Deaths from cardiovascular disease have surged among adults ages 25 to 64 living in rural areas, a new study shows.

IBM and NASA have developed a new AI foundation model for a wide range of climate and weather applications, with contributions from the Department of Energy’s Oak Ridge National Laboratory. […]

The post IBM and NASA Launch Open-Source AI Model for Advanced Climate and Weather Research appeared first on HPCwire.

It’s a wrap! The Texas Advanced Computing Center (TACC) at UT Austin welcomed more than 100 participants for the 7th annual TACC Symposium for Texas Researchers (TACCSTER). The event exists […]

The post Research Insights, HPC Expertise, Meaningful Collaborations Abound at TACCSTER 2024 appeared first on HPCwire.

March 20, 2024 — The Pawsey Supercomputing Research Centre invites Australian-based research groups to join the Pawsey Uptake Project call. This initiative will provide teams with access to dedicated Pawsey […]

The post Pawsey Invites Australian Researchers to Advance Scientific Innovation Through the Pawsey Uptake Project appeared first on HPCwire.

MILAN, Nov. 6, 2024 — ENEA, Italy’s National Agency for New Technologies, Energy and Sustainable Economic Development, has selected Lenovo for the installation of an HPC system at the Portici […]

The post ENEA Chooses Lenovo for Supercomputer to Accelerate Sustainable Energy Research appeared first on HPCwire.

An additional five rhesus macaque monkeys that escaped from a South Carolina research facility last week have been recovered, meaning about a dozen of the rhesus macaque primates remain at large.

Background: Faced with the limits of synthetic antipyretic substances, in particular their involvement in the occurrence of numerous and often serious adverse effects; the challenge is in search of new antipyretics especially from the African traditional pharmacopoeia. The objective of this study was to evaluate the antipyretic activity of an aqueous extract and a formulation of Ceiba pentandra, with a view to designing an herbal antipyretic drug. Methods: Trials of formulation of an antipyretic syrup with leaves extract of Ceiba pentandra were carried out. The antipyretic activity was investigated by the bewer's yeast induced pyrexia. Physicochemical and microbiological stability tests were carried out on the syrup. Results: It was found with the extract an antipyretic activity at doses of 125 mg/kg and 150 mg/kg. The effect was greater for the 125 mg/kg dose with inhibition percentages ranging from 27.58% to 71.25%. This antipyretic activity was early (from 30 minutes) and was preserved during the four hours of the experiment. The syrup dosed at 125 mg/kg gave an activity similar to that of the extract by significantly reducing the hyperthermia in the rats. Regarding the stability tests, the syrup remained stable both physico-chemically and microbiologically throughout the study period (28 days) both when exposed to low temperature (5 °±3 ° C) and at high temperature (40°±2° C). Conclusions: Ceiba pentandra leaves have antipyretic activity and could be used for the development of an herbal antipyretic drug.

A new HBO Max teaser offers a glimpse of the upcoming shows viewers can look forward to in the next year.

Netflix's hit docuseries "America's Sweethearts: Dallas Cowboys Cheerleaders" will return for a second season in 2025.

Popular Prime Video series "Harlem" will return for a third season on Jan. 23.

Peacock anounced four more guest stars for "Poker Face" Season 2 on Tuesday, though no premiere date yet.

Chip-maker Nvidia on Friday briefly became the world's most valuable company after surpassing Apple in total market value, but Apple regained its top position by the close of trading.

NASA engineers fired the engines on the X-59 research aircraft in advance of planned test flights to determine if the aircraft can reduce sonic booms and make supersonic flight over land quieter.

TED Fellow and equity bioengineer Erika Moore investigates how cells controlling inflammation behave differently depending on a patient's background. By focusing on the "who" behind the disease, Moore is uncovering why certain diseases disproportionately affect certain ethnicities, paving the way for more inclusive and effective health care.

A new report from NPR publishes a letter from The Hartford describing data they gave to Dan Ariely as having been fraudulently manipulated in a paper based on that data.

The post Honesty Research May Be… Dishonest appeared first on Neuromarketing.

Yale scientists used brain imaging to compare face-to-face meetings with virtual sessions.

The post Your Brain on Zoom Calls: New Research appeared first on Neuromarketing.

After a summer of protests over racial injustice, school districts are embracing anti-bias programs. The problem is: Few studies show they work.

Thousands of teachers will head to the state capital on Wednesday to call for a nearly $10,000 raise over four years and an increase to per-pupil spending.

Previous studies can provide a window into why math learning is taking a big hit during the pandemic, and what educators can do about it.

"I'm running because I'm not happy with the state of education," said veteran educator Kevin Leineweber, who is one of several teachers running for the state's legislature this year.

The search for Missouri's next top education official has begun nearly 10 months after the last one was fired. The state board of education began accepting applications last week.

Many are whipsawed by shutdown recommendations aimed at stemming the coronavirus, and the logistical and financial consequences of those actions.

The 30-year-old had only played 13 games this season.

Penn State is on the verge of doing something that it hasn’t done in more than 40 years. The Nittany Lions can post three straight straight 10-win seasons for the first time since 1980-82 with its next two victories. It would be their sixth season with double-digit wins in nine years, the best such stretch since the program’s golden era from 1977-86. Yet some in the sellout crowd of 110,233 at ...

