; 36:1851-1858Diabetes Care Symposium Full Article
bil Long-Acting Glucagon-Like Peptide 1 Receptor Agonists: A review of their efficacy and tolerability By care.diabetesjournals.org Published On :: 2011-05-01 Alan J. GarberMay 1, 2011; 34:S279-S284Diabetes Treatments Full Article
bil Respective Contributions of Glycemic Variability and Mean Daily Glucose as Predictors of Hypoglycemia in Type 1 Diabetes: Are They Equivalent? By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate the respective contributions of short-term glycemic variability and mean daily glucose (MDG) concentration to the risk of hypoglycemia in type 1 diabetes. RESEARCH DESIGN AND METHODS People with type 1 diabetes (n = 100) investigated at the University Hospital of Montpellier (France) underwent continuous glucose monitoring (CGM) on two consecutive days, providing a total of 200 24-h glycemic profiles. The following parameters were computed: MDG concentration, within-day glycemic variability (coefficient of variation for glucose [%CV]), and risk of hypoglycemia (presented as the percentage of time spent below three glycemic thresholds: 3.9, 3.45, and 3.0 mmol/L). RESULTS MDG was significantly higher, and %CV significantly lower (both P < 0.001), when comparing the 24-h glycemic profiles according to whether no time or a certain duration of time was spent below the thresholds. Univariate regression analyses showed that MDG and %CV were the two explanatory variables that entered the model with the outcome variable (time spent below the thresholds). The classification and regression tree procedure indicated that the predominant predictor for hypoglycemia was %CV when the threshold was 3.0 mmol/L. In people with mean glucose ≤7.8 mmol/L, the time spent below 3.0 mmol/L was shortest (P < 0.001) when %CV was below 34%. CONCLUSIONS In type 1 diabetes, short-term glycemic variability relative to mean glucose (i.e., %CV) explains more hypoglycemia than does mean glucose alone when the glucose threshold is 3.0 mmol/L. Minimizing the risk of hypoglycemia requires a %CV below 34%. Full Article
bil As COVID-19 Slows Human Mobility, Can the Global Compact for Migration Meet the Test for a Changed Era? By www.migrationpolicy.org Published On :: Mon, 27 Apr 2020 16:05:08 -0400 The coronavirus pandemic dramatically reshaped how human mobility is managed just as the Global Compact for Safe, Orderly, and Regular Migration was beginning to move from paper to implementation. As governments face pressing public-health, economic, and other concerns in responding to COVID-19, this MPI Europe commentary explores whether the first comprehensive global agreement on migration can adjust to a changed reality. Full Article
bil PBHS adds mobile chairside patient education system to ADA TV By www.ada.org Published On :: Mon, 10 Feb 2020 09:21:00 -0600 PBHS, Inc. announced in January the launch of Consult Mode, an addition to ADA TV that enables dental providers to demonstrate 3D procedural animations, videos and tutorials chairside via tablets, iPads and other hand-held devices. Full Article
bil ADA comments on surprise billing By www.ada.org Published On :: Thu, 13 Feb 2020 11:36:00 -0600 The American Dental Association is weighing in on two pieces of legislation aimed at streamlining billing procedures for patients. Full Article
bil Vaping bill passes House By www.ada.org Published On :: Mon, 02 Mar 2020 16:37:00 -0600 The U.S. House of Representatives Feb. 28 passed a comprehensive bill designed to address the youth tobacco epidemic. Full Article
bil ADA begins to address coding, billing procedures during COVID-19 outbreak By www.ada.org Published On :: Thu, 19 Mar 2020 16:52:00 -0500 The ADA is releasing a guide intended to help dental offices navigate issues related to coding and billing for virtual check-ins in the midst of the COVID-19 outbreak. Full Article
bil ADA urges third-party payers to adapt coding, billing procedures to help patients recover By www.ada.org Published On :: Thu, 09 Apr 2020 16:51:00 -0500 The American Dental Association sent a letter to third-party payers urging that administrators of dental benefit plans adjust and adapt reimbursement procedures important to dentists and patients — including coverage for temporary procedures and adjusting fee schedules to account for cost of increasing infection control procedures ¬— in the midst of the “unprecedented and extraordinary circumstances dentists and their patients face” during the pandemic. Full Article
bil Organized dentistry asks Congress for flexibility in Paycheck Protection Program loans By www.ada.org Published On :: Wed, 06 May 2020 15:46:00 -0500 The Organized Dentistry Coalition is asking Congress for flexibility in the Paycheck Protection Program to allow dentists to purchase personal protective equipment as states begin the reopening phase of the COVID-19 pandemic. Full Article
