Shelves went tumbling down at Walmart.

Shelvin Mack made six of his seven 3s in the second half and scored 25 points, leading the No. 5 seeded Bulldogs over No. 12 Texas-El Paso

Rock band Fleetwood Mac will perform this fall at Bankers Life Fieldhouse.

The Indiana congressional delegation introduced a House resolution expressing support for the goals and ideas of ''Stomach Cancer Awareness Month."

Cape Maclear (aka Chembe) is a small fishing village on Lake Nyasa (Lake Malawi) in Malawi. It has one dirt road leading into (and straight out of) town. Along this road, there are a few hostels, some dive shops, a handful of vendors selling curios and fruit and a few bars. The pace of life here is . . . very . . . slow.

When the Chargers legend isn't carrying a team on his back, Rivers has been far more efficient.

Yunanistan güvenlik güçlerinin, gözaltına aldıkları sığınmacıları Türkiye sınırına doğru sürdükleri ve Meriç nehrinden Türkiye'ye geçmeye zorladıkları iddia edildi.

A show billed as "The Adventures of Kesha and Macklemore" resembles a summer popcorn movie at Ruoff Home Mortgage Music Center.

Rock band Fleetwood Mac will perform this fall at Bankers Life Fieldhouse.

40 restaurants in all fill the small, Downtown Indianapolis neighborhood

Rock band Fleetwood Mac will perform this fall at Bankers Life Fieldhouse.

An overview of Macau, including key facts, political leaders and notes on the media

A chronology of key events

Key facts, figures and dates

The author of the new book “Making Comics” has a plan for her grant windfall: the study of the “split” in the human brain between writing and drawing.

Mack carried the ball 19 times for 126 yards and a touchdown and added two catches for 33 yards and a touchdown on Sunday against the Bills.

Harper has had one spectacular season — earning him a unanimous MVP award in 2015 — surrounded by some very good but not great years. Machado, on the other hand, projects more favorably and doesn't carry a significant liability.

The reality TV star wrote that she and her husband, real estate developer Michael Darby, are "savoring every moment."

Apple has released the third beta versions of iOS 13.5, iPadOS 13.5, and MacOS Catalina 10.15.5. Separately, watchOS 6.2.5 beta 3 and tvOS 13.4.5 beta 3 are also available for testing. The third beta versions of iOS 13.5 and iPadOS 13.5 are actually reversioned from iOS 13.4.5 and iPadOS 13.4.5, so if you were testing ... Read More

Want to use iCloud Photos on Mac? In its simplest form iCloud Photos is a sync service that makes sure your iPhone, iPad, Apple Watch, Apple TV, and Mac all have every photo you’ve taken, all ready at a moment’s notice. That means you can access the photos from any other device with the feature ... Read More

How would you like to switch AirPods between iPhone, iPad, and Mac? Or what if you’d like to switch AirPods from iPhone to Apple Watch or even Apple TV? If you have a pair of AirPods and multiple Apple devices, you can easily switch AirPods and AirPods Pro between any of your other Apple products, ... Read More

MacOS Catalina introduced a handy way to tile windows for multitasking, improving upon the split screen multitasking features that were available in previous MacOS releases. These new simple tiling window multitasking options are available from any window, and now you can easily choose to tile a window to the left or right side of the ... Read More

If you’re looking to make a career move from programmer to AI specialist, this is the ideal place to start. Based on Laurence Moroney's extremely successful AI courses, this introductory book provides a hands-on, code-first approach to help you build confidence while you learn key topics.You’ll understand how to implement the most common scenarios in machine learning, such as computer vision, natural language processing (NLP), and sequence modeling for web, mobile, cloud, and embedded runtimes.

If you’re training a machine learning model but aren’t sure how to put it into production, this book will get you there. Kubeflow provides a collection of cloud native tools for different stages of a model’s lifecycle, from data exploration, feature preparation, and model training to model serving. This guide helps data scientists build production-grade machine learning implementations with Kubeflow and shows data engineers how to make models scalable and reliable.

Theme Cruise to Panama (Shakespeare at Sea / MacMania)

Hear about travel to Macedonia as the Amateur Traveler talks to Kelsey of CineTraveler.com about her recent trip to this country in the Balkans. Macedonia is just north of Greece and probably best known as the home for Alexander the Great but Kelsey found much more to recommend in this much too overlooked country. In a week they were able to see much of the country.