One more teacher was elected to state legislature in a closely contested race.

Tennessee Lady Vols basketball will open the 2025-26 season with a neutral-site matchup against NC State in Greensboro at First Horizon Coliseum

Lady Vols basketball relied on its best 3-point shooting night of the season to close out a win over Middle Tennessee State on Tuesday

Wen Grace Chen
Nov 9, 2022; 42:8498-8507
Symposium and Mini-Symposium

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Randy L. Buckner
Aug 24, 2005; 25:7709-7717
Neurobiology of Disease

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

A recent release on the “Ranking Web of Research Centers” site ranks FAO as fourth among 8000 global research institutions in 2016 for use of its online information. [...]

It’s a significant milestone – but what does the GFCM actually do? What has it achieved so far?

Since its creation, the GFCM has evolved into an efficient [...]

Chris Mah, researcher at the Smithsonian Institution's National Museum of Natural History in the invertebrate zoology department, describes the characteristics of different sea star species observed on the final dive of the Laulima O Ka Moana expedition. (Credit: Video courtesy of the NOAA Office of Ocean Exploration and Research, 2017 Laulima O Ka Moana)

Sara Seagers groundbreaking research ranges from the detection of exoplanet atmospheres to innovative theories about life on other worlds to development of novel space mission concepts. Dubbed an astronomical Indiana Jones, she is on a quest to discover a true Earth twin. A professor at MIT, she was named in Time magazines 25 Most Influential in Space.

Mineralogist Bob Hazen talks about what he loves about walking along the coast of the Chesapeake Bay, hunting for fossils and shark teeth hidden in the sand

Megan Leftwich, an engineering professor at George Washington University, is building a robotic flipper based on her observations of sea lions

Credit: Carlos Jaramillo, German Bayona and Edward Duarte, using Gplates and VideoPad by NCHsoftware

We're over here making podcasts, and you're over there listening. Let's bridge that gap! We want to know more about you, like: why you're listening, what your favorite topics are, and what Smithsonian magazine can do to make "There's More to That" even better. Tell us what you think at  smithsonianmag.com/podcastsurvey (https://www.smithsonianmag.com/podcastsurvey) .

See how researchers at Smithsonian's National Zoo are trying to glean insight into elephant foraging behavior and more.

After five people perished on a controversial submersible dive to the wreckage of the Titanic in June, we got to thinking about what genuine undersea exploration looks like. In this episode, we speak with Tony Perrottet, who profiled the late OceanGate CEO Stockton Rush for Smithsonian magazine in 2019, about our ancient fascination with exploring hostile environments. Then we’re joined by Susan Casey, who has written four best-selling books about the ocean and its creatures, the newest of which is The Underworld: Journeys to the Depths of the Ocean. Susan tells us why understanding the ocean is key to humanity’s survival, and how, while serious research and shipwreck tourism may have some overlap, they remain two very different things. Read Tony Perrottet’s June 2019 (https://www.smithsonianmag.com/innovation/worlds-first-deep-diving-submarine-plans-tourists-see-titanic-180972179/) Smithsonian (https://www.smithsonianmag.com/innovation/worlds-first-deep-diving-submarine-plans-tourists-see-titanic-180972179/) profile (https://www.smithsonianmag.com/innovation/worlds-first-deep-diving-submarine-plans-tourists-see-titanic-180972179/) of Stockton Rush. Learn more about Tony and his work at his site (http://tonyperrottet.com/) . Read an excerpt from Susan Casey’s new book, The Underworld: Journeys to the Depths of the Ocean (https://www.smithsonianmag.com/science-nature/inside-the-nerve-racking-dive-to-an-active-submarine-volcano-180982687/) . Learn more about Susan and her work at her site (https://susancasey.com/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Episode artwork by Emily Lankiewicz (contains elements by Madelgarius (https://commons.wikimedia.org/wiki/File:Titan_(mod%C3%A9lisation_sketchup_-_twilight_render_-_Gimp).jpg) , via Wikimedia Commons under CC BY-SA 4.0) Music by APM Music.

Used more for grasping than locomotion, seahorse tails are both flexible and uniquely strong. (Video courtesy Dominique Adriaens, UGent)

The 12,000 year old skeleton of a teenage girl was found in Hoyo Negro, an underwater cave system on the Yucatan Peninsula.

Credit: Leftwich Lab

Two lionfish in Papua New Guinea swim gracefully

Whether you're a passionate astronomer or a beginner eager to explore the cosmos, join us as we deep-dive into seasonal skywatching. Gain valuable insights into identifying meteors, stars, and fascinating deep-sky objects that grace the night sky. Interested in learning more? Check out this piece from Smithsonian Magazine on the celestial events to watch in 2024: https://www.smithsonianmag.com/science-nature/nine-dazzling-celestial-events-to-watch-in-2024-180983505/ And don't forget to subscribe to our channel for more exciting videos exploring the wonders of the natural world. --- Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald

The American Ingenuity Award winner is on the brink of using the human genome to provide better diagnostics for deadly diseases

Teeth are key to identifying elderly remains

A melting glacier caused a mountain in Greenland to collapse into a narrow fjord, setting off an oscillating wave that rattled seismic detectors around the world