bil Prognostic Significance of Long-term HbA1c Variability for All-Cause Mortality in the ACCORD Trial By care.diabetesjournals.org Published On :: 2020-03-30T13:26:58-07:00 OBJECTIVEThe association between high glycemic variability and all-cause mortality has been widely investigated in epidemiological studies but rarely validated in glucose-lowering clinical trials. We aimed to identify the prognostic significance of visit-to-visit HbA1c variability in treated patients in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial population.RESEARCH DESIGN AND METHODSWe studied the risk of all-cause mortality in relation to long-term visit-to-visit HbA1c variability, expressed as coefficient of variation (CV), variability independent of the mean (VIM), and average real variability (ARV), from the 8th month to the transition. Multivariable Cox proportional hazards models were used to estimate adjusted hazard ratio (HR) and 95% CI.RESULTSCompared with the standard therapy group (n = 4,728), the intensive therapy group (n = 4,755) had significantly lower mean HbA1c (6.6% [49 mmol/mol] vs. 7.7% [61 mmol/mol], P < 0.0001) and lower CV, VIM, and ARV (P < 0.0001). In multivariate adjusted analysis, all three HbA1c variability indices were significantly associated with total mortality in all patients as well as in the standard- and intensive-therapy groups analyzed separately. The hazard ratios for a 1-SD increase in HbA1c variability indices for the all-cause mortality were 1.19 and 1.23 in intensive and standard therapy, respectively. Cross-tabulation analysis showed the third tertile of HbA1c mean and VIM had significantly higher all-cause mortality (HR 2.05; 95% CI, 1.17–3.61; P < 0.01) only in the intensive-therapy group.CONCLUSIONSLong-term visit-to-visit HbA1c variability was a strong predictor of all-cause mortality. HbA1c VIM combined with HbA1c mean conferred an increased risk for all-cause mortality in the intensive-therapy group. Full Article
bil Erratum. Randomized Controlled Trial of Mobile Closed-Loop Control. Diabetes Care 2020;43:607-615 By care.diabetesjournals.org Published On :: 2020-04-03T07:56:03-07:00 Full Article
bil Blood Pressure Variability and Risk of Heart Failure in ACCORD and the VADT By care.diabetesjournals.org Published On :: 2020-04-23T13:10:44-07:00 OBJECTIVEAlthough blood pressure variability is increasingly appreciated as a risk factor for cardiovascular disease, its relationship with heart failure (HF) is less clear. We examined the relationship between blood pressure variability and risk of HF in two cohorts of type 2 diabetes participating in trials of glucose and/or other risk factor management.RESEARCH DESIGN AND METHODSData were drawn from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial and the Veterans Affairs Diabetes Trial (VADT). Coefficient of variation (CV) and average real variability (ARV) were calculated for systolic (SBP) and diastolic blood pressure (DBP) along with maximum and cumulative mean SBP and DBP during both trials.RESULTSIn ACCORD, CV and ARV of SBP and DBP were associated with increased risk of HF, even after adjusting for other risk factors and mean blood pressure (e.g., CV-SBP: hazard ratio [HR] 1.15, P = 0.01; CV-DBP: HR 1.18, P = 0.003). In the VADT, DBP variability was associated with increased risk of HF (ARV-DBP: HR 1.16, P = 0.001; CV-DBP: HR 1.09, P = 0.04). Further, in ACCORD, those with progressively lower baseline blood pressure demonstrated a stepwise increase in risk of HF with higher CV-SBP, ARV-SBP, and CV-DBP. Effects of blood pressure variability were related to dips, not elevations, in blood pressure.CONCLUSIONSBlood pressure variability is associated with HF risk in individuals with type 2 diabetes, possibly a consequence of periods of ischemia during diastole. These results may have implications for optimizing blood pressure treatment strategies in those with type 2 diabetes. Full Article
bil Commercially Available Insulin Products Demonstrate Stability Throughout the Cold Supply Chain Across the U.S. By care.diabetesjournals.org Published On :: 2020-04-27T16:36:14-07:00 OBJECTIVEA recent publication questioned the integrity of insulin purchased from U.S. retail pharmacies. We sought to independently validate the method used, isotope dilution solid-phase extraction (SPE) liquid chromatography mass spectrometry (LC-MS), and expand analysis to two U.S. Pharmacopeia (USP) methods (high-performance LC with ultraviolet detection and LC-MS).RESEARCH DESIGN AND METHODSEach method was used to evaluate nine insulin formulations, purchased at four pharmacies, within five geographic locations in the U.S.RESULTSAll human and analog insulins measured by the USP methods (n = 174) contained the expected quantity of active insulin (100 ± 5 units/mL). When using isotope dilution SPE-LC-MS, units-per-milliliter values were well below product labeling due to unequal recovery of the internal standard compared with target insulin.CONCLUSIONSInsulin purchased from U.S. pharmacies is consistent with product labeling. Full Article