Hear about travel to Michigan's Upper Peninsula (the UP)  as the Amateur Traveler talks to Jennifer Schuitema from Grand Rapids Michigan about travel to the northern remote part of the Great Lake State.

Ironic toxic masculinity is in fashion! The Duke Cannon Naval Supremacy Big Brick of Bar Soap for Men [Amazon] promises that those thusly-soaped will smell of "naval supremacy", "productivity" or other humorously-abstract scents. (More traditionally "manly" odors such as tobacco, leather, burned vegetation, etc. are also available).

The veil of humor is threadbare -- "get clean and smell good without using feminine shower gels and accessories" -- but I'll admit that I do bathe in warm turpentine and it really helps.

Are you ready for images of the best “soap but for MEN” product you’ve ever seen? pic.twitter.com/kVAWb57UlF

— Shayna Moon, Unity Lich (@qorquiq) May 8, 2020

UPDATE: Here's a balding treatment called "Lethal Uprising", spotted by Greg Sideyr.

I'll see your Naval Supremacy, and raise you pic.twitter.com/UJE9wxeRvp

— ????Greg | Applied Eschatology ???? (@Greg_Sideyr) May 8, 2020

Looking forward to Internecine Violence Toothpaste, Shambolic Venezeulan Coup Ice Cream, and Silently Endure Prison Abuse Hemmorhoid Cream with Aloe Vera. Read the rest

William Bao Bean, managing director of Chinaccelerator, explains how investments in artificial intelligence and machine learning are helping marketers improve user targeting and return on investment.

So you've decided to hike Machu Picchu? Well great! There's no doubt that you're in for the experience of a lifetime. However, the truth of the matter is that now you've got some additional decisions to make. You see, there's more than one route to arrive to the world-famous Inca site, and even once you've arrived there are a few choices to make as well.

But don't fret! If you're looking to hike Machu Picchu, we've got the information you need to start planning your trip.

Hike Machu Picchu: Arriving to the Site

1. Classic Inca Trail

The Classic Inca Trail is a four-day trek stretching some 42 kilometers along an ancient road built by the Incas themselves. This is undoubtedly the most famous route to Machu Picchu, and it's the one way that offers the opportunity to enter the city through its storied Sun Gate. Frankly, we've got tons of information on the Inca Trail on other pages of our site, so we won't waste too much space being redundant here. Check out these pages for more information on the trail's itinerary as well as for access to an Inca Trail map.

2. One-Day Inca Trail

Whether you're crunched for time or simply don't feel physically up to four full days of trekking, don't fret--a small taste of the world-famous Inca Trail is still available to you! A number of tour companies offer an abridged version of the trek, either one full day of hiking or a shortened day followed by a night of camping and a dawn arrival at Machu Picchu. Besides the Inca Trail's famed destination, the one-day version of the trek also takes you past Wiñay Wayna, another favorite ruins along the trail. The bad news here is that you'll still need to reserve one of only a few hundred daily Inca Trail passes, meaning that, just like the full Inca Trail, you'll need to book this trek months in advance.

3. Lares Trail

Just north of the world-famous Sacred Valley sits the comparatively lesser-known Lares Valley, and whereas the former can be swarmed with tourists especially during the high season, life in the Lares Valley continues humming along relatively unchanged. So whether you're looking for a simpler, more culturally-immersive experience or if you just didn't book an Inca Trail pass in time, the Lares Trail is an excellent option! Lucky for you, we've already gathered plenty of information on the Lares Trail including the trek's daily itinerary and a side-by-side comparison of the Lares and Inca Trails if you're struggling to decide how to hike Machu Picchu.

4. Vilcabamba Traverse Route

Warning--this option is neither for the faint of heart nor the out of shape! The Vilcabamba Traverse Route is one of the newest on the Peru trekking circuit, clocking in at nearly 100 kilometers over the course of a week of trekking. Though very difficult, the route is especially rewarding--think a variety of diverse biomes and the ruins of Choquequirao, often compared to Machu Picchu although less than 40% of the site has been excavated (pictured above). Though visited by only 5,000 or so brave trekkers last year, be warned--the local government is pushing a plan to build a cable car to the site! If you want to see the ruins in their current, undisturbed state, it would be best to go sooner than later.