bil Early Metabolic Features of Genetic Liability to Type 2 Diabetes: Cohort Study With Repeated Metabolomics Across Early Life By care.diabetesjournals.org Published On :: 2020-04-28T14:58:19-07:00 OBJECTIVEType 2 diabetes develops for many years before diagnosis. We aimed to reveal early metabolic features characterizing liability to adult disease by examining genetic liability to adult type 2 diabetes in relation to metabolomic traits across early life.RESEARCH DESIGN AND METHODSUp to 4,761 offspring from the Avon Longitudinal Study of Parents and Children were studied. Linear models were used to examine effects of a genetic risk score (162 variants) for adult type 2 diabetes on 229 metabolomic traits (lipoprotein subclass–specific cholesterol and triglycerides, amino acids, glycoprotein acetyls, others) measured at age 8 years, 16 years, 18 years, and 25 years. Two-sample Mendelian randomization (MR) was also conducted using genome-wide association study data on metabolomic traits in an independent sample of 24,925 adults.RESULTSAt age 8 years, associations were most evident for type 2 diabetes liability (per SD-higher) with lower lipids in HDL subtypes (e.g., –0.03 SD, 95% CI –0.06, –0.003 for total lipids in very large HDL). At 16 years, associations were stronger with preglycemic traits, including citrate and with glycoprotein acetyls (0.05 SD, 95% CI 0.01, 0.08), and at 18 years, associations were stronger with branched chain amino acids. At 25 years, associations had strengthened with VLDL lipids and remained consistent with previously altered traits, including HDL lipids. Two-sample MR estimates among adults indicated persistent patterns of effect of disease liability.CONCLUSIONSOur results support perturbed HDL lipid metabolism as one of the earliest features of type 2 diabetes liability, alongside higher branched-chain amino acid and inflammatory levels. Several features are apparent in childhood as early as age 8 years, decades before the clinical onset of disease. Full Article
bil Instability of Insulin Aspart Diluted in Dextrose By care.diabetesjournals.org Published On :: 2020-05-07T12:33:01-07:00 Full Article
bil The Unpopular Realities of the Eligibility By schoolpsychologistfiles.blogspot.com Published On :: Wed, 13 Jan 2010 13:34:00 +0000 The eligibility criteria for special education services is black and white. (I'm not talking about the color of skin.) Either the student fits the criteria or does not fit the criteria. The committee comes together with all the test data and then reviews the criteria for each disability. Either the student is eligible or not. They meet the criteria or they do not meet the criteria. Sounds easy, right? The kids who obviously fit the criteria easily qualify for special education services. The kids who clearly do not fit criteria for special education do not qualify for special education services. It should just be that easy. Sometimes it is. I've been in the field long enough to see that eligibility is not always this magical process that determines special education from regular education. Sometimes eligibility decisions are a nightmare. What about all the gray kids that aren't clearly black or white?! For some kids, determining if they meet the criteria is tough. The black and white criteria makes it difficult to know what to do for the gray kids. The most difficult eligibility meetings are the ones where some members feel the student meets criteria and other members do not. These can lead to heated discussions. There are sometimes different ways to look at data and opinions of how to look at it may vary. Remember that the real issue the student who is cared about by school staff and especially parents which makes the decision emotional. It can be hard to be objective at times. It is not uncommon to hear "but they need it," even when the data does not support it.There are kids who qualify for special education services at one point, then are found ineligible at another time. Sometimes this happens because the student has made improvements and no longer requires special education services to be successful. Other times this happens because criteria has changed, the criteria is slightly different in a new different school system, or because test data is slightly different after a few years. In my opinion, this is when the system and criteria fails. I'd like to see ways to address the students who at one time fit the criteria, no longer fit criteria, but still require services.Why is the criteria so rigid? The main reason is because special education is funded by the government and they keep a tight reign on eligibility criteria. School staff is pressured by the administration, who is pressured by the State, who is pressured by the Federal government. There is a call for identification to be accurate to ensure that funds are properly spent. The only way the government can determine if the funds are being used appropriately is to enforce that schools are using clear criteria guidelines for identification. All that being said, I believe in the process (for the most part). However, it's created by humans meaning there will be errors. If I had a say, I'd make some changes. I do believe there needs to be criteria. No matter who sets the criteria there will always be those gray kids that are just right on the border of eligible or not eligible. The worst mistake that can be made in my opinion is telling a family that the child has a disability when in fact the child does not. The child grows up with the belief that he or she has a disabling condition, when that could have been prevented. Disability identification can be life changing for a person. That is why I believe we need criteria. A strong opinion by a teacher or parent that "she needs it" is not enough data for me to look a child and say they are struggling because of a disability. Want to learn more about the eligibility process?Eligibility Process FAQWhat every parent needs to know about the referral processIneligible for special education Full Article Special Education Assessment Special Education Eligibility struggling learner