Hike Machu Picchu: Once You're There

5. Huayna Picchu

Just because you've finally arrived at Machu Picchu doesn't mean your hiking experience has to end! The famous mountain soaring in the background of most iconic Machu Picchu photos is possible to hike, and the experience is certainly recommended. The views from the top are great, and on the way down you can even take a back route to the storied Temple of the Moon. For more information on Huayna Picchu, you can check out this past post on our site.

So that's it for today! If you're planning to hike Machu Picchu and have any questions you'd like to ask us, feel free to reach out in the comments section below. And, if you've already done one of these hikes, feel free to share your experience as well. We appreciate all of your comments!

Machu Picchu, Peru

Although it's one of the most well-known archaeological wonders of the world, Machu Picchu still holds plenty of secrets and is on our shortlist of must-see destinations on a Peru trip.

Add picture with a caption showing actual clients with names linking to review.

Machu Picchu is an enigma, some would say a paradox because it is known as both the best known yet least known about of the Inca sites. Since its discovery on July 24, 1911, by North American Hiram Bingham, Machu Picchu has been considered one of the world's greatest architectural and archaeological monuments, due to its extraordinary magnificence and harmonious structure. Machu Picchu is definitely one of the most fascinating sites in Peru.

At 2,400 meters above sea level, in the province of Urubamba, department of Cusco, Machu Picchu surprises us because of the way its stone constructions are spread over a narrow and uneven mountain top, bordering a sheer 400 meter cliff side of the Urubamba River canyon.

Why and how was Machu Picchu built?

Machu Picchu is a citadel shrouded in mystery, and to this day archaeologists have not definitively uncovered the purpose of this city of stone. The site covers an area of about one square mile, and stands in a region that the Incas considered to be magical, due to the meeting of the Andes mountains with the mighty Amazon river. When 135 bodies were discovered while exploring the site, 109 of which were female, some believed that Machu Picchu could have been a monastery where acllas (young girls) were trained to serve the Inca and the Willac Uno (High Priest). Others said it may simply have been an advance settlement for further expansions planned by the Incas. Perhaps the mystery may never be fully explained.

The surprising perfection and beauty of Machu Picchu's walls, built by joining stone to stone without using any cement or adhesive whatsoever, has led to many theories developing around how the city was constructed as well. It is said that a bird by the name of Kak'aqllu knew the formula for softening rock but by command, perhaps by the ancient Inca gods, had its tongue torn out. Others say there was a magic plant that could dissolve and compress stone. Nonetheless, mysteries and myths aside, the obvious wisdom and skill of the city's ancient builders -- evidenced by Machu Picchu's many squares, aqueducts, watchtowers, observatories and its sun clock -- is quite clear.

Many people may be drawn to Peru by Machu Picchu, yet it is considered by many of our guests, to be just one of many of the ruins featuring on the "highlights reel"of their trip. See reviews to read more

How to get to Machu Picchu - One day or multi day trails

You can take a one day trip to Peru from Cuzco or Lima, and walk up to this citadel in the clouds high in the Andes, or you can take some time to get acclimatised and trek via several trails that lead to Machu Picchu, most taking around 4 to 5 days to complete. Alot of people begin their Peru trip with the intent of visiting Machu Picchu, but don't know how much more there is to see and do in and around Machu Picchu.

After all, if you are going to Peru to experience a South American trip of a lifetime, why not learn about all the activities and other ruins there are to discover.

Popular activities on our Peru trips (including Machu Picchu):

1. Hiking the Lares or Classic Inca Trail
2. Exploring Machu Picchu - facts about Machu Picchu
3. Hiking in the Amazon jungle
4. Sea kayaking on Lake Titicaca
5. Staying with a local family on Amantani Island
6. Hiking Sacsayhuamán fortress
7. Hiking and cycle in the Sacred Valley of the Incas
8. Exploring Cuzco
9. Cycling through Andean villages and La Raya Pass
10. Hiking Amantani and Taquile Islands

[link to above pages Will]

You may be surprised at the number of activities you can do in Peru, in fact it's a surprise to alot of people that it is possible to enjoy these "non Machu Picchu focused" activities at all. Our philosophy is a little different to many tour companies, we believe that if you are going to travel all the way to a new country to experience a whole new culture, why not experience as many perspectives, local cultures and ruins as you can while you are there.

Obviously the most popular trail chosen by visitors wanting to visit Machu Picchu is the Inca Trail. Some people prefer the Lares trail because it offers a much more immersive experience in Peruvian village culture. If you wants to experience some of the traditions and village life the early Inca's enjoyed, you can stay with their descendants in one of the many villages along the Lares Trail.