bil Assessing Bilingual Individuals By schoolpsychologistfiles.blogspot.com Published On :: Thu, 14 Oct 2010 01:00:00 +0000 Two years into my position in a culturally diverse school system has taught me many things that I never would have learned in my previous position in a school system with much less diversity. I had hoped to be bilingual by now, but I’m not even close to that goal. However, I do have the training to conduct assessments with bilingual students. Thanks to Samuel Ortiz, Ph.D. for his workshops, research, and books that we use so much in our system. Thanks to the other Psychologists in my system for mentoring me and helping me learn this process. It has helped us to better identify which students have a disability and which students only look like they have a disability because of their performance on tests that are not standardized on children with different cultural and linguistic backgrounds. Learning a second language is not a disability. Just because a student is struggling academically, does not mean he should qualify for special education.What everyone involved in school needs to know:It takes many years for a person learning a language to develop academic use of language to the same level as monolingual individuals. It does not always seem that way when a person has excellent conversational skills in English. However, social use of language is not as sophisticated as academic use of language. Students can appear to be fluent, when in actuality the language and vocabulary is not on grade level. If a student’s comprehension and expression of language is below grade level, academics will naturally be below grade level as well. This is not the same as having a disabling condition.A child with good social use of language, but developing academic use of language often looks to teachers like a student with a disability, when in reality the student may be a typically developing second language learner. Special education is not the answer for this student; the answer comes through hard work, patience, and instruction through a high quality English as a Second Language Program. In the past (and currently in many systems) this child would be misidentified as a student with a disability and inappropriately put into special education programs.What Parents need to know:Traditional assessments are not standardized for use with culturally and linguistically diverse students, so typical interpretation of scores on these assessments are inappropriate. When school systems try to use these assessments in the traditional way and then apply the unreliable scores into eligibility criteria, it’s frankly scary.If you are a parent of an English Language learner, insist that a bilingual assessment be administered. I recognize that the irony of this statement is that many parents of bilingual students are not reading this blog as it is in English only. I don’t really have a good answer for that at this time.What Teachers need to know:If you are a teacher, recognize that academic language competency takes time and it requires additional assessment tools to tease out if the difficulties are primarily the result of language and cultural differences or if it is the result of a disability.What School Psychologists need to know:If you are a School Psychologist and not using the Cattell-Horn-Carroll Cross-Battery Assessment, I strongly encourage you to take a look. Here is an article from the National Association of School Psychologists Website by Samuel Ortiz, Ph.D. on resources for cultural competency. http://www.nasponline.org/resources/culturalcompetence/ortiz.pdf Advocate that all School Psychologists in your system be trained to administer bilingual assessments or at least have someone competent on hand for these assessments. You can’t hire a School Psychologist in every possible language you might need, so it only makes sense for all School Psychologists to be trained to assess all students. It takes more time to do the assessment, interpret data, and write a report and it requires the use of hiring an interpreter for portions of the assessment, but it is well worth the time and money to properly identify these students. If your school system does not see it this way, bring it up as a solution to disproportionality. Full Article Diversity Special Education Assessment
bil Differing DREAMs: Estimating the Unauthorized Populations That Could Benefit under Different Legalization Bills By www.migrationpolicy.org Published On :: Fri, 20 Oct 2017 13:10:45 -0400 2017 saw the introduction of several bills—two of them by Senate Republicans in the weeks following the Trump administration’s announcement that it would terminate the Deferred Action for Childhood Arrivals (DACA) program—that would provide a pathway to conditional and then legal permanent residence to unauthorized immigrants brought to the United States as children, if they meet a range of educational, professional, and other criteria. Full Article