If you want to hike the traditional route,  take a sneak peak below at some of what the Inca Trail has to offer.

Hike to Machu Picchu on the ancient Inca Trail

The Inca Trail between the Sacred Valley of the Urubamba River and the mysterious abandoned citadel of Machu Picchu is one of the world's classic treks. Climbing out of the river valley, crossing rugged mountain passes over 13,000 ft high, the trail winds through the Andes, passing numerous significant Inca ruins en route before descending through the Sun Gate to the silent stone city of Machu Picchu. To hike the Inca Trail is a thrilling experience and a great privilege. You need a permit from the Peruvian government to set foot on it, and there are strict limits on the number of permits issued each year.

But the Inca Trail is much more than a great hike. It is one small portion of an incredible network of such trails crossing high mountain ranges, bleak deserts, and raging Andean rivers, tying the Inca Empire together. At its peak expansion, Tahuantinsuyo (or The Four Corners as the empire was known) extended from what is now southern Colombia in the north, to central Chile in the south, covering a distance of about 5500 km (3400 mi). To rule such a vast domain, the emperor, or Inca, forged a remarkable communications system of approximately 18,600 miles of trails, paved through much of its length, stepped where need be, through tunnels where necessary, and using gossamer suspension bridges built of straw ropes to cross rivers unfordable in the wet season.

The roads served to move the conquering Inca armies, and were generally wide enough for a minimum of two warriors to travel abreast. A system of runners stationed at rest houses known as tambos sped messages along the roadways, much like the Pony Express mail of the old American West. The Inca, at his empire's capital in Cuzco, could receive news from far away Quito as rapidly as a letter crosses between the two cities in today's mail.

As remarkable as this highway system was in the days when it was built, used and maintained, it is an astounding testimony to its construction that so many segments remain serviceable today, after half a millennium of neglect. Clearly the Inca highway system ranks as one of the greatest engineering achievements of pre-industrial man.

The full Inca Trail is approximately 40km long. Spread over 4 days, this amounts to about five hours walking per day, although you can walk at your own pace - you are not forced to walk with your group the whole time. It is not a difficult walk, although there are a couple of high passes, and a steep climb on the second day, so a basic level of fitness is required.

Alternative Routes To Get To Machu Picchu other than the Inca Trail (link to another page how to get to machu picchu)

Lares Trail (link)

Inca Trail (link)

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History of Machu Picchu

Archaeological evidence uncovered around the site suggests that the area was first used for agricultural purposes back in 760 B.C.

The war of Vilcambamba Pachacutec in 1440 established the first settlement at the site. It was called the Tahuantinsuyo Empire which was later followed by the formation of the government of Manco Capac.

It is thought that Machu Picchu was first inhabited by 300-1000 inhabitants, who were of the highest Class or "llactas".

The valleys around these areas were important for their agricultural contribution, however after death of the Emperor Pachacutec, it lost it's importance, with the establishment of new sites like Ollaytantambo and Vilcambamba. The building of these new sites by his successors, in more accessible terrain made Machu Picchu less appealing.

From 1527 to 1532, two brothers Huáscar and Atahualpa fought against each other in a civil war over the Inca Empire. Their father, Inca Huayna Capac had given each brother a section of the empire to manage, one in Huáscar in Cuzco and Atahualpa in Quito. When Huayna Capac and his heir, Ninan Cuyuchi, died somewhere between 1525 and 1527, the two brothers Atahualpa and Huáscar went to war over who should rule.  The population who had come to live in the Machu Picchu area from rural or remote locations left after the war ended to return to where they came from. Later another brother, Manco Inca was sent into exile in Vilcambamba, and Machu Picchu was deserted.

Antonio Raimondi was an Italian geographer and scientist from Milan who visited Machu Picchu in 1851. In 1867 Augusto Berns arrived to mine the site.

Hiram Bingham re-discovered the ruins in 1911. He documented and publicised his "discovery".

Hiram Bingham

17 June 2019

5 December 2019

12 March 2015 , Volume 91, Number 2

Yves André
J. Amer. Math. Soc. 33 (2020), 363-380.
Abstract, references and article information

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

7 May 2020 , Volume 96, Number 3

Saverio Cinti
Nov 1, 2005; 46:2347-2355
Research Articles

7 May 2020 , Volume 96, Number 3