bil Side-by-Side Comparison of 2013 Senate Immigration Bill with 2006 and 2007 Senate Legislation By www.migrationpolicy.org Published On :: Mon, 01 Apr 2013 00:00:00 -0400 This fact sheet compares key components of immigration reform outlined in the 2013 Senate immigration bill against provisions included in bills considered by the Senate in 2006 and 2007: border security, detention, and enforcement; worksite enforcement; visa reforms; earned legalization of unauthorized immigrants; strengthening the U.S. economy and workforce; and integration of new Americans. Full Article
bil Side-by-Side Comparison of 2013 Senate Immigration Bill with Individual 2013 House Bills By www.migrationpolicy.org Published On :: Thu, 01 Aug 2013 00:00:00 -0400 This fact sheet offers a detailed review of the comprehensive immigration reform legislation approved by the U.S. Senate in June 2013 and compares its major provisions with those of the five targeted immigration bills approved by the House Judiciary Committee and the House Homeland Security Committee. Full Article
bil Watch: Pete Davidson says Bill Hader recommended him for 'SNL' By www.upi.com Published On :: Fri, 08 May 2020 09:59:32 -0400 Pete Davidson discussed on "The Tonight Show" how Bill Hader helped him land a spot on "Saturday Night Live." Full Article
bil Brexit Day—Is This the Dawning of the Age of Immobility? By www.migrationpolicy.org Published On :: Mon, 27 Jan 2020 17:25:38 -0500 Brexit Day, on January 31, 2020, marks a dramatic turn for the United Kingdom as it leaves the European Union, in significant measure because it wants to control its immigration destiny. But it remains unclear whether Brexit will allow the United Kingdom to cast a net wider for the global workers it seeks or will deepen the moat around the island. Either way, Brexit is likely to spark new forms of mobility—and immobility. Full Article
bil Turning the Tide: Addressing the Long-Term Challenges of EU Mobility for Sending Countries By www.migrationpolicy.org Published On :: Thu, 21 Nov 2019 17:52:46 -0500 Amid ongoing debates about the costs and benefits of free movement, this MPI Europe webchat examines big-picture trends of East-West migration; considers possible policy responses at regional, national, and EU levels to alleviate some of the challenges; and reflects on realistic actions that could be taken under the incoming European Commission. Full Article
bil Under Lockdown Amid COVID-19 Pandemic, Europe Feels the Pinch from Slowed Intra-EU Labor Mobility By www.migrationpolicy.org Published On :: Fri, 01 May 2020 09:07:52 -0400 Border closures and lockdowns amid the COVID-19 pandemic have put a chill on intra-EU labor mobility, most immediately with the difficulty for European farmers to gain access to much-needed seasonal workers and for health-care institutions to get care workers. This article explores how these workers, who often face difficult situations, may be more vulnerable now. It also takes on implications for intra-EU labor mobility post-pandemic. Full Article
bil A Nod to Irresponsibility By www.washingtonpost.com Published On :: Mon, 14 May 2007 00:00:00 EDT Accountability is in the air in Washington. At one end of Pennsylvania Avenue, Paul Wolfowitz is struggling to save his job as president of the World Bank after getting caught arranging a sweetheart deal for his, well, sweetheart. A few blocks down the road, President Bush faces endless questions... Full Article Opinions A Nod to Irresponsibility
bil Legal Migration for Work and Training: Mobility Options to Europe for Those Not in Need of Protection By www.migrationpolicy.org Published On :: Fri, 18 Oct 2019 10:55:17 -0400 As EU Member States struggle to deliver on the European Union's call to expand channels for foreign workers, they should focus more on attracting the middle- and low-skilled third-country nationals needed by the labor market yet for whom few opportunities for admission exist. They also would do well to consider their migration policies in light of labor market, foreign policy, and development objectives, rather than as a means to reduce irregular migration, this report cautions. Full Article
bil MPI Analysis of All State ESSA Accountability Plans Finds Fractured Picture of Education Policy for English Learners & Differing Approaches By www.migrationpolicy.org Published On :: Tue, 11 Feb 2020 16:45:31 -0500 WASHINGTON – Four years since the Every Student Succeeds Act (ESSA) was signed into law, all 50 states, the District of Columbia and Puerto Rico have developed accountability plans that include blueprints for serving English Learners (ELs), as well as measuring these students’ progress and being accountable for their outcomes. This marked a significant development, as EL performance was previously not well integrated with factors that determined whether a school was performing well or poorly. Full Article
bil Understanding Which English Learners Are Counted on School Accountability Measures—and When By www.migrationpolicy.org Published On :: Thu, 12 Mar 2020 11:24:03 -0400 WASHINGTON – The federal Every Student Succeeds Act of 2015 (ESSA) requires states to publicly report annual performance and graduation rates for students in a range of areas, breaking out results for subgroups with unique characteristics, including English Learners (ELs). The objective is to help schools identify and close achievement gaps experienced by historically underserved groups of students. Full Article